This part-1 includes:
1. General structural features of viruses
2. Life cycle of virus, in general
3. Stages of life cycle of viruses at which antiviral drugs act
4. Classification of antiviral drugs on the basis of
Viruses against which they act
MOA of Antiviral drugs and
Chemical structure
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Pharmacy Academy Tutorial on Antiviral Drugs
1. An academy for Pharmacy and Pharmacology
Presents a Tutorial Video on
By Prof. Sunil Bakliwal (M.Pharm, S.R.F.) M: 7588834590
Antiviral Drugs- Part 1
Online and Offline Classes Available
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2. This part-1 includes:
1. General structural features of viruses
2. Life cycle of viruses, in general
3. Stages of life cycle of viruses at which antiviral
drugs act
4. Classification of antiviral drugs on the basis of
Viruses against which they act
MOA of Antiviral drugs and
Chemical structure
3. VIRUSES
Viruses are obligate intracellular pathogens.
Capsid
Capsomeres
DNA or RNA
Envelope
Spike
Tegument
General Structural Features of Virus:
4. The life cycle of viruses differs greatly between species but there are six common
basic stages. These are:
Virus life cycle
1. Attachment to a host cell
2. Viral entry into host cell (Viral penetration)
3. Release of viral genes and possibly enzymes into the host cell (Uncoating)
4. Replication of viral components using host-cell machinery (involve Reverse
transcription for some RNA viruses) (Reverse transcription is the synthesis of DNA
from RNA).
5. Assembly of viral components into virions (Maturation) (A virion is an intact
viral particle that has ability to infect a new host cell).
6. Release of virions to infect new host cells:
The newly formed virions are released from the cell by:
1) sudden breaking of the cell membrane (cell lysis), or
2) budding through the membrane to form virus envelope
The released virions are now ready to infect the other host cells.
5. Antiviral Drugs
Antiviral drugs are used to treat viral infections
Antiviral drugs act by arresting the viral life cycle at various
stages such as:
1. virus attachment to host cell receptors, penetration, or uncoating.
Uncoating is the release of viral genome in the host cell.
2. inhibiting virus-associated enzymes such as Reverse transcriptase and
others.
3. inhibiting viral transcription and translation
4. interfering with viral regulatory proteins.
5. interfering with glycosylation, phosphorylation, sulfation, and so on.
6. interfering with the assembly and release of virions
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Next presentation :
Antiviral Drugs- Part 2