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3/30/2022 Sree Siddaganga College of Pharmacy, Tumkur 1
INTRODUCTION ON DISEASE
• DEFINITION
It is a chronic inflammatory disease associated with airway
hyper-responsiveness that leads to recurrent attacks of
breathlessness, chest tightness,cough,wheezing which varies
in frequency from person to person
3/30/2022 2
EPIDEMIOLOGY
3/30/2022 3
According to WHO 300 million people
suffer from asthma and 2 Lac 55,000
people died of asthma in 2005
Asthma is most common chronic
disease in children
Asthma death will increase by 20% in
next 10 years
TYPES
3/30/2022 4
CHRONIC ASTHMA
SEVERE ACUTE ASTHMA
EXERCISE INDUCED ASTHMA
NOCTURNAL ASTHMA
ETIOLOGY/CAUSES
5
This Photo by Unknown Author is licensed under CC BY
Genetic factors account for 35 to 75% of suseptibility
Environmental risks factors that cause asthma-Traffic fumes,
Smoking or social economic status, exposure to tobacco
Bronchoconstriction-It is the narrowing of the airways to
react to stimuli or tigger to cause an asthma attack
Hyperresponsiveness
Childhood infections example:Respiratory Syncytial Virus
Allergen exposure example:Pollen,Animal dander
Indoor Pollution
RISK FACTORS
• Asthma attack
• Respiratory Failure
• In Childers- Growth Delay, High risk for learning disability
• In Adults- frequent Sick, Higher risk for depression
• Common to both- Permanent narrowing of bronchial tube, Higher risk
of obesity
3/30/2022 6
COMPLICATIONS
• Parent with Asthma
• Having a sever respiratory infection as a child
• Having an allergic conditions or being exposed to certain
chemical irritants or Industrial dusts in the workplace
SIGNS
• Wheezing
• Increased mucous secretion
• Narrow/Closed small airway
• Edema
• Contraction bronchiole smooth muscle
SYMPTOMS
• Breathlessness
• Cough- Chest tightness
• Dyspnea
3/30/2022 7
CLINICAL MANIFESTATION
DIAGNOSIS
•Lung function assessment by
using Spirometer
•It is reported as FEV1/FVC ratio.
•It is a reproducible measure of the
capabilities of the lungs
•Peak flow meter measures
PEFR(Peak Expiratory Flow
Rate)
3/30/2022 8
This Photo by Unknown Author is licensed under CC BY-SA
PATIENT DEMOGRAPHIC DETAILS
• PATIENT NAME: XYZ
• AGE: 00Years
• GENDER: Female
• IP NO:00000
• UNIT: Respiratory Care Unit
• WARD: Semiprivate Ward
• DOA: 00/00/000
• DOD: 00/00/0000
3/30/2022 9
SUBJECTIVE EVIDENCE
A 00yrs old Female patient was admitted to hospital with
c/o of Breathlessness,Fever,Cough and Chest pain while
coughing.
3/30/2022 10
PAST MEDICAL HISTORY: Nothing
Significant
PAST MEDICATION HISTORY: Nothing
significant
FAMILY HISTORY: Nothing significant
SOCIAL HISTORY: Nothing significant
ALLERGIES: Not known allergies
3/30/2022 11
PATIENT HISTORY
Sree Siddaganga College of Pharmacy, Tumakuru
3/30/2022 12
PHYSICAL & SYSTEMIC
EXAMINATION
•CVS:S1S2 heard
•BP: 100/60mmhg
•RS: NVBS heard
•SPO2: 99%
•PR: 80b/min
OBJECTIVE EVIDENCE
TEST OBSERVED VALUES NORMAL VALUES
ESR 44mm/hr 0-30mm/hr
3/30/2022 13
 ESR- Erythrocyte Sedimentation Rate
ASTHMA
3/30/2022 14
PROVISIONAL DIAGNOSIS
LAB TEST
3/30/2022 15
TEST TEST VALUE NORMAL VALUE
Hb 13.4mg/dl 12-16mg/dl
ESR 44mm/hr 0-30mm/hr
PLATELETS 3.3 lakhs 2.4-3.5lakhs
RBS 128mg/dl 80-140mg/dl
RBC. 4.3million cells/mcL 4.2-5.2million cells/mcL
WBC 8100cells/cu mm 4,500-10,000cells/mcL
UREA 23mg/dl 15-45mg/dl
CREATININE 1.1mg/dl 0.5-1.5mg/dl
FINAL DIAGNOSIS
ASTHMA
3/30/2022 16
Sree Siddaganga College of Pharmacy, Tumakuru
SUBJECTIVE EVIDENCE
• Fever
• Breathlessness
• Cough Since 2days
OBJECTIVE EVIDENCE
•Increased ESR
•ESR-44mm/hr (1-30mm/hr)
3/30/2022 17
ASSESSMENT
From the subjective and objective evidence it has
been diagnosed as ASTHMA
3/30/2022 18
GOALS OF THERAPY
Prevent disease progression.
Relieve symptoms.
Improve exercise tolerance.
Improve health status
Patient Specific
oTo relieve cough & fever
oTo cure breathlessness & chest pain
Disease Specific
oTo reduce ESR level
3/30/2022 19
TRATMENT CHART
DRUGS
BRAND GENERIC
ROUTE DOSE FREQUENCY DAYS
01 02
Inj. DERIPHYLLIN
ETOFYLLINE+
THEOPHYLLINE
IV 2ml 1-0-1  .  .
T. PANTOP PANTOPRAZOLE P/O 40mg 1-1-1  .
Inj. DEXONA DEXAMETHASON
E
IV 2ml 1-0-1  .  .
Inj. METROGYL METRONIDAZOL
E
IV 2ml 1-0-0  .
NEUROBION FORTE THIAMINE/VITAM
IN B
P/O 10mg 1-1-1  .  .
3/30/2022 20
PROGRESS REPORT
•DAY 01
O/E
BP : 110/80mm Hg
Pulse Rate : 88bpm
Respiratory Rate: 24bpm
Rx
• Inj. Deriphylline
• T. Pantop
• Neurobion forte
• Inj. Dexona
Soft and nutritional diet is advised
3/30/2022 21
•DAY 02
O/E
• BP 120/80mmHg
• Pulse rate 82bpm
• Respiratory rate 25bpm
Rx
Inj. Deryphylline
Inj. Dexona
Neurobion forte
Inj. metrogyl
Patient is conscious and no fresh complaints.
3/30/2022 22
DAY 03
O/E
BP 110/80mmHg
PR 92bpm
RR 22bpm
• No fresh complaints.
• Patient is well.
• Patient is ready for
discharged.
DISCHARGE MEDICATION
DRUGS
BRAND GENERIC ROUTE DOSE FREQUENCY
T. DOXOVET DEXOFYLLINE P/O 400MG 1-0-0
T. PANTOP PANTOPRAZOLE P/O 40MG 1-0-1
3/30/2022 23
MONITORING PARAMETERS
 Spirometry should be done at the time of diagnosis
Heart rate.
Respiratory rate
Monitor vital signs and watch for signs and symptoms
3/30/2022 24
PROBLEMS IDENTIFIED
 PANTOPRAZOLE + THEOPHYLLINE
Pantoprazole increase toxicity of theophyllin
i.e Prolonged use of proton pump inhibitors can cause hypochlorhydria which
in turn causes paristalsis in small intestine
3/30/2022 25
PATIENT COUNSELLING
ABOUT DISEASE :
• It is mainly a respiratory track infection
• It is a chronic inflammatory disease associated with airway hyper-
responsiveness that leads to recurrent attacks of breathlessness,
chest tightness,cough,wheezing which varies in frequency from
person to person
• Educate the patient about aim of the treatment and the possible
side effects
• Educate the patient about the cause risk factor and other’s
• Prevent further complications
3/30/2022 26
ABOUT MEDICATION :
Take medication as prescribed by the doctors
Do not miss or double the dose
Advise the patient about drug reaction drug dosage
Name and strength of the medication
Reason why it has been prescribed
How to take the medication
Advice on correct storage
Drug :Inj. DERIPHYLLIN
• Pharmacological class: Bronchodialator
• USE:Dilates and relaxes the airway muscles
• ADR: Nausea,Diarrhea,Abdominal Pain
3/30/2022 27
Drug :Pantop
• Pharmacological class: Proton Pump Inhibitor
• USE:Decreases the acidity of stomach
• ADR:Headache,Constipation,Sever stomach pain
Drug :Inj Dexona
• Pharmacological class: Carticosteriods
• USE:To treat inflammatory conditions and for relieving pain
• ADR:Indigestion,Weight gain
Drug :Inj Metrogyl
• Pharmacological class: Antibiotics
• USE:Used to treat variety of infections
• ADR:Stomach pain,Vomitting
Drug :Neurobion Forte
• Pharmacological class: B-Complex Vitamins
• USE:Used to treat Vit-B Deficiencies
• ADR: Anemia, Fatigue
3/30/2022 28
LIFE STYLE MODIFICATION:
What to do?
• Regular Check up
• Maintain ideal Body weight
• Follow a proper healthy diet that is:
• Drink boiled water in plenty
• Light food should be taken at night and all sour substances should be almost
restricted
• Clove-Clove has expectorant properties hence it is effective in the treatment
of asthma also Garlic regular use of garlic can reduce the severity of
asthmatic attacks as follows Ginger-Ginger is used in treatment of asthma
due to its expectorant properties
• 2-3 dry figs each morning clears the respiratory track
• Exercise like swimming,walking&yoga
• Plenty of sleep (8 hours)
3/30/2022 29
This Photo by Unknown Author is licensed under CC BY-NC-ND
LIFE STYLE MODIFICATION:
What not to do?
• Smoking
• Exposure to allergens,dust and pollution
• Excessive physical exercise (Long distance running)
• Food such as curd, buttermilk and heavy milk products like cheese,paneer
etc.. which has natural tendency to accumulate the mucus
• Overeating. Take light dinner one hour before going to bed
• Dietary habits that leads to overweight which increase the risk of asthma
(High sodium intake, Fast foods)
• Use of sulfites (Pickles, Grape juice ,wine)
3/30/2022 30
THANK
YOU

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Asthma Case Presentation.pptx

  • 1. 3/30/2022 Sree Siddaganga College of Pharmacy, Tumkur 1
  • 2. INTRODUCTION ON DISEASE • DEFINITION It is a chronic inflammatory disease associated with airway hyper-responsiveness that leads to recurrent attacks of breathlessness, chest tightness,cough,wheezing which varies in frequency from person to person 3/30/2022 2
  • 3. EPIDEMIOLOGY 3/30/2022 3 According to WHO 300 million people suffer from asthma and 2 Lac 55,000 people died of asthma in 2005 Asthma is most common chronic disease in children Asthma death will increase by 20% in next 10 years
  • 4. TYPES 3/30/2022 4 CHRONIC ASTHMA SEVERE ACUTE ASTHMA EXERCISE INDUCED ASTHMA NOCTURNAL ASTHMA
  • 5. ETIOLOGY/CAUSES 5 This Photo by Unknown Author is licensed under CC BY Genetic factors account for 35 to 75% of suseptibility Environmental risks factors that cause asthma-Traffic fumes, Smoking or social economic status, exposure to tobacco Bronchoconstriction-It is the narrowing of the airways to react to stimuli or tigger to cause an asthma attack Hyperresponsiveness Childhood infections example:Respiratory Syncytial Virus Allergen exposure example:Pollen,Animal dander Indoor Pollution
  • 6. RISK FACTORS • Asthma attack • Respiratory Failure • In Childers- Growth Delay, High risk for learning disability • In Adults- frequent Sick, Higher risk for depression • Common to both- Permanent narrowing of bronchial tube, Higher risk of obesity 3/30/2022 6 COMPLICATIONS • Parent with Asthma • Having a sever respiratory infection as a child • Having an allergic conditions or being exposed to certain chemical irritants or Industrial dusts in the workplace
  • 7. SIGNS • Wheezing • Increased mucous secretion • Narrow/Closed small airway • Edema • Contraction bronchiole smooth muscle SYMPTOMS • Breathlessness • Cough- Chest tightness • Dyspnea 3/30/2022 7 CLINICAL MANIFESTATION
  • 8. DIAGNOSIS •Lung function assessment by using Spirometer •It is reported as FEV1/FVC ratio. •It is a reproducible measure of the capabilities of the lungs •Peak flow meter measures PEFR(Peak Expiratory Flow Rate) 3/30/2022 8 This Photo by Unknown Author is licensed under CC BY-SA
  • 9. PATIENT DEMOGRAPHIC DETAILS • PATIENT NAME: XYZ • AGE: 00Years • GENDER: Female • IP NO:00000 • UNIT: Respiratory Care Unit • WARD: Semiprivate Ward • DOA: 00/00/000 • DOD: 00/00/0000 3/30/2022 9
  • 10. SUBJECTIVE EVIDENCE A 00yrs old Female patient was admitted to hospital with c/o of Breathlessness,Fever,Cough and Chest pain while coughing. 3/30/2022 10
  • 11. PAST MEDICAL HISTORY: Nothing Significant PAST MEDICATION HISTORY: Nothing significant FAMILY HISTORY: Nothing significant SOCIAL HISTORY: Nothing significant ALLERGIES: Not known allergies 3/30/2022 11 PATIENT HISTORY Sree Siddaganga College of Pharmacy, Tumakuru
  • 12. 3/30/2022 12 PHYSICAL & SYSTEMIC EXAMINATION •CVS:S1S2 heard •BP: 100/60mmhg •RS: NVBS heard •SPO2: 99% •PR: 80b/min
  • 13. OBJECTIVE EVIDENCE TEST OBSERVED VALUES NORMAL VALUES ESR 44mm/hr 0-30mm/hr 3/30/2022 13  ESR- Erythrocyte Sedimentation Rate
  • 15. LAB TEST 3/30/2022 15 TEST TEST VALUE NORMAL VALUE Hb 13.4mg/dl 12-16mg/dl ESR 44mm/hr 0-30mm/hr PLATELETS 3.3 lakhs 2.4-3.5lakhs RBS 128mg/dl 80-140mg/dl RBC. 4.3million cells/mcL 4.2-5.2million cells/mcL WBC 8100cells/cu mm 4,500-10,000cells/mcL UREA 23mg/dl 15-45mg/dl CREATININE 1.1mg/dl 0.5-1.5mg/dl
  • 16. FINAL DIAGNOSIS ASTHMA 3/30/2022 16 Sree Siddaganga College of Pharmacy, Tumakuru
  • 17. SUBJECTIVE EVIDENCE • Fever • Breathlessness • Cough Since 2days OBJECTIVE EVIDENCE •Increased ESR •ESR-44mm/hr (1-30mm/hr) 3/30/2022 17
  • 18. ASSESSMENT From the subjective and objective evidence it has been diagnosed as ASTHMA 3/30/2022 18
  • 19. GOALS OF THERAPY Prevent disease progression. Relieve symptoms. Improve exercise tolerance. Improve health status Patient Specific oTo relieve cough & fever oTo cure breathlessness & chest pain Disease Specific oTo reduce ESR level 3/30/2022 19
  • 20. TRATMENT CHART DRUGS BRAND GENERIC ROUTE DOSE FREQUENCY DAYS 01 02 Inj. DERIPHYLLIN ETOFYLLINE+ THEOPHYLLINE IV 2ml 1-0-1  .  . T. PANTOP PANTOPRAZOLE P/O 40mg 1-1-1  . Inj. DEXONA DEXAMETHASON E IV 2ml 1-0-1  .  . Inj. METROGYL METRONIDAZOL E IV 2ml 1-0-0  . NEUROBION FORTE THIAMINE/VITAM IN B P/O 10mg 1-1-1  .  . 3/30/2022 20
  • 21. PROGRESS REPORT •DAY 01 O/E BP : 110/80mm Hg Pulse Rate : 88bpm Respiratory Rate: 24bpm Rx • Inj. Deriphylline • T. Pantop • Neurobion forte • Inj. Dexona Soft and nutritional diet is advised 3/30/2022 21 •DAY 02 O/E • BP 120/80mmHg • Pulse rate 82bpm • Respiratory rate 25bpm Rx Inj. Deryphylline Inj. Dexona Neurobion forte Inj. metrogyl Patient is conscious and no fresh complaints.
  • 22. 3/30/2022 22 DAY 03 O/E BP 110/80mmHg PR 92bpm RR 22bpm • No fresh complaints. • Patient is well. • Patient is ready for discharged.
  • 23. DISCHARGE MEDICATION DRUGS BRAND GENERIC ROUTE DOSE FREQUENCY T. DOXOVET DEXOFYLLINE P/O 400MG 1-0-0 T. PANTOP PANTOPRAZOLE P/O 40MG 1-0-1 3/30/2022 23
  • 24. MONITORING PARAMETERS  Spirometry should be done at the time of diagnosis Heart rate. Respiratory rate Monitor vital signs and watch for signs and symptoms 3/30/2022 24
  • 25. PROBLEMS IDENTIFIED  PANTOPRAZOLE + THEOPHYLLINE Pantoprazole increase toxicity of theophyllin i.e Prolonged use of proton pump inhibitors can cause hypochlorhydria which in turn causes paristalsis in small intestine 3/30/2022 25
  • 26. PATIENT COUNSELLING ABOUT DISEASE : • It is mainly a respiratory track infection • It is a chronic inflammatory disease associated with airway hyper- responsiveness that leads to recurrent attacks of breathlessness, chest tightness,cough,wheezing which varies in frequency from person to person • Educate the patient about aim of the treatment and the possible side effects • Educate the patient about the cause risk factor and other’s • Prevent further complications 3/30/2022 26
  • 27. ABOUT MEDICATION : Take medication as prescribed by the doctors Do not miss or double the dose Advise the patient about drug reaction drug dosage Name and strength of the medication Reason why it has been prescribed How to take the medication Advice on correct storage Drug :Inj. DERIPHYLLIN • Pharmacological class: Bronchodialator • USE:Dilates and relaxes the airway muscles • ADR: Nausea,Diarrhea,Abdominal Pain 3/30/2022 27
  • 28. Drug :Pantop • Pharmacological class: Proton Pump Inhibitor • USE:Decreases the acidity of stomach • ADR:Headache,Constipation,Sever stomach pain Drug :Inj Dexona • Pharmacological class: Carticosteriods • USE:To treat inflammatory conditions and for relieving pain • ADR:Indigestion,Weight gain Drug :Inj Metrogyl • Pharmacological class: Antibiotics • USE:Used to treat variety of infections • ADR:Stomach pain,Vomitting Drug :Neurobion Forte • Pharmacological class: B-Complex Vitamins • USE:Used to treat Vit-B Deficiencies • ADR: Anemia, Fatigue 3/30/2022 28
  • 29. LIFE STYLE MODIFICATION: What to do? • Regular Check up • Maintain ideal Body weight • Follow a proper healthy diet that is: • Drink boiled water in plenty • Light food should be taken at night and all sour substances should be almost restricted • Clove-Clove has expectorant properties hence it is effective in the treatment of asthma also Garlic regular use of garlic can reduce the severity of asthmatic attacks as follows Ginger-Ginger is used in treatment of asthma due to its expectorant properties • 2-3 dry figs each morning clears the respiratory track • Exercise like swimming,walking&yoga • Plenty of sleep (8 hours) 3/30/2022 29 This Photo by Unknown Author is licensed under CC BY-NC-ND
  • 30. LIFE STYLE MODIFICATION: What not to do? • Smoking • Exposure to allergens,dust and pollution • Excessive physical exercise (Long distance running) • Food such as curd, buttermilk and heavy milk products like cheese,paneer etc.. which has natural tendency to accumulate the mucus • Overeating. Take light dinner one hour before going to bed • Dietary habits that leads to overweight which increase the risk of asthma (High sodium intake, Fast foods) • Use of sulfites (Pickles, Grape juice ,wine) 3/30/2022 30

Editor's Notes

  1. DEXAMETHASONE + THEOPHYLLINE Dexamethasone will decrease the level or effect of theophylline by affecting heptic/intestinal enzyme CYP3A4 metabolism
  2. Exercise regularly which can help insulin more effectively lower your blood sugar level and can help control the frequency and severity of asthma attack