Complex Systems Biology Informed Data Analysis and Machine Learning
TaylorSmith_CV
1. Taylor D. Smith, B.S.
100 Lakeshore Dr, Apt 117
Lexington, KY 40502
Telephone: (859) 229-6994 / e-mail: taylor@taylorsmith.tech
EDUCATION
University of Kentucky, Lexington, KY 2013
B.S. Chemistry (Biochemistry Option)
Summa Cum Laude
Departmental Honors
University of Kentucky, Lexington, KY 2013
B.S. Mathematics
Summa Cum Laude
Departmental Honors
Cumulative GPA: 3.93
GRE Verbal: 160
GRE Quantitative: 158
GRE Analytical: 4.5
PCAT Composite Score: 430 (94
th
percentile)
Awards/Honors
Merck Index Award ($250) 2013
Arts and Sciences, Department of Chemistry
University of Kentucky
Kash Senior Pre-Med Scholarship ($750) 2012
College of Arts and Sciences
University of Kentucky
Commonwealth Scholarship ($10,000) 2009
University of Kentucky
POST BACCALAUREATE WORK
Spinal Cord and Brain Injury Research Center Sept 2013 – Dec 2015
University of Kentucky, Lexington, KY
Laboratory Technician
Biochemistry and Magnetic Resonance Imaging
MEMBERSHIPS AND SCIENTIFIC SOCIETIES
American Chemical Society 2013
Phi Beta Kappa National Academic Honor Society 2013
Golden Key International Honour Society 2011
2. PUBLICATIONS
Patel S.P., Sullivan P.G., Pandya J.D., Goldstein G.A., VanRooyen J.L., Yonutas H.M.,
Eldahan K.C., Morehouse J., Magnuson D.S., Rabchevsky A.G. N-acetylcysteine amide
preserves mitochondrial bioenergetics and improves functional recovery following spinal
trauma. 2014. Experimental Neurology 257: 95-105. Acknowledged.
Patel S.P., Smith T.S., VanRooyen J.L., Powell D., Cox D.H., Sullivan P.G., Rabchevsky A.G.
Serial Diffusion Tensor Imaging In Vivo Predicts Long-Term Functional Recovery and
Histopathology in Rats Following Different Severities of Spinal Cord Injury. Dec 2015.
Journal of Neurotrauma. Co-First Author.
Visavadiya N.P., Patel S.P., VanRooyen J.L., Sullivan P.G., Rabchevsky A.G. Cellular and
subcellular oxidative stress parameters following severe spinal cord injury. 2016. Redox
Biology 8(2016): 59-67. Acknowledged.
Posters/Abstracts:
Smith T.D., Patel S.P., Rabchevsky A.G. Analysis of Markers of Oxidative Damage in Rat
Spinal Cord Following Spinal Cord Injury. University of Kentucky Department of Chemistry
Undergraduate Poster Competition, Lexington, KY. April 2013.
Patel S.P., VanRooyen J.L., Visavadiya N.P., Smith T.D., Sullivan P.G. and Rabchevsky A.G.
2014. Treatment with ketone bodies preserves mitochondrial function and reduces
oxidative stress following contusion spinal cord injury. Society for Neuroscience Annual
Meeting, Washington, DC. November 2014.
Rabchevsky A.G., Eldahan K.C., VanRooyen J.L., Wang C.Y., Smith T.D., Cox D.H., Patel
S.P. Gabapentin management of autonomic dysreflexia: effects on system inflammation.
Society for Neuroscience Annual Meeting, Washington, DC. November 2014.
VanRooyen J.L., Patel S.P., Eldahan K.C., Smith T.D., Cox D.H., Rabchevsky A.G.
Mitochondrial Supplementation after Spinal Cord Injury Maintains Cellular Bioenergetics.
Bluegrass Society for Neuroscience Day, Lexington, KY. March 2015.
VanRooyen J.L., Patel S.P., Eldahan K.C., Smith T.D., Cox D.H., Rabchevsky A.G.
Mitochondrial Transplantation to Restore Cellular Bioenergetics after Spinal Cord Injury.
UK Healthcare Clinical Neuroscience Expo, Lexington, KY. March 2015
RESEARCH PROJECTS
In-vivo quantitative assessment of spinal cord injury using diffusion tensor imaging
PI: Alexander G. Rabchevsky | 2013 – 2015
• Magnetic resonance (MR) and diffusion tensor (DT) imaging sequence development and
optimization for in-vivo assessment of rat spinal cord
3. • Independent operation of MRI scanner including animal handling and image acquisition
• Software development and scripting for assessment of acquired MR and DT images
• Development and testing of specific metrics to quantify and prognosticate spinal cord
injury severity from MR and DT images
Pharmacological interventions for neuroprotection following traumatic spinal cord
injury
PI: Alexander G. Rabchevsky | 2013 – 2015
• Biochemical assays including western blot and ELISA of markers of oxidative stress and
inflammation
• Rodent behavioral assessments including locomotor and kinematic gait assessments
• Tissue staining, microscopy, and histological analysis of injured spinal cord tissue
Gabapentin Management of Autonomic Dysreflexia
PI: Alexander G. Rabchevsky | 2013 – 2015
• Development of algorithms to analyze recorded telemetric data (i.e. blood pressure and
heart rate) to detect and quantify numbers of spontaneous events of autonomic
dysreflexia
• Development of algorithms and software to quantitatively assess hemodynamics and
severity of recorded, induced events of autonomic dysreflexia
Contributions of the mTOR signaling pathway to the development and extent of
autonomic dysreflexia
PI: Alexander G. Rabchevsky | 2015
• Western blot analysis for members of mTOR pathway and markers of neuronal activity
• Incorporation of novel electric field sensors into existing telemetric recording apparatus with
subsequent analysis and validation
Skills
Magnetic Resonance Imaging
• Sequence development/optimization
• Image acquisition and data processing
• Discreet quantitative and morphological assessments of MR images
Software development and application scripting
• Operating system shell scripting (strength: linux)
• Visual Basic for Applications (VBA)
• Limited experience in signal processing
• Developed full ‘software suite’ for MRI analysis of rat spinal cord including installer,
manual, and individual analysis modules
Biochemistry
• Western Blot
• ELISA
• Fluorospectrometry
Surgical/Behavioral
• Rodent anesthesia administration
4. • Pre/Post-surgical rodent care
• BBB and BMS locomotor rating scales
• Quantitative kinematic gait analysis
Administrative
• Laboratory supply ordering and inventory management
• Reconciliation and accounts payable
• Maintaining legal/ethical/environmental compliance in a scientific laboratory setting
References
Alexander G. Rabchevsky, PhD
Professor of Physiology
Department of Physiology
Spinal Cord and Brain Injury Research Center
University of Kentucky College of Medicine
B471 BBSRB, 741 S. Limestone St., Lexington KY 40536
Phone: (859) 323-0267
E-mail: agrab@uky.edu
Patrick G. Sullivan
Associate Professor
Department of Anatomy and Neurobiology
Spinal Cord and Brain Injury Research Center
University of Kentucky College of Medicine
B461 BBSRB, 741 S. Limestone St., Lexington KY 40536
Phone: (859) 323-4684
E-mail: patsullivan@uky.edu
Samir Patel
Research Assistant Professor
Department of Physiology
Spinal Cord and Brain Injury Research Center
University of Kentucky College of Medicine
B461 BBSRB, 741 S. Limestone St., Lexington KY 40536
Phone: (859) 323-6477
E-mail: skpate2@uky.edu