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1. PROFESSOR PANKAJ G. JANI. M.MED., FRCS.
DEPT. OF SURGERY, UNIVERSITY OF NAIROBI. KENYATTA
NATIONAL HOSPITAL
CHAIR. EXAMINATIONS AND CREDENTIALS COMMITTEE
COSECSA
INT. ONCOLOGY CONF. NAIROBI, OCTOBER
2011
3. RECTAL CANCER
Progress in MULTIMODAL
THERAPY of Rectal Cancer is one
of the BEST examples of success of
Clinical Research in the last 2
decades.
4.
5. RECTAL CARCINOMA – RECENT
ADVANCES -- OVERALL
1.SPHINCTER SAVING PROCEDURES – UP
FROM 15% TO 50% -- NO COLOSTOMY
(IMPROVED QOL)
2. OVERALL FIVE YR SURVIVAL – UP FROM
30% TO 60%
3. DEPTH OF INVASION – DECREASED BY
40%-60% WITH ADJUVANT Rx
4. LYMPH NODE STATUS AND REC. FREE
SURVIVAL - SAME
7. MOLECULAR BIOLOGY
DNA CHIP TECH. – DNA SEQUENCE
CHECKED
-- APC GENE – FAP
-- MISMATCH REPAIR GENES – HNPCC
SUCH PTS.(5%) PUT ON A
SURVEILLANCE PROG. --PROPHYLACTIC
SURGERY
8. MOLECULAR BIOLOGY
DNA SEQUENCE OF MICROSATELLITE
INSTABILITY
-- GOOD RESPONSE WITH 5 FU CHEMO.
P21 MARKER POSITIVE – RADIOSENSITIVE
9. MOLECULAR BIOLOGY
P53 PROTEIN MUTANT EXPRESSED --
RADIORESISTANT
KRAS, DCC, AND P53 -- IF +ve – POOR PROGNOSIS
MICROSATELLITE INSTABILITY OR LOW Cox2
EXPRESSION & P21 MARKER – IF +ve – GOOD
PROGNOSIS
25. II USE OF CH/RT
(NEOADJUVANT/ADJUVANT)
PTS WITH POOR HISTOLOGY
PTS WITH EXTRA MURAL SPREAD (MRI)
PTS WITH INVOLVED NODES (ERUS)
PTS WITH EMVI (MRI)
27. RADIOTHERAPY
EUROPEAN APPROACH
(25G/5CYCLES)
SHORT COURSE – LOW
DOSE – IMMEDIATE
SURGERY
NO CHANGE IN PATH
STAGING
LOWER COST
BETTER COMPLIANCE
DOSE EQUIVALENT TO
30-33G
EXPECT 66%
REDUCTION IN LOCAL
RECURRENCE
AMERICAN APPROACH
(45 – 54G/28 CYCLES)
PROLONGED COURSE –
HIGH DOSE – DELAYED
SURGERY
BETTER SURGICAL
TOLERANCE
MORE TUMOR
REGRESSION
EXPECT >80%
REDUCTION IN LOCAL
RECURRENCE
28.
29. III SURGICAL TECHNIQUE
TRADITIONAL
PROCTECTOMY PERFORMED
-- In the DARK
-- Using BLUNT Dissection
-- Without attention to ANATOMIC
Detail
RESULTED in
-- Bloody operation
-- Increased -- Autonomic Nerve injury
-- Local Rec.
30. SURGERY - TRADITIONAL
ANT. RESECTION – UPPER ⅓ RECTAL
CA
LOW ANT.RESCETION - MID ⅓
RECTAL CA
A.P.R. - LOWER ⅓ RECTAL
CA
ANY TUMOR 10cms FROM ANAL
VERGE -- APR
32. RECTAL CARCINOMA RECENT
ADVANCES
>100 YEARS SINCE MILES DESCRIBED
ABDOMINO-PERINEAL-RESECTION
>25 YEARS SINCE HEALD DESCRIBED
TOTAL MESORECTAL EXCISION
33. III SURGICAL TECHNIQUE
RECENT ADV.
TOTAL MESORECTAL EXISION
( EXICISION OF FASCIA
ENVELOPING THE FAT PAD
AROUND THE RECTUM.)
SAUSAGE APPEARANCE
34. SURGERY – RECENT ADVANCES
LOW-ANT RESECTION – UPTO ≏
6cms FROM ANAL VERGE
APR – ONLY IF SPHINCTOR
FUNCTION COMPROMISED
35. RECTAL CANCER – RECENT
ADVANCES
CAREFUL ASSESSMENT OF SxS
EARLY DIGNOSIS WITH
ACCURATE STAGING
CH/RT - FOR SELECTED PTS
- PROCTOSCOPY
- SIGMOIDOSCOPY
- DRE
- ERUS
- MRI