The market for enzymes in medicine is growing. The global market for medical enzymes is estimated at $6 billion in 2010. The market is growing at a compound annual growth rate (CAGR) of 3.9%, to reach $7.2 billion in 2015.Therapeutic enzymes are the biggest segment in terms of revenues generated. This sector was valued at $5.3 billion in 2010 and is expected to increase at a 3.6% compound annual growth rate (CAGR) to reach $6.3 billion in 2015.Enzymes used in molecular research will experience the fastest compound annual growth rate (CAGR), 6.2%, over the study period. This sector was worth $546 million in 2010 and should reach nearly $739 million by 2015. INTRODUCTIONSTUDY GOAL OBJECTIVESBCC’s goal in conducting this study is to provide an overview of the current and future characteristics of the global market for medical enzymes. The key objective is to present a comprehensive analysis of the current market and its future direction as an important tool for increasing the efficiency and specificity of the products in which medical enzymes are used.This report explores present and future strategies within the medical enzymes market, which includes the therapeutic, diagnostics, and molecular research sector. The improvisation of the market, the setbacks, and the needs of the market are discussed in this report. The nomenclature, history, and the classification of different types of enzymes are also discussed.A detailed analysis of the structure of the medical enzymes industry has been conducted. Revenues are broken down by global region. Sales figures are estimated for the 5-year period from 2010 through 2015.Applications or the uses of medical enzymes are also discussed separately in the report, with emphasis on the usage in various disease sectors. The report also covers the usage of enzymes for diagnostic purposes and in molecular research like sequencing, mapping, and so on. The report also covers significant patents and their number in each category.REASONS FOR DOING THIS STUDYA rapid increase in enzyme knowledge has resulted in harvesting the advantages of enzymes in almost every field of life. Enzymes are not only used for industrial purposes but also are used in various fields of the healthcare industry including therapeutics, diagnostics, and molecular research. Modern industries have now begun to explore the advantages of enzymes in their production processes. This has led to a growing market for enzymes. Genetic engineering technology has made it possible to produce the enzymes in a form identical to the one that normally takes place in the human body. The increasing competition, patent expirations, and new technologies are taking this industry in a new direction. Although the industry did see a setback in 2009 due to some manufacturing problems and FDA regulations, new advancements and increased spending in research and development are causing the market to grow. This study looks at almost all of the systems affected by these factors. Acquisition strategies and collaborations by companies are also covered in this report. This study also discusses the strength and weaknesses of each type of technology in light of the new technologies, growing competition, and changing customer needs.CONTRIBUTIONS of THE STUDY AND ITS INTENDED AUDIENCE This study contributes to the areas of market growth in therapeutic, diagnostic, and research enzyme manufacturers and users. Pharmaceutical, chemical, biochemical, and biotechnical companies, industries, and research institutes will find this study to be of interest. SCOPE of THE STUDY The scope of this study encompasses medical or medicinal enzymes, bio-technical, pharmaceutical, and biotechnology markets. BCC analyzes each market and its applications, regulatory environment, technology involved, market projections, and market share. Technological issues include the latest trends and developments. METHODOLOGYBCC conducted a comprehensive literature se
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Medical Enzymes: Technologies and Global Markets
Published on March 2011
Report Summary
The market for enzymes in medicine is growing. The global market for medical enzymes is estimated at $6 billion in 2010. The market
is growing at a compound annual growth rate (CAGR) of 3.9%, to reach $7.2 billion in 2015.
Therapeutic enzymes are the biggest segment in terms of revenues generated. This sector was valued at $5.3 billion in 2010 and is
expected to increase at a 3.6% compound annual growth rate (CAGR) to reach $6.3 billion in 2015.
Enzymes used in molecular research will experience the fastest compound annual growth rate (CAGR), 6.2%, over the study period.
This sector was worth $546 million in 2010 and should reach nearly $739 million by 2015.
INTRODUCTION
STUDY GOAL OBJECTIVES
BCC’s goal in conducting this study is to provide an overview of the current and future characteristics of the global market for
medical enzymes. The key objective is to present a comprehensive analysis of the current market and its future direction as an
important tool for increasing the efficiency and specificity of the products in which medical enzymes are used.
This report explores present and future strategies within the medical enzymes market, which includes the therapeutic, diagnostics,
and molecular research sector. The improvisation of the market, the setbacks, and the needs of the market are discussed in this
report. The nomenclature, history, and the classification of different types of enzymes are also discussed.
A detailed analysis of the structure of the medical enzymes industry has been conducted. Revenues are broken down by global
region. Sales figures are estimated for the 5-year period from 2010 through 2015.
Applications or the uses of medical enzymes are also discussed separately in the report, with emphasis on the usage in various
disease sectors. The report also covers the usage of enzymes for diagnostic purposes and in molecular research like sequencing,
mapping, and so on. The report also covers significant patents and their number in each category.
REASONS FOR DOING THIS STUDY
A rapid increase in enzyme knowledge has resulted in harvesting the advantages of enzymes in almost every field of life. Enzymes
are not only used for industrial purposes but also are used in various fields of the healthcare industry including therapeutics,
diagnostics, and molecular research.
Modern industries have now begun to explore the advantages of enzymes in their production processes. This has led to a growing
market for enzymes. Genetic engineering technology has made it possible to produce the enzymes in a form identical to the one that
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normally takes place in the human body.
The increasing competition, patent expirations, and new technologies are taking this industry in a new direction. Although the industry
did see a setback in 2009 due to some manufacturing problems and FDA regulations, new advancements and increased spending in
research and development are causing the market to grow. This study looks at almost all of the systems affected by these factors.
Acquisition strategies and collaborations by companies are also covered in this report. This study also discusses the strength and
weaknesses of each type of technology in light of the new technologies, growing competition, and changing customer needs.
CONTRIBUTIONS of THE STUDY AND ITS INTENDED AUDIENCE
This study contributes to the areas of market growth in therapeutic, diagnostic, and research enzyme manufacturers and users.
Pharmaceutical, chemical, biochemical, and biotechnical companies, industries, and research institutes will find this study to be of
interest.
SCOPE of THE STUDY
The scope of this study encompasses medical or medicinal enzymes, bio-technical, pharmaceutical, and biotechnology markets.
BCC analyzes each market and its applications, regulatory environment, technology involved, market projections, and market share.
Technological issues include the latest trends and developments.
METHODOLOGY
BCC conducted a comprehensive literature search, which included technical newsletters and journals, and many other sources. Data
were collected through interviews and correspondence with various chemical, biotechnical, food and beverages, and technical
experts. Projections were based on estimates such as the current number of end users, potential end users, mergers and
acquisitions, and market trends.
Table of Content
CHAPTER ONE: INTRODUCTION STUDY GOAL OBJECTIVES REASONS FOR DOING THIS STUDY CONTRIBUTIONS OF THE
STUDY AND ITS INTENDED AUDIENCE SCOPE OF THE STUDY METHODOLOGY INFORMATION SOURCES
ANALYSTS’ CREDENTIALS RELATED BCC RESEARCH REPORTS BCC ONLINE SERVICES DISCLAIMER CHAPTER
TWO: EXECUTIVE SUMMARY EXECUTIVE SUMMARY SUMMARY TABLE WORLDWIDE REVENUE OF MEDICAL ENZYMES
MARKET, THROUGH 2015 ($ MILLIONS) SUMMARY FIGURE WORLDWIDE REVENUE OF MEDICAL ENZYMES MARKET, 2010
AND 2015 ($ MILLIONS) CHAPTER THREE: OVERVIEW DEFINITIONS STRUCTURE OF ENZYMES ACTIVATION ENERGY
SPECIFICITY ENZYME SUBSTRATE INTERACTION CONDITIONS OF ENZYME ACTION NOMENCLATURE OF ENZYMES
HISTORY OF ENZYMES CLASSIFICATION OXIDOREDUCTASES TRANSFERASES HYDROLASES LYASES ISOMERASES
LIGASES REAL-LIFE APPLICATIONS OF ENZYMES METABOLIC ENZYMES DIGESTIVE ENZYMES FOOD ENZYMES THE
HUMAN BODY NEEDS ENZYMES ENZYMES IN MEDICINE TABLE 1 EXAMPLES OF ENZYMES, THEIR SOURCES AND
REACTIONS THEY CATALYZE THERAPEUTIC ENZYMES Enzyme Therapy TABLE 2 THERAPEUTIC ENZYMES Asparaginase
Collagenase Glutaminase Hyaluronidase Beta-Lactamase Rhodanase Streptokinase Trypsin Uricase Urokinase DIAGNOSTIC
ENZYMES Catalase Cholesterol Esterase (CE) Glucose Oxidase Horseradish Peroxidase Xanthine Oxidase TABLE 3 DIAGNOSTIC
ENZYMES ENZYMES FOR BIOMEDICAL RESEARCH Lysozyme Micrococcal Nuclease Taq DNA Polymerase Recombinant HIV
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Reverse Transcriptase TABLE 4 BIOMEDICAL ENZYMES CHAPTER FOUR: CLASSIFICATION OF ENZYMES CLASSIFICATION
OF MEDICAL ENZYMES THERAPEUTIC ENZYMES DIGESTIVE ENZYMES TABLE 5 PANCREATIC ENZYME PRODUCTS
LYSOSOMAL ENZYMES TABLE 6 LYSOSOMAL ENZYME PRODUCTS THROMBOLYTIC ENZYMES TABLE 7 THROMBOLYTIC
ENZYME PRODUCTS OTHER ENZYMES TABLE 8 OTHER ENZYME PRODUCTS DIAGNOSTIC ENZYMES
OXIDOREDUCTASES TABLE 9 EXAMPLES OF OXIDOREDUCTASE HYDROLASES TABLE 10 EXAMPLES OF HYDROLASES
TRANSFERASES TABLE 11 EXAMPLES OF TRANSFERASES LYASES TABLE 12 EXAMPLES OF LYSASES ENZYMES FOR
BIOMEDICAL RESEARCH LYSING ENZYMES TABLE 13 EXAMPLES OF LYSING ENZYMESCLEAVING ENZYMES TABLE 14
EXAMPLES OF CLEAVING ENZYMES SYNTHESIZING ENZYMES TABLE 15 EXAMPLES OF SYNTHESIZING ENZYMES
JOINING ENZYMES TABLE 16 EXAMPLES OF JOINING ENZYMES ALKALINE PHOSPHATASE TABLE 17 EXAMPLES OF
ALKALINE PHOSPHATASE ENZYMES CHAPTER FIVE: REGULATORY ASPECTS REGULATORY ASPECTS TABLE 18 NEW
APPROVALS FOR THERAPEUTIC ENZYMES TABLE 19 NEW DRUG APPLICATIONS FOR THERAPEUTIC ENZYMES CHAPTER
SIX: INDUSTRY STRUCTURE MANUFACTURERS/ SUPPLIERS FOR THERAPEUTIC ENZYMES DIGESTIVE ENZYME
PRODUCTS/PANCREATIC ENZYME PRODUCTS TABLE 20 LEADING MANUFACTURERS/SUPPLIERS OF DIGESTIVE ENZYME
PRODUCTS/PANCREATIC ENZYME PRODUCTS LYSOSOMAL ENZYME PRODUCTS TABLE 21 LEADING
MANUFACTURERS/SUPPLIERS OF LYSOSOMAL ENZYME PRODUCTS THROMBOLYTIC ENZYME PRODUCTS TABLE 22
LEADING MANUFACTURERS/SUPPLIERS OF THROMBOLYTIC ENZYME PRODUCTS OTHER THERAPEUTIC ENZYMES
TABLE 23 LEADING MANUFACTURERS/SUPPLIERS OF OTHER ENZYME PRODUCTS MANUFACTURERS/ SUPPLIERS FOR
DIAGNOSTIC ENZYMES OXIDOREDUCTASES TABLE 24 LEADING MANUFACTURERS/SUPPLIERS OF OXIDOREDUCTASES
HYDROLASES TABLE 25 LEADING MANUFACTURERS/SUPPLIERS OF HYDROLASES TRANSFERASES TABLE 26 LEADING
MANUFACTURERS/SUPPLIERS OF TRANSFERASES OTHER DIAGNOSTICS (LYASES, LIGASES, AND ISOMERASES) TABLE
27 LEADING MANUFACTURERS/SUPPLIERS OF LYASES, LIGASES, AND ISOMERASES MANUFACTURERS/ SUPPLIERS FOR
ENZYMES USED IN MOLECULAR RESEARCH CLEAVING ENZYMES TABLE 28 LEADING MANUFACTURERS/SUPPLIERS OF
LYSOSOMAL ENZYME PRODUCTS SYNTHESIZING ENZYMES TABLE 29 LEADING MANUFACTURERS/SUPPLIERS OF
SYNTHESIZING ENZYMES OTHER ENZYMES USED IN RESERACH TABLE 30 LEADING MANUFACTURERS/SUPPLIERS OF
OTHER ENZYMES USED IN RESEARCH MARKET SHARES OF INDUSTRY LEADERS DIGESTIVE ENZYME PRODUCTS
/PANCREATIC ENZYME PRODUCTS TABLE 31 WORLDWIDE MARKET SHARES OF DIGESTIVE ENZYME MANUFACTURERS,
2009 (%) FIGURE 1 WORLDWIDE MARKET SHARES OF DIGESTIVE ENZYME MANUFACTURERS, 2009 (%) LYSOSOMAL
ENZYME PRODUCTS TABLE 32 WORLDWIDE MARKET SHARES OF LYSOSOMAL ENZYME MANUFACTURERS, 2009 (%)
FIGURE 2 WORLDWIDE MARKET SHARES OF LYSOSOMAL ENZYME MANUFACTURERS, 2009 (%) THROMBOLYTIC
ENZYME PRODUCTS TABLE 33 WORLDWIDE MARKET SHARES OF THROMBOLYTIC ENZYME MANUFACTURERS, 2009 (%)
FIGURE 3 WORLDWIDE MARKET SHARES OF THROMBOLYTIC ENZYME MANUFACTURERS, 2009 (%) OTHER
THERAPEUTIC ENZYME PRODUCTS TABLE 34 WORLDWIDE MARKET SHARES OF THROMBOLYTIC ENZYME
MANUFACTURERS, 2009 (%) FIGURE 4 WORLDWIDE MARKET SHARES OF OTHER ENZYMES MANUFACTURERS, 2009 (%)
OXIDOREDUCTASES TABLE 35 WORLDWIDE MARKET SHARES OF OXIDOREDUCTASE MANUFACTURERS, 2009 (%)
FIGURE 5 WORLDWIDE MARKET SHARES OF OXIDOREDUCTASE MANUFACTURERS, 2009 (%) HYDROLASES TABLE 36
WORLDWIDE MARKET SHARES OF HYDROLASE MANUFACTURERS, 2009 (%) FIGURE 6 WORLDWIDE MARKET SHARES
OF HYDROLASE MANUFACTURERS, 2009 (%) TRANSFERASES TABLE 37 WORLDWIDE MARKET SHARES OF
TRANSFERASE MANUFACTURERS, 2009 (%) FIGURE 7 WORLDWIDE MARKET SHARES OF TRANSFERASE
MANUFACTURERS, 2009 (%) OTHERS DIGNOSTIC ENZYMES (LYASES, LIGASES, AND ISOMERASES) TABLE 38
WORLDWIDE MARKET SHARES OF OTHER DIAGNOSTIC ENZYME MANUFACTURERS, 2009 (%) FIGURE 8 WORLDWIDE
MARKET SHARES OF OTHER DIAGNOSTIC ENZYME MANUFACTURERS, 2009 (%) CLEAVING ENZYMES TABLE 39
WORLDWIDE MARKET SHARES OF CLEAVING ENZYME MANUFACTURERS, 2009 (%) FIGURE 9 WORLDWIDE MARKET
SHARES OF CLEAVING ENZYME MANUFACTURERS, 2009 (%) SYNTHESIZING ENZYMES TABLE 40 WORLDWIDE MARKET
SHARES OF SYNTHESIZING ENZYME MANUFACTURERS, 2009 (%) FIGURE 10 WORLDWIDE MARKET SHARES OF
SYNTHESIZING ENZYME MANUFACTURERS, 2009 (%) OTHER ENZYMES USED IN RESEARCH TABLE 41 WORLDWIDE
MARKET SHARES OF MANUFACTURERS OF OTHER ENZYMES USED IN RESEARCH, 2009 (%) FIGURE 11 WORLDWIDE
MARKET SHARES OF MANUFACTURERS OF OTHER ENZYMES USED IN RESEARCH, 2009 (%) CHAPTER SEVEN: NEW
DEVELOPMENTS THERAPEUTIC ENZYMES TABLE 42 NEW DEVELOPMENTS IN THERAPEUTIC ENZYMES DIAGNOSTIC
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ENZYMES MOLECULAR RESEARCH ENZYMES CHAPTER EIGHT: MARKET ANALYSIS TABLE 43 GLOBAL MARKET FOR
MEDICAL ENZYMES, THROUGH 2015 ($ MILLIONS) FIGURE 12 GLOBAL MARKET FOR MEDICAL ENZYMES, THROUGH 2015
($ MILLIONS) THERAPEUTIC ENZYMES TABLE 44 GLOBAL MARKET FOR THERAPEUTIC ENZYMES MARKET BY TYPE,
THROUGH 2015 ($ MILLIONS) FIGURE 13 GLOBAL MARKET FOR THERAPEUTIC ENZYMES MARKET BY TYPE, THROUGH
2015 ($ MILLIONS) DIGESTIVE ENZYMES Market Overview Market Revenue TABLE 45 WORLDWIDE MARKET FOR DIGESTIVE
ENZYMES BY REGION, THROUGH 2015 ($ MILLIONS) FIGURE 14 WORLDWIDE MARKET FOR DIGESTIVE ENZYMES BY
REGION, THROUGH 2015 ($ MILLIONS) LYSOSOMAL ENZYMES Market Overview Market Revenue TABLE 46 WORLDWIDE
MARKET FOR LYSOSOMAL ENZYME PRODUCTS BY REGION, THROUGH 2015 ($ MILLIONS) FIGURE 15 WORLDWIDE
MARKET FOR LYSOSOMAL ENZYME PRODUCTS BY REGION, THROUGH 2015 ($ MILLIONS) THROMBOLYTIC ENZYMES
Market Overview Market Revenue TABLE 47 WORLDWIDE MARKET FOR THROMBOLYTIC ENZYME PRODUCTS, BY REGION,
THROUGH 2015 ($ MILLIONS) FIGURE 16 WORLDWIDE MARKET FOR THROMBOLYTIC ENZYME PRODUCTS, BY REGION,
THROUGH 2015 ($ MILLIONS) OTHER THERAPEUTIC ENZYMES Market Overview Market Revenue TABLE 48 WORLDWIDE
MARKET FOR OTHER ENZYME PRODUCTS, BY REGION, THROUGH 2015 ($ MILLIONS) FIGURE 17 WORLDWIDE MARKET
FOR OTHER ENZYME PRODUCTS BY REGION, THROUGH 2015 ($ MILLIONS) MARKET SHARES TABLE 49 WORLDWIDE
THERAPEUTIC ENZYME MARKET SHARES, BY REGION, 2009 (%) FIGURE 18 WORLDWIDE THERAPEUTIC ENZYME
MARKET SHARES, BY REGION, 2009 (%) DIAGNOSTIC ENZYMES TABLE 50 GLOBAL MARKET FOR DIAGNOSTICS ENZYMES
BY TYPE, THROUGH 2015 ($ MILLIONS) FIGURE 19 GLOBAL MARKET FOR DIAGNOSTICS ENZYMES BY TYPE, 2008-2015 ($
MILLIONS) OXIDOREDUCTASES Market Overview Market Revenue TABLE 51 WORLDWIDE MARKET FOR
OXIDOREDUCTASES BY REGION, THROUGH 2015 ($ MILLIONS) FIGURE 20 WORLDWIDE MARKET FOR
OXIDOREDUCTASES, BY REGION, 2008-2015 ($ MILLIONS) HYDROLASES Market Overview Market Revenue TABLE 52
WORLDWIDE MARKET FOR HYDROLASES, BY REGION, THROUGH 2015 ($ MILLIONS) FIGURE 21 WORLDWIDE MARKET
FOR HYDROLASES, BY REGION, 2008-2015 ($ MILLIONS) TRANSFERASES Market Overview Market Revenue TABLE 53
WORLDWIDE MARKET FOR TRANSFERASES, BY REGION, THROUGH 2015 ($ MILLIONS) FIGURE 22 WORLDWIDE MARKET
FOR TRANSFERASES, BY REGION, 2008-2015 ($ MILLIONS) OTHERS (LYASES, LIGASES, AND ISOMERASES) Market
Overview Market Revenue TABLE 54 WORLDWIDE MARKET FOR OTHER ENZYMES (LYASES, LYDASES, AND ISOMERASES),
BY REGION, THROUGH 2015 ($ MILLIONS) FIGURE 23 WORLDWIDE MARKET FOR OTHER ENZYMES (LYASES, LYDASES,
AND ISOMERASES), BY REGION, 2008-2015 ($ MILLIONS) MARKET SHARES TABLE 55 WORLDWIDE DIAGNOSTICS ENZYME
MARKET SHARES, BY REGION, 2009 (%) FIGURE 24 WORLDWIDE DIAGNOSTICS ENZYME MARKET SHARES, BY REGION,
2009 (%) ENZYMES USED FOR MOLECULAR RESEARCH TABLE 56 GLOBAL MARKET FOR MOLECULAR RESEARCH
ENZYMES, BY TYPE, THROUGH 2015 ($ MILLIONS) FIGURE 25 GLOBAL MARKET FOR MOLECULAR RESEARCH ENZYMES,
BY TYPE, THROUGH 2015 ($ MILLIONS) CLEAVING ENZYMES Market Overview Market Revenue TABLE 57 WORLDWIDE
MARKET FOR CLEAVING ENZYMES, BY REGION, THROUGH 2015 ($ MILLIONS) FIGURE 26 WORLDWIDE MARKET FOR
CLEAVING ENZYMES, BY REGION, THROUGH 2015 ($ MILLIONS) SYNTHESIZING ENZYMES Market Overview Market Revenue
TABLE 58 WORLDWIDE MARKET FOR SYNTHESIZING ENZYMES, BY REGION, THROUGH 2015 ($ MILLIONS) FIGURE 27
WORLDWIDE MARKET FOR SYNTHESIZING ENZYMES, BY REGION, 2008-2015 ($ MILLIONS) OTHER ENZYMES USED IN
RESEARCH Market Overview Market Revenue TABLE 59 WORLDWIDE MARKET FOR OTHER ENZYMES USED IN RESEARCH,
BY REGION, THROUGH 2015 ($ MILLIONS) FIGURE 28 WORLDWIDE MARKET FOR OTHER ENZYMES USED IN RESEARCH,
BY REGION, 2008-2015 ($ MILLIONS) MARKET SHARES TABLE 60 WORLDWIDE ENZYMES USED IN MOLECULAR
RESEARCH, MARKET SHARES, BY REGION, 2009 FIGURE 29 WORLDWIDE ENZYMES USED IN MOLECULAR RESEARCH,
MARKET SHARES, BY REGION, 2009 (%) CHAPTER NINE: MARKET BY APPLICATIONS APPLICATIONS FOR THERAPEUTIC
ENZYMES MARKET REVENUE TABLE 61 GLOBAL SALES OF THERAPEUTIC ENZYMES, BY APPLICATIONS, THROUGH 2015
($ MILLIONS) FIGURE 30 GLOBAL SALES OF THERAPEUTIC ENZYMES, BY APPLICATIONS, THROUGH 2015 ($ MILLIONS)
MARKET OVERVIEW Cardiovascular Diseases TABLE 62 WORLDWIDE MARKET SHARE OF THERAPEUTIC ENZYME
MANUFACTURERS IN CARDIOVASCULAR DISEASE MARKET IN 2009 (%) FIGURE 31 WORLDWIDE MARKET SHARE OF
THERAPEUTIC ENZYME MANUFACTURERS IN CARDIOVASCULAR DISEASE MARKET, 2009 (%) Cancer and Associated
Complications TABLE 63 WORLDWIDE MARKET SHARE OF THERAPEUTIC ENZYME MANUFACTURERS IN THE CANCER
MARKET, 2009 (%) FIGURE 32 WORLDWIDE MARKET SHARE OF THERAPEUTIC ENZYME MANUFACTURERS IN THE
CANCER MARKET, 2009 (%) Pulmonary Embolism TABLE 64 WORLDWIDE MARKET SHARE OF THERAPEUTIC ENZYME
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MANUFACTURERS IN THE PULMONARY EMBOLISM MARKET, 2009 (%) FIGURE 33 WORLDWIDE MARKET SHARE OF
THERAPEUTIC ENZYME MANUFACTURERS IN THE PULMONARY EMBOLISM MARKET, 2009 (%) Pompe Disease TABLE 65
WORLDWIDE MARKET SHARE OF THERAPEUTIC ENZYME MANUFACTURERS IN THE POMPE DISEASE MARKET, 2009 (%)
FIGURE 34 WORLDWIDE MARKET SHARE OF THERAPEUTIC ENZYME MANUFACTURERS IN POMPE DISEASE MARKET,
2009 (%) Fabry Disease TABLE 66 WORLDWIDE MARKET SHARE OF THERAPEUTIC ENZYME MANUFACTURERS IN THE
FABRY DISEASE MARKET, 2009 (%) FIGURE 35 WORLDWIDE MARKET SHARE OF THERAPEUTIC ENZYME
MANUFACTURERS IN THE FABRY DISEASE MARKET, 2009 (%) Gaucher’s Disease TABLE 67 WORLDWIDE MARKET
SHARE OF THERAPEUTIC ENZYME MANUFACTURERS IN THE GAUCHER’S DISEASE MARKET, 2009 (%) FIGURE 36
WORLDWIDE MARKET SHARE OF THERAPEUTIC ENZYME MANUFACTURERS IN THE GAUCHER’S DISEASE
MARKET, 2009 (%) MucopolysaccharidosesTABLE 68 WORLDWIDE MARKET SHARE OF THERAPEUTIC ENZYME
MANUFACTURERS IN THE MUCOPOLYSACCHARIDOSES MARKET, 2009 (%) FIGURE 37 WORLDWIDE MARKET SHARE OF
THERAPEUTIC ENZYME MANUFACTURERS IN THE MUCOPOLYSACCHARIDOSES MARKET, 2009 (%) Cystic Fibrosis and
Associated Complications TABLE 69 WORLDWIDE MARKET SHARE OF THERAPEUTIC ENZYME MANUFACTURERS IN THE
CYSTIC FIBROSIS AND ASSOCIATED DISEASE MARKET, 2009 (%) FIGURE 38 WORLDWIDE MARKET SHARE OF
THERAPEUTIC ENZYME MANUFACTURERS IN THE CYSTIC FIBROSIS AND ASSOCIATED DISEASE MARKET, 2009 (%) Other
Diseases TABLE 70 WORLDWIDE MARKET SHARE OF THERAPEUTIC ENZYME MANUFACTURERS IN THE OTHER DISEASES
MARKET, 2009 (%) FIGURE 39 WORLDWIDE MARKET SHARE OF THERAPEUTIC ENZYME MANUFACTURERS IN THE OTHER
DISEASES MARKET, 2009 (%) THERAPEUTIC ENZYMES MARKET SHARE BY APPLICATIONS TABLE 71 WORLDWIDE
MARKET SHARE FOR THERAPEUTIC ENZYMES BY APPLICATIONS IN 2009 (%) FIGURE 40 WORLDWIDE MARKET SHARE
FOR THERAPEUTIC ENZYMES BY APPLICATIONS, 2009 (%) DIAGNOSTIC ENZYMES TABLE 72 GLOBAL SALES OF
DIAGNOSTIC ENZYMES, BY APPLICATIONS, THROUGH 2015 ($ MILLIONS) FIGURE 41 GLOBAL SALES OF DIAGNOSTIC
ENZYMES, BY APPLICATIONS, THROUGH 2015 ($ MILLIONS) MARKET SHARE OF APPLICATIONS OF DIAGNOSTIC
ENZYMES TABLE 73 WORLDWIDE MARKET SHARE OF DIAGNOSTICS ENZYMES, BY APPLICATION, 2009 (%) FIGURE 42
WORLDWIDE MARKET SHARE OF DIAGNOSTICS ENZYMES, BY APPLICATION, 2009 (%) MOLECULAR RESEARCH
ENZYMES TABLE 74 GLOBAL SALES OF MOLECULAR RESEARCH ENZYMES, BY APPLICATIONS, THROUGH 2015 ($
MILLIONS) FIGURE 43 GLOBAL SALES OF MOLECULAR RESEARCH ENZYMES, BY APPLICATIONS, THROUGH 2015 ($
MILLIONS) MOLECULAR CLONING GENOTYPING SEQUENCING GENE MAPPING OTHERS MARKET SHARES OF
MOLECULAR RESEARCH ENZYMES BY APPLICATION TABLE 75 WORLDWIDE MARKET SHARES FOR MOLECULAR
RESEARCH ENZYMES, BY APPLICATION, 2009 (%) FIGURE 44 WORLDWIDE MARKET SHARES FOR MOLECULAR
RESEARCH ENZYMES, BY APPLICATION, 2009 (%) CHAPTER TEN: PATENT ANALYSIS PATENTS BY YEAR TABLE 76
NUMBER OF PATENTS, BY YEAR, 2006-2010 FIGURE 45 NUMBER OF PATENTS BY YEAR, 2006-2010 FIGURE 46 NUMBER
OF PATENTS BY YEAR, 2006-2010 (%) PATENTS BY CATEGORY TABLE 77 PATENTS BY CATEGORY FOR MEDICINAL
ENZYMES, 2006-2010 FIGURE 47 PATENTS BY CATEGORY FOR MEDICINAL ENZYMES AGENTS, 2006-2010 PATENTS BY
TYPE TABLE 78 THERAPEUTIC ENZYME PATENTS BY TYPE, 2006-2010 FIGURE 48 THERAPEUTIC ENZYMES PATENTS BY
TYPE, 2006-2010 .... 156TABLE 79 DIAGNOSTICS ENZYMES PATENTS BY TYPE, 2006-2010 FIGURE 49 DIAGNOSTICS
ENZYMES PATENTS BY TYPE, 2006-2010 TABLE 80 RESEARCH ENZYMES PATENTS BY TYPE, 2006-2010 FIGURE 50
RESEARCH ENZYMES PATENTS BY TYPE, 2006-2010 PATENTS BY COMPANY TABLE 81 NUMBER OF U.S. PATENTS BY
COMPANY FOR MEDICINAL ENZYMES, 2006-2010 FIGURE 51 NUMBER OF U.S. PATENTS BY COMPANY FOR MEDICINAL
ENZYMES, 2006-2010 PATENTS BY COUNTRY TABLE 82 NUMBER OF U.S. PATENTS BY COUNTRY FOR MEDICINAL
ENZYMES, 2006-2010 FIGURE 52 NUMBER OF U.S. PATENTS BY COUNTRY FOR MEDICINAL ENZYMES, 2006-2010 TABLE
83 PATENT SHARES BY COUNTRY FOR MEDICINAL ENZYMES, 2006-2010 (NUMBER/%) FIGURE 53 PATENT SHARES BY
COUNTRY FOR MEDICINAL ENZYMES, 2006-2010 (%) PATENTS BY ASSIGNEE TABLE 84 PATENTS BY TYPE OF ASSIGNEE
FOR MEDICINAL ENZYMES, 2006-2010 FIGURE 54 PATENTS BY ASSGINEE TYPE FOR MEDICINAL ENZYMES, 2006-2010
CHAPTER ELEVEN: CURRENT SITUATION FACTORS AFFECTING ENZYMES MARKET FDA LAW AND APPROVALS ORPHAN
DRUG DESIGNATION INCREASED RESEARCH AND DEVELOPMENT AND FUNDS .... 167MERGERS AND ACQUISITIONS
COLLABORATIONS AND AGREEMENTS BRAND AND PRICES MANUFACTURING ISSUES CHAPTER TWELVE: COMPANY
PROFILES AGILENT TECHNOLOGIES AMANO ENZYME INC. AMPHASTAR PHARMACEUTICALS INC. ASAHI KASEI PHARMA
AUXILIUM PHARMACEUTICALS INC. AXCAN PHARMA INC. BBI ENZYMES BIOCATALYSTS LTD BIOMARIN
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PHARMACEUTICALS INC. BOEHRINGER INGELHEIM GMBH BIOSPECIFIC TECHNOLOGIES CORP. CSL BEHRING DIGESTIVE
CARE INC. EKR THERAPEUTICS ENZON PHARMACEUTICALS INC. EURAND N.V. EUSA PHARM GE HEALTHCARE LIFE
SCIENCES GENENTECH INC. GENZYME CORP. GENZYME DIAGNOSTICS HALOZYME THERAPEUTICS INC ISTA
PHARMACEUTICALS LIFE TECHNOLOGIES CORP. PROMEGA CORP. PROTALIX BIOTHERAPEUTICS INC. ROCHE APPLIED
SCIENCES SANOFI-AVENTIS U.S. SHIRE PLC SIGMA ALDRICH CORP. SOLVAY PHARMACEUTICAL INC. THERMO FISHER
SCIENTIFIC, INC. APPENDIX ABBREVIATIONS
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