Chemical mediators of Inflammation Vasoactive amines Lipid products Cytokines Products of complement activation Arachidonic acid metabolites

22. C_X_C chemokines C-C chemokines C chemokines CX3C chemokines
have one amino acid
residue separating the
fist two of the four
conserved cysteine
residues
have the fist two
conserved cysteine
residues adjacent
lack the first and third
of the four conserved
cysteines
contain three amino
acids between the
two cysteines
• Act primarily on
neutrophils
• Secreted by
macrophages,
endothelial cells
• Function- Activation
and chemotaxis of
neutrophils
• E.g. IL-8
• attract
monocytes,
eosinophils,
basophils and
lymphocytes
• specific for
lymphocytes
• e.g. lymphotactin
• cell surface bound
protein- promotes
strong adhesion of
monocytes andT
cells
• potent chemo-
attractant
• E.g. fractalkine