Giampaolo Morciano JC - 04/06/2010
Human populations use a variety of subsistence strategies to exploit an exceptionally broad range of ecoregions and dietar...
61 human populations: 52  in the HGDP  4  HapMap Phase III 5  additional populations Luhya, Maasai, Tuscans, Gujarati Vase...
Bailey’s Ecoregion Map For each population were gathered… … according to their main mode of subsistence and dietary specia...
Detecting signals between SNPs and environmental variables To  assess evidence for selection related to each environmental...
On the basis of these BFs    a  transformed rank statistic   that was scaled to be between 0 and 1. Calculating this tran...
Assessing the evidence for an excess of functional SNPs in the tail of the distribution
 
<ul><li>Roots and tubers  : Yoruba, Papuan, Melanesian, Karitiana, Surui  </li></ul><ul><li>Foraging  : Biaka, Vasekela, M...
(C)  Polar  : Russian, Maritime Chukchee, Yakut (D)  Dry  : Amhara, San, Hazara, Mongola, Xibo, Pima
Two NS SNPs have extremely high BFs and provide convincing signals of adaptations to dietary specializations: Rs162036  (M...
Identification of Pathways that were targeted by selection
Results of genome – wide association studies with disease and other complex traits
Discussion Selection on standing, rather than new alleles, may have played a prominent role in adaptation to new environme...
Hunting and gathering are the modes of subsistence that characterized human populations since their emergence in Africa un...
<ul><li>The strongest signal was observed for the  polar  domain </li></ul><ul><li>cold temperature </li></ul><ul><li>low ...
<ul><li>This approach is similar to previous analyses based on F ST : </li></ul><ul><li>compare populations on the basis o...
Maybe results due solely to background selection.  The elimination of deleterious alleles reduces the effective population...
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Giampaolo morciano jc

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Giampaolo morciano jc

  1. 1. Giampaolo Morciano JC - 04/06/2010
  2. 2. Human populations use a variety of subsistence strategies to exploit an exceptionally broad range of ecoregions and dietary components. These aspects of human environments have changed dramatically during human evolution, giving rise to new selective pressures. This study aims to clarify the genetics underlying the adaptative responses to these transitions.
  3. 3. 61 human populations: 52 in the HGDP 4 HapMap Phase III 5 additional populations Luhya, Maasai, Tuscans, Gujarati Vasekela Kung, Amhara, Naukan Yup’ik and Maritime Chukchee, Australian Aborigines AFRICA   ASIA       EUROPA Bantu   Ctrl/South Eastern ASIA     Adygei Biaka   Balochi Khmer Mongola      Basque Mandenka   Brahui Dai Naxi   French Mbuti pygmy   Burusho Daur Oroqen   North Italian Mozabite   Hazara Han  (N.  China ) She   Orcadian San   Kalash Han  (S.  China ) Tu   Russian Yoruba   Makrani Hezhen Tujia   Sardinian     Pashtun Japanese Xibo   Tuscan     Sindhi Lahu Yakut   NATIVE AMERICA   Uyghur Miao Yi   Colombian        OCEANIA Karitiana   Western ASIA   Melanesian Maya   Bedouin   Papuan Pima   Druze   Surui    
  4. 4. Bailey’s Ecoregion Map For each population were gathered… … according to their main mode of subsistence and dietary specialization.
  5. 5. Detecting signals between SNPs and environmental variables To assess evidence for selection related to each environmental variable, we contrasted the allele frequencies for each SNP across populations that differ with respect to the environmental variable. Bayesian linear model method BF
  6. 6. On the basis of these BFs  a transformed rank statistic that was scaled to be between 0 and 1. Calculating this transformed rank statistic allowed us to control for some aspects of SNP ascertainment and differences in allele frequencies across SNPs. To summarize the evidence for selection for each SNP for the two categories of variables as a whole, we calculated a minimum rank statistic by finding the minimum of the transformed rank statistics across all subsistence and ecoregion variables.
  7. 7. Assessing the evidence for an excess of functional SNPs in the tail of the distribution
  8. 9. <ul><li>Roots and tubers : Yoruba, Papuan, Melanesian, Karitiana, Surui </li></ul><ul><li>Foraging : Biaka, Vasekela, Mbuti, Maritime Chukchee, Australian Aborigines </li></ul>
  9. 10. (C) Polar : Russian, Maritime Chukchee, Yakut (D) Dry : Amhara, San, Hazara, Mongola, Xibo, Pima
  10. 11. Two NS SNPs have extremely high BFs and provide convincing signals of adaptations to dietary specializations: Rs162036 (MTRR gene): folate – poor roots and tubers pathways  starch and sucrose metabolism and folate biosynthesis Rs4751995 (PLRP2): use of cereals as the main dietary component pathways  role in a plant – based diet Cytogenetic Location: 5p15.3-p15.2
  11. 12. Identification of Pathways that were targeted by selection
  12. 13. Results of genome – wide association studies with disease and other complex traits
  13. 14. Discussion Selection on standing, rather than new alleles, may have played a prominent role in adaptation to new environments, supported by expectations of selection models for quantitative traits, specifically that selection will generate small allele frequency shifts at many loci until the population reaches a new optimum. [No HARD SWEEP MODEL] Some of most interesting signals seem to be adaptations to dietary specializations  cultural adaptations played an important role in our ability to diversify. Genetic adaptations to dietary specializations in human population may be widespread!
  14. 15. Hunting and gathering are the modes of subsistence that characterized human populations since their emergence in Africa until the transition to intensive agriculture. Given that our ancestors were foragers, the signal we observe in the contrast between forager and nonforager populations is likely to reflect adaptations to more specialized diets in horticulture, animal farming, and agriculture. NAT2 drug metabolizing enzyme gene
  15. 16. <ul><li>The strongest signal was observed for the polar domain </li></ul><ul><li>cold temperature </li></ul><ul><li>low UV radiation </li></ul><ul><li>limited resources </li></ul>a lesser signal extent for dry and humid temperate domains may reflect ancient adaptations during the dispersal of modern human populations lack of a significant excess of signals associated with the humid tropical domain may be due to a combination of factors energy metabolism and temperature homeostasis
  16. 17. <ul><li>This approach is similar to previous analyses based on F ST : </li></ul><ul><li>compare populations on the basis of environmental variables </li></ul><ul><li>use of a test statistic (BF) </li></ul>The overlap in the tails from global F ST and the minimum ranks for subsistence and ecoregion, respectively, are slightly less than expected by chance.
  17. 18. Maybe results due solely to background selection. The elimination of deleterious alleles reduces the effective population size of the genic regions compared to the less constrained nongenic regions. <ul><li>Purifying rather than positive selection could potentially account for the excess of genic SNPs correlated with environmental variables. They cannot rule out this possibility, but… </li></ul><ul><li>the enrichment of genic and NS SNPs becomes more pronounced in the more extreme lower tails </li></ul><ul><li>the enrichment of NS SNPs is quantitatively greater than genic SNPs </li></ul>

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