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Gregor
Mendel and
his wacky
peas
What is genetics?
The
scientific
study of
heredity
Gregor Mendel
Born in 1822 in
Czechoslovakia.
Became a monk at
a monastery in
1843.
Taught biology and
had interests in
statistics.
Also studied at the
University of Vienna
Mendel continued
Most famous for his
work with pea plants
Between 1856 and
1863 he grew and
tested over 28,000
pea plants
(That’s what he is
contemplating so
seriously in the
picture)
Why Peas?
Easy to grow.
Easily identifiable
traits
Trait – a specific
characteristic
Can work with large
numbers of samples
Mendel’s experiments
The first thing Mendel did was
create a “pure” plant or true-
breeding plant.
 True breeding – If the parent repeatedly
only produce offspring with the same trait
• For example: A plant
true-breeding for
purple flowers will
always produce
offspring with purple
flowers.
Mendel’s experiments
What happens if you cross two
plants which are true-breeding for
contrasting traits???
purple flowers x white flowers
wrinkled seeds x smooth seeds
tall plants x short plants
etc, etc, etc,
Mendel’s experiments
He always found the
same pattern
He discovered that
even though one of the
parent plants had white
flowers, ALL of the
offspring had purple
flowers!
True-breeding parents
Hybrids
Mendel’s experiments
Mendel repeated this experiment with
other traits, in every case, one trait
“won out”
 For example: Purple flower color “won out”
over white flower color. Smooth seed texture
“won out” over wrinkled seed texture.
Mendel’s experiments
Mendel called the trait that
“won out” in the offspring
dominant (purple flowers) .
He called the trait that
dissappeared in the offspring
recessive (white flowers) .
Mendel’s experiments
What would happen when
Mendel let the offspring self-
pollinate? Was the next
generation true-breeding for
the dominant trait?
Would Mendel continue to see
only purple flowers?
No!
The white
flowers
reappeared
(about ¼)
From his experiments, Mendel
concluded two things
1. Inheritance is determined by factors
passed on from one generation to
another.
 Today these “factors” are called genes, but
Mendel knew nothing about chromosomes,
genes or DNA because there terms hadn’t
been identified yet
 Allele – difference forms of a gene
From his experiments, Mendel
concluded two things
2. Some alleles are dominant while
other are recessive.
• An organism with a dominant allele for
a trait will always express that allele.
• An organism with a recessive allele for
a trait will express that form only when
the dominant allele is not present.
Which led him to create to
“laws” of inheritance
1. The Law of Segregation: Two
factors (alleles) control each
specific characteristic (gene).
These factors (alleles) are
separated during the formation of
gametes (sex cells).
Which led him to create to
“laws” of inheritance
2. The Law of Independent
Assortment: Factors (alleles) for
different characteristics (genes) are
distributed to gametes (sex cells)
independently. This means that the
allele for seed texture isn’t
dependent on the allele for plant
height, etc.
Probability
The likelihood of a
particular event
occurring.
Can be expressed as a
fraction, percent or ratio.
The more trials performed, the closer
the actual results to the expected
outcomes.
Punnett Square
A diagram used to
show the probability
or chances of a
certain trait being
passed from one
generation to
another.
Using a Punnett square
1. Gametes are placed above and
to the left of the square
2. Offspring are placed in the
square.
3. Capital letters represent
dominant alleles. (Y)
4. Lower case letters represent
recessive alleles. (y)
Punnett square example
In a cross between PP x Pp. What percent of
the offspring would you expect to be purple?
P = purple, p = white One parent goes here
One
parent
goes
here
Let’s do another one…
In a cross between Pp x Pp. What percent of
the offspring would you expect to be white?
P = purple, p = white
Dominant – allele, which if present, will
ALWAYS be expressed
 Represented by a capital letter, usually the first
letter of the dominant trait
Recessive – allele, which will only be
expressed in the absence of a dominant
allele
 Represented by a lowercase letter, the same
letter as the dominant trait, just lowercase
For example: Tall is dominant over short,
T = tall, t = short
Homozygous = when an organism
has two identical alleles.
YY or yy
Heterozygous = when an organism
has different alleles.
Yy
Genotype
The genetic makeup
Symbolized with letters
For example: Tt or TT
Phenotype
Physical appearance of an organism
Description of the trait
For example: Tall, short, purple, white
Some exceptions to
Mendel’s principles:
Some alleles are neither
dominant nor recessive.
Many traits are controlled by
more than one gene (polygenic
traits)
Incomplete dominance
A situation in which neither allele is
dominant.
When both alleles are present a “new”
phenotype appears that is a blend of
each allele.
Alleles will be represented by capital
letters only.
Japanese four-o-clock
flowers
Red flower plant genotype = RR
White flower plant genotype = WW
Pink flower plant genotype = RW
What happens when a
red flower is crossed
with a white flower?
According to
Mendel either
some white and
some red or all
offspring either
red or white.
All are pink
Codominance
When two alleles both appear in the
phenotype.
Usually signified using superscripts.
example: color of hair coat in cattle.
crcr = red hairs
cwcw = white hairs
crcw = roan coat (mixture of both colors)
Roan cattle inheritance
Multiple allele
inheritance
When two or more alleles contribute to
the phenotype.
Human blood types: A,B,O and AB
A and B are codominant to each other.
Both A and B are dominant over O.
How common are the
different blood types?
Polygenic traits
Traits controlled by two or more
genes.
Examples:
Human height,
eye and skin
color

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Intro to Genetics.ppt

  • 3. Gregor Mendel Born in 1822 in Czechoslovakia. Became a monk at a monastery in 1843. Taught biology and had interests in statistics. Also studied at the University of Vienna
  • 4. Mendel continued Most famous for his work with pea plants Between 1856 and 1863 he grew and tested over 28,000 pea plants (That’s what he is contemplating so seriously in the picture)
  • 5. Why Peas? Easy to grow. Easily identifiable traits Trait – a specific characteristic Can work with large numbers of samples
  • 6. Mendel’s experiments The first thing Mendel did was create a “pure” plant or true- breeding plant.  True breeding – If the parent repeatedly only produce offspring with the same trait • For example: A plant true-breeding for purple flowers will always produce offspring with purple flowers.
  • 7. Mendel’s experiments What happens if you cross two plants which are true-breeding for contrasting traits??? purple flowers x white flowers wrinkled seeds x smooth seeds tall plants x short plants etc, etc, etc,
  • 8. Mendel’s experiments He always found the same pattern He discovered that even though one of the parent plants had white flowers, ALL of the offspring had purple flowers! True-breeding parents Hybrids
  • 9. Mendel’s experiments Mendel repeated this experiment with other traits, in every case, one trait “won out”  For example: Purple flower color “won out” over white flower color. Smooth seed texture “won out” over wrinkled seed texture.
  • 10. Mendel’s experiments Mendel called the trait that “won out” in the offspring dominant (purple flowers) . He called the trait that dissappeared in the offspring recessive (white flowers) .
  • 11. Mendel’s experiments What would happen when Mendel let the offspring self- pollinate? Was the next generation true-breeding for the dominant trait? Would Mendel continue to see only purple flowers?
  • 13. From his experiments, Mendel concluded two things 1. Inheritance is determined by factors passed on from one generation to another.  Today these “factors” are called genes, but Mendel knew nothing about chromosomes, genes or DNA because there terms hadn’t been identified yet  Allele – difference forms of a gene
  • 14. From his experiments, Mendel concluded two things 2. Some alleles are dominant while other are recessive. • An organism with a dominant allele for a trait will always express that allele. • An organism with a recessive allele for a trait will express that form only when the dominant allele is not present.
  • 15. Which led him to create to “laws” of inheritance 1. The Law of Segregation: Two factors (alleles) control each specific characteristic (gene). These factors (alleles) are separated during the formation of gametes (sex cells).
  • 16. Which led him to create to “laws” of inheritance 2. The Law of Independent Assortment: Factors (alleles) for different characteristics (genes) are distributed to gametes (sex cells) independently. This means that the allele for seed texture isn’t dependent on the allele for plant height, etc.
  • 17. Probability The likelihood of a particular event occurring. Can be expressed as a fraction, percent or ratio. The more trials performed, the closer the actual results to the expected outcomes.
  • 18. Punnett Square A diagram used to show the probability or chances of a certain trait being passed from one generation to another.
  • 19. Using a Punnett square 1. Gametes are placed above and to the left of the square 2. Offspring are placed in the square. 3. Capital letters represent dominant alleles. (Y) 4. Lower case letters represent recessive alleles. (y)
  • 20. Punnett square example In a cross between PP x Pp. What percent of the offspring would you expect to be purple? P = purple, p = white One parent goes here One parent goes here
  • 21. Let’s do another one… In a cross between Pp x Pp. What percent of the offspring would you expect to be white? P = purple, p = white
  • 22. Dominant – allele, which if present, will ALWAYS be expressed  Represented by a capital letter, usually the first letter of the dominant trait Recessive – allele, which will only be expressed in the absence of a dominant allele  Represented by a lowercase letter, the same letter as the dominant trait, just lowercase For example: Tall is dominant over short, T = tall, t = short
  • 23. Homozygous = when an organism has two identical alleles. YY or yy Heterozygous = when an organism has different alleles. Yy
  • 24. Genotype The genetic makeup Symbolized with letters For example: Tt or TT Phenotype Physical appearance of an organism Description of the trait For example: Tall, short, purple, white
  • 25. Some exceptions to Mendel’s principles: Some alleles are neither dominant nor recessive. Many traits are controlled by more than one gene (polygenic traits)
  • 26. Incomplete dominance A situation in which neither allele is dominant. When both alleles are present a “new” phenotype appears that is a blend of each allele. Alleles will be represented by capital letters only.
  • 27. Japanese four-o-clock flowers Red flower plant genotype = RR White flower plant genotype = WW Pink flower plant genotype = RW
  • 28. What happens when a red flower is crossed with a white flower? According to Mendel either some white and some red or all offspring either red or white. All are pink
  • 29. Codominance When two alleles both appear in the phenotype. Usually signified using superscripts. example: color of hair coat in cattle. crcr = red hairs cwcw = white hairs crcw = roan coat (mixture of both colors)
  • 31. Multiple allele inheritance When two or more alleles contribute to the phenotype. Human blood types: A,B,O and AB A and B are codominant to each other. Both A and B are dominant over O.
  • 32. How common are the different blood types?
  • 33. Polygenic traits Traits controlled by two or more genes. Examples: Human height, eye and skin color