2. MCRC Biobanking: The Basic Concept
Make quality tissue collection and retrieval easy for the researcher
•Regulatory Framework
•Sample Collection Logistics
•Sample Quality
•Informatics
•Sample Access
3. Collaborating Trusts
MCRC Biobank
Pennine Acute Hospitals Trust
The Christie NHS Foundation Trust
South Manchester NHS Foundation Trust
Salford Royal NHS Foundation Trust
HPB
Breast
Colorectal Skin Urology Gynaecology Haematological Malignancies
Lung Breast Head & Neck Colorectal
Breast Upper GI Urology Neurology
10. Melanoma Tissue Collection Pathway
Collect Fresh From Theatres
Fresh Cut-Up in Pathology
Diagnostic Sample
Research Sample
Mouse model of tumour
Frozen Tissue for Nucleic Acid Extraction
Fixed Tissue for Staining
11. Evolving the Collections
Requirement
Considerations
Prospective Fresh Tissue
•Availability of tissue
•Staff available for sample delivery
•Media for keeping samples viable
Use for Animal Models
•Specific consent for animal models
•Size of tumour tissue
Alternative Sample Types (fluids, plucked hair)
•Routes / logistics of sample collection
Serial Blood Collection inc CTCs
•Biobank Technician presence in clinic
Past samples (e.g. pre- treatment/primary tumours)
•Specific consent
•Requesting blocks from local hospitals
Sampling tumour in different areas
•Further input from pathology
Clinical Trial Sample Collection
•Space for sample storage
•Different protocols for each trial
12. Biobank Projects by Type
17
39
10
8
Fresh Tissue
Banked Samples
Archive FFPE/TMA
Prospective Protocol
Total Approved Projects By Type
0
2
4
6
8
10
12
14
16
Fresh Tissue
Banked Samples
Archive FFPE/TMA
Prospective Protocol
Active Projects By Type (Total 33*)
13. Tissue Microarrays
•Current disease areas include prostate, bladder, lung
•Link to clinical databases
•Recently obtained Section 251 Support which allows the Biobank to link archival samples to clinical data
•Support through Surgical Oncology Research Theme – Data Manager employed
15. Research Biopsies
•Working with clinical teams to introduce sample collection as a research only procedure
•How tumours change over time
•Comparing primary and metastatic tumours in patients
•Research into why patients are relapsing on targeted treatments
•Pilot to being in Malignant Melanoma - 2014
16. Key Success Drivers
•Established network model with existing infrastructure and pathways for sample collection
•Excellent clinical engagement across all cancer disease types
•Robust governance framework for tissue and data
•Proven track record of providing quality samples
•Research needs drive the sample collection, not the other way round