Reaching SDG 2 of ending hunger and making agriculture more sustainable presents major challenges. Smallholder farmers, especially in Sub-Saharan Africa and Asia, will be key to achieving this goal as they produce about 80% of the food in these regions. For smallholders to be more productive and sustainable, they need support through a transformation agenda. This transformation is complex and must be tailored to local conditions and rooted in scientific knowledge. New technologies are increasingly available to smallholders that can help boost productivity. Scientists are needed to analyze research, synthesize findings, and work with local stakeholders to support smallholder farming. The AgriFoSe2030 Program focuses on sustainable intensification in Sub-Saharan Africa and Southeast Asia to improve