An overview of colorectal carcinoma at oncology department new
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CRC retrospective study.
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An overview of colorectal carcinoma at oncology department new
- 1. AN OVERVIEW OF COLORECTAL CARCINOMA AT ONCOLOGY DEPARTMENT OF BANGABANDHU SHEIKH MUJIB MEDICAL UNIVERSITY(BSMMU):2 YEARS EXPERIENCE Prof. Sarwar Alam Chairman Department of oncology,BSMMU. Prepared by Dr.S.M.Nazmul Alam,Resident, Oncology,BSMMU.
- 2. BACKGROUND • Colorectal carcinoma(CRC) is an important public health problem affecting the caecum,colon & rectum. • There are nearly one million new cases of colorectal cancer diagnosed world wide each year(9.7% of overall cancer) & half a million death(8% of overall death worldwide).
- 4. ETIOLOGY
- 6. DIAGNOSTIC TOOL • Biochemistry-CBC,LFT, CEA ,CA 19-9 • Colonoscopy & Biopsy confirmation • Imaging-CXR • CT or MRI with contrast of chest,abdomen & pelvis. • PET scanning
- 7. TREATMENT MODALITIES • Surgery,only universally accepted curative treatment • Adjuvant chemotherapy. • Neoadjuvant therapy for locally advanced rectal carcinoma. • Radiotherapy
- 8. CHEMO REGIMEN • FOLFOX • XELOX • Mayo regimen • IFL • FOLFIRI • FUFOX • IROX • Monoclonal antibodies like Bevacizumab,cetuximab.
- 9. BACKGROUND IN BANGLADESH • As well as in Bangladesh it is one of the emerging cancer among the population. • It is the 8th leading cancer in bangladesh. • In male it ranked 6th and in female it ranked 9th position according to hospital based cancer registry report 2014 by NICRH.
- 10. AIM AND OBJECTIVE • Investigate various epidemiological prevalence like age,sex,family history,personal habit • site of primary cancer,presence of metastasis & stage at presentation as well as the response of treatment.
- 11. MATERIAL AND METHOD • Study type- retrospective study • Study population- 200 Patients • Study period - December 2014 to December 2016. • Research data form containg detailed history, clinical examinations, staging,previous treatment, present treatment plan and follow up records were evaluated.
- 13. RESULT • AGE-Mean age of patients at diagnosis was 47 years with a range from 25 to 70 years. • GENDER-63% were male and 37 % were female. • TOBACCO-53% patients were smoker. • 23% patients had positive family history.
- 14. AGE AT PRESENTATION 7 12 17 16 51 22 21 24 22 8 0 10 20 30 40 50 60 25-29 30-34 35-39 40-44 45-49 50-54 55-59 60-64 65-69 70-above No.of patient Age of the patient
- 15. GENDER DISTRIBUTION male female 0 5 10 15 20 25 30 35 25-29 30-34 35-39 40-44 45-49 50-54 55-59 60-64 65-69 70-above male female Age of the patient No.of patient
- 16. PRESENTATION 56 4243 20 24 6 abdominal pain altered bowel habit bleeding weakness anemia & others weight loss number of presentation as per symptoms
- 17. ANATOMICAL DISTRIBUTION 46% 20% 16% 9% Ascending colon Rectum sigmoid colon transverse and desce3nding
- 18. MORPHOLOGICAL TYPE OF CARCINOMA 97% 3% adenocarcinoma lymphoma
- 19. STAGE AT TIME OF DIAGNOSIS 23 68 9 0 10 20 30 40 50 60 70 80 stage 2 stage 3 stage 4 stage
- 21. TREATMENT 60% 35 % 5 % XELOX FOLFOX Mayo regim
- 22. CHEMOCARD
- 24. CONCLUSION • Colorectal cancer is a common form of malignancy with identifiable risk factors. • Treatment can improve overall survival,especially when the disease is diagnosed at an early stage.
- 25. CONCLUSION CRC is a disease that requires multidisciplinary teamwork. A well defined guideline for screening,biopsies,surgical and medical management is important to screen appropriate patients,reduce its incidence and care for those affected by this disease
- 26. THANK YOU ALL
Editor's Notes
- This is the bar diagram showing the age wise distribution of the pts
- Abdominal pain – 56 Change in bowel habit – 42 Hematochezia or melena – 43 Weakness – 20 Anaemia without other GIT symptoms – 24 Weight loss – 6
- Affected site - ascending colon - 46% Rectum – 20% Sigmoid colon – 16% Transeverse and descending colon – 9%
- 97 % patient had adenocarcinoma,rest had lymphoma.
- Chart showing percentage of patient at time of diagnosis by presentation.this shows that the greater percentage present at stage 2 that is 68 percentage followed by stage 1 and then 3.
- 9 % were in advanced stage with distant metastasis,rest had undergone operation before chemo
- Treatment by XELOX regimens(60%) FOLFOX regimens( 35 %) Mayo regimens( 5 %)
- Colonoscopy report showing familial adenomatous polyposis