1. P.W. Hoffman 1
Peter W. Hoffman, Ph.D.
7 West Chestnut Hill Avenue 215 964 3931
Philadelphia, PA 19118 email: phoffman@ndm.edu
EDUCATION:
Ohio State University, Columbus, Ohio
Ph.D., Molecular Genetics, March, 1989
M.S., Molecular Genetics, March, 1987
St. Lawrence University, Canton, New York
B.S., Biology, 1974
EXPERIENCE:
Notre Dame of Maryland University (Previously College of Notre Dame of Maryland),
Baltimore, Maryland (1995 – Present)
Professor Emeritus (2015-Present)
Chair, Department of Biology (1999 - 2004, 2006 – 2008, 2013 to 2015)
Responsible for all aspects of departmental administration, including class
scheduling, budgeting and personnel management.
Led the department during a move to a new facility, faculty searches,
departmental self-studies, and the development of an assessment program.
Interim Director, Elizabeth Morrissy Honors Program (Spring 2009)
Responsible for administration of all activities of the program while permanent
director was on sabbatical.
Director, Office of ResearchDevelopment (2004 - 2009)
Responsible for directing and monitoring all activities the Office of Research
Development, funded by a $247,000 NIH grant and charged with stimulating
funded research activities and fostering faculty and student research activities.
Professor (2010 – Present)
Associate Professor (2002 - 2009)
Tenured (2004)
Assistant Professor (1995 - 2001)
Teaching Responsibilities:
Art and Place – An art history tour of southeast Pennsylvania that I
conceived and developed. Team taught with Art Department Chair.
Genetics and Genomics for Clinical Practice – developed course
Genetics Lecture and Laboratory – developed course
Morrissy Honors Genetics – developed course
Developmental Biology Lecture and Laboratory - developed course
Introductory Cell Biology – Lecture and Laboratory
Cell Biology Lecture and Laboratory - developed course
Microbiology Laboratory
Senior Seminar - developed course
Molecular Techniques - developed course
Genethics – co-developed course
Medical Genetics – developed course

2. P.W. Hoffman 2
Research:
Gene expression in the central nervous system, especially control of the
NMDA receptor subunits.
Biotransformation employing the fungus, Cunninghamella elegans.
Committee and Other Service:
Member, University Planning Committee (2012-2014)
Committee was responsible for budget development and
university-wide strategic planning
Member, V. P. of Student Development Search Committee (2012)
Member, University Implementation Committee (2011)
Member, Strategic Planning Committee (2011)
Chair, Athletic Director Search Committee (2010)
Manage and coordinate efforts of a committee to hire an Athletic
Director for the College.
Co Coordinator B.A./PharmD Program (2010)
Lead effort to design and implement this program.
Member, President’s Taskforce on Curriculum (2009)
View curriculum and programs of the College to increase
enrollment and optimize resources.
Chair, Athletic Director Search Committee (2009)
Manage and coordinate efforts of a committee to hire an Athletic
Director for the College.
Co-Chair, Nancy Kreiter Student ResearchDay Taskforce (2007 -
2011)
Developed the first campus-wide exhibition of student research
and independent projects at Notre Dame.
Member, Board of Director’s Undergraduate Enrollment Taskforce
(2008)
Coordinator, Sister Alma McNicholas Women Scientists Program/Sr
Alma Science Year (2007 - Present)
Developed cooperative program with Johns Hopkins School of
Medicine and secured internal funds for continuation of program.
Program expanded to full year funding 2013.
Chair, Athletic Director Search Committee (2006)
Manage and coordinate efforts of a committee to hire an Athletic
Director for the College.
Member, Pharmacy School Taskforce (2005 - 2006)
Taskforce was charged with investigating the feasibility of starting
a school of pharmacy at College of Notre Dame. Pharmacy School
opened in fall of 2009.
Member, College of Notre Dame Strategic Planning
Committee (2005 to 2008)
Coordinator, College of Notre Dame / Johns Hopkins School of
Medicine Women Scientists Initiative (2005 - 2007)

3. P.W. Hoffman 3
Coordinator, Biotechnology Emphasis (2005 - 2007)
Responsible for Emphasis design, implementation and oversight.
NCAA Faculty Athletics Representative (2005 - Present)
Morrissy Honors Advisory Council (2002 – 2006, 2010 to Present)
Responsible for reviewing structure of the Morrissy Honors
Program and continuing over-sight of program.
Member, Faculty Issues Committee (2000 - 2002)
Responsible for ensuring a supportive and effective working
environment for the faculty and served as a liaison to the Research and
Development Taskforce.
Member, Knott Science Addition Committee (1996 - 2000)
Oversight of planning and construction of an $8 million addition to
Knott Science Building which includes classroom, office and
laboratory space.
Grant Support:
Principal Investigator, NIH FRESP Grant (2004 - 2009)
Received a $247,000 grant to develop Office of Research
Development and fund grant writing education and on-campus
research support.
Recipient, Notre Dame Researchand Development Grant for
Personal Research(2006 - 2008)
Recipient NSF ResearchOpportunity Award (2005)
Received $13,000 for summer research to initiate studies on C.
elegans neurobiology.
Recipient, American Society for Engineering Education Summer
Faculty ResearchGrant (Summer 2000)
Co-Principal Investigator, "A Coordinated Cross-Course Approach
to Upper Division Undergraduate Laboratory Education"(1996)
Received a $120,000 NSF/ILI grant to College of Notre Dame of
Maryland Biology Department to develop interactive
undergraduate laboratories in the biological sciences.
Evaluator, Intel Science Talent Search (2009-Present)
This is one of the most prestigious science awards for high school seniors. Over
one million dollars in scholarships and prizes are awarded. Past contestants have
gone on to win eight Nobel Prizes and ten MacArthur Fellowships. Thirty have
been elected to the National Academy of Sciences.
On-line Curator, Proteome Inc. (2000 - 2001)
Responsible for reviewing, synthesizing, and curating information from journal
articles for the Proteome BioKnowledge Library, an online proteomics database.

4. P.W. Hoffman 4
IRTA Fellow, National Institute on Aging, Gene Expression and Aging Section
(1992 - 1995)
Developed gene expression studies related to neurodegenerative diseases of the
central nervous system, particularly Alzheimer’s disease. Defined sequence
elements in the promoter of the amyloid precursor protein which interact with
transcription factors SP1 and USF.
Post Doctoral Fellow, Howard Hughes Medical Institute, Johns Hopkins School of
Medicine (1988 - 1992)
Mapped sites of cAMP-dependent protein kinase phosphorylation of subunits of
the nicotinic acetylcholine receptor expressed in Xenopus oocytes, and the effects
of phosphorylation on desensitization of the channel in the laboratory of Dr.
Richard Huganir.
Graduate ResearchAssociate, Ohio State University, Department of Molecular
Genetics (1981 - 1987)
Studied yeast mitochondrial gene expression and mRNA splicing and defined
sequences influencing self-splicing activity of intron AI3, a group I
intron, in the laboratory of Dr. Philip S. Perlman.
ACADEMIC HONORS AND PROFESSIONAL ACTIVITIES:
Dean’s Faculty, University of Maryland Dental School
Member, The Society for Neuroscience
Member, Council on Undergraduate Research
Reviewer, CUR Quarterly
ABSTRACTS, POSTERS, AND SEMINARS:
“Biotransformation of Osajin and Pomiferin by Cunninghamella elegans”
Saba Shahzad, Benora McBride, Alexandra Ashworth, Paulo Carvalho, Ehab
Abourashed, Peter Hoffman (2014) Poster presented at Nancy Kreiter Student
Research Day.
“Gene Therapy: Overview, History, and Ethical Considerations” 2014-2015
Invited presentation to a graduate class in medical ethics at Rowan University
School of Osteopathic Medicine
“Revisiting the Biotransformation of the Antimalarial Compound Artemisinin”
Paulo Carvalho, Susan Unfried, Katlyn Gourley and Peter Hoffman (2013)
American Association of Collages of Pharmacy Annual Meeting.
“Optimizing Cunninghamella elegans Transformation of Artemisinin”
S. Rebecca Unfried, Peter Hoffman, and Paulo Carvalho. (2013) Poster
presented at Nancy Kreiter Student Research Day.

5. P.W. Hoffman 5
“Gene Therapy: Overview, History, and Ethical Considerations” 2013 Invited
presentation to a graduate class in medical ethics at University of Medicine and
Dentistry of New Jersey (UMDNJ)
“Preparing for Teaching and Research Careers at Liberal Arts and Sciences
Institutions” (2010) Invited presentation to Johns Hopkins School of Medicine
Postdoctoral Association.
Bai, G., Hoffman, P.W., Liu, A., Zhu, Y. (2005) HnRNP A/B proteins are trans-
activators of the NR1 gene. Program No. 721.21. 2005 Abstract Viewer/Itinerary
Planner. Washington, D.C.: Society for Neuroscience CD-ROM.
“The Extramural Associate Program at College of Notre Dame” presented at
NIH-EARDA Technical Assistance Regional Workshop “EA Program (2005):
Same Mission, Different Approach”. Huntsville Alabama.
Hoffman, P. W., Liu, A. G., Zhuang, Z. Y., Bai, G. (2002) Negative Regulation
of the NR2A Promoter by Re1/NRSE. Program No. 244.12. 2002 Abstract
Viewer/Itinerary Planner. Washington, D.C.: Society for Neuroscience CD-ROM.
Hoffman, P.W., Getz, S.L., Bai, G. and Kusiak, J.W. (1997) Influence of CRE
Sites on Promoter Activity of the NMDAR1 Gene. Abstracts of the 27th Annual
Meeting of the Society for Neuroscience. 23:928
Hoffman, P.W. and Chernak, J.M. (1995) Regulation of the Rat Amyloid
Precursor Protein Gene Involves SP1 and USF DNA Recognition Sequences and
Proteins. Abstracts of the 25th Annual Meeting of the Society for Neuroscience.
21:206.
Chernak, J.M., Hoffman, P.W., Minowa, T., Mouradian, M.M. and Roth, G.S.
(1995) DNA-Protein Complexes formed between D2 Dopamine Receptor
Promoter Oligonucleotides and Nuclear Proteins from Brain Regions of Young
and Old Rats. Abstracts of the 25th Annual Meeting of the Society for
Neuroscience. 21:91.
"Transcriptional Regulatory Elements of the Rat Amyloid Precursor Protein Gene
Promoter" presented to Parke-Davis Pharmaceutical Research, Ann Arbor MI,
January 1995.
Qu, Z., Doherty, C., Hoffman, P.W. and Huganir, R.L. (1994) Regulation of
Tyrosine Phosphorylation of the Nicotinic Acetylcholine Receptor by the
Postsynaptic 43K Protein. Abstracts of the 24th Annual Meeting of the Society
for Neuroscience. 20:841.

6. P.W. Hoffman 6
Hoffman, P.W. and Chernak, J.M. (1994) Transcriptional Regulatory Elements
of the Rat Amyloid Precursor Protein (APP) Gene Promoter. Abstracts of the 24th
Annual Meeting of the Society for Neuroscience. 20:1641.
Qu, Z., Doherty, C., Hoffman, P.W. and Huganir, R.L. (1994) Regulation of
Tyrosine Phosphorylation of the Nicotinic Acetylcholine Receptor by the
Postsynaptic 43K Protein. Abstracts of the Third International Symposium on the
Cholinergic Synapse. 3:P3.10.
Chernak, J.M. and Hoffman, P.W. (1994) Functional Analysis of the Rat
Amyloid Precursor Protein (APP) Gene Promoter. Neurobiology of Aging. 15
Supplement 1:S61.
Chernak, J.M. and Hoffman, P.W. (1993) Transcriptional Activity and
Regulation of the Rat Amyloid Precursor Protein (APP) Promoter. Abstracts of
the 23rd Annual Meeting of the Society for Neuroscience. 19:1034.
Hoffman, P.W., Ravindran, A.and Huganir, R.L. (1992) Site-Specific
Mutagenesis of the cAMP-dependent Phosphorylation Sites of the Nicotinic
Acetylcholine Receptor. Journal of Cellular Biochemistry. Supplement
16E:228.
Hoffman, P.W., Choi, K.L., Kienker, P., Yellen, G. and Huganir, R.L. (1989)
Site-Specific Mutagenesis of the Phosphorylation Sites of the Nicotinic
Acetylcholine Receptor. Abstracts of the 19th Annual Meeting of the Society for
Neuroscience. 15:677.
PUBLICATIONS:
Hoffman, P.W., Fletcher, H.L. and Dwyer, P.W. (2009) Using Undergraduate
Research to Connect with External Constituencies. CUR Quarterly. 29(5):16-19
Bai, G. and Hoffman, P. W. (2008) Transcriptional regulation of NMDA
receptor expression. In VanDongen, A., editor. Biology of the NMDA Receptor,
London: Taylor & Francis.
Liu, A., Hoffman, P.W., Lu, W. and Bai, G. (2004) NF-κB site interacts with
Sp factors and upregulates the NR1 promoter during neuronal differentiation. J.
Biol. Chem. 279(17):17449–17458.
Bai, G., Zhuang, Z., Liu, A., Chai, Y. and Hoffman, P. W. (2003) The Role of
the RE1/NRSE Element in Activation of the NR1 Promoter during Neuronal
Differentiation. J. Neurochem. 86(4):992-1005.
Liu, A., Zhiye, Z., Hoffman, P. W., and Bai, G. (2003) Functional
Analysis of the Rat N-methyl-D-aspartate Receptor 2A promoter: Multiple

7. P.W. Hoffman 7
Transcriptional Start Points, Positive Regulation by Sp Factors and
Translational Regulation. J. Biol. Chem. 278(29):26423-34.
Chernak. J.M., Hoffman, P.W., Minowa, T., Mouradian, M.M. and Roth, G.S.
(1997) Interaction of Nuclear Factors from Young and Old Rat Brain Regions
with Regulatory Sequences of the D2 Dopamine Receptor Gene Promoter.
Molecular Brain Research. 44:113-124.
Qu, Z., Apel, E.D., Doherty, C.A., Hoffman, P.W., Merlie, J.P. and Huganir,
R.L. (1996) Regulation of the Synapse-Associated Protein Rapsyn Regulates
Tyrosine Phosphorylation of Proteins Colocalized at Nicotinic Acetylcholine
Receptor Clusters. Mole. and Cell. Neuroscience. 8:171-184.
Guo, W.W., Moran, J.V., Hoffman, P.W., Henke, R.M., Butow, R.A. and
Perlman, P.S. (1995) The Mobile Group I Intron 3 of the Yeast Mitochondrial
COXI Gene Encodes a 35 kDa Processed Protein that is an Endonuclease but not
a Maturase. J. Biol. Chem. 270(26): 15563.
Hoffman, P.W. and Chernak, J.M. (1995) Transcription Factors SP1 and USF
Interact with and Influence the Activity of the Rat APP Gene Promoter. Nucleic
Acids Research. 23(12):2229.
Hoffman, P.W. and Chernak, J.M. (1994) The Rat Amyloid Precursor Protein
Promoter Contains Two DNA Regulatory Elements Which Influence High Level
Gene Expression. Biochemical Biophysical Research Communications. 201:610.
Hoffman, P.W., Ravindran, A.and Huganir, R.L. (1994) Role of
Phosphorylation in Desensitization of Acetylcholine Receptors Expressed in
Xenopus Oocytes. J. Neuroscience. 14(7):4185.