7 guidelines are provided for effective supply chain segmentation design: 1) Coordinate supply chain architecture around customer needs rather than existing capabilities, 2) Accurately determine real costs-to-serve for each segment by avoiding aggregations, 3) Tighten cross-functional collaboration to unlock new value propositions, 4) Select the optimal number of segments, typically between 3 to 5, 5) Make shared infrastructure the default to drive efficiencies and optimize profitability, 6) Realign resource plans to deliver the new segmented supply chain architecture, and 7) Create fresh visibility across the entire value network using relevant metrics and data.