The document discusses the severity and seriousness of adverse drug reactions (ADRs). It defines four levels of severity - mild, moderate, severe, and lethal - based on the extent to which ADRs influence a patient's daily life. Mild ADRs do not require antidotes or prolonged treatment/hospitalization and cause minor symptoms like drowsiness. Moderate ADRs may require changes to treatment but not discontinuation of necessary drugs, and can result in prolonged hospitalization or specific treatment for symptoms such as urinary issues or mood changes. The document provides this information about ADR severity in the context of a student's class on pharmacovigilance, citing a reference textbook.

1. Topic : Severity And Seriousness
Student Name : Misal Ranjit Shashikant
Year : Final Year
Semester: VIII
Roll No : 26

2. The Severity
Severity -
Extent to which ADR's influence the day to
day life of patient.
kotch & Lasagna classify severity :
a) Mild
b) Moderate
c) Severe
d) Lethal

3. a) Mild :-
➢ no antidote Requires
➢ no treatment , hospitalization not prolonged
Symptoms: Drowsiness,Constipation. Nuasea, vomiting, Sleep
disturbance
b) Moderate :-
➢ Change in treatment tig but no necessary discontinuation if drug
is
required.
➢ Hospitalization may prolonged
➢ Specific Treatment is required.
Symptoms:
Difficulty in urination , Mood changes , Increase in WBC Count ,
Decrease glucose
lev

6. Seriousness of ADR :

8. Reference :
A book of Pharmacovigilance,
By Dr. Agnimitra Dinda and Monika Saxena,
Thakur Publications,
First edition 2021,
Page No : 40-41

9. Thank you ...