CLINICAL TOXICOLOGY QUESTIONS PDF. Clinical toxicolgy dealt with the toxicity of the medicine in the human body once used at the higher dose . beside of clinical toxicology there are forensic toxicology that dealwith environment . toxicology is the wide course that has many field of applications.

1. CLINICAL
TOXICOLOGY
DISCUSSION QUESTIONS ABOUT
CLINICATOXICOLOGY
=MEMORISATION

2. GENERALITY OF CLINICAL TOXICOLOGY
1. What are the purposes of clinical toxicology
2. What are the Common causes of death in acute poisoned
patients
3. What should you do to the poisoned patient (approach)
4. With an example ,differentiate the clinical signs from vital
signs of poisoned patient.

3. What are the chemical are toxic target to the
following and set out the antidotes.
Organ
5. Liver
6. Lung
7. Brain
8. Kidney
9. heart
Target toxic chemical

4. GENERALITY OF CLINICAL TOXICOLOGY
10.What should you do while you are treating acute poisoned
patients
11.State the goals of clinical toxicology
12.What are the primary vital sign to maintain in the poisoned
patients
13.List and explain the methods should be applied in
prevention of absorption of poison in acute poisoned
patients.

5. Generality of clinical toxicology
14. When the emetic technique is contra indicated in the poisoned patient??
15. How the emesis technic is conducted to induce the absorption of poison
16. Explain how can you manage the treatment of patients with acute poisoning
slide 13
17. It is not necessary to use ipecac when the poison are excreted into bile in
active form , why ???.
18. Explain how can you manage the toxicity in the poisoned patient with long
time passed exposed to poison slide 24

6. Generality of clinical toxicology
19. Discuss the strategies could be applied in the treatment of
the poisoned patient
20. Explain why it is important to determine the real time of
poison exposure.
21. How the volume distribution of the poison can help you
in the intoxicated poisoned patients management.

7. Generality of clinical toxicology
23. Explain why it is important to know this
while conducting treatment of poison
24. Time of exposure
25. Volume of distribution

8. General overview
26.General approach of
poisoned patients,
discuss
Slide 32

11. Correspond the following
odor
1Bitter almond
2
3mothballs
4
5garlic
poison
•1
•2Hydrogen sulfide or mercaptans
•3
•4methylsalicylate
•Organophosphate,DMSO,Thall

12. Types of toxic syndrome, discuss
@4type of toxics
syndroms which are

13. The following are the signs of
anticholinergic toxic syndrome except
©Tachycardia
©Hypertension
©Myosis
©Hyperpyrexia
©Dry skin
©Delirium
©Presence of bowel sound
©Urinary retention

14. The following are sympathomimetic
toxic syndrome except
@Hyperpyrexia
@Mydriasis
@Hypotension
@Piloerection
@Diaphoresis
@Hypertension
@none

15. The following are the signs of
cholinergic toxic syndrome except
Lacrimation
Dry mouth
Urination
Constipation
Edema
Diaphoresis
Tachycardia
mydriasis

16. The following are the narcotic toxic
syndromes except
@Bradycardia
@Hypothermia
@Coma
@Absence of bowel sound
@Edema
@Mydriasis
@hypoventilation

17. Choose the syndrome correctly match with the case
®Narcotic toxic syndrome
®Cholinergic toxic syndrome
®Adrenergic toxic syndrome
®Muscarinic toxic syndrome

18. Difference between them
Hemoperfusion:
generally cleaning
the blood
Hemodialysis:
cleaning the blood
due to the renal
failure
Example of
supportive TX:
exposure to
oxy,increase mineral
What is antidote of
cardiotonic such
digoxin

19. Treatment type
@Discuss the general treatment from the
specific treatment of intoxicated patients
@The parameters that ae important in the
clinical laboratory intoxication treatment

20. answer
@Anion gap ( formular slide44)
@Arterial gas pressure
@Osmolar gap

21. Some importants formulae

23. Gastric lavage

24. @When does bowel irrigation is
contra indicated. Slide63
@Technique used in enhancing
poison elimination

25. Conducting hemodialysis
@What are the criteria of poison to
consider :
@when conducting hemodialysis
@When conducting Hemoperfusion

26. Complete by A(Hemodialysis and Hemoperfusion),
B(hemodialysis only), C(Hemoperfusion only)
@High water solubility
@Low volume of distribution
@High toxins affinity to adsorbant
@Low molecular weight
@Less water soluble
@Low protein binding
@High molecular weight

27. Complete by A(Hemodialysis and Hemoperfusion),
B(hemodialysis only), C(Hemoperfusion only) as suitable
techniques
@Alcohol
@Isonizied
@Theophylline
@Calcium
@Paraquat
@Amanita toxins
@Meprobamate
@phenobarbital

28. True or false , the following are accessed by
charcoal in detoxication
@Digoxin
@Theophyllline
@Iodine
@Dapsone
@Iron
@Potassium
®Alcohol
®Cyanide
®Sulfuric acid
®Sodium
hydroxide

29. Regarding the antidotes
The antidote are one of the most useful in the
management of poison in patient.
When the antidotes are expected to be used
What are the main types of specific antidotes are
available

30. Regarding the antidotes
poisons
1
2 imipramine
3 Paracetamol
4
5 morphine
6 digoxin
7 Physostigmine
8
antidotes
1 Ethanol
2
3
4 vitamin K
5
6
7
8 Vitamin B6

31. Regarding the antidote
POISONS
®1 Ethylene glycol
®2
®3
®4 Iron
®5
®6 lead
®7 methotrexate
®8.mercury
®9
®10 Acarbose
®11.valproate liver toxicity
ANTI-DOTES
©1.
©2 Hydroxycobalamin
©3 Sodium bicarbonate
©4
©5.Atropine
©6
©7
©8
©9Fomepazole
©10
©11

32. Regarding the decontamination
The following are most
commonly used in the GI
decontamination except
®Use of IPECAC syrup
®Gastric lavage
®Whole bowel irrigation
®Use of activated charcoal
®All are mostly used
The following are used in the
to enhance the toxins
elimination except
@Hemodialysis
@Purgation
@Hemoperfusion
@Diuresis
@Multiple activated charcoal dose
@None are correct
@All are considered

33. Regarding medical error in detoxification
@Discuss the challenges that appear in
treatment of intoxicated patients that almost
bring to the severity of intoxication and even
death of patients
@Answer slide 85

34. Ragarding the activated charcoal
@Why it is necessary to consider
the time of exposure before
starting the administration of the
charcoal
@Why the activated charcoal is
not effective to all poison for
detoxification
@What are the factor that
influence the efficacy of charcoal
in detoxification
®When does the multiple dose of
the activated charcoal are
commonly indicated . Answer slid
91
®Ration charcoal over toxins
®10:1 for optimum adsorption
®In which patient situation the
charcoal is contra indicated in the
treatment.

35. END OF PART ONE
M.
I.
N. Good luck
A. All the best
N. Success to u all
I. My wishes