2. Oog Melanoom
• ~140 patienten per jaar lft 50-70j
• Diagnose: routine onderzoek, slecht zicht
• Behandeling:
– Verwijderen oog
– Bestraling
• Ondanks behandeling 50% metastase
zeer slecht prognose
• Research: Zoektocht naar prognostische markers.
http://www.erasmusmc.nl/47457/51016/227068/oogmelanoom
3. Data en monsters
• ErasmusMC EPD (Elpado)
• Arts onderzoekers
– ( Pathologie verslag, Opzet nieuwe assay/analyse)
• Materiaal: Bloed ( in de tijd), tumor weefsel , gezond weefsel etc
--- DNA /RNA
• Testen: Array, NGS, Chromosoom, FISH, QPCR, SSEQ, IHC
Research support tool ! (mini LIMS Filemaker )
n= 900 personen
n= 10.000 monsters
n= 371/24.000 Arrays
n= 263/6.000 NGS
4.
5. Inheritance model Study (smallest entity)
Clinical data X Clinical data analysis
Genesis X Front Office X Sample prep X Lab service ( Analysis 1) X Lab Staf X Counseling
Study
PI ----------
Project - Sponsor
Governor
DATA - Finance - Informed Consent
OOG Tumor
E. Kilic
ROMS
Prof Vingerling
10. Data
production
Arrays/NGS
Local Network
Author publication folder
Final
Optional:
Analysis software, OS
Reference files
Managed Tape model
Track & Trace MyLTO service (web based)
- TapeMyLTOservice Basic: data to tape + 2 copies+ index
- Tape Storage, data migration, distribution, 5000 arrays or 200 wes/20WGS /LTO6 n=50
TAR- Copy - Checksums
LTO 5-6 6.25 Tb/2,5 Tb raw
LTO 8 12 Tb/ 4 Tb raw ( 2017)
Tape Governance ( PI etc)
Tape ID
Tape type etc.
Index files Tape content
DOI publication_ID
Link production/data tapes
Tape location / migration?
……
pptArray
NGSClin
Index file
Production archive tapes
TAR - Copy- Checksums
Index file
Distribution: Research, Education, Healthcare ……. patient!! Governance KEYS!!
Publication archive tapes
Data production Publications
11. Acknowledgements:
PI(s) Emine Kilic
Annelies de Klein
Governor(s) Prof Vingerling
Sponsor ROMS
Data rentmeester Bert Eussen
Analisten & onderzoekers
Dashboard design Rianne Kosterman W Kooning HRO
Biomics NGS
Int. medicine Arrays
Pathologie
ICT research Tape/index support
Carelliance Peter Walgemoed
Fortados Tape LTO storage service