Due to its prevalence worldwide, osteoporosis is considered a serious public health concern. Currently it is estimated that over 200 million people worldwide suffer from this disease.

1. Osteoporosis...Osteoporosis...
and its Prevalenceand its Prevalence
Md. Reyashat Azim (Abir)Md. Reyashat Azim (Abir)
Senior Product ExecutiveSenior Product Executive
Strategic Marketing Department (SMD)Strategic Marketing Department (SMD)
HealthCare Pharmaceuticals LtdHealthCare Pharmaceuticals Ltd

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Know Osteoporosis forKnow Osteoporosis for
NO OsteoporosisNO Osteoporosis

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Definition of OsteoporosisDefinition of Osteoporosis
 Excessive osteoclast mediated bone resorption
 Compromised bone strength
 Increased risk of fracture at all skeletal sites
Boyle WJ, et al. Nature. 2003;423:337-342.
NIH Consensus Development Panel. JAMA. 2001;285:785-795.
Normal
“Osteoporosis is one of the most common and debilitating
chronic diseases, and a global healthcare problem.”
International Osteoporosis Foundation
Osteoporosis
“Osteoporosis has financial, physical, and psychosocial
consequences, all of which significantly affect the
individual, the family, and the community.”
NIH Consensus Statement
A skeletal disorder characterized by…

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WHO Definition of OsteoporosisWHO Definition of Osteoporosis
The WHO Working Group defines osteoporosis
according to measurements of bone mineral density
(BMD) using dual-energy X-ray absorptiometry
(DEXA). Thus osteoporosis is defined as a bone
density T score at or below 2.5 standard deviations (T
score) below normal peak values for young adults.
The WHO definition of osteoporosis only takes into
consideration measurement of bone density, with no
component of bone quality.

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Loss of Bone Mass With AgeLoss of Bone Mass With Age

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Prevalence ofPrevalence of OsteoporosisOsteoporosis

7. Osteoporosis-related fractures in women compared withOsteoporosis-related fractures in women compared with
other leading diseasesother leading diseases
Ref: International Osteoporosis Foundation

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 Worldwide
- 1 in 3 women
- 1 in 8 men
over the age of 50 have osteoporosis.
Osteoporosis PrevalenceOsteoporosis Prevalence

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Osteoporosis Prevalence: GenderOsteoporosis Prevalence: Gender
80% of those affected
by osteoporosis are
women.
 20% of those affected
by osteoporosis are men.

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Consequences ofConsequences of OsteoporosisOsteoporosis

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When Bones BreakWhen Bones Break
 The main serious consequence of Osteoporosis is -
FRACTURE
Major complication is fracture leading to:
- Increased morbidity
- Increased mortality
- Decreased quality of life

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[Ref: National Osteoporosis Foundation]
Approximately 1 in 2 women and 1 in 4
men over age 50 will have an osteoporosis
related fracture in their remaining lifetime.
Prevalence of osteoporosis-related fracturesPrevalence of osteoporosis-related fractures

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Prevalence of osteoporosis-related fracturesPrevalence of osteoporosis-related fractures
Wrist fracture
men 1 in 40 (2.5%)
women 1 in 6 (16%)
Spinal fracture
men 1 in 20 (5%)
women 1 in 6 (16%)
Hip fracture
men 1 in 17 (6%)
women 1 in 6 (17.5%)

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Risk of having second fractureRisk of having second fracture
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The risk of having a second fracture was
found to be similar for women and men.
Ref: Evid. Based Med. 2007;12;123

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- Women with hip fracture are at a four fold greater risk of a
second one.
- 1 in 4 (25%) people die within a year of the fracture
- 1 in 4 become disabled
- 2 of the 4 can walk again but with lower mobility than
before.
- Many become isolated and depressed.
Ref: International Osteoporosis Foundation
Risk of having second fracture : HIPRisk of having second fracture : HIP

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Patients with vertebral fracture are at five-fold
greater risk of another fracture within 1 year.
Ref: International Osteoporosis Foundation
Risk of having second fracture : VETEBRALRisk of having second fracture : VETEBRAL

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Symptoms and Warning SignsSymptoms and Warning Signs
 People may not know that they have
osteoporosis until they break a bone.
 Vertebral (spinal) fractures may
initially be felt or seen in the form of
- Persistent, unexplained back pain
- Loss of height
- Spinal deformities such as
kyphosis or stooped posture.

18. Thank YouThank You