Aromasin is a medication used to treat breast cancer in postmenopausal women. It works by inhibiting the aromatase enzyme, which reduces estrogen production. This stops cancer growth fueled by estrogen. Common side effects include hot flashes, joint pain, and fatigue. Aromasin has been shown to reduce the risk of breast cancer recurrence when taken after tamoxifen treatment for 2-3 years in postmenopausal women with hormone receptor-positive, early-stage breast cancer.

1. BREAST CANCER TREATMENT WITH AROMASIN
Aromasin isa cancer treatmentmedicine,whichcomeswithmultiplebenefitsaswell assome side
effectstoo.Like anyothercancer medicine therewillbe side effectsbutthe benefitsare goodenough
to weighdownthe side effects.The mainapplicationof thisproductisinbreastcancer treatment.
Several typesof breastcancercan be treatedwiththe medicine.Aromasingenericisalsoreferredtoas
AromasinExemestane.Italsoinhibitscancerfromreturning.
In womenthe hormone estrogenplaysabad role innaturallyincreasingthe size andspreadof cancer
cells.Thiscan be reversedandstoppedwhenthe amountof estrogenreleasedonbodycanbe
controlledandstopped.The medicine doesthe same.Butthatis one reason,thatit isnot usedon
womenwhoare still fertile andinchildbearingage.Aromasin(chemical name:exemestane)isan
aromatase inhibitorapprovedbythe U.S.Food andDrug Administration(FDA) totreat:
 postmenopausalwomendiagnosedwithhormone-receptor-positive,early-stagebreastcancer
afterthey’ve takentamoxifenfor2 to 3 yearsto reduce the riskof the cancer comingback
 postmenopausalwomendiagnosedwithadvanced-stage ormetastatichormone-receptor-
positive breastcancer
WomenstoptakingtamoxifenwhentheystarttakingAromasin.
Aromatase inhibitorscan’tstopthe ovariesfrommakingestrogen,soaromatase inhibitorsare mainly
usedto treatpostmenopausal women.Butbecause aromatase inhibitorsare somuchmore effective
than tamoxifeninpostmenopausalwomen,researcherswonderedif there were awayto successfully
treat premenopausal womendiagnosedwithhormone-receptor-positive,early-stage breastcancerwith
an aromatase inhibitor.Resultsfromthe SOFT(Suppressionof OvarianFunctionTrial)studypublishedin
2015 suggestthatpremenopausal womendiagnosedwithhormone-receptor-positive breastcancercan
be successfullytreatedwithAromasinif theirovarianfunctionissuppressed.If you’re apremenopausal
womanwillingtotake medicine tosuppressyourovaries,youmaybe able totake Aromasininsteadof
tamoxifenforyourhormonal therapytreatment.
Aromasinwon’tworkonhormone-receptor-negative breastcancer.
Aromasinisa pill takenonce a day.Most doctors recommendtakingAromasinatthe same time each
day.You shouldnottake Aromasinif youare breastfeeding,pregnant,tryingtogetpregnant,orif there
isany chance thatyou couldbe pregnant.Aromasinmaycause damage to developingembryos.You
shoulduse aneffective non-hormonal type of birthcontrol — suchas condoms,a diaphragmalongwith
spermicide, oranon-hormonal I.U.D. –while youare takingAromasin.Askyourdoctorwhichtype of
non-hormonal birthcontrol wouldbe bestforyou,aswell ashow longyoushoulduse thistype of birth
control afteryou stoptakingAromasin.
Aromasin Works
Exemestane isatype of hormone therapydrugincludedinthe groupof aromatase inhibitordrugs,and
definedbythe National CancerInstitute (NCI) DrugDictionaryasa “syntheticandrogenanalogue”that

2. “bindsirreversiblytoandinhibitsthe enzyme aromatase,therebyblockingthe conversionof cholesterol
to pregnenolone andthe peripheral aromatizationof androgenicprecursorsintoestrogens.”The drugis
usedforthe treatmentof breastcancerand it isusuallytaken inthe formof tabletsonce a dayaftera
meal overthe course of a fewyears.The mechanismof actionof exemestaneisbasedonaddressingthe
hormonesthatstimulate breastcancergrowth.
In menstruatingwomenthe growthof breastcanceris promotedbyfemale sex hormonescalled
estrogenandprogesterone,whichare producedinthe ovaries.Inmenopausal womenthe productionof
these hormonesnolongeroccurinthe ovaries.Aftermenopause,hormonesare mainlyproduced
througha processthat transformandrogenssex hormonesproducedbythe adrenal glands — into
estrogen.Thistransformationiscalledaromatase.Exemestane worksbyblockingaromatase inorderto
decrease the levelsof estrogeninthe bodyandstopcancer growthor breastcancer recurrence.
Aromasin for Breast Cancer
Exemestane wasapprovedbythe U.S.FDA inOctober2005. The drugis commercializedunderthe
brand name AromasinbyPfizer,andisusedasan adjuvanttreatmentinpostmenopausal womenwho
sufferfromestrogenreceptorpositiveearly-stage breastcancer.Womengenerallybegintaking
exemestane afterthey’ve beenontamoxifenfortwotothree years,thenswitchtoexemestane fortwo
to three years,fora total of five consecutiveyearsof adjuvanthormonal therapy.
The FDA’sapproval of the drug wasbasedon a double-blind,multi-center,international clinical trial that
included4,724 postmenopausal womenwithearlystage breastcancer,knownasthe Intergroup
Exemestane Study(IES).
“Aftera mediandurationof randomizedtherapyof 27monthsand witha mediandurationof follow-up
of 34.5 months,DFS[disease-free survival] wassignificantlyimprovedinpatientswhoswitchedto
exemestane comparedtothose whocontinuedtamoxifen,”accordingtothe NCI.“In the hormone
receptor-positive subpopulationrepresentingabout85 percentof the trial patients,DFSwas
significantlyimprovedinthe exemestanearmcomparedtothe tamoxifenarm.”
The same studyindicatedthatthe mostcommonside effectsfromthe treatmentinclude hotflashes,
fatigue,jointpain,headache,insomnia,increasedsweating,hypertension,anddizziness.More rare
adverse events,suchasheartproblems,canalsooccur.
BreastCancer Newsisstrictlya newsandinformationwebsiteaboutthe disease.Itdoesnotprovide
medical advice,diagnosisortreatment.Thiscontentisnotintendedtobe a substitute forprofessional
medical advice,diagnosis,ortreatment.Alwaysseekthe advice of yourphysicianorotherqualified
healthproviderwithanyquestionsyoumayhave regardingamedical condition.Neverdisregard
professionalmedical advice ordelayinseekingitbecause of somethingyouhave readonthiswebsite.
Aromasin with afinitor

3. AromasinAfinitorisacombinationwhere the comboof the twodrugs AromasinandAffinitorhelps
reduce the symptomsof advancedbreastcancerin patients.Asaresultthe growthand advancementof
the cancer in advancedstagesisslowed.Thisresultsinalongerlife of the patients.
Benefits of Aromasin
The large IES(IntergroupExemestane Study)trial wasstartedin1998 andcomparedswitchingto
Aromasinaftertakingtamoxifenfor2 to 3 years tostayingon tamoxifenfor5years.The resultshave
shownthat switchingtoAromasinfor2 to 3 yearsAFTER takingtamoxifen2to 3 years(fora total of 5
yearsof hormonal therapymedicine)wasbetterthanstayingontamoxifenfor5 yearsfor:
 increasingthe time before the cancercomesbackinthose whoexperience arecurrence
 reducingthe riskof a newcancerdevelopinginthe otherbreast
 for postmenopausal womendiagnosedwithhormone-receptor-positive,early-stage breast
cancer.
Researchpublishedin2011 showedthatAromasincanlowerriskinhigh-risk,postmenopausal women
who’ve neverbeendiagnosedwithbreastcancer.Aromasinisnot approvedbythe FDA forthisuse,but
doctorsmay considerita good alternative totamoxifenorEvista.In2013, the AmericanSocietyof
Clinical Oncology(ASCO) releasednewguidelinesonusinghormonal therapymedicinestoreduce breast
cancer riskinhigh-riskwomen.Theseguidelinesrecommendthatdoctorstalkto high-risk
postmenopausalwomenaboutusingAromasintoreduce risk.ASCOisa national organizationof
oncologistsandothercancercare providers.ASCOguidelinesgive doctorsrecommendations for
treatmentsthatare supportedbymuchcredible researchandexperience.
It’spossible thatthe FDA may approve Aromasintobe usedto reduce riskinhigh-risk,postmenopausal
womenwhohaven’tbeendiagnosed.
Side effects Aromasin
The common side effectsof Aromasinare hairloss,hotflashes,jointpains,bonepains,dizziness,
excessivesweating,diarrhea,nausea,insomniaandtiredness.
If the side effectsworsensandyouexperience more troubleslikeunexplainedvaginalbleeding,severe
depressionormoodswings,bone fractures,extreme tirednessornauseaandvomiting,yellow eyesand
skin,anddark coloredurine,thenyoumustinstantlytellthe doctoraboutit.
Problemsandcase historiesincludingbloodclotformations,bone problems,heartproblems,
cholesterol issues,andkidneyandliverrelatedproblemsmustbe discussedwiththe doctor.
Precautionswhiletakingthe medicine
The drug is takenonce a day orally.Ithas to be takenas toldby the doctor. Pregnantwomenare at risk
fromthe drug,and hence nopregnantwomenshouldhandle thisorgetexposedtothis.The drugmay

4. enterbodythroughskinandlungstoo, andhence inhalingthe dustof the tabletsmaypose problemfor
pregnantwomen.
Basedon the severitypatients maygetan increasedordecreaseddose of the drug.If yousee that
breastlumpsare worsenedyoumustimmediatelyreportthe doctor.
Estrogensandestrogenblockingdrugscaninterfere withthe activityof the medicine.Hence youmust
discussall the drugsyou are takingwhenyouare prescribedthismedicine.
How it is used in body building?
In manymalesthe amountof estrogenishighinthe bodygivinginunwantedside effectslikeenlarged
breasttissuesandreductionorconversionof testosterone into otherformsthatare notgood fora
muscularand masculine body.Hence the bestwaytostopthisis byinhibitingthe maincausative
enzyme behindthiswhichisaromatase.Aromatase canbe stoppedfromproducingestrogenwhen
Aromasinistaken.Asa resulta muscularbodycan be easilyachievedthroughbodybuildingefforts.
That is whybodybuildersuse Aromasinbodybuildingtherapy.
The tabletsare available onlineandone maygetthe cost or price listonline fromrelevantwebsites.
Because Aromasinlowersthe amountof estrogeninthe body,lessestrogenreachesbone cells,which
can leadto bone thinningandweakeningandahigher-than-averageriskof brokenbones.Thisside
effectcanbe verytroublingforsome women.If youhave osteoporosis,yourdoctormayrecommend
that youtake tamoxifenratherthanAromasinbecause of thispossible sideeffect.
Othercommonside effectsof Aromasinare:
 bone and jointpain
 hot flashes
 fatigue
 headache
 insomnia
 increasedsweating
Some womenmayhave otherside effectswhile takingAromasin:
 nervousness
 dizziness
 dry skin
 diarrhea
 visionchanges
 hair changes
Some side effectsmaymeanthatyou’re havinganallergicreactiontoAromasin.If youhave shortness
of breathor chestpain,call your doctorimmediately.

5. For more informationvisitusourwebsite:http://www.healthinfi.com