PurushothamKN1

purushotham acu saccp puru sacp knp purushotham kn accp acp m pharmacy chemistry pharmaceutical chemistry advanced medicinal chemistry process chemistry education medicinal chemistry knowledge pharmacy purushotham k n function of leukotrienes biosynthesis of leukotrienes biosynthesis of prostaglandin thromboxanes leukotrienes prostaglandins eicosanoids peptidomimetics application of thromboxanes biosynthesis of thromboxanes amc sar quinolines sar of quinolines up&down procedure fixed dose procedure acute oral toxicity acutetoxicitystudies special toxicity studies chronic toxicity acute toxicity toxicity study important oecd guideline objectives of oecd oecd guidelines local restrictions global restrictions peptide backbone modify of peptidomimetics iso 14001 fire hazards ppe personal protection equipment hazard labels of chemicals msds material safety data sheet industrial safety chiral inversion protein binding carrier mediated transporter passive intestinal absorption types of case study designs of case study case study applications case study pharmacokinetic monitoring stategies to combat resistance defective apoptosis increased dna repair drug inactivation alternations in drug targets drug resistance combating drug resistance enzyme inhibitors in medicine enzyme inhibition by drugs irreversible inhibition reversible inhibition enzyme inhibitors michaelis – menten equation enzyme kinetics introduction to enzyme moa of ranitidine sar of hydantoin moa of gabapentin moa of benzodiazepines moa of barbiturates types of seizures h1 and h2 receptor antagonist anticonvulsant data analysis system robotic system suitable assay method chemical or compound library elements of hts importance of hts microtiter plates high through output screening drugs inhibiting ne storage moa of anticholinergic drugs anticholineterase cholinergic agonist parasympathetic nervous system sympathetic nervous system autonomic nervous system cholinergic agents adrenergic agents carbonyl group non classical bioisosters classical bioisosters classification of bioisosters bioisosteric replacement categories of analogs goals of analog design analog design ace inhibitors calcium channel blockers ganglion blockers adrenergic neuron blockers adrenergic blockers centrally acting drugs diuretics hypertention anti hypertensive agents the rate theory occupation theory nuclear receptors kinase-linked receptors g-protein-coupled receptors ligand-gated ion channels types of receptor lipoproteins receptors biological drug targets enol acids oxicams synthesis of indomethacin cyclooxygenases cox-2 inhibitors cox-1 inhibitors cox-2 cox-1 cox drug target clinical observation drug metabolism studies nonrandom screening random screening lead discovery stages of drug discovery drug discovery design of peptidomimetics types of peptidomimetics peptides aoc healthcare health causes coronary artery spasms causes of prinz metal angina types of angina prinz metal angina spacer/linker prodrug macromolecular prodrug bioprecursor prodrug carrier linked prodrug history of prodrug types of prodrug prodrug uses of prodrug prodrug uses application of prodrugs drug design prodrugs for stability prodrug design prodrugs rationale of prodrug design local anaestehtics intravenous anaesthetics r and s configuration l and d configuration cis and trans configuration diastereomer enantiomer stereoisomers chirality isomerism technical feasibility familiarity solvents selection selection of raw material expedient route reaction progress reducing agents metallic hydrides mpv reduction reduction process hydrogen transfer reactions adam’s catalyst heterogenous catalysis catalytic hydrogenation synthesis methods synthetic strategy lab scale reactor scale-up types scale up process impurities in api impurities drug impurities residual solvents inorganic impurities genotoxic impurities types of impurities sources of impurities unit process halogenation process kinetics and the rate equation halogenating agents kinetics of halogenation types of halogenation halogenation rotary vacuum filtration vacuum filtration pressure filtration centrifugal filtration pressure and vacuum filtration theory of filtration filtration process unit processes chemical reaction reaction postgraduate fermentaion process fermentation chemisrty extraction process extraction distillation process evaporators crystallization process evaporation process crystallization distillation evaporation master of pharmacy m.pharm oxidation process oxidizing agents oxidation sulfanamides sar of sulphanamides sulphonamides mc 20-21 anesthetics local anesthetics iit amiis bhu rguhs 5th sem bg nagara