Tagrisso 80mg (osimertinib) tablet is an anticancer drug that inhibits the growth and spread of cancer cells in the body, this treatment is used after other cancer drugs have not been success. Its indicated for type of non-small cell lung cancer

1. Tagrisso 80 mg tablet
Tagrisso 80mg (osimertinib) tablet is an anticancer drug that
inhibits the growth and spread of cancer cells in the body.
Tagrisso 80mg tablet treatment is used after other cancer drugs
have not been success. Its indicated for type of non-small cell
lung cancer.
Indication:
Tagrisso 80mg tablet is mainly indicated for the treatment of
non-small lung cancer by first line treatment.
Dosage & Administration:
Tagrisso tablet mainly indicated for non-small cell lung cancer,
its first line treatment and dose prescribed is 80mg po per day.
This dose can be continuing till disease progression and
unsusceptible toxicity.
Oral route is given, should be swallowed not to be chewed
Tagrisso tablet may be given with or without food at the same
time ever day.
If over dosage occurs: Tagrisso 80mg tablet has no specific
over dosage, it should follow supportive and treat
symptomatically.
Mechanism Of Action

2. Tagrisso 80 mg tablet is a cancer medication which inhibits the
growth and development of cancer cell and Tagrisso 80mg tablet
is also a Tyrosine Kinase Inhibitor (TKI). Which irreversible
interferes with the Epidermal Growth Factor Receptors (EGFRs)
suppress sensitizing-mutations (EGFRm) and TKI-resistance
mutation T790M.
Pharmacokinetic
Absorption:
peak plasma concentration duration is 6hr
Distribution:
plasma protein is 95% and volume of distribution is 918L
Metabolism:
The metabolic pathway is oxidation and dealkylation and
osimertinib are metabolites by AZ7550 and AZ5104.
Elimination:
Excreted through 68% in feces and 14% urine. Half-life
elimination is 48hr and clearance is 14.3L/hr
Precautions
Care To Be Taken :
Allergic condition against Tagrisso 80mg tablet or any other
medication inform your doctor.

3. Regarding your past medical drug used which include in
prescription, nonprescription, vitamins & supplements,
nutritional products just inform the doctor.
If you had long QT syndrome, irregular heartbeat, heart failure,
low in Na, K, Ca or Mg in your blood, eye problem and lung
disease, inform the doctor.
Avoid use of Tagrisso 80mg tablet if you are pregnant. It will
harm the baby unborn, while using Tagrisso 80mg tablet use
correct birth control to prevent pregnancy and for at least 2
weeks after your treatment ends. Tagrisso 80mg tablet may
affect the ability to have children in women. Inform your doctor
if you planning to pregnant.
Drug Interaction
Tagrisso 80mg tablet + strong CYP3A4 inducer → decrease the
exposure of Osimertinib
Tagrisso 80mg tablet +itraconazole (strong CYP3A4 inhibitor)
→ increase Osimertinib plasma concentration
Interaction with omeprazole leads to effect of gastric acid
reducing
Rosuvastatin with Tagrisso 80mg tablet will altered the plasma
concentration.
Pregnancy

4. There are no or insufficient data from the use of Tagrisso 80mg
in pregnant women. In animals have shown reproductive
toxicity, due to the side effects and pre clinical data the drug will
cause harm to fetal when administered to a pregnant woman.
Tagrisso 80mg is not recommended during pregnancy and in
women of childbearing ability have not using contraception.
Tagrisso Side Effects
If any side effect caused by Tagrisso 80mg tablet, inform your
doctor of the symptoms like Back ache; constipation; rash and
itching; diarrhea; dry or cracking skin; eczema; decrease in
appetite; vomiting and nausea. Serious effects: fast or pounding
heartbeat, dyspnea, swelling of ankles or feet, feeling
lightheaded, chest pain, extreme tiredness.
Storage
Store below 300C
Tagrisso 80mg Shell life is 24 months
Store in a tight container, protected from sunlight and freezing
Keep it in children resistance
Use before the expiry date of the medicine
Discuss with your healthcare professional that how to dispose
the drug.

5. Contact us:
Email Id : applepharmaceutical@gmail.com
Phone No : +91- 9987711567
Website : http://anti-cancer-drugs.com/tagrisso-80mg.php