Gilbert syndrome

1. Gilbert syndrome
Epidemiology • Most common inherited disorder of bilirubin metabolism
Pathogenesis
• ↓ Hepatic UDP glucuronosyltransferase activity → ↓ conjugation
of bilirubin
Clinical findings
• Recurrent episodes of mild jaundice
• Provoked by stress (eg, febrile illness, fasting, dehydration,
vigorous exercise, menstruation, surgery)
Diagnosis
• ↑ Unconjugated bilirubin (ie, indirect hyperbilirubinemia)
• Normal CBC, blood smear, reticulocyte count
• Normal AST, ALT, alkaline phosphatase
Treatment • Benign; no treatment required