HISTORY, CONCEPT AND ITS IMPORTANCE IN DRUG DEVELOPMENT.pptx
MPG 507.ppt
1. PRIMEASIA UNIVERSITY
Presentation
Course Code: MPG-507
Course Title: Molecular Genetics.
Submitted To
Name: Nowshin Jahan
Lecturer
Department of Microbiology
PRIMEASIA UNIVERSITY
Submitted By
Md.Hasanuzzaman (223 012 061) Israt Jahan (223 017 061)
Kamrunnar (223 013 061) Mst. Mohona Islam (223 018 061)
Mohammad Mazedur Rahman (23 015 061)
Department: M.S.C in Microbiology
Department of Microbiology
PRIMEASIA UNIVERSITY
Data of Submission: 23-12-2022
2. GAS GANGRANE
Aka clostridial/oedmatous mynecrosis/myonecrosis/malignant
oedema a highly lethal necrosis soft tissue infection of skletal
muscle caused by toxin and gas producing Clostridium species.
3. WHAT IS GAS GANGRANE
Gas gangrane is a condition that arise when a
considarable mass of body tissue dies(necrosis),
this may occur at any injury, infection or in people
suffering from any chronic health problem
afeecting blood circulation. It is a bacterial
infection that produces tissue gas in gangrane. This
deadly from usually cused by Clostridium
perfeingens bacteria.
It can affect any part of the body but typically starts
in the toes, feet, fingers and hands.
5. SYMPTOMS
High fever
Painful swelling. Skin turns pale to
brownish red
Heaviness in affected extremity
Shock
Sweating
Massive tissue destruction
Blackening of the skin
Sever pain around the skin of wound
Blisters with gas bubbles from nrear
the infected area
The heartbeat and breathing become
rapid.
6. PATHOGENESIS
Bacteria enters the
broken skin or wound
Spors are produced
The bacteria
present in
circulating
system
The anaerobic tissue
present
The bacteria are grow
and ferment the
muscle carbohydrate
The toxins and
enzymes are
produced
Example of enzyme-
colagenases,
proteases, lipase
These enzyme will kill
other host celland extend
the anaerobic environment
Produce gases and
destroy the tissues
7. EPIDEMIOLOGY
The person at risk with-
• Diabetes Mallitus, blood vessel disease and colon
cancer.
• If they contact with contaminated cloth and other
foreign materials.
• Trauma or recent sergical wound.
• Post-operative clostridial infection after a ruptured
appendix, bowel perforation, colon resection etc. can
also lead to gas gangrene.
8. INVESTIGATIONS
1.Skin culture test to determine the presence of
Clostridium perfringens as well as other bacteria.
2. Blood tests to look for an abnormally high white
blood cell count that can indicate an infection.
3. Imaging tests like a routine X-ray, to look at tissues
and check for the presence of gas; or special studies
like MRI (magnetic resonance imaging) or
arteriogram.
4. Surgery to assess the spread of gas gangrene
within the body.
9. TREATMENT
1. Debridement, a surgical procedure to remove dead, damaged and
infected tissues is performed.
2. Amputation, which is the surgical removal of arm or leg, is sometimes
done to prevent the spread of infection.
3. Antibiotics are given to control the infection.
4. Hyperbaric oxygen therapy is used to treat Clostridium perfringens
infection.
5. Repairing damaged blood vessels to improve blood flow to the affected
area.
6. Performing a type of reconstructive surgery called skin graft to treat
damaged tissues. During a skin graft, your physician will remove healthy
skin from an unaffected part of the body and attach the same over the
damaged area. This helps in restoring any skin damage caused by gas
gangrene.
7. Sometimes septic abortion can lead to the development of uterine gas
gangrene, and it requires removal of the uterus.
10. PREVENTION
Cleanin the wound H2O2+NS
Any skin injury should be cleaned
thoroughly. Appropriate antibiotic therapy
should be given.
Avoid contaminated materials.
Impaired circulation in patients with poor
circulation.
Avoiding tobacco products
Caring for existing health conditions
like diabetes or arterial disease proper
Treatment with hyperbaric pxygen to treat
the Gas Gangrane.
Antitoxin
Avoid heated environment
