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GIM Journal Club
Friday March 9th 2018
Dr. Don Redelmeier
Wasim Mansoor
Selection Criteria
Inclusion Exclusion
- Participants from USA, EU, Australia (2008 –
2016)
- Symptomatic atrial fibrillation
- Failure or intolerance to anti-arrhythmics
- LVEF ≤ 35%
- NYHA class ≥ II
- ICD/CRTD with Home Monitoring capabilities
implanted
- Previous left heart ablation procedure for AF
- Contraindication to chronic anticoagulation
therapy
- Documented left atrial diameter >6 cm
- ACS or CVA within 2 months
- Planned cardiovascular intervention
- Listed for heart transplant
- Cardiac assist device implanted
- Life expectancy ≤ 12 months
- Uncontrolled hypertension
- Untreated thyroid disease
- Dialysis
- Mental or physical disability
- Pregnant or actively breast feeding
Baseline
Characteristics
What was the Main Result?
Secondary Outcome: What about All Cause Mortality ?
Subgroup
Analysis
• Failure of Blinding
• Post-randomization exclusions
• Inadequate search for toxicity
What’s wrong with this study?
Question Score
1. Were they really randomized? 0.8
2. Are the patients similar to our own? 0.8
3. Are the results both statistically and clinically
significant?
1.0
4. Is the maneuver feasible? 0.7
5. Are all relevant outcomes reported? 0.5
6. Were all entered patients accounted for at the
conclusion?
0.7
What would David Sackett Say?
Total = 4.5 / 6.0 = 75%

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Castle AF.ppt

  • 1. GIM Journal Club Friday March 9th 2018 Dr. Don Redelmeier Wasim Mansoor
  • 2. Selection Criteria Inclusion Exclusion - Participants from USA, EU, Australia (2008 – 2016) - Symptomatic atrial fibrillation - Failure or intolerance to anti-arrhythmics - LVEF ≤ 35% - NYHA class ≥ II - ICD/CRTD with Home Monitoring capabilities implanted - Previous left heart ablation procedure for AF - Contraindication to chronic anticoagulation therapy - Documented left atrial diameter >6 cm - ACS or CVA within 2 months - Planned cardiovascular intervention - Listed for heart transplant - Cardiac assist device implanted - Life expectancy ≤ 12 months - Uncontrolled hypertension - Untreated thyroid disease - Dialysis - Mental or physical disability - Pregnant or actively breast feeding
  • 4. What was the Main Result?
  • 5. Secondary Outcome: What about All Cause Mortality ?
  • 7. • Failure of Blinding • Post-randomization exclusions • Inadequate search for toxicity What’s wrong with this study?
  • 8. Question Score 1. Were they really randomized? 0.8 2. Are the patients similar to our own? 0.8 3. Are the results both statistically and clinically significant? 1.0 4. Is the maneuver feasible? 0.7 5. Are all relevant outcomes reported? 0.5 6. Were all entered patients accounted for at the conclusion? 0.7 What would David Sackett Say? Total = 4.5 / 6.0 = 75%