2. INTRODUCTION ON DISEASE
• DEFINITION
It is a chronic inflammatory disease associated with airway
hyper-responsiveness that leads to recurrent attacks of
breathlessness, chest tightness,cough,wheezing which varies
in frequency from person to person
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3. EPIDEMIOLOGY
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According to WHO 300 million people
suffer from asthma and 2 Lac 55,000
people died of asthma in 2005
Asthma is most common chronic
disease in children
Asthma death will increase by 20% in
next 10 years
5. ETIOLOGY/CAUSES
5
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Genetic factors account for 35 to 75% of suseptibility
Environmental risks factors that cause asthma-Traffic fumes,
Smoking or social economic status, exposure to tobacco
Bronchoconstriction-It is the narrowing of the airways to
react to stimuli or tigger to cause an asthma attack
Hyperresponsiveness
Childhood infections example:Respiratory Syncytial Virus
Allergen exposure example:Pollen,Animal dander
Indoor Pollution
6. RISK FACTORS
• Asthma attack
• Respiratory Failure
• In Childers- Growth Delay, High risk for learning disability
• In Adults- frequent Sick, Higher risk for depression
• Common to both- Permanent narrowing of bronchial tube, Higher risk
of obesity
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COMPLICATIONS
• Parent with Asthma
• Having a sever respiratory infection as a child
• Having an allergic conditions or being exposed to certain
chemical irritants or Industrial dusts in the workplace
8. DIAGNOSIS
•Lung function assessment by
using Spirometer
•It is reported as FEV1/FVC ratio.
•It is a reproducible measure of the
capabilities of the lungs
•Peak flow meter measures
PEFR(Peak Expiratory Flow
Rate)
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10. SUBJECTIVE EVIDENCE
A 00yrs old Female patient was admitted to hospital with
c/o of Breathlessness,Fever,Cough and Chest pain while
coughing.
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11. PAST MEDICAL HISTORY: Nothing
Significant
PAST MEDICATION HISTORY: Nothing
significant
FAMILY HISTORY: Nothing significant
SOCIAL HISTORY: Nothing significant
ALLERGIES: Not known allergies
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PATIENT HISTORY
Sree Siddaganga College of Pharmacy, Tumakuru
19. GOALS OF THERAPY
Prevent disease progression.
Relieve symptoms.
Improve exercise tolerance.
Improve health status
Patient Specific
oTo relieve cough & fever
oTo cure breathlessness & chest pain
Disease Specific
oTo reduce ESR level
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20. TRATMENT CHART
DRUGS
BRAND GENERIC
ROUTE DOSE FREQUENCY DAYS
01 02
Inj. DERIPHYLLIN
ETOFYLLINE+
THEOPHYLLINE
IV 2ml 1-0-1 . .
T. PANTOP PANTOPRAZOLE P/O 40mg 1-1-1 .
Inj. DEXONA DEXAMETHASON
E
IV 2ml 1-0-1 . .
Inj. METROGYL METRONIDAZOL
E
IV 2ml 1-0-0 .
NEUROBION FORTE THIAMINE/VITAM
IN B
P/O 10mg 1-1-1 . .
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21. PROGRESS REPORT
•DAY 01
O/E
BP : 110/80mm Hg
Pulse Rate : 88bpm
Respiratory Rate: 24bpm
Rx
• Inj. Deriphylline
• T. Pantop
• Neurobion forte
• Inj. Dexona
Soft and nutritional diet is advised
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•DAY 02
O/E
• BP 120/80mmHg
• Pulse rate 82bpm
• Respiratory rate 25bpm
Rx
Inj. Deryphylline
Inj. Dexona
Neurobion forte
Inj. metrogyl
Patient is conscious and no fresh complaints.
22. 3/30/2022 22
DAY 03
O/E
BP 110/80mmHg
PR 92bpm
RR 22bpm
• No fresh complaints.
• Patient is well.
• Patient is ready for
discharged.
24. MONITORING PARAMETERS
Spirometry should be done at the time of diagnosis
Heart rate.
Respiratory rate
Monitor vital signs and watch for signs and symptoms
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25. PROBLEMS IDENTIFIED
PANTOPRAZOLE + THEOPHYLLINE
Pantoprazole increase toxicity of theophyllin
i.e Prolonged use of proton pump inhibitors can cause hypochlorhydria which
in turn causes paristalsis in small intestine
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26. PATIENT COUNSELLING
ABOUT DISEASE :
• It is mainly a respiratory track infection
• It is a chronic inflammatory disease associated with airway hyper-
responsiveness that leads to recurrent attacks of breathlessness,
chest tightness,cough,wheezing which varies in frequency from
person to person
• Educate the patient about aim of the treatment and the possible
side effects
• Educate the patient about the cause risk factor and other’s
• Prevent further complications
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27. ABOUT MEDICATION :
Take medication as prescribed by the doctors
Do not miss or double the dose
Advise the patient about drug reaction drug dosage
Name and strength of the medication
Reason why it has been prescribed
How to take the medication
Advice on correct storage
Drug :Inj. DERIPHYLLIN
• Pharmacological class: Bronchodialator
• USE:Dilates and relaxes the airway muscles
• ADR: Nausea,Diarrhea,Abdominal Pain
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28. Drug :Pantop
• Pharmacological class: Proton Pump Inhibitor
• USE:Decreases the acidity of stomach
• ADR:Headache,Constipation,Sever stomach pain
Drug :Inj Dexona
• Pharmacological class: Carticosteriods
• USE:To treat inflammatory conditions and for relieving pain
• ADR:Indigestion,Weight gain
Drug :Inj Metrogyl
• Pharmacological class: Antibiotics
• USE:Used to treat variety of infections
• ADR:Stomach pain,Vomitting
Drug :Neurobion Forte
• Pharmacological class: B-Complex Vitamins
• USE:Used to treat Vit-B Deficiencies
• ADR: Anemia, Fatigue
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29. LIFE STYLE MODIFICATION:
What to do?
• Regular Check up
• Maintain ideal Body weight
• Follow a proper healthy diet that is:
• Drink boiled water in plenty
• Light food should be taken at night and all sour substances should be almost
restricted
• Clove-Clove has expectorant properties hence it is effective in the treatment
of asthma also Garlic regular use of garlic can reduce the severity of
asthmatic attacks as follows Ginger-Ginger is used in treatment of asthma
due to its expectorant properties
• 2-3 dry figs each morning clears the respiratory track
• Exercise like swimming,walking&yoga
• Plenty of sleep (8 hours)
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30. LIFE STYLE MODIFICATION:
What not to do?
• Smoking
• Exposure to allergens,dust and pollution
• Excessive physical exercise (Long distance running)
• Food such as curd, buttermilk and heavy milk products like cheese,paneer
etc.. which has natural tendency to accumulate the mucus
• Overeating. Take light dinner one hour before going to bed
• Dietary habits that leads to overweight which increase the risk of asthma
(High sodium intake, Fast foods)
• Use of sulfites (Pickles, Grape juice ,wine)
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DEXAMETHASONE + THEOPHYLLINE
Dexamethasone will decrease the level or effect of theophylline by affecting heptic/intestinal enzyme CYP3A4 metabolism
Exercise regularly which can help insulin more effectively lower your blood sugar level and can help control the frequency and severity of asthma attack