The healthcare industry is upgrading its services to reach the last miles of the nation. India has recorded several startups that target the population that was left behind in this complete health benefits programme. Female entrepreneurs are leading some of these startups as they have witnessed problems at ground zero level.

1. MAY 2022
www.swiftnlift.in
Dr. Jaisheela Padmanabhan
Founder & CEO
Ascribe
Healthcare
Solutions
Private
Limited
Top 10
Rising
Startups In
2022
Top industries in Tamil
Nadu
Why startups are
important for
healthcare industry?
Economy of Tamil
Nadu

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MAY 2022
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6. From the
EDITOR
I
n today’s corporate atmosphere, modern
organizations thrive and succeed for a variety
of reasons. Some are recognized for their
products, while others are known for their
services, and yet others are known for less clearly
defined characteristics like strong brand loyalty
or captivating advertising campaigns.
However, if you look at the firms that genuinely
stand out today as obvious leaders in their
industries, you’ll see that they all have one thing
in common: they all value innovation. Different
startups from every corner of the nation are
introducing practically visionary solutions to
the market. Startup entrepreneurs maintain a
different approach than the regular/traditional
business model.
Every state in India has its own independent
plans to increase the number of businesses
in the state and encourage the younger
generation to take active participation in the
employment generation. Chennai is one of the
most important port cities for business in India.
Located in the southern part of the nation,
the city caters to multiple industries such as
automobiles, information technology, electronics

7. manufacturing, textiles, etc. The traditional
approach has been at the forefront
of the city.
Chennai Port is the third oldest port in India,
serving for more than 100 years in the nation’s
maritime trade. From a trade perspective,
Chennai has several MNC manufacturing
units which produce goods for domestic
as well as international markets. Having a
reliable port is an added advantage to the
trade. But there’s always a limit to such a
business model. Startups have come up with
an innovative approach to serving in the
services industry.
Startups from Chennai have created an
impact that is encouraging new startup ideas
from this coastal city. It is not just on ground
startup environment in Chennai, Space
startups are even in the race to innovate &
deliver small-scale rocket launchers with
3D printed rocket engine. A combination
of experienced professionals and university
professors guides the young ideas created
out of the youth that are rising at large.
On the cover page of our edition of “Top 10
Rising Startups In Chennai 2022”, we have
Dr. Jaisheela Padmanabhan, Founder & CEO
of Ascribe Healthcare Solutions Private
Limited. This startup was built by the founder
from scratch. It covers healthcare billing and
revenue cycle management.
SwiftNLift focuses on spot-lighting firms
and startups that contribute to shaping
lives better, intending to make our society a
better place. It was a collective effort made
by our team to bring you this edition. As
the Chief Editor, I am grateful to you as our
reader. I hope you enjoy reading this piece
of our effort. We have other sections filled
with trusted and resourceful knowledge and
information to enhance your reading habits.
Nilesh Sabe
Chief Editor
- Nilesh Sabe

8. C O N T E N T S
COVER STORY
A R T I C L E S
18
Top industries in
Tamil Nadu
24
Why startups
are important
for healthcare
industry?
30
Economy of
Tamil Nadu
34
Rejuvenation of
skin cell
Ascribe
Healthcare
Solutions
Private
Limited

9. Doozy Robotics
Hubino
Trance Home India
Services Pvt Ltd
Inaluz Pvt Ltd
Fusion VR
Jana Analysis
NIN Energy India
Private Limited
Qruize Inc
Dhvani Analytic
Intelligence Pvt Ltd

10. Dr. Jaisheela
Padmanabhan
Founder & CEO

11. Top 10
Rising
Startups In
2022
Ascribe
Healthcare Solutions
Private Limited

12. The healthcare industry is upgrading its services
to reach the last miles of the nation. India has
recorded several startups that target the population
that was left behind in this complete health benefits
programme. Female entrepreneurs are leading some
of these startups as they have witnessed problems at
ground zero level.
We had an opportunity to interview one such
visionary, Entrepreneur & Founder of Ascribe
Healthcare Solutions Jaisheela Padmanabhan.
As a first-generation entrepreneur,
what challenges were on the path while
establishing Ascribe Healthcare?
Being first in the history of my family to dive into
the sea of doing business on my own, I got very
little advice & support from my closest and most
trustworthy people. Unlike in jobs where the boss
and seniors mentor, there was nobody to guide me for
quite some time. As a first-generation entrepreneur,
there were no bridges connecting me to the world
of business. It is just the hunger for something more
passionate and meaningful that was and is driving
me towards entrepreneurship.
Building a strong team, retaining them and facing
difficulties to pitch the ideas, values and vision to the
team so that they are ready to work and stay with
the company.
Robust cash flow is essential for survival. Strong
financial planning and budgeting were needed
because, by the time the client pays the invoices,
I had to ensure that I pay everything on time from
employee salary and bills. While waiting to get paid,
make it difficult to run a business smoothly.
Staying self-motivated, cool-headed and strongly
determined during the times when every
circumstance and situation is not in favor or a plan
not working as expected.
Tell us about your background.
I graduated with my degree in Physiotherapy; I also
hold my credentials from the American association
of professional coders. Recently, a few months ago,
I graduated in clinical cosmetology and aesthetics.
Along with my entrepreneur journey, I am pursuing
my clinical practice.
What made you enter the Healthcare
technology industry?
The healthcare industry has evolved immensely
over the years, and much of that change has been
driven by technology. The transformative power of
technology could obviously not be missing from the
healthcare sector. Even though it is a sector requiring
highly skilled individuals with many years of studies,
it is also a very demanding one in infrastructure
and tools.
And the timing couldn’t be better, as spending or
working in this sector is increasing at a rapid rate.
What are your Goals & Objectives?
My goals are to “GO-Global” and to build the business
strong enough in revenue that it will continuously
support the education of 10000 children. Not just
a first-generation entrepreneur, I am also a first-
generation female graduate. In my life, it’s only
the education that gave me the success and truly
transformed my life and I want to give the same hope
and share the light with the less privileged. I strongly
believe in working with transparency, integrity
and generosity.
Ascribe Healthcare
Solutions Private Limited

13. Tell us about your services.
Ascribe Healthcare Solutions, a revenue cycle
management expert; we render superlative healthcare
billing & coding solutions to clients through a
reliable outsourcing model. Our services include:
Doctor’s credentialing, EFT Enrolment, Eligibility
and Benefits Verification, Medical Coding, Patient
Demography, Charge Entry, Payment Posting,
AR and Denial Management, Insurance appeal
and its process, Medical records review, Medical
records summarization, Daily Report preparation
and management.
We are a core value-driven company with global
clients in India, USA, Dubai, Oman, Qatar, Hong
Kong and Australia.
☐ Year of Founding: 2015
☐ Founding Members: 01
☐ Office Locations:
Chennai - India, Delaware-USA,
Dubai- UAE.
☐ Company Strength: 100 +
☐ Website:
www.ascribehealthcare.com
Dr. Jaisheela
Padmanabhan
Founder & CEO

14. Company Logo Company Name
Company
Management
Jana Analysis Manoharan Duraisamy, CEO
Trance Home India Services
Pvt Ltd
Kuttimanibaladurai Rajendran,
Founder & CEO
Dhvani Analytic Intelligence
Pvt Ltd
Prof. Krishnan Balasubramaniam
Fusion VR
Dr. C SS Bharathy, Founder
Hubino Sathees K Ramasamy, CEO
Qruize Inc Ezhil Arasan Babaraj,
Principal Founder & CEO
Inaluz Pvt Ltd The Team
Doozy Robotics The Team
NIN Energy India
Private Limited
The Team
TOP 10 RISING STAR
Top 10
Rising
Startups In
2022

15. Company Description Website
Digitizing the process of meidcal treatment &
outcome data to transform Oncology care https://www.janaanalysis.com/
Social assistance at every step to develop a society
of change https://trancehome.com/
Deep & Machine learning algorithms developed
for Automatic Defect Recognition (ADR) using
knowledge & data driven tools.
https://www.dhvani-analytic-intelligence.com/
home.html
Customer focused AR-VR & Industry 4.0
solutuions for making the digital transformation
journey seamless
https://www.fusionvr.in/
Digital services for building a truly tech enabled
future https://www.hubino.com/
Empowering automation consulting & solutions
for global business https://www.qruize.com/
Solar energy solutions for green energy
productuion https://www.inaluz.com/
Integrating robotics technology in healthcare,
hospitality, retail, warehouse, etc for dynamic future https://doozyrobotics.com/
Helping improve energy efficiency for better
energy consumption https://ninenergy.com/
IN CHENNAI -2022
RTUPS

16. Chennai, India, May 14, 2022 / SwiftNLift PR:
The virtual event PEAK (Program for Engineers’ Advanced
Knowledge), an Industry-Academia Series for students
in the field of Engineering and Technology organised by
The Southern India Chamber of Commerce and Industry,
Chennai on Saturday, 14th May 2022, received an
overwhelming response from college students across
the country.
The participation of thousands of students from Top colleges like Sri Venkateswara College of
Engineering, Chennai. Vellore Institute of Technology, Vellore. Symbiosis Institute of Technology,
Pune. Francis Xavier Engineering College Tirunelveli. Rajalakshmi Engineering College, Chennai.
National Engineering College kovilpatti. Kalasalingam University, Krishnan Koil, CPAT TVS, Chennai
made this virtual event a grand success.
The participants actively asked many thought-provoking questions about AI and data science
to the two eminent panel speakers, Mr. Ramana Prasad, Chairman, AI World School, Governing
Council member- Centre for Innovation (CFI) IIT Madras, International Catrobat Foundation,
Gra University of Technology, Austria and Mr. Gopi Koteeswaran, Chair, SICCI EIS Committee &
Founder, Dzruptiv AI.
There were discussions on How to become an AI Expert, Career opportunities in AI, Limitations
of AI, choice of organizations to work for, and how students can upskill themselves. Session
Moderator, Mr. George Koshi, Chair, SICCI Employability Taskforce & Director - Learning and
Development, Sify Technologies Limited.
Mr. Ramana Prasad, interacted with students about the need of continuous learning, upskilling,
developing creative and innovative skills, and learning computer science skills. He also mentioned
that his organisation is working on providing AI training to students in schools students should have
a zeal for learning, and focus on the fundamentals.
Mr. Gopi explained how students should connect the theoretical concepts with real life. He also
asked students to be super curious, focus on sharpening their mind, and participate in various
global events and contests.
Mr. Ramana Prasad thanked The Southern India Chamber of Commerce and Industry (SICCI) for
conducting such an interactive virtual event. He also mentioned that such sessions need to be
conducted frequently to provide valuable insights to students from engineering and
technology fields.
PEAK (Program for Engineers’ Advanced Knowledge),– A Highly
Interactive and Thought-provoking Session for The Students by SICCI
PRESS REALEASE

17. Regards,
Mohammed Zabiullah Hamid
Global Engagement - Brand Strategist
Mobile: +91 90921 78692
Webpage: aiworldschool.com
About SwiftNLift PR
Swiftnlift Press Release (www.swiftnlift.com) has a history of working with clients from a diverse
range of industries including Image Consulting, Automotives, Fast Moving Consumer Goods
(FMCG), Finance and Banking, Food, Retailing, Organizing Sports, Events, Governments and
Associations, Healthcare, and Pharmaceutical and more.
Swiftnlift PR boast 4+ years of experience in Public Relations and other digital communication
services like Digital PR, social media management, website management, content marketing,
and more.
Swiftnlift PR agency helps to create stories and narratives like media companies in order to appeal
& attract customers and get the products and services to the potential marketplace.
The core services offered by Swiftnlift PR include reputation management, corporate
communications, crisis, and issue management, employee communications, financial
communications, and policy & regulatory communications. The company is not just a PR agency
but is a communications partner that is able to deliver messages to the masses all
across the world.
Media Contact
Sam Mathew
Media Co-ordinator
SwiftNLift PR
Contact No: +1 614 356 7742
m.sam@swiftnlift.com
Workflow solutions for PR / CSR / MARKETING
www.swiftnlift.com
Copyright © 2021 Swiftnlift. All rights reserved

18. Top industries in Tamil Nadu
Several industries are booming in Tamil Nadu. Tamil
NaduisrankedthirstindustrialstateinIndiafollowed
by Maharashtra and Gujarat. Textile, sugar, paper,
leather, cement, electrical equipment, automobiles,
information technology (IT), tourism and many
more industries have covered the Tamil Nadu State.
Tamil Nadu Industrial Development Corporation
(TIDCO) encourages large and medium scale
industries in Tamil Nadu through new joint venture
projects in the manufacturing sector. TIDCO has
shifted more towards infrastructure projects with the
liberalization of industrial licensing and controls. It
boostsSpecialIndustrialAreas(SIA)andAgricultural
Export zones (AEZ) through joint ventures.
New industrial policy in the state
While the State Government focuses on improving the
State’s competitiveness in the new growth sectors, it is
also committed to revitalizing traditional industrial
sectors, with the stated goal of making Tamil Nadu a
regional gateway to Asia and a top-ranking exporter of
manufactured goods. The state’s policy has emphasized
facilitating and incentivizing large mother industries
to locate in Tamil Nadu. The new industrial policy
emphasizes the balanced development of traditional
and modern industries.
Promotion of SEZs for footwear and leather
processing, agro-processing and export of agro
products, and establishment of co-generation
18 MAY 2022 SwiftNLift

19. 19
MAY 2022 SwiftNLift

20. plants and ethanol units in sugar mills are some of
the initiatives started in the new industrial policy
in the traditional industrial sector. High priority
is for the promotion of industries in high-tech
areas like semiconductors, electronic hardware
and nanotechnology.
Manufacturing and engineering industry
It is one of the vibrant sectors in Tamil Nadu.
It contributes greatly to the industrial output.
It covers the manufacturing of machinery,
transport parts, basic metal & alloy industries and
metal products.
Automobile industry
The automobile industry contributes 8% of Tamil
Nadu’s GDP. This industry accounts for approximately
21% of passenger cars and 33% of commercial
vehicles produced in India. Chennai is the home of
30% of India’s automobiles and 35% of its automotive
components. Because of its industrial dominance,
Chennai has earned the moniker “Detroit of
Southern Asia.”
Leather industry
The growth of the leather industry is because of
the large tannery base established over the last two
centuries. The annual turnover of the industrial
sector including tanneries, shoe factories, garment
and leather goods-producing units is Rs.4,500 crores,
of which Rs.2,750 crores is the income from export.
According to the Tamil Nadu New Industrial Policy
2003, the state has 70% of leather tanning capacity in
India and 38% of leather footwear and components.
The exports from Tamil Nadu are valued at about
US $ 762 million, which accounts for 42 % of Indian
leather exports.
Paper industry
Tamil Nadu is India’s second-largest paper producer,
trailing only Andhra Pradesh.
PapermillscanfindinPukkathuraiintheKancheepuram
district,Bhavanisagar,Pallipalyam,Pugalur,Paramathi,
Vellore, Coimbatore, Udumaliapettai, Thoppampatti,
Nillakkottai, and Cheranmadevi.
Food industry
TamilNadu’sfoodandbeverageindustryarethriving.
Mango pulp is manufactured and exported. Instant
food and cooking ingredients are manufactured
and marketed both locally and internationally.
Snacks and biscuits are widely distributed. Tamil
Nadu’s long coastline provides opportunities for
marine-based industries.
20 MAY 2022 SwiftNLift

21. Sugar industry
Tamil Nadu accounts for roughly 10% of total
sugar production in India. The cooperative sector
employs the vast majority of sugar units in the state.
Tamil Nadu currently has 42 sugar mills, with 16 in
the cooperative sector, 3 in the public sector, and 23
in the private sector. Sugar mills are concentrated
in the districts of Villupuram, Cuddalore,
Vellore, Erode, Coimbatore, Thiruvannamalai,
Thiruchirappalli, Thanjavur, and Madurai.
Cement industry
Tamil Nadu ranks fourth in cement production in
the country. It accounts for 10% of total cement
production in the country. Tamil Nadu Cements
Corporation Limited (TANCEM) is wholly
owned by the Government of Tamil Nadu and
produces Ordinary Portland Cement (OPC) and
Super Star Cement that exceeds Indian standards.
Sankari, Madukarai, Ariyalur, Dalmiapuram,
Manamadurai, Thulukapatti, Allankulam,
Sankarnagar, and Thazhaiyuthu are major cement
industry centres.
Chemical industry
The majority of Tamil Nadu’s chemical industries
have concentrated in and around Chennai
(Manali), Cuddalore, Panangudi (Nagapattinam),
and Thuthukudi.
SPIC (Southern Petrochemical Industries
Corporation Ltd.) and Manali Petrochemicals
Ltd. are two notable chemical industries in Tamil
Nadu. Pfizer Pharmaceuticals and Dow Chemicals
are two major chemical companies with research
and development facilities in Chennai.
Electronics industry
Electronics is an emerging industry in Tamil Nadu.
Many prominent global telecommunications like
Nokia, Flextronics, Motorola, Sony-Ericsson,
Foxconn, Samsung, Cisco, Moser Baer, and
Dell have picked Chennai as their South Asian
manufacturing hub.
Textile industry
It is the major industry in Tamil Nadu. It provides
large-scale employment and prominent source of
foreign exchange.
IT industry
Tamil Nadu has always been a welcoming state to
investors. Proactive government policies and the
state’s peaceful environment attract investors from
all over the world. Tamil Nadu is the preferred
destination for all multinational IT companies. Few
examples of IT companies in Tamil Nadu include
Amazon,Aspiresystems,BhavanCybertech,Consim,
CSS Corp, Cognizant, HCL, Ford, Zoho and others
- Varada Ukidave
21
MAY 2022 SwiftNLift

24. The Healthcare industry is one of the fastest-growing
industries not only in India but also all over the world.
It significantly contributes in terms of employment
and revenue. Hospitals, medical devices, clinical trials,
outsourcing, telemedicine, medical tourism, health
insurance, and medical equipment are all part of the
Indian healthcare industry.
The industry is expanding at a rapid pace as a result of
improved coverage, services, and increased spending
by both public and private players. Doctors are also
like scientists as they are continuously doing research
and analysis to find new and better things. Healthcare
innovations should not be taken for granted.
Startups are aims to implement new ideas. Startups are
an integral part of healthcare innovations.
After all, the core of the startup is to rethink and adopt
its disruptive nature to challenge norms and seek
more efficient and higher-quality outcomes. It makes
sense that, as the healthcare industry faces numerous
challenges, including COVID; startups become a valid
and vital part of industry conversations and movements.
Importance of startups
Some key importances of startups are
mentioned below:
■ Startups find a solution rapidly
Startups come with new ideas and innovative
solutions much faster than well-established firms.
The startups can specialize in an ultra-specific area
which established firms may not do with dedicated
time or other issues.
■ Needformoreperspectivesonhealthcaresolutions
Unfortunately, bias is the reality in medical research.
To achieve an exact result, research should include
diverse perspectives and data. Startups can research
with diverse perspectives to implement their ideas.
Why startups are important
for healthcare industry?
24 MAY 2022 SwiftNLift

25. ■ Innovation
The main goal of the startups is innovation. They
enter the market with unique ideas. They can
find creative solutions to complex problems in
the industry.
■ Support
Startups based on technology support the healthcare
industry. AI has great applications in healthcare. AI
is a significant component in healthcare innovations.
For example, AI aided in the global recovery from
the COVID-19 pandemic, which lasted nearly two
years. AI has been used in the healthcare industry
for a variety of purposes, including early detection of
COVID-19, patient assistance, and so on.
Challenges of healthcare
India faces some challenges in the healthcare sector
including limited access, investment and an increase
in chronic disease burden. These challenges may be an
opportunity for any startup.
☐ Need of Startup
The gap between the needs of care seekers and
traditional healthcare services is increasing. And
it becomes a major challenge for the healthcare
industry. It is unaffordable for the healthcare sector.
On the other hand, these factors lead to the growth
of the healthcare startups ecosystem and encourage
them to innovate. Startups not only help the patients
to get qualitative healthcare services but also create
employment. According to Invest India, the sector
will create 40 Mn jobs by 2030.
List of best startups in India
Some of the startups in the healthcare industry are
listed here:
☐ Netmeds
Netmeds is an online platform for pharmacy.
Netmeds has millions of active customers and
deliveries over 19, 000 PIN codes in the country. It is
also known as ‘India ki Pharmacy’.
25
MAY 2022 SwiftNLift

26. ☐ ImpactGuru
The vision of the startup is to make healthcare
accessible to all and save more lives. It is a crowd
funding platform for medical purpose.
☐ Docplexus
This platform is for doctors. Doctors can create their
communities on the platform and discuss problems
all around the globe. Phanish Chandra is the founder
of Docplexus. It has more than 2,75,000 doctor
members.
☐ Mera Medicare
MeraMedicare is a healthcare startup founded by
Pankaj Gupta. MeraMedicare offers home delivery of
medications in 2 to 12 hours and a 15% discount on
almost all medications. It is a dependable and hassle-
free method of ordering medications.
☐ 3Hcare
3Hcare is a healthcare startup based in Delhi. It is
a healthcare services marketplace on the internet.
3Hcare provides comprehensive information on
healthcare services in India. Users can simply visit
3Hcare’s website to learn more about diagnostic
centers and hospitals that meet their needs. The name
“3Hcare” stands for “Help, Health, and Happiness,”
and it represents the startup’s goal of assisting people
in maintaining their health and happiness.
Final thought
The healthcare industry is constantly evolving in terms
of disease, treatment, and research. Startups contribute
to the growth and development of the industry as
a whole. Startups are important in all sectors of the
healthcare industry.
- Varada Ukidave
26 MAY 2022 SwiftNLift

27. 00
MAY 2022 SwiftNLift

30. Tamil Nadu is India’s fourth-largest state located on the
southern coast of India. It ranks first as a state in the total
number of factories and industrial workers. Between
the years 2015-16 and 2020-21, Gross State Domestic
Product (GSDP) grew at a Compound Annual Growth
Rate (CAGR) of 10.56% to reach Rs 19.43 trillion (USD
265.49 billion). In 2020-21, the contribution of the
tertiary sector to the State’s Gross State Value Added
(GSVA) at current prices was 54.26% followed by the
secondary sector at 32.39%.
Total commodities exports from the state stood at US$
30.02 billion in the financial year 2020. In the financial
year 2021, exports stood at US$ 26.16 billion.
The economic structure of Tamil Nadu has transformed
from the Primary sector in the 1960s to tertiary activities
in the 2000s.
The main contributors to the economy of Tamil Nadu
are agriculture, fishing and forestry, resources and
power, manufacturing, services and transportation.
Agriculture, fishing and forestry
Since1960,thestatehasbeenself-sufficientinfoodgrain
production. The lad crops for domestic consumption
are rice, millet and other cereals, peanuts and pulses,
sugarcane, cotton, cashews and chilies. Many farmers
also grow livestock, main cows for the dairy industry,
poultry, goat and sheep.
Tamil Nadu is also the top fish producer in India. The
major yield is from marine fishing. State also has an
active forestry sector with pulpwood, babul, firewood,
bamboo and teak as primary products and Rubber is
also an important crop.
Resources and power
Mineralslikelimestone,bauxite,gypsum,lignite(brown
coal), magnesite, and iron ore are major minerals
mined in Tamil Nadu. Neyveli, an opencast lignite mine
is one of the largest mines in India. Tamil Nadu, as an
Economy o
f Tamil Nadu
30 MAY 2022 SwiftNLift

31. industrialized and urbanized state, ranks among the
top three states in terms of electricity generation. As of
September 2018, Tamil Nadu’s total installed capacity
was around 30,200 MW, with 11,500 MW coming from
solar and wind energy.
Tamil Nadu has the distinction of being India’s
renewable energy leader, having adopted clean energy
sources and established wind farms as early as 1995. It
now generates more wind power than Denmark and
the Netherlands combined. Its products use to fuel a
thermal-power plant which provides much of the state’s
electricity. The majorly of the energy requirement of
Tamil Nadu is generated by thermal power plants. Also,
hydroelectric plants, particularly along the Kaveri River
and its tributaries, provide an important secondary
source of energy. The state is also a leader in wind
energy generation.
Manufacturing
Tamil Nadu is one of India’s most industrialized states,
with the manufacturing sector accounting for more than
one-third of the state’s GDP. Heavy vehicle production,
such as automobiles, agricultural equipment, military
vehicles, and railway cars, is one of the state’s major
industries; the railway coach factory at Perambur (near
Chennai) is one of Asia’s largest. One of the biggest
electrical equipment public sector companies BHEL has
its manufacturing unit in Tiruchirappalli and Ranipet.
The Tamil Nadu state government owns the Tamil Nadu
Newsprint and Papers (TNPL), the world’s largest
bagasse-based paper mills in Karus, Tamil
Nadu. Chennai has an oil refinery
and a petrochemical plant.
Textile milling,
foodprocessing,andtheproductionofpharmaceuticals,
chemicals, and electronic parts and equipment are also
important manufacturing activities. Coimbatore is
referred to as the “Manchester of South India” due to its
extensive textile industry, and it is also known as “the
Pump City” because it supplies half of India’s motor and
pump requirements.
Handicrafts are also abundant in Tamil Nadu,
particularlybrass,bronze,andcopperware,leatherwork,
hand-loomed silk, kalamkari (hand-painted fabric
using natural dyes), and articles made of carved wood,
palm leaf, and cane.
Tuticorin is known as the ‘Gateway of Tamil Nadu’. It is
a larger producer of chemicals. It all produces 70% of
total salt production in the state and 30% in the country.
Services
The service sector is developing since the 20th century.
And by 21 century it is the largest contributor to the
state’s economy. Expansion in the IT industry has
been the priority of the economic development policy.
The state also encourages tourism, infrastructure
development project, restaurants, and cultural &
recreational attractions.
The state government is stimulating industrial parks
such as Rubber Park, Apparel Parks, Floriculture
Park, TIDEL Park for IT/ITS, TICEL BioPark for
Biotechnology, Siruseri IT Park, Elcot SEZ and Agro
Export Zones among others. Two major seaports
are there in Tamil Nadu. The international airport at
Meenambakkam is one of the largest airports in India.
- Varada Ukidave
31
MAY 2022 SwiftNLift

34. Rejuvenation o
f skin cell
The Babraham Institute has devised a mechanism to
‘time jump’ human skin cells by 30 years, effectively
turning back the clock for cells without affecting their
specialized function.
Researchers in the Institute’s Epigenetic research
(Epigenetic is the study of how your behaviors and
environment can cause changes that affect the way your
genes work.) department have been able to partially
repair the function of aged cells while also revitalizing
molecular measurements of biological age.
Regenerative medicine
Our cell’s ability to function reduces as we age, and the
genome collects signs of aging. Regenerative biology
seeks to repair or replace cells, including those that have
died. Our ability to generate ‘induced’ stem cells is one
of the most essential tools in regenerative biology. The
procedure consists of numerous phases, each of which
removes some of the markers that differentiate cells. In
theory, these stem cells can become any cell type, but
scientistshaveyettosuccessfullyreproducetheconditions
that allow stem cells to re-differentiate into all cell kinds.
Stem cells
These are undifferentiated cells that can turn
into specific cells, as the body needs them. Adult
body tissues and embryos are the two sources of
stem cells.
Stem cells present in the following tissues:
■ the brain
■ bone marrow
■ blood and blood vessels
■ skeletal muscles
■ skin
■ the liver
Stem cells are important for the following reasons:
■ It increases understanding of how diseases occur.
■ It generates healthy cells to replace cells affected
by disease (regenerative medicine).
■ It is used to test new drugs for safety
and effectiveness.
34 MAY 2022 SwiftNLift

35. History
The approach dates back to the 1990s when researchers
at the Roslin Institute, Edinburgh established a way of
converting an adult mammary gland cell from a sheep
into an embryo. It resulted in the development of Dolly,
a cloned sheep. The goal of the Roslin team was not to
generate sheep clones or even human clones but to
use the process to create so-called human embryonic
stem cells. Scientists thought that by growing them
into specific tissues like muscle, cartilage, and nerve
cells, they would be able to replace worn-out bodily
parts. Prof Shinya Yamanaka simplified the Dolly
procedure in 2006.
Development
Shinya Yamanaka was the first scientist in 2007 to convert
normal cells with a specified function into stem cells with
the ability to develop into any cell type. The entire process
of stem cell reprogramming takes around 50 days and
involves four critical molecules known as the Yamanaka
factors. The new technique, known as maturation phase
transient reprogramming,’ exposes cells to Yamanaka
factors for only 13 days. Age-related alterations
have been erased at this
point, and the cells
have momentarily
lost their
individuality.
The partially
reprogrammed
cells were
allowed to
d e v e l o p
normally for
a while to see
if their specific
skin cell function
was restored. A
genome study
revealed that
the cells had
regained skin
cell markers
(fibroblasts).
Current and future scenario
The prospective applications of this technology rely on
the cells not just appearing younger, but also functioning
as young cells. Fibroblasts produce collagen, a substance
present in bones, skin, tendons, and ligaments that aids in
tissue structure and wound healing. When compared to
control cells that did not go through the reprogramming
process, the rejuvenated fibroblasts produced more
collagen proteins. Fibroblasts also migrate to places that
require healing. The partially regenerated cells were
examined by making an artificial cut in a layer of cells
in a dish. They discovered that treated fibroblasts moved
faster into the gap than older cells. This is a positive hint
that one day, this study could be utilized to make cells
that repair wounds more effectively.
Thisresearchmayalsoopenothertherapeuticpossibilities
in future. The researcher have observed that it’s also
affects the other linked gene eg. APBA2 gene associates
with Alzheimer’s disease and MAF gene associates with
development of cataract both showed changes in youthful
level of transcription.
Scientist highlighted that the research findings represent
a significant advancement in understanding of cell
reprogramming. Scientist demonstrated that cells can be
rejuvenatedwithoutlosingfunction,andthatrejuvenation
attempts to restore some function to old cells. The fact
that a reversal of ageing indicators observed in genes
associated with diseases is especially encouraging for the
future of this research.
Endnote
The implications of this work are really exciting. Scientists
may eventually be able to find rejuvenating genes that do
not require reprogramming and selectively target them to
minimize the consequences of ageing. This method has
the potential to yield crucial discoveries that could pave
the way for a fantastic therapeutic horizon.
- Varada Ukidave
35
MAY 2022 SwiftNLift