- 2-Deoxy-D-glucose (2DG) is a glucose analog that was developed as an oral drug for COVID-19 by India's Defense Research and Development Organization (DRDO). - Clinical trials showed 2DG is effective against COVID-19, reducing recovery time and supplemental oxygen dependence for moderate patients. - The drug works by inhibiting glycolysis and ATP production within viral cells, blocking synthesis of viral structural components and potentially directly destroying them. No significant side effects were observed during trials.

1. Sushil Kumar
Cancer Biology and MSB Division
CSIR-CDRI Lucknow, India
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2DG Anti COVID 19 Drug
Live COVID19 Virus
Dead COVID 19 Virus

2. CSIR-CDRI
2-Deoxy-D-glucose(2DG) is a analog of D-Glucose
• 2-Deoxy-d-glucose is a glucose molecule which has the 2-hydroxyl group replaced by
hydrogen
• Institute of Nuclear Medicine & Allied Sciences (INMAS) New Delhi, is a laboratory of
DRDO India that developed 2DG as a medicine for COVID19
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3. CSIR-CDRI
Approval of 2DG as Anti COVID19 drug in India
• Drugs Controller General of India approved an anti-COVID oral drug: May 8, 2021
• 2DG as an anti Covid drug developed by DRDO(Defence Research and Development
Organisation (DRDO)India
• Large scale production of 2DG by Dr. Reddy's Laboratories Hyderabad, India
Who's better fit to take 2DG as adjunct therapy
Moderate Covid 19 patients Severe coronavirus patients
2DG
Faster recovery from Covid 19
Reduce supplemental oxygen dependence
03/11

4. CSIR-CDRI
Which form of 2-Deoxy-D-glucose(2DG) used as Anti-Covid 19 drug
2DG as a powder
Water
2DG + Water
Take orally twice a day
First dose Second dose
Before Breakfast Before Dinner
Fasting increase the working efficacy of 2DG in Covid 19 Patients
04/11

5. CSIR-CDRI
Experimental results which proved 2DG is effective against COVID 19
Image from Press Information Bureau (PIB) India
05/11

6. CSIR-CDRI
Graphic showing how 2-DG drug reacts when used to treat SARS-CoV-2 infection
Image from Press Information Bureau (PIB) India
06/11

7. CSIR-CDRI
Expected molecular mechanism of 2DG to kill COVID19 Virus
2DG
(GLUT)Glucose transporters
2DG (Inside of the viral infected cells)
2DG(Out side of the cell)
Oral intake
Inhibit Glycolysis Inhibit ATP Production ROS generation
Results
Blocked synthesis of Viral structural components
such as envelop & neucleocapsid
Directly destroy structural components
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8. CSIR-CDRI
Clinical trials of 2DG as an Anti COVID19 Medicine
Permission from DCGI, India (May2020) for Clinical trial of 2DG in India
Phase II Clinical trials Phase III clinical
trails
6 Hospitals of India 11 Hospitals of India
From May 2020 to October 2020 From December 2020 to March 2021
DRDO, India
CCMB, India
April 2020
First trial of 2DG against COVID 19 Virus
08/11

9. CSIR-CDRI
Side effect of 2DG
• No side effects were found in Covid 19 patients during clinical
trials
• Its safe medicine for Covid 19
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10. CSIR-CDRI
Biomedical applications of 2DG
2DG
Anticancer Drug
Antiviral drug
Imaging agent
PET
CT
Anti-COVID oral drug
To treat Neurological disorders
Epilepsy
Breast Cancer
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11. CSIR-CDRI 11/11