Caffeine is added to some paracetamol medications to potentially increase the pain-relieving effects by acting as a mild stimulant that reduces fatigue. However, studies have shown that while caffeine is claimed to enhance the efficacy of paracetamol, it does not change the peak levels or absorption of paracetamol in the body. Combining caffeine with paracetamol may also increase the risk of side effects without providing significantly improved pain relief according to studies of the two substances together.

1. Reasonsofusing caffeine with Paracetamol:
 Caffeine is a mild stimulant that helps reduce fatigue.
 Caffeine is used in this product to increase the pain relieving
effects of acetaminophen.
 Caffeine is claimed to enhance the efficacy of paracetamol.1
However, peak plasma levels and extent of absorption are
similar for paracetamol with caffeine and paracetamol alone.1
Compared with paracetamol alone, a person taking the
combination of paracetamol with caffeine may be more likely to
experience adverse effects than to get improved analgesia.
 Published trials have assessed the effect of combining caffeine
with paracetamol compared with paracetamol alone in
conditions including tension-type4
and non-migrainous
headaches5, postoperative pain6,7, uterine cramping6 and
primary dysmenorrhoea.