Antisperm antibodies are immunoglobulins produced by the immune system of the body against sperm antigens and it is one of the causes of infertility.

1. A
PRESENTATION
ON
ANTISPERM ANTIBODIES: IMPLICATIONS ON
FERTILITY
BY
SCIENTIST. MORDECAI OWAJIONIRO GODSTIME
AUGUST, 2016.

2.  INTRODUCTION
 ETIOLOGY
 MECHANISM OF ACTION
 IMPLICATIONS ON FERTILITY
 DIAGNOSIS
 TREATMENT
 CONCLUSION
 RECOMMENDATIONS

3.  The testes: immune privileged site.
 Antigenicity of sperm: foreign to the body (YWK-2,
BE-20, rSMP-B, BS-63, BS-17, HED-2 and 75-
kDa).
 History
-Landsteiner: 1899
-Baskin:1932
-Rumke:1954
 Immune tolerance.
 Antisperm antibodies.
(IgG, IgM & IgA).
(Brazdova et al., 2016).

4. MENWOMEN
 Infection
 Undescended testicles
 Twisting of the testicles
 Injury to the testicles
 Testicular biopsy
 Testicular cancer
 Vasectomy
 Congenital absence of the
vas deferens (CAVD)
(Ishahakia, 1988; Khan et al.,
2012).
 Allergic reaction
(Maria et al., 2011).

5.  Spermatotoxicity: compliment
activation produced by IgG.
 Agglutination: interference
with quality or function of
sperm and motility.
 Immobilization of sperm:
impairment of sperm
penetration through cervical
mucus.
(Chiu & Chamley, 2004;
Brazdova et al., 2016).

6.  Interference with sperm
quality or function.
 Interference with
penetration of cervical
mucus.
 Interference with sperm-egg
binding.
 Results above 50% causes
infertility.
(Bronson, 2009; Bronson,
2011).

7.  SAMPLES
-Spermatozoa
-Seminal plasma
-Serum
-Cervical mucus
 METHODS
-Immunobead test (IBT).
-Mixed antiglobulin reaction (MAR)
-Enzyme linked immunosorbent assay
(ELISA).
(Richard, 2011; Mazumdar & Levine,
1998).

8.  ART: IUI, IVF with ICSI.
 Corticosteroid:
Administration of
prednisone.
 Condom therapy.
 Zinc therapy: regulates
immune system, 250mg
of zinc twice/day for
3months.
(Rasanen et al., 1994).

9. The presence of antisperm antibodies (ASA)
reduces male fertility as well as female fertility
significantly, but does not usually prevent
conception altogether. Rather, the effects are
graduated; that is, the larger the immunological
response (concentration of antibodies), the less
likely it is that a pregnancy will occur.

10.  Infertile couples should be
tested for ASA.
 Seminology laboratory
should be established in
FMC, Yenagoa.
 Research on antisperm
antibodies suppression
drugs should be
encouraged.
 Awareness on ASA related
infertility be created.

11. THANKS
FOR
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