1.
Brain Power and EHT®
Introduction
This paper introduces EHT® (eicosanoyl-­‐5-­‐hydroxytryptamide), a proprietary extract
consisting of a naturally occurring mix of bioactive molecules isolated from coffee that
protects and strengthens neuron connections by preventing damage to tau, an essential
brain protein. EHT® works to strengthen microtubules, the structural component of
neurons, by activating PP2A which leads to the formation of strong tau bonds within
microtubules. When weak tau bonds are formed these neurons may be damaged and
weakened by causes, such as head trauma from athletic activity, aging, poor diet,
alcohol consumption and environmental stressors. EHT® has been shown to activate
PP2A, protein phosphatase 2A, and reduce tau hyperphosphorylation it does work to
stabilize your microtubules and neurons which likely helps strengthen your overall brain
power. The amount of variables to that can affect your brain health and its performance
are numerous but our discussion will focus upon the on the benefits of taking EHT®.
Enhance your mind™ with EHT®
“Intellectual growth should commence at birth and cease only at death” a quote from
Albert Einstein that reflects the importance of learning. Advances in technology as well
as the wealth of knowledge available for individuals online and in libraries to educate
themselves with seems endless. A strong healthy brain will allow for a lifetime of
learning and the key to staying young. We are all a students in one way or another that
have different strengths and weakness when it comes to learning. Visual, auditory,
kinesthetic learners all have one universal goal which is to be able to recall information
we have learned at a moment’s notice. In order to complete this task our brain should
be performing optimally.
One important component required to promote better brain health is tau, an essential
brain protein. When strong tau bonds are formed within microtubules, the skeletal
structure that make up neurons, they help to promote better brain health to aid against
environmental stressors as well as physical stressors that we encounter during our day
to day life. EHT® will help promote a healthier brain and correlates with stronger
neuronal connections leading to greater learning potential.
“I want the very best for my children and I know even with the best teachers in the
country educating my family how well my child does in school depends on how strong
their brains are. My wife and I advocate lifelong learning and my children are at a point
in their lives where performing well in school will dictate what paths open up for them
in the future. As a parent I want to see them become successful so that’s why they take
EHT®.” said Max Stock CEO of Signum Biosciences, Inc. EHT® (eicosanoyl-­‐5-­‐
133
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2.
hydroxytryptamide), a proprietary extract consisting of a naturally occurring mix of
bioactive molecules isolated from coffee that protects and strengthens neuron
connections by preventing damage to tau, an essential brain protein. Our goal is to
enhance your mind and Signum Biosciences and Dr. Jeffry Stock, a Princeton University
professor, have discovered the key ingredient in coffee that promotes better brain
health. “My team and I identified EHT®, a component of coffee, as a natural molecule
that works to protect against mental decline and boost overall brain health and
resiliency,” “said Dr. Jeffry Stock.
Anti-­‐oxidant properties of EHT®
We all have role models whether athletes, academians, or artist that we admire for all
contributions that made to their fields which help mold and motivate us. Sidney Rice,
retired Seattle Seahawks wide receiver was asked about EHT® and said “Gives you a lot
of focus and with my business and school work that I have now it’s something that I
need”. Sidney is focusing on education since retiring from football. He is looking to the
unique combination of the EHT® product is what will really give his brain the energy it
needs to perform at its optimal level. The reality is that many student athletes don’t
make it to the professional level so they use their physical attributes to help them get a
first class education at elite academic institutions. They have the foresight to see how
eating healthy and supplementation with vitamins and minerals are essential to a
healthy brain and overall healthy lifestyle. EHT® has anti-­‐oxidant properties that are
beneficial to our overall health. We can see trends with individuals incorporating
superfoods into their diets whose nutritional value has been long recognized as
exceptional. Each season we look forward to learning what new food is added to the
superfood list so that we can incorporate it into our diets. EHT® was compared to two
known anti-­‐oxidants, ascorbic acid (vitamin C) and Trolox, a water-­‐soluble analog of
vitamin E. This analysis showed that EHT® is a much stronger anti-­‐oxidant than Trolox
and only slightly weaker than ascorbic acid (Fig. 6). EC50 concentrations: ascorbic
acid 05.8±0.6 M; EHT® 023.9± 7.8 M; Trolox 0372.1 ±59.5 M.
133
Wall
Street,
Princeton,
NJ
08540
office
732.329.6344
fax
732.329.8344

3.
Fig. 6 EHT® is a direct anti-­‐oxidant. Compounds tested in the ABTS radical scavenging
colorimetric assay: ascorbic acid ( ), EHT ( ) and Trolox ( ). Data shown are means ±
SEM from three independent experiments (Lee KW, 2013)
Utilizing EHT® as a dietary supplement strengthens the brain to enhance performance
and minimize damage caused by a multitude of factors and protect it against injuries,
oxidative stress. EHT® was discovered to benefit everyone for those who want to boost
their brain health and perform at an optimal level. The analysis of EHT® demonstrates
that it contains omega 3 and 6 fatty acids which are polyunsaturated fat, essential for
human health because it cannot be made in the body. Although omega-­‐3, omega-­‐6, and
omega-­‐9 fatty acids all serve different functions within the body, the evidence is clear
that incorporating balanced proportions of both essential and non-­‐essential fatty acids
are necessary for maintaining overall heart health and general wellness. We continue to
learn irrespective of our age and abilities and should continue to strive for success.
Iron rusts from disuse; water loses its purity from stagnation... even so does inaction sap
the vigor of the mind. We must continue to test the limits our minds and improve our
brain power so that we can have a sharper, faster, and stronger brains.
133
Wall
Street,
Princeton,
NJ
08540
office
732.329.6344
fax
732.329.8344