Diploma in Pharmacy, CTEVT Second Year Pharmacology and Pharmacotherapeutics I

1. Anti-tubercular Chemotherapy
and Treatment Regimen

2. • Chemotherapy of Tuberculosis have undergone remarkable changes
• Conventional 12-18 months therapy has been replaced by more
effective and less toxic 6 month short term course
• The goals of anti-tubercular therapy is
• Killing the dividing bacilli
• Killing persisting bacilli
• Prevent emergence of resistance

3. General Principles of Anti-tubercular Therapy
• Combination of 2 or more drugs. Single drug therapy may develop
resistance
• Isoniazid and Rifampicin are effective and have synergistic effect.
Combination of this drug with Pyrazinamide have shorten the
duration of therapy by 6 months
• Single daily dose of all First line drug is preferred.
• Response is fast in first few weeks as the fast dividing cells are
eliminated rapidly. Symptomatic relieve within 2-4 weeks.

4. Treatment Regimen

5. Chemoprophylaxis
• Chemoprevention refers to the administration of a medication for the
purpose of preventing disease or infection.
• Prevent progression of latent tuberculosis to active infection.
• Standard Chemotherapy;
• INH 300 mg or 10mg/kg in Children for 6-12 months
• Combination INH 5 mg/kg and Rifampicin 10mg/kg daily for 6 months

6. DOTS
• Directly observed treatment, short-course DOTS, also known as TB-
DOTS) is the name given to the tuberculosis(TB) control strategy
recommended by the World Health Organization
• According to WHO, "The most cost-effective way to stop the spread
of TB in communities with a high incidence is by curing it.
• The best curative method for TB .

7. .