This presentation with the above title was presented by me as a part of training programme for superspecialty course DM Clinical Pharmacology in Seth GSMC and Kem hospital, Mumbai as a short seminar. Find this for unlimited sharing and may this be of use to all.
3. Problem statements Why read about this topic?
1. CAP* leading cause of death due to
infectious diseases in developed
countries.[1]
2. Huge medical costs, those in the US
alone exceeding $ 10 billion per annum
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*Community Acquired pneumonia
1.Torres A, Peetermans WE, Viegi G, Blasi F. Risk factors for community-acquired pneumonia in adults in Europe: A literature review. Thorax 2013;68:1057-65 3
4. Introduction
GBD* 2015 study lower respiratory tract infections (LRTIs) fourth most
fatal after:
• IHD
• cerebro-VD [1]
LRTI- Acute illness (≤3-week) 1o symptom cough +≥1 other symptoms of
LRT viz expectoration, breathlessness, wheeze/ chest discomfort/pain
includes:
• a/c bronchitis
• pneumonia
• a/c exacerbation of chronic lung diseases such as COPD/bronchiectasis
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Global Burden of Disease
1. GBD 2015 Mortality and Causes of Death Collaborators. Global, regional, and national life expectancy, all-cause mortality, and cause-specific
mortality for 249 causes of death, 1980-2015: A systematic analysis for the global burden of disease study 2015. Lancet 2016;388:1459-544
4
17. Treatment
regimen in
India
1. Beta-
Lactam
2. Macrolides
3. FQs
17 12/21/2022
REF- MAHASHUR A. MANAGEMENT OF LOWER RESPIRATORY TRACT INFECTION IN
OUTPATIENT SETTINGS: FOCUS ON CLARITHROMYCIN. LUNG INDIA 2018;35:143-9.
25. 12/21/2022
Metlay JP. Et al Diagnosis and Treatment of Adults with Community-acquired Pneumonia An Official Clinical Practice Guideline of the American Thoracic Society
and Infectious Diseases Society of AmericaAmerican Journal of Respiratory and Critical Care Medicine Volume 200 Number 7 | October 1 2019 25
26. Summary
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LRTIs are common problems in
day-to-day clinical practice
Antimicrobial therapy is a principal
management
Due to infrastructural limitations
physician resorts to empirical
therapy antimicrobial resistance
Recent changes in guidelines
suggests combination therapy using
macrolide and beta-lactam antibiotic