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BONY SYNGNATHIA (CONGENITAL FUSION OF MAXILLA AND MANDIBLE)
Author : Tahrir N.N. Aldelaimi Author : Ismail Yazdi & Amir Hossein Fakhraee
Journal : EGYPTIAN DENTAL JOURNAL Journal : ARCHIVES OF IRANIAN
MEDICINE
Publication : Vol. 57, 1:3, July, 2011 Publication : Volume 3, Number 3 Jul. 2000
Title :
BONY SYNGNATHIA (CONGENITAL
FUSION OF MAXILLA AND MANDIBLE)
Title :
Congenital Fusion of Maxilla and Mandible
(Bony Syngnathia): A Case Report
Abstract :
Congenital bony fusion of the jaws (syngnathia)
without any other anatomic oral anomalies is a
very rare condition. Numerous cases with
combination of cleft palate, aglossia, and soft or
bony adhesion between the maxilla and mandible
have been reported. Syngnathia could also occur
with popliteal pterygium syndrome and van der
Woude syndrome. This report presents a case of
syngnathia who was attend Maxillofacial surgery
Department at Ramadi Teaching Hospital, Anbar
Province, Iraq, with bilateral maxillo-mandibular
inter-alveolar adhesion, with no other intra-oral
anomalies.
Abstract :
Congenital bony fusion of the jaws (syngnathia)
without any other anatomic oral anomalies is a
very rare condition. Numerous cases with
combination of cleft palate, aglossia, and soft or
bony adhesion between the maxilla and mandible
have been reported. Syngnathia could also occur
with popliteal pterygium syndrome and van der
Woude syndrome.
This report presents a case of syngnathia with
bilateral maxillo-mandibular inter-alveolar
adhesion, unusually with no other intra-oral
anomalies.
Keywords :
Syngnathia, bony fusion, congenital defect,
maxilla, mandible
Keywords :
Congenital bony syngnathia • congenital fusion •
maxilla • mandible • syngnathia
‫المالحظ‬:‫ة‬‫برنامج‬ ‫اشار‬Turnitin‫بين‬ ‫تطابق‬ ‫وجود‬ ‫الى‬‫ال‬Case Report‫الخاص‬‫ب‬‫الدكتورين‬Ismail Yazdi & Amir
Hossein Fakhraee‫عام‬ ‫والمنشور‬0222‫و‬‫ل‬ ‫العلمي‬ ‫المنشور‬‫عام‬ ‫المنشور‬ ‫نزال‬ ‫تحرير‬ .‫أ.د‬0222: ‫باالتي‬ ‫االخير‬ ‫قام‬ ‫حيث‬
2-‫اسم‬ ‫نفس‬ ‫استعمل‬(Title)‫ال‬Case Report‫فقط‬ ‫القوسين‬ ‫موقع‬ ‫تغيير‬ ‫مع‬
0-‫ال‬ ‫بنسخ‬ ‫قام‬Abstract:‫فقط‬ ‫اضاف‬ ‫و‬ ‫تغيير‬ ‫اي‬ ‫دون‬who was attend Maxillofacial surgery Department at
Ramadi Teaching Hospital, Anbar Province, Iraq
3-‫ال‬ ‫في‬ ‫كلمات‬ ‫خمسة‬ ‫اصل‬ ‫من‬ ‫كلمات‬ ‫ثالث‬ ‫نسخ‬Keywords( ‫كلمة‬ ‫باستبدال‬ ‫قام‬ ‫و‬Fusion( ‫عبارة‬ ‫في‬ )Congenital
Fusion( ‫بكلمة‬ )Defect( ‫العبارة‬ ‫لتصبح‬ )Congenital Defect)
2
Author : Tahrir N.N. Aldelaimi Author : Ismail Yazdi & Amir Hossein Fakhraee
Introduction :
Syngnathia is a rare congenital anomaly involving fusion
of maxillary and mandibular bones. The fusion may be due
to soft tissue adhesions between the two or a true bony
fusion between maxilla and mandible1,2. The effected
new born child is presenting with diffi culties in the airway
protection and maintenance as well as feeding problems3.
Most have other associated anomalies like popliteal
pterygium syndrome, Vander Woude syndrome requiring
concurrent management. Surgical management involves
division of the bony fusion or break down of the adhesions
in the fi rst few days of life. Depending upon the severity,
these children present formidable anaesthetic challenges.
The congenital bony fusion of the maxilla and
mandible (bony syngnathia), especially as an
isolated occurrence, is a very rare condition.
Syngnathia mostly appears in association with
other anatomic oral and maxillofacial anomalies.
About few such cases have been reported in the
literature in combination with cleft lip, cleft of
hard and soft palate, aglossia, popliteal pterygium
syndrome1, van der Woude syndrome, aglossia-
adactylia syndrome2, oral soft tissue synechiae,
hypoplasia of the proximal mandible, clefting of
mandible, bifi d tongue, hemifacial microsomia,
small or absent tongue, temporomandibular
(zygomaticomandibular) fusion and some other
regional and systemic anomalies 3-8
Introduction :
Congenital bony fusion of the maxilla and
mandible (bony syngnathia),especially as an
isolated occurrence, is a very rare condition.
Syngnathia mostly appears in association with
other anatomic oral and maxillofacial anomalies.
About 15 such cases have been reported in the
literature in combination with cleft lip, cleft of
hard and soft palate, aglossia, popliteal pterygium
syndrom1, van der Woude syndrome, aglossia-
adactylia syndrome2, oral soft tissue synechiae,
hypoplasia of the proximal mandible, hemifacial
microsomia, cleft of mandible, bifid tongue, small
or absent tongue, temporomandibular
(zygomaticomandibular) fusion and some other
regional and systemic anomalies3-14 This
condition is also seen in autosomal recessive
hypomandibular craniofacial dysostosis. To our
knowledge, only two isolated cases of bony
syngnathia have been reported in the
literature10,14,15 This report presents a case of
congenital syngnathia with bilateral maxillo-
mandibular inter-alveolar adhesion, unusually
with no other oral or maxillofacial anomalies.
‫المالحظ‬:‫ة‬( ‫المقدمة‬ ‫في‬ ‫نزال‬ ‫تحرير‬ .‫أ.د‬ ‫قام‬Introduction)( ‫بنسخ‬51‫من‬ ‫سطرا‬ )Case Report‫في‬ ‫لصقه‬ ‫و‬ ‫انفا‬ ‫المذكور‬
‫برنامج‬ ‫اشار‬ ‫كما‬ ‫تغيير‬ ‫اي‬ ‫بدون‬ ‫العلمي‬ ‫منشوره‬Turnitin
3
Author : Tahrir N.N. Aldelaimi Author : Ismail Yazdi & Amir Hossein Fakhraee
Case Presentation :
A newborn male ( weight 2800g) of 3 days of age
was referred to the Department of Maxillofacial
Surgery of Ramadi Teaching Hospital, Ramadi
city, Anbar Province, Iraq; for evaluation of the
fusion of maxilla and mandible that prevented
oral feeding. Medical consultation and laboratory tests
revealed low blood glucose. Urgently thorough clinical
and radiographical examinations were done and start
feeding via a nasogastric (NG) tube and the patient was
maintained on humidified oxygen by mask. There was no
other associated local or systemic anomaly. Clinical
examination revealed severe trismus due to
adhesion of the jaws, which extended bilaterally
from deciduous canine area to the molar regions
posteriorly and revealed a bony fusion between
the maxilla and the mandible involving the entire
alveolar margin with a small gap about 18 mm on left side
anteriorly in the canine region.
Case Presentation :
A newborn female of 2 days of age was transferred
to the Department of Oral and Maxillofacial
Surgery of Pars Hospital, Tehran, for evaluation of
the fusion of maxilla and mandible, which
prohibited oral feeding. She was admitted to the
neonatal intensive care unit where she was soon fed via a
nasogastric tube.Physical examination revealed
severe trismus due to complete adhesion of the
jaws, which extended posteriorly from the canine
area to the molar regions, bilaterally. The oral
cavity therefore could not be seen.The child was
the product of a normal vaginal delivery with a
birth weight of 2670 g. Systemic examination revealed
no anomalies in the rest of the body, but her general
condition was poor and her rectal temperature rose to
40C.Medical consultation and pertinent laboratory tests
‫المالحظ‬:‫ة‬‫ال‬ ‫في‬Case Presentation‫برنامج‬ ‫اشار‬Turnitin‫قيام‬ ‫الى‬‫نزال‬ ‫تحرير‬ .‫أ.د‬:‫باالتي‬
1-( ‫مقطع‬ ‫بنسخ‬ ‫قام‬Paragraph 1( ‫من‬ ‫مكون‬ )5:‫هو‬ ‫طفيف‬ ‫تغيير‬ ‫مع‬ ‫سطور‬ )
( ‫رقم‬ ‫استخدام‬ : ‫اوال‬3( ‫رقم‬ ‫عن‬ ‫بدال‬ )2)
‫استخدم‬ : ‫ثانيا‬(OF Ramadi Teaching Hospital, Ramadi city, Anbar Province, Iraq( ‫عن‬ ‫بدال‬ )Pars
Hospital, Tehran)
( ‫استخدم‬ : ‫ثالثا‬Male( ‫عن‬ ‫بدال‬ )Female)
( ‫استخدم‬ : ‫رابعا‬weight 2800g( ‫عن‬ ‫بدال‬ )weight of 2670 g)
( ‫كلمة‬ ‫استخدم‬ : ‫خامسا‬Prevented( ‫عن‬ ‫بدال‬ )Prohibited‫لها‬ ‫مترادفه‬ ‫هي‬ ‫و‬ )
2-( ‫مقطع‬ ‫بنسخ‬ ‫قام‬Paragraph 2( ‫من‬ ‫مكون‬ )4:‫هو‬ ‫طفيف‬ ‫تغيير‬ ‫مع‬ ‫سطور‬ )
( ‫كلمة‬ ‫استخدم‬ : ‫اوال‬Clinical( ‫من‬ ‫بدال‬ )Physical‫لها‬ ‫مترادفه‬ ‫هي‬ ‫و‬ )
( ‫ال‬ ‫صياغة‬ ‫اعادة‬ : ‫ثانيا‬which extended posteriorly from the canine area to the molar regions, bilaterally)
( ‫جعلها‬ ‫و‬which extended bilaterally from deciduous canine area to the molar regions posteriorly)
3-( ‫مقطع‬ ‫بنسخ‬ ‫قام‬Paragraph 2( ‫من‬ ‫مكون‬ )3:‫هو‬ ‫طفيف‬ ‫تغيير‬ ‫مع‬ ‫سطور‬ )
( ‫عبارة‬ ‫حذف‬ : ‫اوال‬of the skull and facial bones)
( ‫كلمة‬ ‫استخدام‬ : ‫ثانيا‬Were‫بدال‬ )( ‫عن‬Which)
1
2
1
2
4
The radiographs were obtained with difficulty,
revealed bilateral bony fusion of the maxilla and
mandible, Very feeble motion was palpable over each
temporomandibular joint (TMJ). Family history showed
no similar affliction could be elicited in the past
generations of either the parents and maternal and paternal
history was negative for any facial cleft. All other siblings
were normal. ( Fig. 1 and 2)
failed to reveal the cause of fever. The poor condition of
the baby did not allow a CT scan or MRI to be performed.
The radiography of the skull and facial bones,
which was obtained with difficulty, revealed
bilateral bony fusion of the maxilla and mandible,
normal teeth buds and presence of normally developed
condyles of the temporomandibular joints.The patient was
the first child of an 18-year old mother and a 23-year old
father who were first cousins, healthy and normal. No
similar affliction could be elicited in the past two
generations of either the parents.At the age of 50 days, the
patient’s systemic condition had relatively improved. She
was brought to the operating theater and a planned blind
awake nasal intubation was failed. Tracheostomy was
performed and anesthesia was maintained with nitrous
oxide and oxygen.The syngnathia was divided by means of
a scalpel and fine osteotomes via an intra-oral approach
which allowed the mouth to remain open. On inspection,
no other anomalies of the oral cavity,including tongue,
palate and pharynx were found.Both temporomandibular
joints seemed to function normally. The anesthesia was
without any complication and the patient was sent to the
intensive care unit in fairly good condition. The baby, who
primarily was unable to bottle-feed, probably due to lack of
natal sucking reflex, learned to do so after appropriate
nursing.The pre-existing fluctuating temperature of the
patient remitted after surgery and she was discharged from
the hospital at the end of second postoperative week. A few
weeks later, she was repeatedly readmitted into the hospital
because of high fever and pneumonia, for which she was
treated and discharged in relatively good condition each
time.Finally, the child died at the age of seven months.
Since permission to conduct an autopsy was not given, the
exact cause of death could not be determined. However, a
clinical diagnosis of acute pneumonia had been made.
3
3
5
Author : Tahrir N.N. Aldelaimi Author : Ismail Yazdi & Amir Hossein Fakhraee
Discussion :
Fusion defects of the maxilla and mandible
including other anatomic oral abnormalities are
not common. They may be of the connecting
tissue either fibrous or bony 1,2 Soft tissue fusion
9,10 (synechiae) have been extensively reviewed
by Gartlan et al. (1993) and were classified as
buccopharyngeal membrane remnants or as
ectopic membranes on the basis of their presumed
origin 11 . Bony fusion (syngnathia), particularly
its isolated occurrence, is extremely rare. The
very few cases reported in the literature are mostly
inadequate in description, inconsistent and
confusing in nomenclature and with limited useful
conventional imaging 4,10. The cause of
congenital bony syngnathia is not certain. In
contrast, the review of five cases presented by
Dawson et al (1997) and previously reported
cases provide no evidence of any familial
tendency, history of drug and toxin exposure or
consanguinity3. Congenital bony syngnathia can
be clinically recognized and diagnosed at or after
the birth of the affected neonate without any
exception 3,7. The adequate useful conventional
radiography and / or CT scan can support the
clinical recognition of this condition and its
nature, which causes inability to open the jaws.
The management of patients with congenital
fusion of maxilla and mandible varies according
to the nature and extent of the abnormalities. The
condition is problematic and interferes with
feeding, breathing, general health of the patient
(aspiration pneumonitis), growth and
development, induction of anesthesia. The airway
is the first priority to be secured in the
management of any newborn with trismus.
Thereafter, feeding problems should be overcome
Discussion :
Fusion defects of the maxilla and mandible
including other anatomic oral abnormalities are
not common. They may be of the connecting
tissue either fibrous or bony1-17. Soft tissue
fusion15-16 (synechiae) have been extensively
reviewed by Gartlan et al. (1993) and were
classified as buccopharyngeal membrane
remnants or as ectopic membranes on the basis of
their presumed origin.13Bony fusion
(syngnathia), particularly its isolated occurrence,
is extremely rare. The very few cases reported in
the literature are mostly inadequate in description,
inconsistent and confusing in nomenclature and
with limited useful conventional
imaging3,4,10,14.The cause of congenital bony
syngnathia is not certain. Some of the postulated
causes, from reported cases in the literature, including
Goodacre and Wallace’s summarization of the various
experimental studies performed on the embryological
basis, include persistence of the buccopharyngeal
membrane, amniotic constriction bands in the region of
the developing branchial arches, environmental insults,
drugs such as meclozine and large doses of vitamin
A4,5,14,12.In contrast, the review of five cases
presented by Dawson et al (1997) and previously
reported cases provide no evidence of any
familial tendency, history of drug and toxin
exposure or consanguinity3.A case of a human fetus
with syngnathia without any clinical history7 and also a
case of vitamin A induced bony syngnathia with a cleft of
the secondary palate in rats, treated with vitamin A, has
also been reported17.Congenital bony syngnathia
can be clinically recognized and diagnosed at or
after the birth of the affected neonate without any
exception3,7.The adequate useful conventional
radiography and high resolution or spiral cut CT can
support the clinical recognition of this condition
and its nature, which causes inability to open the
‫المالحظ‬:‫ة‬‫قام‬‫أ‬.‫د‬.‫تحرير‬‫نزال‬‫في‬( ‫المناقشة‬Discussion( ‫بنسخ‬ )05‫سطرا‬ )‫من‬Case Report‫المذكور‬‫انفا‬‫و‬‫لصقه‬‫في‬
‫منشوره‬‫العلمي‬‫بدون‬‫اي‬‫تغيير‬‫كما‬‫اشار‬‫برنامج‬Turnitin( ‫المناقشة‬ ‫ان‬ ‫علما‬Discussion‫ب‬ ‫الخاصة‬ )‫أ‬.‫د‬.‫تحرير‬‫مكونة‬ ‫نزال‬
( ‫من‬05‫سطرا‬ )
6
by placing a nasogastric or gastrotomy tubes.
Since the occurrence of bony fusion of the maxilla
and mandible is extremely rare, and there is high
rate of association between bony syngnathia and
other regional and systemic
malformations3,4,6,8,12, the patient should be
under the supervision of a team of clinicians
skilled in the diagnosis and appropriate treatment
of congenital oral and maxillofacial anomalies 3 .
Surgical division of the bony fusion, under
general anesthesia (blind intubation or via
tracheostomy) is the optimal treatment for the
simple syngnathia in isolated occurrence or cases
with the presence of other anatomic
abnormalities6,8,12 . Proper physical therapy
should be commenced immediately and the infant
should be encouraged to feed normally as soon as
possible3. Maxillomandibular fusion is a rare group of
anomalies varying in severity from simple mocusal
adhesions (synechiae) to extensive bony fusion
(syngnathia). Proper physical therapy and feeding should
be resumed as soon as possible after the surgery. The
significant points about the case reported were; it was an
isolated pure bony fusion without any associated local
(cleft lip/palate) or systemic anomalies; only few cases
exist in the world literature so far.
jaws. The management of patients with
congenital fusion of maxilla and mandible varies
according to the nature and extent of the
abnormalities.The condition is problematic and
interferes with feeding, breathing, general health
of the patient (aspiration pneumonitis), growth
and development, induction of anesthesia
(intubation) etc.However, on the basis of the reports from
the literature, (though they are relatively imprecise and
not consistently well documented), functional results,
especially in the cases with isolated occurrence, are likely
to be good3-5,10,15. But the rarity of this condition
imposes some limitations on standardization of the
treatment.4In terms of jaw function and its outcome, it is
more problematic in complex cases. Dawson, et al having
added five new cases to the literature proposed a system
of classification and elaborated on treatment
recommendations3. Their proposed classification is aimed
at the treatment and likely functional outcome rather than
etiology or pathogenesis of the malformation3. The
airway is the first priority to be secured in the
management of any newborn with trismus.
Thereafter, feeding problems should be overcome
by placing a nasogastric or gastrotomy
tubes.Since the occurrence of bony fusion of the
maxilla and mandible is extremely rare, and there
is high rate of association between bony
syngnathia and other regional and systemic
malformations3-6,8,14 the patient should be
under the supervision of a team of clinicians
skilled in the diagnosis and appropriate treatment
of congenital oral and maxillofacial
anomalies.3Surgical division of the bony fusion,
under general anesthesia (blind intubation or via
tracheostomy) is the optimal treatment for the
simple syngnathia in isolated occurrence or cases
with the presence of other anatomic
abnormalities3-6,8,14. Proper physical therapy
should be commenced immediately and the infant
should be encouraged to feed normally as soon as
possible3.There are at least two significant points about
our case. First, it was an isolated case without any other
regional anatomic anomalies such as cleft lip and palate.
And only two such cases are reported in recent medical
literature10,14.Second, there is consanguinity in the
family (parents are first cousins) which suggests the
7
possibility of autosomal recessive inheritance.The
pathogenesis of this condition still remains obscure
although some developmental defects may have occurred
in the region of the first branchial arch, in which
separation of the maxilla and mandible have failed to
occur. The poor general condition of the infant and her
high fever could be due to an aspiration pneumonitis and
respiratory distress.Whether this case and two similar
cases reported in literature10,14 should be considered as
amild expression related to some of the syndromes of the
head and neck region or categorized as an independent
anomaly, is open to question.
8
Author : Tahrir N.N. Aldelaimi Author : Ismail Yazdi & Amir Hossein Fakhraee
References :
1. Hamamoto J, Matsumoto T. A case of facio-
genito-popliteal syndrome. Ann Plast Surg. 1984;
13: 224-9.
2. Johnsson GF, Robinow M. Aglossia-adactylia.
Radiology. 1978; 128: 127-32.
3. Dawson KH, Gruss JS, Myall RW. Congenital
bony syngnathia. A proposed classification. Cleft
Palate Craniofac J. 1997; 2: 141-6.
4. Rao S, Oak S, Wagh S, Kulkarni M. Congenital
midline palatomandibular bony
fusion with a mandibular cleft and a bifid tongue.
B J Plastic Surg. 1977; 50: 139-41.
5. Kamata S, Satoh K, Vemura T, Onizuka T.
Congenital bilateral zygomaticomandibular
fusion with mandibular hypolasia. B J Plastic
Surg. 1996; 49: 251-3.
6. Gorlin J, Cohen M, Michael, Levin L, Stefan.
Syndromes of Head and Neck. 3rd ed. England:
Oxford University Press; 1990: 630-1, 783.
7. Shah RM. Palatomandibular and maxillo-
mandibular fusion, partial aglossia and cleft
palate in a human embryo. Teratology. 1977; 15:
261-72.
8. Agrawal K, Chandra SS, Sreckumar NS.
Congenital bilateral intermaxillary bony fusion.
Ann Plast Surg. 1993; 30: 163-6.
9. Kamala G, Pillai V, Kamath V, Kumar GS,
Nagamani N. Persistent buccopharyngeal
membrane with cleft palate. Oral Surg Oral Med
Oral Pathol. 1990; 69: 164-6.
10. Dinardo NM, Christion JM, Benneth JA,
Shutack JG. Cleft palate lateral synechia
synchrome. Oral Surg Oral Med Oral Pathol.
1989; 68: 565-6.
11. Gartlan MG, Davies J, Smith RJ. Congenital
oral synechiae. Ann Otol Rhinol Laryngol. 1993;
102: 186-97.
References :
1. Hamamoto J, Matsumoto T. A case of facio-
genito-popliteal syndrome. Ann Plast Surg. 1984;
13: 224-9.
2. Johnsson GF, Robinow M. Aglossia-adactylia.
Radiology. 1978; 128: 127-32.
3. Dawson KH, Gruss JS, Myall RW. Congenital
bony syngnathia. A proposed classification. Cleft
Palate Craniofac J. 1997; 2: 141-6.
4. Rao S, Oak S, Wagh S, Kulkarni M. Congenital
midline palatomandibular bony
fusion with a mandibular cleft and a bifid tongue.
B J Plastic Surg. 1977; 50: 139-41.
5. Kamata S, Satoh K, Vemura T, Onizuka T.
Congenital bilateral zygomaticomandibular fusion
with mandibular hypolasia. B J Plastic Surg. 1996;
49: 251-3.
6. Gorlin J, Cohen M, Michael, Levin L, Stefan.
Syndromes of Head and Neck. 3rd ed. England:
Oxford University Press; 1990: 630-1, 783.
7. Shah RM. Palatomandibular and maxillo-
mandibular fusion, partial aglossia and cleft palate
in a human embryo. Teratology. 1977; 15: 261-72.
8. Agrawal K, Chandra SS, Sreckumar NS.
Congenital bilateral intermaxillary bony fusion.
Ann Plast Surg. 1993; 30: 163-6.
9.Salleh NM. Congenital partial fusion of the mandible and
maxilla. Oral Surg Oral Med Oral Pathol. 1965; 20: 74-6.
10.Miskinyar SA. Congenital mandibulomaxillary
fusion. Plast Reconstr Surg. 1979; 63: 120-1.
11.Behnia H, Shamse MG. Congenital unilateral fusion of
the mandibular and maxillary alveolar ridge, tempo
romandibular joint, and coronoid process. J Oral
Maxillofac Surg. 1996; 54: 773-6.
12.Goodacre TE, Wallace AF. Congenital alveolar fusion.
Br J Plast Surg. 1990; 43: 203-9.
13.Gartlan MG, Davies J, Smith RJ. Congenital
oral synechiae. Ann Otol Rhinol Laryngol. 1993;
102: 186-97.
‫المالحظ‬:‫ة‬‫قام‬‫أ‬.‫د‬.‫تحرير‬‫نزال‬‫في‬‫المصادر‬(References( ‫بنسخ‬ )21‫مصدرا‬ )‫من‬‫ال‬ ‫مصادر‬Case Report‫المذكور‬‫انفا‬‫و‬
‫لصقه‬‫في‬‫منشوره‬‫العلمي‬‫بدون‬‫اي‬‫تغيير‬( ‫اول‬ ‫تسلسل‬ ‫في‬8‫مصادر‬ )
9
12. Miskinyar SA. Congenital
mandibulomaxillary fusion. Plast Reconstr Surg.
1979; 63: 120-1.
14.Nwoku AL, Kekere-Ekun TA. Congenital ankylosis of
the mandible. J Maxillofac Surg. 1986; 14: 150-2.
15.Kamala G, Pillai V, Kamath V, Kumar GS,
Nagamani N. Persistent buccopharyngeal
membrane with cleft palate. Oral Surg Oral Med
Oral Pathol. 1990; 69: 164-6.
16.Dinardo NM, Christion JM, Benneth JA,
Shutack JG. Cleft palate lateral synechia
synchrome. Oral Surg Oral Med Oral Pathol. 1989;
68: 565-6.
17.Nada R. Maxillomandibular ankylosis and cleft palate
in rat embryos. J Dent Res. 1970; 49: 1086-90.

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1.Comparism between Ismail Yazdi & Amir Hossein Fakhraee Article and Tahrir N.N. Aldelaimi Article

  • 1. 1 BONY SYNGNATHIA (CONGENITAL FUSION OF MAXILLA AND MANDIBLE) Author : Tahrir N.N. Aldelaimi Author : Ismail Yazdi & Amir Hossein Fakhraee Journal : EGYPTIAN DENTAL JOURNAL Journal : ARCHIVES OF IRANIAN MEDICINE Publication : Vol. 57, 1:3, July, 2011 Publication : Volume 3, Number 3 Jul. 2000 Title : BONY SYNGNATHIA (CONGENITAL FUSION OF MAXILLA AND MANDIBLE) Title : Congenital Fusion of Maxilla and Mandible (Bony Syngnathia): A Case Report Abstract : Congenital bony fusion of the jaws (syngnathia) without any other anatomic oral anomalies is a very rare condition. Numerous cases with combination of cleft palate, aglossia, and soft or bony adhesion between the maxilla and mandible have been reported. Syngnathia could also occur with popliteal pterygium syndrome and van der Woude syndrome. This report presents a case of syngnathia who was attend Maxillofacial surgery Department at Ramadi Teaching Hospital, Anbar Province, Iraq, with bilateral maxillo-mandibular inter-alveolar adhesion, with no other intra-oral anomalies. Abstract : Congenital bony fusion of the jaws (syngnathia) without any other anatomic oral anomalies is a very rare condition. Numerous cases with combination of cleft palate, aglossia, and soft or bony adhesion between the maxilla and mandible have been reported. Syngnathia could also occur with popliteal pterygium syndrome and van der Woude syndrome. This report presents a case of syngnathia with bilateral maxillo-mandibular inter-alveolar adhesion, unusually with no other intra-oral anomalies. Keywords : Syngnathia, bony fusion, congenital defect, maxilla, mandible Keywords : Congenital bony syngnathia • congenital fusion • maxilla • mandible • syngnathia ‫المالحظ‬:‫ة‬‫برنامج‬ ‫اشار‬Turnitin‫بين‬ ‫تطابق‬ ‫وجود‬ ‫الى‬‫ال‬Case Report‫الخاص‬‫ب‬‫الدكتورين‬Ismail Yazdi & Amir Hossein Fakhraee‫عام‬ ‫والمنشور‬0222‫و‬‫ل‬ ‫العلمي‬ ‫المنشور‬‫عام‬ ‫المنشور‬ ‫نزال‬ ‫تحرير‬ .‫أ.د‬0222: ‫باالتي‬ ‫االخير‬ ‫قام‬ ‫حيث‬ 2-‫اسم‬ ‫نفس‬ ‫استعمل‬(Title)‫ال‬Case Report‫فقط‬ ‫القوسين‬ ‫موقع‬ ‫تغيير‬ ‫مع‬ 0-‫ال‬ ‫بنسخ‬ ‫قام‬Abstract:‫فقط‬ ‫اضاف‬ ‫و‬ ‫تغيير‬ ‫اي‬ ‫دون‬who was attend Maxillofacial surgery Department at Ramadi Teaching Hospital, Anbar Province, Iraq 3-‫ال‬ ‫في‬ ‫كلمات‬ ‫خمسة‬ ‫اصل‬ ‫من‬ ‫كلمات‬ ‫ثالث‬ ‫نسخ‬Keywords( ‫كلمة‬ ‫باستبدال‬ ‫قام‬ ‫و‬Fusion( ‫عبارة‬ ‫في‬ )Congenital Fusion( ‫بكلمة‬ )Defect( ‫العبارة‬ ‫لتصبح‬ )Congenital Defect)
  • 2. 2 Author : Tahrir N.N. Aldelaimi Author : Ismail Yazdi & Amir Hossein Fakhraee Introduction : Syngnathia is a rare congenital anomaly involving fusion of maxillary and mandibular bones. The fusion may be due to soft tissue adhesions between the two or a true bony fusion between maxilla and mandible1,2. The effected new born child is presenting with diffi culties in the airway protection and maintenance as well as feeding problems3. Most have other associated anomalies like popliteal pterygium syndrome, Vander Woude syndrome requiring concurrent management. Surgical management involves division of the bony fusion or break down of the adhesions in the fi rst few days of life. Depending upon the severity, these children present formidable anaesthetic challenges. The congenital bony fusion of the maxilla and mandible (bony syngnathia), especially as an isolated occurrence, is a very rare condition. Syngnathia mostly appears in association with other anatomic oral and maxillofacial anomalies. About few such cases have been reported in the literature in combination with cleft lip, cleft of hard and soft palate, aglossia, popliteal pterygium syndrome1, van der Woude syndrome, aglossia- adactylia syndrome2, oral soft tissue synechiae, hypoplasia of the proximal mandible, clefting of mandible, bifi d tongue, hemifacial microsomia, small or absent tongue, temporomandibular (zygomaticomandibular) fusion and some other regional and systemic anomalies 3-8 Introduction : Congenital bony fusion of the maxilla and mandible (bony syngnathia),especially as an isolated occurrence, is a very rare condition. Syngnathia mostly appears in association with other anatomic oral and maxillofacial anomalies. About 15 such cases have been reported in the literature in combination with cleft lip, cleft of hard and soft palate, aglossia, popliteal pterygium syndrom1, van der Woude syndrome, aglossia- adactylia syndrome2, oral soft tissue synechiae, hypoplasia of the proximal mandible, hemifacial microsomia, cleft of mandible, bifid tongue, small or absent tongue, temporomandibular (zygomaticomandibular) fusion and some other regional and systemic anomalies3-14 This condition is also seen in autosomal recessive hypomandibular craniofacial dysostosis. To our knowledge, only two isolated cases of bony syngnathia have been reported in the literature10,14,15 This report presents a case of congenital syngnathia with bilateral maxillo- mandibular inter-alveolar adhesion, unusually with no other oral or maxillofacial anomalies. ‫المالحظ‬:‫ة‬( ‫المقدمة‬ ‫في‬ ‫نزال‬ ‫تحرير‬ .‫أ.د‬ ‫قام‬Introduction)( ‫بنسخ‬51‫من‬ ‫سطرا‬ )Case Report‫في‬ ‫لصقه‬ ‫و‬ ‫انفا‬ ‫المذكور‬ ‫برنامج‬ ‫اشار‬ ‫كما‬ ‫تغيير‬ ‫اي‬ ‫بدون‬ ‫العلمي‬ ‫منشوره‬Turnitin
  • 3. 3 Author : Tahrir N.N. Aldelaimi Author : Ismail Yazdi & Amir Hossein Fakhraee Case Presentation : A newborn male ( weight 2800g) of 3 days of age was referred to the Department of Maxillofacial Surgery of Ramadi Teaching Hospital, Ramadi city, Anbar Province, Iraq; for evaluation of the fusion of maxilla and mandible that prevented oral feeding. Medical consultation and laboratory tests revealed low blood glucose. Urgently thorough clinical and radiographical examinations were done and start feeding via a nasogastric (NG) tube and the patient was maintained on humidified oxygen by mask. There was no other associated local or systemic anomaly. Clinical examination revealed severe trismus due to adhesion of the jaws, which extended bilaterally from deciduous canine area to the molar regions posteriorly and revealed a bony fusion between the maxilla and the mandible involving the entire alveolar margin with a small gap about 18 mm on left side anteriorly in the canine region. Case Presentation : A newborn female of 2 days of age was transferred to the Department of Oral and Maxillofacial Surgery of Pars Hospital, Tehran, for evaluation of the fusion of maxilla and mandible, which prohibited oral feeding. She was admitted to the neonatal intensive care unit where she was soon fed via a nasogastric tube.Physical examination revealed severe trismus due to complete adhesion of the jaws, which extended posteriorly from the canine area to the molar regions, bilaterally. The oral cavity therefore could not be seen.The child was the product of a normal vaginal delivery with a birth weight of 2670 g. Systemic examination revealed no anomalies in the rest of the body, but her general condition was poor and her rectal temperature rose to 40C.Medical consultation and pertinent laboratory tests ‫المالحظ‬:‫ة‬‫ال‬ ‫في‬Case Presentation‫برنامج‬ ‫اشار‬Turnitin‫قيام‬ ‫الى‬‫نزال‬ ‫تحرير‬ .‫أ.د‬:‫باالتي‬ 1-( ‫مقطع‬ ‫بنسخ‬ ‫قام‬Paragraph 1( ‫من‬ ‫مكون‬ )5:‫هو‬ ‫طفيف‬ ‫تغيير‬ ‫مع‬ ‫سطور‬ ) ( ‫رقم‬ ‫استخدام‬ : ‫اوال‬3( ‫رقم‬ ‫عن‬ ‫بدال‬ )2) ‫استخدم‬ : ‫ثانيا‬(OF Ramadi Teaching Hospital, Ramadi city, Anbar Province, Iraq( ‫عن‬ ‫بدال‬ )Pars Hospital, Tehran) ( ‫استخدم‬ : ‫ثالثا‬Male( ‫عن‬ ‫بدال‬ )Female) ( ‫استخدم‬ : ‫رابعا‬weight 2800g( ‫عن‬ ‫بدال‬ )weight of 2670 g) ( ‫كلمة‬ ‫استخدم‬ : ‫خامسا‬Prevented( ‫عن‬ ‫بدال‬ )Prohibited‫لها‬ ‫مترادفه‬ ‫هي‬ ‫و‬ ) 2-( ‫مقطع‬ ‫بنسخ‬ ‫قام‬Paragraph 2( ‫من‬ ‫مكون‬ )4:‫هو‬ ‫طفيف‬ ‫تغيير‬ ‫مع‬ ‫سطور‬ ) ( ‫كلمة‬ ‫استخدم‬ : ‫اوال‬Clinical( ‫من‬ ‫بدال‬ )Physical‫لها‬ ‫مترادفه‬ ‫هي‬ ‫و‬ ) ( ‫ال‬ ‫صياغة‬ ‫اعادة‬ : ‫ثانيا‬which extended posteriorly from the canine area to the molar regions, bilaterally) ( ‫جعلها‬ ‫و‬which extended bilaterally from deciduous canine area to the molar regions posteriorly) 3-( ‫مقطع‬ ‫بنسخ‬ ‫قام‬Paragraph 2( ‫من‬ ‫مكون‬ )3:‫هو‬ ‫طفيف‬ ‫تغيير‬ ‫مع‬ ‫سطور‬ ) ( ‫عبارة‬ ‫حذف‬ : ‫اوال‬of the skull and facial bones) ( ‫كلمة‬ ‫استخدام‬ : ‫ثانيا‬Were‫بدال‬ )( ‫عن‬Which) 1 2 1 2
  • 4. 4 The radiographs were obtained with difficulty, revealed bilateral bony fusion of the maxilla and mandible, Very feeble motion was palpable over each temporomandibular joint (TMJ). Family history showed no similar affliction could be elicited in the past generations of either the parents and maternal and paternal history was negative for any facial cleft. All other siblings were normal. ( Fig. 1 and 2) failed to reveal the cause of fever. The poor condition of the baby did not allow a CT scan or MRI to be performed. The radiography of the skull and facial bones, which was obtained with difficulty, revealed bilateral bony fusion of the maxilla and mandible, normal teeth buds and presence of normally developed condyles of the temporomandibular joints.The patient was the first child of an 18-year old mother and a 23-year old father who were first cousins, healthy and normal. No similar affliction could be elicited in the past two generations of either the parents.At the age of 50 days, the patient’s systemic condition had relatively improved. She was brought to the operating theater and a planned blind awake nasal intubation was failed. Tracheostomy was performed and anesthesia was maintained with nitrous oxide and oxygen.The syngnathia was divided by means of a scalpel and fine osteotomes via an intra-oral approach which allowed the mouth to remain open. On inspection, no other anomalies of the oral cavity,including tongue, palate and pharynx were found.Both temporomandibular joints seemed to function normally. The anesthesia was without any complication and the patient was sent to the intensive care unit in fairly good condition. The baby, who primarily was unable to bottle-feed, probably due to lack of natal sucking reflex, learned to do so after appropriate nursing.The pre-existing fluctuating temperature of the patient remitted after surgery and she was discharged from the hospital at the end of second postoperative week. A few weeks later, she was repeatedly readmitted into the hospital because of high fever and pneumonia, for which she was treated and discharged in relatively good condition each time.Finally, the child died at the age of seven months. Since permission to conduct an autopsy was not given, the exact cause of death could not be determined. However, a clinical diagnosis of acute pneumonia had been made. 3 3
  • 5. 5 Author : Tahrir N.N. Aldelaimi Author : Ismail Yazdi & Amir Hossein Fakhraee Discussion : Fusion defects of the maxilla and mandible including other anatomic oral abnormalities are not common. They may be of the connecting tissue either fibrous or bony 1,2 Soft tissue fusion 9,10 (synechiae) have been extensively reviewed by Gartlan et al. (1993) and were classified as buccopharyngeal membrane remnants or as ectopic membranes on the basis of their presumed origin 11 . Bony fusion (syngnathia), particularly its isolated occurrence, is extremely rare. The very few cases reported in the literature are mostly inadequate in description, inconsistent and confusing in nomenclature and with limited useful conventional imaging 4,10. The cause of congenital bony syngnathia is not certain. In contrast, the review of five cases presented by Dawson et al (1997) and previously reported cases provide no evidence of any familial tendency, history of drug and toxin exposure or consanguinity3. Congenital bony syngnathia can be clinically recognized and diagnosed at or after the birth of the affected neonate without any exception 3,7. The adequate useful conventional radiography and / or CT scan can support the clinical recognition of this condition and its nature, which causes inability to open the jaws. The management of patients with congenital fusion of maxilla and mandible varies according to the nature and extent of the abnormalities. The condition is problematic and interferes with feeding, breathing, general health of the patient (aspiration pneumonitis), growth and development, induction of anesthesia. The airway is the first priority to be secured in the management of any newborn with trismus. Thereafter, feeding problems should be overcome Discussion : Fusion defects of the maxilla and mandible including other anatomic oral abnormalities are not common. They may be of the connecting tissue either fibrous or bony1-17. Soft tissue fusion15-16 (synechiae) have been extensively reviewed by Gartlan et al. (1993) and were classified as buccopharyngeal membrane remnants or as ectopic membranes on the basis of their presumed origin.13Bony fusion (syngnathia), particularly its isolated occurrence, is extremely rare. The very few cases reported in the literature are mostly inadequate in description, inconsistent and confusing in nomenclature and with limited useful conventional imaging3,4,10,14.The cause of congenital bony syngnathia is not certain. Some of the postulated causes, from reported cases in the literature, including Goodacre and Wallace’s summarization of the various experimental studies performed on the embryological basis, include persistence of the buccopharyngeal membrane, amniotic constriction bands in the region of the developing branchial arches, environmental insults, drugs such as meclozine and large doses of vitamin A4,5,14,12.In contrast, the review of five cases presented by Dawson et al (1997) and previously reported cases provide no evidence of any familial tendency, history of drug and toxin exposure or consanguinity3.A case of a human fetus with syngnathia without any clinical history7 and also a case of vitamin A induced bony syngnathia with a cleft of the secondary palate in rats, treated with vitamin A, has also been reported17.Congenital bony syngnathia can be clinically recognized and diagnosed at or after the birth of the affected neonate without any exception3,7.The adequate useful conventional radiography and high resolution or spiral cut CT can support the clinical recognition of this condition and its nature, which causes inability to open the ‫المالحظ‬:‫ة‬‫قام‬‫أ‬.‫د‬.‫تحرير‬‫نزال‬‫في‬( ‫المناقشة‬Discussion( ‫بنسخ‬ )05‫سطرا‬ )‫من‬Case Report‫المذكور‬‫انفا‬‫و‬‫لصقه‬‫في‬ ‫منشوره‬‫العلمي‬‫بدون‬‫اي‬‫تغيير‬‫كما‬‫اشار‬‫برنامج‬Turnitin( ‫المناقشة‬ ‫ان‬ ‫علما‬Discussion‫ب‬ ‫الخاصة‬ )‫أ‬.‫د‬.‫تحرير‬‫مكونة‬ ‫نزال‬ ( ‫من‬05‫سطرا‬ )
  • 6. 6 by placing a nasogastric or gastrotomy tubes. Since the occurrence of bony fusion of the maxilla and mandible is extremely rare, and there is high rate of association between bony syngnathia and other regional and systemic malformations3,4,6,8,12, the patient should be under the supervision of a team of clinicians skilled in the diagnosis and appropriate treatment of congenital oral and maxillofacial anomalies 3 . Surgical division of the bony fusion, under general anesthesia (blind intubation or via tracheostomy) is the optimal treatment for the simple syngnathia in isolated occurrence or cases with the presence of other anatomic abnormalities6,8,12 . Proper physical therapy should be commenced immediately and the infant should be encouraged to feed normally as soon as possible3. Maxillomandibular fusion is a rare group of anomalies varying in severity from simple mocusal adhesions (synechiae) to extensive bony fusion (syngnathia). Proper physical therapy and feeding should be resumed as soon as possible after the surgery. The significant points about the case reported were; it was an isolated pure bony fusion without any associated local (cleft lip/palate) or systemic anomalies; only few cases exist in the world literature so far. jaws. The management of patients with congenital fusion of maxilla and mandible varies according to the nature and extent of the abnormalities.The condition is problematic and interferes with feeding, breathing, general health of the patient (aspiration pneumonitis), growth and development, induction of anesthesia (intubation) etc.However, on the basis of the reports from the literature, (though they are relatively imprecise and not consistently well documented), functional results, especially in the cases with isolated occurrence, are likely to be good3-5,10,15. But the rarity of this condition imposes some limitations on standardization of the treatment.4In terms of jaw function and its outcome, it is more problematic in complex cases. Dawson, et al having added five new cases to the literature proposed a system of classification and elaborated on treatment recommendations3. Their proposed classification is aimed at the treatment and likely functional outcome rather than etiology or pathogenesis of the malformation3. The airway is the first priority to be secured in the management of any newborn with trismus. Thereafter, feeding problems should be overcome by placing a nasogastric or gastrotomy tubes.Since the occurrence of bony fusion of the maxilla and mandible is extremely rare, and there is high rate of association between bony syngnathia and other regional and systemic malformations3-6,8,14 the patient should be under the supervision of a team of clinicians skilled in the diagnosis and appropriate treatment of congenital oral and maxillofacial anomalies.3Surgical division of the bony fusion, under general anesthesia (blind intubation or via tracheostomy) is the optimal treatment for the simple syngnathia in isolated occurrence or cases with the presence of other anatomic abnormalities3-6,8,14. Proper physical therapy should be commenced immediately and the infant should be encouraged to feed normally as soon as possible3.There are at least two significant points about our case. First, it was an isolated case without any other regional anatomic anomalies such as cleft lip and palate. And only two such cases are reported in recent medical literature10,14.Second, there is consanguinity in the family (parents are first cousins) which suggests the
  • 7. 7 possibility of autosomal recessive inheritance.The pathogenesis of this condition still remains obscure although some developmental defects may have occurred in the region of the first branchial arch, in which separation of the maxilla and mandible have failed to occur. The poor general condition of the infant and her high fever could be due to an aspiration pneumonitis and respiratory distress.Whether this case and two similar cases reported in literature10,14 should be considered as amild expression related to some of the syndromes of the head and neck region or categorized as an independent anomaly, is open to question.
  • 8. 8 Author : Tahrir N.N. Aldelaimi Author : Ismail Yazdi & Amir Hossein Fakhraee References : 1. Hamamoto J, Matsumoto T. A case of facio- genito-popliteal syndrome. Ann Plast Surg. 1984; 13: 224-9. 2. Johnsson GF, Robinow M. Aglossia-adactylia. Radiology. 1978; 128: 127-32. 3. Dawson KH, Gruss JS, Myall RW. Congenital bony syngnathia. A proposed classification. Cleft Palate Craniofac J. 1997; 2: 141-6. 4. Rao S, Oak S, Wagh S, Kulkarni M. Congenital midline palatomandibular bony fusion with a mandibular cleft and a bifid tongue. B J Plastic Surg. 1977; 50: 139-41. 5. Kamata S, Satoh K, Vemura T, Onizuka T. Congenital bilateral zygomaticomandibular fusion with mandibular hypolasia. B J Plastic Surg. 1996; 49: 251-3. 6. Gorlin J, Cohen M, Michael, Levin L, Stefan. Syndromes of Head and Neck. 3rd ed. England: Oxford University Press; 1990: 630-1, 783. 7. Shah RM. Palatomandibular and maxillo- mandibular fusion, partial aglossia and cleft palate in a human embryo. Teratology. 1977; 15: 261-72. 8. Agrawal K, Chandra SS, Sreckumar NS. Congenital bilateral intermaxillary bony fusion. Ann Plast Surg. 1993; 30: 163-6. 9. Kamala G, Pillai V, Kamath V, Kumar GS, Nagamani N. Persistent buccopharyngeal membrane with cleft palate. Oral Surg Oral Med Oral Pathol. 1990; 69: 164-6. 10. Dinardo NM, Christion JM, Benneth JA, Shutack JG. Cleft palate lateral synechia synchrome. Oral Surg Oral Med Oral Pathol. 1989; 68: 565-6. 11. Gartlan MG, Davies J, Smith RJ. Congenital oral synechiae. Ann Otol Rhinol Laryngol. 1993; 102: 186-97. References : 1. Hamamoto J, Matsumoto T. A case of facio- genito-popliteal syndrome. Ann Plast Surg. 1984; 13: 224-9. 2. Johnsson GF, Robinow M. Aglossia-adactylia. Radiology. 1978; 128: 127-32. 3. Dawson KH, Gruss JS, Myall RW. Congenital bony syngnathia. A proposed classification. Cleft Palate Craniofac J. 1997; 2: 141-6. 4. Rao S, Oak S, Wagh S, Kulkarni M. Congenital midline palatomandibular bony fusion with a mandibular cleft and a bifid tongue. B J Plastic Surg. 1977; 50: 139-41. 5. Kamata S, Satoh K, Vemura T, Onizuka T. Congenital bilateral zygomaticomandibular fusion with mandibular hypolasia. B J Plastic Surg. 1996; 49: 251-3. 6. Gorlin J, Cohen M, Michael, Levin L, Stefan. Syndromes of Head and Neck. 3rd ed. England: Oxford University Press; 1990: 630-1, 783. 7. Shah RM. Palatomandibular and maxillo- mandibular fusion, partial aglossia and cleft palate in a human embryo. Teratology. 1977; 15: 261-72. 8. Agrawal K, Chandra SS, Sreckumar NS. Congenital bilateral intermaxillary bony fusion. Ann Plast Surg. 1993; 30: 163-6. 9.Salleh NM. Congenital partial fusion of the mandible and maxilla. Oral Surg Oral Med Oral Pathol. 1965; 20: 74-6. 10.Miskinyar SA. Congenital mandibulomaxillary fusion. Plast Reconstr Surg. 1979; 63: 120-1. 11.Behnia H, Shamse MG. Congenital unilateral fusion of the mandibular and maxillary alveolar ridge, tempo romandibular joint, and coronoid process. J Oral Maxillofac Surg. 1996; 54: 773-6. 12.Goodacre TE, Wallace AF. Congenital alveolar fusion. Br J Plast Surg. 1990; 43: 203-9. 13.Gartlan MG, Davies J, Smith RJ. Congenital oral synechiae. Ann Otol Rhinol Laryngol. 1993; 102: 186-97. ‫المالحظ‬:‫ة‬‫قام‬‫أ‬.‫د‬.‫تحرير‬‫نزال‬‫في‬‫المصادر‬(References( ‫بنسخ‬ )21‫مصدرا‬ )‫من‬‫ال‬ ‫مصادر‬Case Report‫المذكور‬‫انفا‬‫و‬ ‫لصقه‬‫في‬‫منشوره‬‫العلمي‬‫بدون‬‫اي‬‫تغيير‬( ‫اول‬ ‫تسلسل‬ ‫في‬8‫مصادر‬ )
  • 9. 9 12. Miskinyar SA. Congenital mandibulomaxillary fusion. Plast Reconstr Surg. 1979; 63: 120-1. 14.Nwoku AL, Kekere-Ekun TA. Congenital ankylosis of the mandible. J Maxillofac Surg. 1986; 14: 150-2. 15.Kamala G, Pillai V, Kamath V, Kumar GS, Nagamani N. Persistent buccopharyngeal membrane with cleft palate. Oral Surg Oral Med Oral Pathol. 1990; 69: 164-6. 16.Dinardo NM, Christion JM, Benneth JA, Shutack JG. Cleft palate lateral synechia synchrome. Oral Surg Oral Med Oral Pathol. 1989; 68: 565-6. 17.Nada R. Maxillomandibular ankylosis and cleft palate in rat embryos. J Dent Res. 1970; 49: 1086-90.