1. SHOAIB ALAM, MD, M. Sc.
Current Appointment Professor of Medicine
Division of Pulmonary & Critical Care Medicine, University of Arkansas for
Medical Sciences (UAMS), Little Rock, Arkansas
December 11, 2015 to-date [Visiting / part-time faculty since October 04, 2016]
Other Work Locum Work / Including Visiting Consultant Shaukat Khanum Memorial Cancer
& Research Hospital, Lahore
Pulmonary & Critical Care Medicine
Jan 01, 2015 to December 2015
Previous Appointments Staff Clinician / Pulmonologist
Cardiovascular & Pulmonary Medicine Branch
National Heart Lung ad Blood Institute (NHLBI)
National Institute of Health (NIH), Bethesda, Maryland
June 02, 2009 to December 30, 2014. [See Annex 1 for details]
Assistant Professor of Medicine
Division of Pulmonary, Allergy and Critical Care, Penn. State University-Hershey
Medical Center, Hershey, Pennsylvania
July 01, 2004 to June 02, 2009
Board Certifications Board Certifications
Board Certified Internal Medicine: ABIM 2001
Board Certified Pulmonary Medicine: ABIM 2004
Board Certified Critical Care Medicine: ABIM 2005
Board Certified Sleep Medicine: ABSM 2005
Board Re-certification Internal Medicine: ABIM 2011
Board Re-certification Pulmonary Medicine: ABIM 2014
Board Re-certification Critical Care Medicine: ABIM 2015
Specialized Training Pulmonary Hypertension and Pulmonary Vascular Diseases
Elective rotation in Pulmonary Hypertension and Pulmonary vascular Diseases at
University of Pennsylvania with Dr. Harold Palevsky
April 30, 2004 to September 1, 2004.
Education Formal Medical Education
Penn. State University-Hershey Medical Center, Hershey, Pennsylvania
Fellowship, Pulmonary and Critical Care Medicine (and Sleep Medicine)
July 01, 2001 to June 30, 2004.
47 Sologne Circle
Little Rock, AR 82223
Phone: 501 686 5525 (Day)
717 608 0040 (Cell)
E-mail: shoaibalam@yahoo.com
SAlam@uams.edu

2. Hanneman University-Monmouth Med Center, Long Branch, New Jersey
Residency, Internal Medicine: July 01, 1998 to June 30, 2001.
King Edward Medical College, Lahore, Pakistan
M.B.B.S., Bachelor of Medicine, Bachelor of Surgery. (1989 –1995)
Extra-Medical Education
Government College, Lahore, Pakistan
M. Sc. Physics, (1991-1993).
B. Sc. Physics, Mathematics A & B Courses (1989-1991).
Fellowship Training Clinical
Fellow, Division of Pulmonary, Allergy and Critical Care, Penn. State University-
Hershey Medical Center, Hershey, Pennsylvania
July 01, 2001 to June 30, 2004.
Research
Affiliate-Research Fellow, Center for Nuclear Magnetic Resonance (NMR)
Research, Penn. State University, Hershey, Pennsylvania.
Mentors: Qing X. Yang Ph.D. and Michael B. Smith, Ph.D.
Fellowship Research Project
Assessment of Various Lung Infiltrates by Magnetic Resonance Imaging Using
Multiple Inhaled Gases Enhancement
Research Grant Tobacco Formula funding 2004-2005 (Grant: $250,000), for the project “MRI
Study of Lung Injury in aging rats and IPF Patients”
I was Co-Principal Investigator of the study.
Current Clinical Interests 1. Lung Diseases in Immunocompromised Host
2. Pulmonary Arterial Hypertension and Pulmonary Vascular Diseases
Started First Comprehensive Pulmonary Arterial Hypertension and Pulmonary
Vascular Diseases Program in Central Pennsylvania through Penn. State U.
3. Interstitial Lung Diseases.
4. Scleroderma / Connective Tissue Disorders Related Pulmonary Diseases.
5. Advanced Lung Diseases.
Research Interests / Projects
Current Research Interests
1. See Annex 1 for details.
2. Pulmonary Arterial Hypertension Pathogenesis and Novel Therapies
3. Lung Imaging
4. Novel ways of early detection of disease progression.
Past Research Projects
MAIN PROJECTS
1. Assessment of Various Lung Infiltrates by Magnetic Resonance Imaging Using
Multiple Inhaled Gases Enhancement.
2. MRI Study of Lung Injury in aging rats and IPF Patients.
OTHER COLLABORATIVE WORK
1. Clinical Study Assessing SSR126517E (3.0 mg s.c. once weekly) in Pulmonary
Embolism Therapy Approach-Study Site Sub Investigator. An industry
sponsored, multicenter, randomized, double-blind placebo-control drug trial.
2. Outcome in Pulmonary Embolism Based on Clot Burden and Length of
Treatment. Faculty Advisor. A retrospective study by a pulmonary and
critical care fellow at Penn. State.

3. 3. Outcome and Characteristics of Patients with Elevated Pulmonary Vascular
Resistance as well as Elevated Pulmonary Capillary Pressure, without
known left ventricular systolic dysfunction or valvular heart disease
compared to WHO-I Pulmonary Arterial Hypertension. Faculty Advisor. A
retrospective study by a pulmonary and critical care fellow at Penn. State.
4. Restless Leg Syndrome: Neural Mechanisms Uncovered Using Eyeblink
Classical Conditioning. Clinical Collaborator. A clinical study attempting to
elucidate neural mechanisms responsible of RLS using a standard cerebellar
learning paradigm, called eyeblink classical conditioning and MR
spectroscopy to analyze iron contents and various neurotransmitters in
various parts of brain. The study involves comparison of various parameters
before and one week after temporary interruption of RLS therapy in RLS
patient versus controls. Study also assesses quality of life in theses patients.
5. Validation of Equation for Predicting Metabolic Rate in Critical Care
Patients. Sub-investigator. A prospective study using indirect-calorimetry to
validate the equation (using body weight, height, body temperature) to
predict the metabolic rate in critically ill patients.
Publications
Original Papers, Reviews & Book Chapters
1. E“Prostacyclin-Analog Therapy In Sickle Cell Pulmonary Hypertension.” Nargues
A. Weir, Rehan Saiyed, Shoaib Alam, Anna Conrey, Himanshu D. Desai, M.
Patricia George, Jennifer H. Keeley, Elizabeth S. Klings, Alem Mehari, James G.
Taylor, Caterina P. Minniti, Gregory J. Kato. Haematologica January 2017
haematol.2015.131227
2. levated Transpulmonary Gradient and Cardiac Magnetic Resonance-Derived Right
Ventricular Remodeling Predict Outcomes in Sickle Cell Disease. Nguyen KL, Alam
S, Tian X, Mehari A, Leung SW, Seamon C, Allen D, Minniti CP, Sachdev V, Arai AE,
Kato GJ. Haematologica. 2016 Feb; 101 (2):240-3
3. Oscillatory haematopoiesis in adults with sickle cell disease treated with
hydroxycarbamide. Baird JH, Minniti CP, Lee JM, Tian X, Wu C, Jackson M, Alam S,
Taylor JG 6
th
, Kato GJ. British Journal of Haematology. 2015 Mar; 168 (5): 737-46
4. “Hemodynamic Predictors of Mortality in Adults with Sickle Cell Disease”. Alem
Mehari*, Shoaib Alam*, Xin Tian, Michael J. Cuttica, Christopher F. Barnett5,
George Miles, Dihua Xu, Catherine Seamon, Patricia Adams-Graves, Oswaldo L.
Castro, Caterina P. Minniti7, Vandana Sachdev, James G. Taylor VI, Gregory J.
Kato, Roberto F. Machado. *Equally contributing authors. Am J Respir Crit Care
Med 2013, VOL 187, No 8 (2013), pp. 840-847.
5. Characterizing non-linear dependencies among pairs of clinical variables
and imaging data. Caban JJ, Bagci U, Mehari A, Alam S, Fontana JR, Kato
GJ, Mollura DJ. Conf Proc IEEE Eng Med Biol Soc. 2012; 2012:2700-3
6. Non-invasive Indicators of Pulmonary Hypertension from Pulmonary Veins
Quantification in Sickle Cell Disease”. Guido H. Jajamovich, Vivek Pamulapati,
Shoaib Alam, Alem Mehari, Gregory J. Kato, Bradford J. Wood, Marius George
Linguraru. Manuscript accepted for International Symposium on Biomedical
Imaging (ISBI) 2012. (Paper ID: 1802).
7. Computer-Assisted Diagnostic Tool to Quantify the Pulmonary Veins in Sickle Cell
Associated Pulmonary Hypertension”. Guido H. Jajamovich, Vivek Pamulapati,
Shoaib Alam, Alem Mehari, Gregory J. Kato, Bradford J. Wood
1
, Marius George
Linguraru. Manuscript accepted for International Society for Optics and Photonics
(SIPE), Biomedical Applications in Molecular, Structural, and Functional Imaging
conference 2012. (Paper Number: 8317-54).
8. “Sickle Cell Disease-Associated Pulmonary Hypertension: The Effect of Anemia

4. and High Cardiac Output”. Invited Review. Shoaib Alam, MD, and Gregory J Kato,
MD. Int J Clin Rev 2011;07:08 doi: 10.5275/ijcr.2011.07.08
9. Postmortem and imaging based analyses reveal CNS decreased myelination in
restless legs syndrome. James R. Connor
a,*
, Padmavathi Ponnuru
a
,
Byeong-Yeul
Lee
b
, Gerald D. Podskalny
c
, Shoaib Alam
d
, Richard P. Allen
e
, Christopher J. Earley
e
,
Qing X. Yang
f
. Sleep Medicine 12 (2011) 614-619 .
10. Predicting dead space ventilation in critically ill patients using clinically available
data. Frankenfield, David C. MS, RD; Alam, Shoaib MD; Bekteshi, Edgar MD; Vender,
Robert L. MD, FACP Critical Care Medicine:January 2010 - Volume 38 - Issue 1 - pp
288-291
11. “Analysis of Estimation Methods for Resting Metabolic Rate in Critically Ill Adults”
Frankenfield DC, Colemam A, Alam S, Cooney RN. Journal of Parentral and Entral
Nutrition Vol 33; Number 1: 27-36, Jan/Feb 2009.
12. “Standard therapies for pulmonary arterial hypertension”. Alam S,
Palevsky HI. Clin Chest Med. 2007 Mar;28(1):91-115.
13. “Respiratory Systems Abnormalities and Clinical Milestones for Patients with
Amyotrophic Lateral Sclerosis with Emphasis upon Survival” Vender RL, Mauger D,
Walsh S, Alam S, Simmons Z. Amyotroph Lateral Scler. 2007 Feb;8(1):36-41.
14. “Foreign Body Aspiration During Esophagogastroduodenoscopy With Band Ligation
[Brief Reports]” Betancourt, Manuel MD, Bekteshi, Edgar MD, Toth, Jennifer MD,
Alam, Shoaib MD. Journal of Bronchology & Interventional Pulmonology, Vol 15 (3)
July 2008 pp 204-205
15. A chapter on “Pulmonary Venoocclusive Disease” in web-based text book “E-
medicine” Hakim Azfar Ali, Shoaib Alam. 2009.
16. A chapter on “Dyspnea” in “Ambulatory Medicine”, Shoaib Alam, Marius Figueredo,
Rehan Haque-2007. Lippincott Williams & Wilkins. ISBN-13: 978-0-7817-6495-7.
17. A chapter on “Solitary Pulmonary Nodules” in “Ambulatory Medicine”, Marius
Figueredo, Shoaib Alam-2007. Lippincott Williams & Wilkins. ISBN-13: 978-0-7817-
6495-7.
18. A chapter on “Pulmonary Hypertension and Acute Right Heart Syndrome” in
Text Book “Respiratory Emergencies”. Shoaib Alam, Harold Palevsky. Hodder
Arnold Publications; 1 edition (November 13, 2006) ISBN-10: 0340811951.
19. A chapter on “Secondary Lung Tumors” in web-based text book “E-medicine”
Rebecca Bascom, Shoaib Alam, et al. 2006.
20. A chapter on “Pneumothorax” in web-based text book “E-medicine” Rebecca
Bascom, Shoaib Alam, et al. 2006.
21. “Baum’s Text Book of Pulmonary Diseases-Book Review”, Shoaib Alam, Robert
Gillio. JAMA, Vol. 291 No. 19, May 19, 2000.
Abstracts & Case Reports
22. Diffusion lung capacity changes in Hodgkin Lymphoma patients before and after
ABVD chemotherapy. Abdullah M, Alam S, Zafar W, Majid A, Wahla AS. Abstract.
European Respiratory Society World Congress, Amsterdam 2015. European
Respiratory Journal, September 01, 2015: Vol 46, issue suppl 59
23. “Increased Transpulmonary Gradient in Patients with Sickle Cell Associated
Pulmonary Hypertension Predicts Poor Prognosis and is Associated with
RV Dysfunction by MRI”. Kim-Lien Nguyen1
, Shoaib Alam1
, Xin Tian3
, Steve
W. Leung1,4
, Catherine Seamon2
, Caterina P. Minniti2
, James G. Taylor VI2
,
Vandana Sachdev1
, Andrew E. Arai1
, Gregory J. Kato2
. Abstract. “5° World
Symposium on Pulmonary Hypertension, Nice. 2013

5. 24. “RV dysfunction by MRI is associated with elevated transpulmonary
gradient and poor prognosis in patients with sickle cell associated
pulmonary hypertension”. Kim-Lien L Nguyen*, Shoaib Alam, Xin Tian,
Steve W Leung, Catherine Seamon, Caterina P Minniti, James G Taylor,
Vandana Sachdev, Andrew E Arai, Gregory J Kato. Abstract. Journal of
Cardiovascular Magnetic Resonance 2013, 15(Suppl 1):O43 (Poster and
Oral Presentation)
25. “Spectrum of Pulmonary Fibrosis CT Findings in Sickle Cell Disease Using an
Enhanced Visual Scoring System”. Les Roger Folio DO, MPH, Jenifer
Willmann Siegelman MD, MPH, Alem Mehari MD, Daniel Joseph
Mollura MD, Jesus J Caban PhD, Joe Fontana MD, Alam Shoaib MD,
Genevieve Jacobs, Gregory J. Kato MD. Abstract. Radiological Society of
North America Annual Meeting, 2012.
26. “Increased Transpulmonary Gradient Predicts Functional Class, Mortality,
and RV Dysfunction by MRI in Patients with Sickle Cell Associated
Pulmonary Hypertension”. Nguyen, Kim-Lien, Shoaib Alam, Xian Tian,
Steve W. Leung, Catherine Seamon, Caterina Minniti, James G. Taylor,
Vandana Sachdev, Andrew E. Arai, and Gregory J. Kato. Abstract. BLOOD.
Vol. 120. No. 21. AMER SOC HEMATOLOGY, 2012. (Poster and Oral
Presentation)
27. “Study of Clinical Characteristics of Sickle Cell Disease Patients Developing Cor-
Pulmonale during Acute Hospitalization”. Shoaib Alam, MD, Alem Mehari, MD,
Gregory J. Kato, MD, Nargues A. Weir, MD, Caterina P. Minniti, MD, James C.
Taylor III, MD, Roberto Machado, MD, Mark T. Gladwin, MD, Abstract. American
Thoracic Society Annual Meeting, 2011. Am J Respir Crit Care Med
183;2011:A5945.
28. “Pulmonary Function in Adult With Sickle Cell Related Pulmonary Hypertension”
Alem Mehari, Xin Tian, Shoaib Alam, Les Folio, Jenifer Siegelman, Genevieve
Jacobs, Daniel Mollura, Gregory J. Kato, Joseph Fontana. Abstract. American
Thoracic Society Annual Meeting, 2011. Am J Respir Crit Care Med
183;2011:A1932.
29. “Abnormal Methacholine Challenge Associated with Pulmonary Arterial
Hypertension in Adults with Sickle Cell Disease”. Alem Mehari, Xin Tian, Shoaib
Alam, Roberto F. Machado, Mark T. Gladwin, Gregory J. Kato, Joseph Fontana.
Abstract. American Thoracic Society Annual Meeting, 2011. Am J Respir Crit Care
Med 183;2011:A2013.
30. “Serum transferrin: An independent predictor of mortality in sickle cell anemia”.
Zahra Pakbaz, Mariana Hildesheim, Shoaib Alam, Darlene Allen, Caterina R.
Minniti, James G. Taylor VI, Gregory J. Kato. Abstract. American Society of
Hematology Annual Meeting, 2011
31. “Decreased Plasma HDL, ApoA-I, and PON1 Activity but Unaltered Triglycerides
During Sickle Cell Vaso-occlusive Crisis”. Lita A Freeman, Xunde Wang, Catherine
Seamon, Marlene Peters-Lawrence, Laurel Mendelsohn, Shoaib Alam, James G
Taylor VI, Caterina P Minniti, Gregory J Kato. Abstract. Arteriosclerosis,
Thrombosis, and Vascular Biology Annual Meeting, 2011.

6. 32. “A Lower Tissue Doppler E/Ea Threshold Predicts Diastolic Dysfunction in Sickle
Cell Patients”. Hannoush H, Kato G, Machado R, Gladwin M, Mehari A, Alam S,
Minniti C, Taylor J, Sachdev V. Abstract. American Society of Echocardiography
Annual Meeting, 2011.
33. “Hemodynamic Parameters Predict Mortality In Sickle Cell Disease-Related
Pulmonary Hypertension”. Alem Mehari, MD, Xin Tian, MD, Shoaib Alam, MD,
Dihua Xu, MD, Catherine Seamon, RN, Mark T. Gladwin, MD, Roberto F.
Machado, MD and Gregory J. Kato, MD Abstract. American Society of
Hematology Annual Meeting, 2010
34.
“Hemodynamic Predictors of Mortality in Sickle Cell-Related Pulmonary
Hypertension”. Alem Mehari, Xin Tian, Dihua Xu, Catherine Seamon, Shoaib
Alam., Mark T. Gladwin, Roberto F. Machado, and Gregory J. Kato. Abstract.
Sickle Cell Disease Association of America Annual Meeting, 2010.
35.
“Evaluation of Exercise Capacity in Children with SCD by Six Minute Walk Test”.
Caterina P. Minniti, MD, Shoaib Alam, MD, Gregory J. Kato, MD, Mehdi Nouraie,
MD, PhD
,
Craig Sable, MD, Gregory Ensing, MD, Andrew Campbell, MD, Sohail
Rana, MD, Deepika Darbari, MD,
1
Mark T. Gladwin, MD, Oswaldo L. Castro, MD,
and Victor R. Gordeuk, MD. Abstract. American Society of Hematology Annual
Meeting, 2010
36. “Prevalence and Impact of Elevated Pulmonary Capillary Wedge Pressures in
Patients with Advanced Lung Disease Listed for Transplantation”. Alam S, Weir N,
Nathan SD. Abstract. American Thoracic Society Annual Meeting, 2010. Am J
Respir Crit Care Med 181;2010:A3394.
37. “Screening at NIH for Pulmonary Hypertension in Sickle Cell Disease”. James G.
Taylor VI, Darlene Allen, Catherine Seamon, Marlene Peters-Lawrence, Mary
Jackson, Mary K. Hall, Amy Chi, Brandi Dobbs, Anna Kokkalis Conrey, Laurel
Mendelsohn, James Nichols, Shoaib Alam, Caterina Minniti and Gregory J. Kato.
Abstract. Sickle Cell Disease Association of America Annual Meeting, 2010.
38. “Prospective Evaluation of the Effect of Anthropometrical, Hematological, and
Echocardiographic variables on Six Minute Walk Distance in Children and
Adolescents with Sickle Cell Disease”. CP Minniti
1
, S Alam, M Nouraie, A.
Campbell, S Rana, L Luchtman-Jones, O Castro, V Gordeuk and GJ Kato. Abstract.
Pittsburg Annual Lung Meeting, 2009
39. “Diaphragmatic Paralysis Associated with a Parvovirus B-19 Infection”. Martin
Karlicek, MD*, Pablo de la Cerda, MD and Shoaib Alam, MD. Case Report. Chest,
October 2009 (Chest Meeting Abstracts 2009 136: 12S-d.
40. “New Onset of Wegner’s Granulomatosis in a Patient with Idiopathic Pulmonary
Hypertension Treated with Epoprostenol”. Pablo de la Cerda, MD*, Martin Karlicek,
MD and Shoaib Alam, MD. Case Report. Chest, October 2009 (Chest Meeting
Abstracts 2009 136: 42S-c.
41. “Distribution of Pulmonary Embolism Risk Factors Based on Age at Presentation” N.
Adampour, M.D., S. Alam, M.D., M.G. Benninghoff, M.S., D.O., L. Sweer, M.D.,
Abstract. Proceedings of American Thoracic Society Annual Meeting, 2009
[Accepted for Oral Presentation].
42. “Outcomes of Pulmonary Emboli Based on Clot Burden and Length of
Anticoagulation-A retrospective study” M. G. Benninghoff, T. S. King S. Alam, .

7. Abstract. Proceedings of American Thoracic Society Annual Meeting, 2008. [A183-
2008].
43. “Decreased R2 and Increased Concentrations of Multiple Cerebral Metabolites in
the Restless Leg Syndrome (RLS) Brain: Exploring Iron Deficiency Consequence in
RLS”. B. Y. Lee, J. Vesek, E. Farace, S. Alam, J. R. Connor, Q.X. Yang. Abstract.
Proceedings of International Society of Magnetic Resonance in Medicine Annual
Meeting, 2008 [A: 4945]
44. “Voxel-based Morphometry Study in Restless Leg Symdrome (RLS): Volumetric
Increase in Multiple Brain Regions”. B. Y. Lee, J. Vesek, S. Alam, J.R. Connor, Q. X.
Yang. Abstract. Proceedings of International Society of Magnetic Resonance in
Medicine Annual Meeting, 2008 [A: 5828].
45. “Prediction of Resting Metabolic Rate in Critically Ill Patients” D. Frankenfield, A.
Schubert, S. Alam. Abstract. American Society for Parentral and Entral Nutrition
Annual Meeting, 2008.
46. “Splenic Marginal Zone Lymphoma masquerading as ANA positive acute
pneumonitis” H. Sheikh, S. Alam, H. Mobeen. Case Report. American College of
physician –Pennsylvania Chapter Annual Meeting, 2007.
47. “Do Systemic Corticosteroids Alone Increase the Risk of Pneumocystis jiroveci
Pneumonia in Pulmonary Patients?” D. Direso, D.O., S. Alam, M.D., V. Imadojemu,
M.D., K. Ingraham, D.O., M. Obrien, D.O., Abstract. Proceedings of American
Thoracic Society Annual Meeting, 2007 [A859-2007].
48. “Absolute Lymphocyte Counts in Non-HIV Patients with Pneumocystis jiroveci
Pneumonia” D. Direso, D.O., S. Alam, M.D., V. Imadojemu, M.D., M. Obrien, D.O., K.
Ingraham, D.O., Abstract. Proceedings of American Thoracic Society Annual
Meeting, 2007 [A859-2007].
49. “Interstitial Lung Disease Associated with Proximal Muscle Weakness and Skin
Rash, Developed after Pravostatin Use”, Shoaib Alam, MD*; Robert L. Vender, MD;
Kathleen M. Chaisson, MD; Shazia Riaz, MBBS Case Report, Chest, October
2003(Sup)124: 243s-b-244s-b.
50. “Diffuse Alveolar Hemorrhage after Open Heart Surgery”, Shoaib Alam, MD*;
Robert L. Vender, MD; Kathleen M. Chaisson, MD Case Report, Chest, October
2003(Sup) 124: 294s-a-295s-a.
51. “Vasospasm and Fatal Cerebral Infarction Associated with Sumatriptan Use in
Migraine”, Shoaib Alam, MD*; Yakub I. Khan, MD; Todd Gruber, MD; Shazia Riaz,
Case Report, MBBS Chest, October 2003(Sup) 124: 311s-312s.
52. “Narcolepsy Following an Insect Bite”, Shoaib Alam, MD*; Kevin Gleeson, MD;
Kathleen M. Chaisson, MD. Case Report, Chest, October 2003(Sup) 124: 306s-a-
307s-a.
Manuscripts undergoing Peer Review or In-Preparation
1. “Abnormal Methacholine Challenge Associated with Pulmonary Arterial
Hypertension in Adults with Sickle Cell Disease”. Alem Mehari, MD1, 2
,
Shoaib Alam, MD1
, Xin Tian PhD3
, Joseph Fontana MD1,
, and Gregory J.
Kato, MD. 2013
2. “Computer Aided Texture Analysis of PULmonary computed Tomograms
(CATAPULT) Predicts Risk of Pulmonary Hypertension and Death in Adults
with Sickle Cell Disease”. Les R Folio, DO, MPH, Jesus Caban, PhD, Alem
Mehari, MD, Jenifer Siegelman, MD, MPH, Genevieve Jacobs, BS, Xin Tian,
PhD, Joseph R. Fontana, MD, Shoaib Alam, MD, Gregory J. Kato, MD,
Daniel J. Mollura, MD. 2013

8. 3. “Validation of a Simple Novel One-Minute Stair Climbing Test for
Functional Assessment in Advanced Lung Diseases Patients”. Shoaib Alam,
Nargues Weir, Mary Smith, Scott Barnett, Steven D. Nathan. 2013
4. “Clinical Characteristics of Sickle Cell Disease Patients Developing Cor-
Pulmonale during Acute Hospitalization”. Shoaib Alam, MD, George Miles,
MD, Nargues Weir, MD, Alem Mehari, MD,
Vandana Sachdev, MD,
Courtney Fitzhugh, MD, James G. Taylor VI, MD, Caterina P. Minniti, MD,
Mark T. Gladwin, MD, Roberto F. Machado, MD, Gregory J. Kato, MD. 2013
Invited Presentations
Pulmonary and Critical Care Grand Rounds at Jefferson University Hospital, Philadelphia,
Pennsylvania on “Secondary Pulmonary Hypertension; What is Expected? What is Out of
Proportion?” December 07, 2011.
Administrative and Other Experience
Administrative, Research and Teaching Experience at Penn. State University
During my five years as Assistant Professor of Pulmonary and Critical Care Medicine at Penn.
State University-Hershey Medical Center Started First Comprehensive Pulmonary Arterial
Hypertension and Pulmonary Vascular Diseases Program in Central Pennsylvania through
Penn. State and mentored many pulmonary and critical care fellows, residents and medical
students. Developing the curriculum for students and residents on Pulmonary Service.
Conducted board review sessions for fellows. Actively participated in recruiting process of
fellows for the fellowship program. Collaborated with multiple researchers on campus.
Participated in quality improvement activities.
Administrative, Research and Teaching Experience at Intramural NIH/NHLBI
See Annex 1 for details
Reorganized the Pulmonary Hypertension Program
Re-organized the Pulmonary Hypertension Clinical and Research Program at Intramural
National Heart Lung and Blood Institute to improve performance on Pulmonary Arterial
Hypertension Specific Drugs prescription practices and expanded the scope of clinical research
related to pulmonary arterial hypertension.
Scientific Review of New Research Protocols
Served on Cardiovascular and Pulmonary Medicine Branch/Pulmonary and Vascular Medicine
Branch Scientific Review Board, responsible for reviewing the scientific merit of the
forthcoming research protocols
Quality Improvement Activities
Participated in Quality Improvement (QI) projects and review of reports for Bronchoscopy
Services as well as for general QI processes for pulmonary and vascular medicine branch
Other Scholastic University of the Punjab, Lahore, Pakistan
Accomplishments Proficiency Certificate in French Language & Communication, 1990
Alliance Fransais De Lahore, Pakistan.
Preliminary Level in French Language & Communication, 1991
Iranian Cultural Center, Lahore, Pakistan.
Diploma in Persian Language & Literature, 1992
Interests Tourism and Sightseeing
Country Boat Rowing, Hiking & Mountaineering, Chess
Literature reading, prose writing

9. Personal Born and raised in Pakistan, fluent in English, Urdu, Punjabi, Hindi and other
regional languages, proficiency in French and Persian.
Memberships Member American Thoracic Society (ATS) 2001 to-date.
Member American College of Chest Physicians (ACCP) 2002 to-date.
Member European Respiratory Society (ERS) 2001 to 2012.
Member Pulmonary Hypertension Association (PHA) 2004 to 2012.
Member American Society of Echocardiography (ASE) 2008 to 2012.
Member Pennsylvania Thoracic Society (PTS) 2001-2004.
Member Society of Critical Care Medicine (SCCM) 2001-2004.
Member International Society of Magnetic Resonance in Medicine (ISMRM) 2001-2005.
References Available upon request

10. ANNEX: 1
NATIONAL HEART, LUNG AND BLOOD / NATIONAL INSTITUTES OF HEALTH,
BETHESDA, MARYLAND
[June 01, 2009 to December 30, 2014]
EXPERIENCE AT NIH CLINICAL CENTER (www.cc.nih.gov)
CLINICAL EXPERIENCE:
General Clinical Service:
Worked as Staff Clinician / Pulmonologist, a primarily clinical job that involved providing coverage for
pulmonary clinical service for inpatient, outpatient and procedure service. Large portion of clinical
workload involved providing pulmonary consultations for floor and intensive care unit patients,
performing bronchoscopies for bronchoalveolar lavage, transbronchial biopsies and transbronchial
needle aspiration biopsies. Large proportions of patients were immune-compromised host enrolled in
National Cancer Center (NCI), National Institute of Allergy and Infectious Diseases (NIAID) and
National Heart, Lung and Blood Institute (NHLBI) research protocols undergoing research involving
novel therapies or various kinds of Stem Cell Transplantation.
The clinical service also involved providing consultations for Pediatric Patients and also performing
bronchoscopies in Pediatric Patients.
Pulmonary Arterial Hypertension Service:
Managed Pulmonary Arterial Hypertension program for NIH Clinical Center involving managing
patients with pulmonary hypertension, providing expert consultations for NHLBI and other institutes
at NIH. Performing Right Heart Catheterizations for clinical and research purposes.
Sickle Cell Disease Service:
This service included taking care of Sickle Cell Disease Patients (primarily patients with pulmonary
hypertension or patients who have undergone matched related donor allogeneic stem cell
transplantation).
MENTORING AND TEACHING EXPERIENCE:
- Mentored Pulmonary Arterial Hypertension Fellow, Alem Mehari, MD (currently Assistant
Professor of Pulmonary and Critical Care at Howard University and leading Pulmonary
Hypertension Program)
- Co-Mentored Advanced Cardiovascular Imaging Fellow, from UCLA Kim-Lien Nguyen,
MD on
her project examining hemodynamic and MRI predictors of early mortality in patients with
Sickle Cell Disease related pulmonary hypertension
- Teaching of Pulmonary and Critical Care Fellows from Walter Reed National Military Medical
Center, Bethesda, Maryland on NIH Clinical Center Pulmonary Service.
- Teaching of NCI and NHLBI Hematology-Oncology Fellows on NIH Clinical Center Sickle Cell
Service

11. RESEARCH EXPERIENCE
Scientific Review of Research Protocols:
Served on scientific committee for branch scientific review of new research protocols at Pulmonary
and Vascular Medicine Branch (PVMB) and Cardiovascular and Pulmonary Medicine Branch (CPB) at
NIH Clinical Center.
Data Monitoring and Safety Board (DSMB):
Participated in DSMB activities as investigator.
Clinical Support for Research:
Provided clinical support for diverse ongoing Adult and Pediatric Research Protocols under various
institutes at NIH Clinical Center.
Following is the list of Research Protocols where my involvement was more direct:
RESEARCH PROJECTS / PROTOCOLS
ROLE: LEAD INVESTIGATOR
A Pilot Study of Treatment of Adults with Sickle Cell Disease Associated Pulmonary Hypertension Based
on Hemodynamic Stratification: Safety and Tolerability Study of Imatinib and Carvedilol.
NIH-CC Protocol: 12-H-0093
www.clinicaltrials.gov: NCT01568645
ROLE: ASSOCIATE INVESTIGATOR
A Phase 1, Placebo-Controlled, Randomized, Double-Blind Study to Evaluate the Safety, Tolerability,
Pharmacokinetics, and Pharmacodynamics of Escalating, Single or Multiple Oral Doses of Aes-103 in
Subjects with Stable Sickle Cell Disease.
NIH-CC Protocol: 12-H-0127
www.clinicaltrials.gov: NCT01597401
Microvascular and Cardiac Dysfunction in Sickle Cell Disease
NIH-CC protocol: 12-H-0124
www.clinicaltrials.gov: NCT01602809
End-alveolar Carbon Monoxide as a Measure of Erythrocyte Survival and Hemolytic Severity in Sickle
Cell Disease
NIH-CC Protocol: 12-H-0069
www.clinicaltrials.gov: NCT01547793
A Pilot Study of the Effect of Spironolactone Therapy on Exercise Capacity and Endothelial Dysfunction
in Pulmonary Arterial Hypertension.
NIH-CC Protocol: 12-CC-0211
www.clinicaltrials.gov: NCT01712620
THE IMPROVE TRIAL: Improving Pain Management and Outcomes with Various Strategies of Patient-
Controlled Analgesia (PCA)
NIH-CC Protocol: 10-H-0031
www.clinicaltrials.gov: NCT00999245
A Randomized, Placebo-Controlled, Double-Blind Pilot Study of Pioglitazone Hydrochloride in Severe,
Refractory Asthma
NIH-CC Protocol: 09-H-0244
www.clinicaltrials.gov: NCT00994175

12. Pulmonary Hypertension and the Hypoxic Response in SCD
NIH-CC Protocol: 07-H-0181
www.clinicaltrials.gov: NCT00495638
Treatment of Pulmonary Hypertension and Sickle Cell Disease with Sildenafil Therapy
NIH-CC Protocol: 07-H-0177
www.clinicaltrials.gov: NCT00492531
Cardiopulmonary Function Assessment and NO Based Therapies for Patients with Hemolysis-
Associated Pulmonary Hypertension
NIH-CC Protocol: 06-H-0202
www.clinicaltrials.gov: NCT00352430
A Prospective, Multicenter, Double-Blind, Randomized, Placebo-Controlled Study of Nitric Oxide for
Inhalation in the Acute Treatment of Sickle Cell Pain Crisis
NIH-CC Protocol: 05-H-0019
www.clinicaltrials.gov: NCT00094887
Studies of the Natural History of Sickle Cell Disease and Other Hemolytic Disorders
NIH-CC Protocol: 04-H-0161
www.clinicaltrials.gov: NCT00081523
Inhaled Nitric Oxide and Transfusion Therapy for Patients with Sickle Cell Anemia and Secondary
Pulmonary Hypertension
NIH-CC Protocol: 01-H-0223
www.clinicaltrials.gov: NCT00023296
Determining the Prevalence and Prognosis of Secondary Pulmonary Hypertension in Adult Patients
with Sickle Cell Anemia
NIH-CC Protocol: 01-H-0088
www.clinicaltrials.gov: NCT00011648
Evaluation and Treatment of Pulmonary Patients not Participating in Research (Training Protocol)
NIH-CC Protocol: 97-H-0061
www.clinicaltrials.gov: NCT00001621
Hydroxyurea in Primary Arterial Hypertension
NIH-CC Protocol: T-H-0271
Collection of Blood from Volunteers and Patients for Studies of Endothelial Function and Systemic
Inflammation
NIH-CC Protocol: 03-H-0015