1. ASSINGMENT WORK
STUDENT NAME :- SAURABH VERMA
DEPARTMENT :- PHARMACOINFORMATIC
INSTITUTE :- NIPER, KOLKATA
SUBJECT :- (DATABASE MANAGEMENT)
( SYSTEM)
STUDENT NAME :- SAURABH VERMA
DEPARTMENT :- PHARMACOINFORMATIC
INSTITUTE :- NIPER, KOLKATA
SUBJECT :- (DATABASE MANAGEMENT)
( SYSTEM)

2. To get the protien sequence and observe
structure and superimpose with ligand,get the pi
value and mol.wt of that sequence and
Glycosylation
Assignment Work

3. • >3E63:A|PDBID|CHAIN|SEQUENCE
• RDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEV
VAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCY
• SAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICK
GMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLT
• KVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFG
VVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHL
• IELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDL
ALRVDQIRDNMA
Fragment-based discovery of JAK-2 inhibitors

4. Molecular Description
• Classification: Transferase
• Structure Weight: 34888.05
• Molecule: Tyrosine-protein kinase JAK2
• Polymer: 1
• Type: protein
• Length: 293
• Chains: A
• EC#: 2.7.10.2 3.1.13.2
• Organism: Homo sapiens
• UniProtKB: Search PDB | O60674
• PDB Display Files :-3E63

5. Sequence Display

6. SEQUENCE

7. 3D- VIEW

9. LIGAND PROTIEN INTERACTION

10. 5-phenyl-1H-indazol-3-amine
(5-B2)

11. RESULT OF MOTIF FINDER
IN SEQUENCE

12. 1 MOTIF

13. 2-MOTIF

14. Database of protein domains, families and
functional sites

15. PROTIEN SITE

16. PROTIEN SITE

17. MOLECULAR WEIGHT
• The Sequence Manipulation Suite: Protein
Molecular Weight
Results for 293 residue sequence
"3E63:A|PDBID|CHAIN|SEQUENCE" starting
"RDPTQFEERH".
The protein weighs 34.47 kilodaltons

18. CALCULATE THE PI VALUE OF PROTIEN SEQUENCE

19. PI- TABLE

20. NetOGlyc 4.0 Server
The NetOglyc server produces neural network predictions of mucin type GalNAc O-
glycosylation sites in mammalian proteins.

21. OUTPUT DESCRIPTION

22. END
THANKU