LYMPHOMA PPT

4. Hodgkin lymphoma
Classical subtypes – Nodular Sclerosis
Mixed cellularity
Lymphocyte rich
Lymphocyte depleted
Lymphocyte predominance

8. Lymph node structure

16. Classification (WHO)
 Nodular Sclerosis Classical Hodgkin
 Mixed cellularity
 Lymphocyte rich
 Lymphocyte depleted
 Lymphocyte predominance
 First 4 types – Reed- sternberg cells have similar
immunotype, Lymphocyte predominance have
distinctive B cell immunophenotype.

17. Pathogenesis
 Activation of the transcription factor NF-kB is common event in
classical hodgkin.
 NF-kB can be activated by –
1. EBV infection
2. EBV tumor cells LMP-1
3. Loss of function mutations in IkB or A20(alpha induced protein 3)
 Activation of NF-kB by EBV or other mechanism rescues crippled
germinal centre B cells from apoptosis, further mutations turn these to
RS cells.
 RS cell – aneuploid and possess diverse aclonal chromosomal
aberrations.
 Most common is gain in REL protooncogene that contribute to increase
in NF-kB activity.

18. Pathogenesis

19. Pathogenesis

40. Non hodgkin
lymphoma(NHL)

49. Treatment
 DLBCL are aggressive tumor that are rapidly fatal
without t/t
 Intensive chemotherapy
 Adjuvant anti- CD20
DLBCL with myc translocation have worse prognosis.

79. Thank you