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Like a Needle in a Haystack: Rates and
Algorithms for Group Testing
Leonardo Baldassini
Joint work with Oliver Johnson, Matthew Aldridge and Karen Gunderson
19 December 2014
Warm-up examples
• Molecular biology (DNA screening)
• Recommender systems
Leo Baldassini Rates and Algorithms for Group Testing 19 December 2014 1 / 24
Warm-up examples
• Molecular biology (DNA screening)
• Recommender systems
• Spectrum sensing
• High-throughput screening techniques
• Network tomography
• Cryptography and cyber security
Leo Baldassini Rates and Algorithms for Group Testing 19 December 2014 1 / 24
DNA screening
Problem
Find a specific, rare sequence of nucleotides among many DNA samples
Leo Baldassini Rates and Algorithms for Group Testing 19 December 2014 2 / 24
DNA screening
Problem
Find a specific, rare sequence of nucleotides among many DNA samples
Leo Baldassini Rates and Algorithms for Group Testing 19 December 2014 2 / 24
DNA screening
Problem
Find a specific, rare sequence of nucleotides among many DNA samples
1
2
3
4
Leo Baldassini Rates and Algorithms for Group Testing 19 December 2014 2 / 24
DNA screening
Problem
Find a specific, rare sequence of nucleotides among many DNA samples
1
2
3
4
qPCR
Leo Baldassini Rates and Algorithms for Group Testing 19 December 2014 2 / 24
DNA screening
Problem
Find a specific, rare sequence of nucleotides among many DNA samples
1
2
3
4
qPCR
+
≥ 1 match
in sample
Leo Baldassini Rates and Algorithms for Group Testing 19 December 2014 2 / 24
DNA screening
Problem
Find a specific, rare sequence of nucleotides among many DNA samples
1
2
3
4
qPCR
+
≥ 1 match
in sample
−
no match
in sample
Leo Baldassini Rates and Algorithms for Group Testing 19 December 2014 2 / 24
Recommender systems
Problem
Suggest songs to a user based on his past preferences.
Leo Baldassini Rates and Algorithms for Group Testing 19 December 2014 3 / 24
Recommender systems
Problem
Suggest songs to a user based on his past preferences.
User selects
song
Leo Baldassini Rates and Algorithms for Group Testing 19 December 2014 3 / 24
Recommender systems
Problem
Suggest songs to a user based on his past preferences.
User selects
song
RS proposes
song
Leo Baldassini Rates and Algorithms for Group Testing 19 December 2014 3 / 24
Recommender systems
Problem
Suggest songs to a user based on his past preferences.
User selects
song
RS proposes
song
+
−
Leo Baldassini Rates and Algorithms for Group Testing 19 December 2014 3 / 24
Recommender systems
Problem
Suggest songs to a user based on his past preferences.
User selects
song
RS proposes
song
+
−
RS adjusts guess
on stylis-
tic features
Leo Baldassini Rates and Algorithms for Group Testing 19 December 2014 3 / 24
Recommender systems
Problem
Suggest songs to a user based on his past preferences.
User selects
song
RS proposes
song
+
−
RS adjusts guess
on stylis-
tic features
Leo Baldassini Rates and Algorithms for Group Testing 19 December 2014 3 / 24
What do they have in common?
COMMON FEATURES
Leo Baldassini Rates and Algorithms for Group Testing 19 December 2014 4 / 24
What do they have in common?
COMMON FEATURES
• Search for sparse property
Leo Baldassini Rates and Algorithms for Group Testing 19 December 2014 4 / 24
What do they have in common?
COMMON FEATURES
• Search for sparse property
• Property can be tested on
groups
Leo Baldassini Rates and Algorithms for Group Testing 19 December 2014 4 / 24
What do they have in common?
COMMON FEATURES
• Search for sparse property
• Property can be tested on
groups
GROUP TESTING
Search methods to recover a sparse
subset of items from a population
that share a feature which can be
detected on groups
Leo Baldassini Rates and Algorithms for Group Testing 19 December 2014 4 / 24
Boolean group testing
0 1 0 0 0 0 1 1 0 0 1 0
defectives K
population
N
Leo Baldassini Rates and Algorithms for Group Testing 19 December 2014 5 / 24
Boolean group testing
0 1 0 0 0 0 1 1 0 0 1 0
defectives K
population
N
0 0 0 0 0 0 1 1 0 0 1 0
0 0 0 0 1 0 1 0 1 1 0 0
0 1 0 1 0 0 0 0 0 0 1 0
1 0 1 0 0 0 1 1 0 0 0 0
0 0 1 1 0 0 0 0 1 1 0 0
0 0 0 1 0 0 0 0 0 0 0 0
1 0 0 0 0 0 0 0 0 0 0 1
1 0 0 1 0 0 0 0 0 1 0 0
0 0 0 1 0 0 0 0 0 0 0 0
0 0 0 1 0 0 0 1 0 0 0 0
0 0 0 0 0 0 0 0 1 0 0 0
test design
X
Leo Baldassini Rates and Algorithms for Group Testing 19 December 2014 5 / 24
Boolean group testing
0 1 0 0 0 0 1 1 0 0 1 0
defectives K
population
N
0 0 0 0 0 0 1 1 0 0 1 0
0 0 0 0 1 0 1 0 1 1 0 0
0 1 0 1 0 0 0 0 0 0 1 0
1 0 1 0 0 0 1 1 0 0 0 0
0 0 1 1 0 0 0 0 1 1 0 0
0 0 0 1 0 0 0 0 0 0 0 0
1 0 0 0 0 0 0 0 0 0 0 1
1 0 0 1 0 0 0 0 0 1 0 0
0 0 0 1 0 0 0 0 0 0 0 0
0 0 0 1 0 0 0 1 0 0 0 0
0 0 0 0 0 0 0 0 1 0 0 0
test design
X
1
1
1
1
0
0
0
0
0
0
0
test oucomes
y
Leo Baldassini Rates and Algorithms for Group Testing 19 December 2014 5 / 24
Boolean group testing
0 1 0 0 0 0 1 1 0 0 1 0
defectives K
population
N
0 0 0 0 0 0 1 1 0 0 1 0
0 0 0 0 1 0 1 0 1 1 0 0
0 1 0 1 0 0 0 0 0 0 1 0
1 0 1 0 0 0 1 1 0 0 0 0
0 0 1 1 0 0 0 0 1 1 0 0
0 0 0 1 0 0 0 0 0 0 0 0
1 0 0 0 0 0 0 0 0 0 0 1
1 0 0 1 0 0 0 0 0 1 0 0
0 0 0 1 0 0 0 0 0 0 0 0
0 0 0 1 0 0 0 1 0 0 0 0
0 0 0 0 0 0 0 0 1 0 0 0
test design
X
1
1
1
1
0
0
0
0
0
0
0
test oucomes
y
Leo Baldassini Rates and Algorithms for Group Testing 19 December 2014 5 / 24
Boolean group testing
0 1 0 0 0 0 1 1 0 0 1 0
defectives K
population
N
0 0 0 0 0 0 1 1 0 0 1 0
0 0 0 0 1 0 1 0 1 1 0 0
0 1 0 1 0 0 0 0 0 0 1 0
1 0 1 0 0 0 1 1 0 0 0 0
0 0 1 1 0 0 0 0 1 1 0 0
0 0 0 1 0 0 0 0 0 0 0 0
1 0 0 0 0 0 0 0 0 0 0 1
1 0 0 1 0 0 0 0 0 1 0 0
0 0 0 1 0 0 0 0 0 0 0 0
0 0 0 1 0 0 0 1 0 0 0 0
0 0 0 0 0 0 0 0 1 0 0 0
test design
X
1
1
1
1
0
0
0
0
0
0
0
test oucomes
y
Leo Baldassini Rates and Algorithms for Group Testing 19 December 2014 5 / 24
Boolean group testing
0 1 0 0 0 0 1 1 0 0 1 0
defectives K
population
N
0 0 0 0 0 0 1 1 0 0 1 0
0 0 0 0 1 0 1 0 1 1 0 0
0 1 0 1 0 0 0 0 0 0 1 0
1 0 1 0 0 0 1 1 0 0 0 0
0 0 1 1 0 0 0 0 1 1 0 0
0 0 0 1 0 0 0 0 0 0 0 0
1 0 0 0 0 0 0 0 0 0 0 1
1 0 0 1 0 0 0 0 0 1 0 0
0 0 0 1 0 0 0 0 0 0 0 0
0 0 0 1 0 0 0 1 0 0 0 0
0 0 0 0 0 0 0 0 1 0 0 0
test design
X
1
1
1
1
0
0
0
0
0
0
0
test oucomes
y
|N| = N, |K| = K
K = N1−β
, β > 0
Leo Baldassini Rates and Algorithms for Group Testing 19 December 2014 5 / 24
Boolean group testing
0 1 0 0 0 0 1 1 0 0 1 0
defectives K
population
N
0 0 0 0 0 0 1 1 0 0 1 0
0 0 0 0 1 0 1 0 1 1 0 0
0 1 0 1 0 0 0 0 0 0 1 0
1 0 1 0 0 0 1 1 0 0 0 0
0 0 1 1 0 0 0 0 1 1 0 0
0 0 0 1 0 0 0 0 0 0 0 0
1 0 0 0 0 0 0 0 0 0 0 1
1 0 0 1 0 0 0 0 0 1 0 0
0 0 0 1 0 0 0 0 0 0 0 0
0 0 0 1 0 0 0 1 0 0 0 0
0 0 0 0 0 0 0 0 1 0 0 0
test design
X
1
1
1
1
0
0
0
0
0
0
0
test oucomes
y
|N| = N, |K| = K
K = N1−β
, β > 0
particularly good for
non-adaptive algorithms
Leo Baldassini Rates and Algorithms for Group Testing 19 December 2014 5 / 24
Anatomy of an algorithm
N
K possible
defective
subsets
sequence of
test groups
X ∈ {0, 1}T×N
Encoding
Tests {xi yi }T
i=1 → K
Decoding
adaptivity
Recovered
set K
Leo Baldassini Rates and Algorithms for Group Testing 19 December 2014 6 / 24
Anatomy of an algorithm
N
K possible
defective
subsets
sequence of
test groups
X ∈ {0, 1}T×N
Encoding
Tests {xi yi }T
i=1 → K
Decoding
adaptivity
Recovered
set K
log2
N
K bits label
Leo Baldassini Rates and Algorithms for Group Testing 19 December 2014 6 / 24
Anatomy of an algorithm
N
K possible
defective
subsets
sequence of
test groups
X ∈ {0, 1}T×N
Encoding
Tests {xi yi }T
i=1 → K
Decoding
adaptivity
Recovered
set K
log2
N
K bits label
each test encodes
part of the label
Leo Baldassini Rates and Algorithms for Group Testing 19 December 2014 6 / 24
Rate of group testing (algorithms)
RA =
log2
N
K
TA
bits per test
Leo Baldassini Rates and Algorithms for Group Testing 19 December 2014 7 / 24
Rate of group testing (algorithms)
RA =
log2
N
K
TA
bits per test
RA measures how much we learn with each test, on average.
Leo Baldassini Rates and Algorithms for Group Testing 19 December 2014 7 / 24
Rate of group testing (algorithms)
RA =
log2
N
K
TA
bits per test
RA measures how much we learn with each test, on average.
R∗
A (β) supremum of rates for algorithm A.
Leo Baldassini Rates and Algorithms for Group Testing 19 December 2014 7 / 24
Rate of group testing (algorithms)
RA =
log2
N
K
TA
bits per test
RA measures how much we learn with each test, on average.
R∗
A (β) supremum of rates for algorithm A. (Yes, it’s bounded).
Leo Baldassini Rates and Algorithms for Group Testing 19 December 2014 7 / 24
WHY DO WE LIKE RATES?
Leo Baldassini Rates and Algorithms for Group Testing 19 December 2014 8 / 24
Universal upper bound for noiseless GT
Theorem (Aldridge, B., Johnson, 2013)
The probability of success of any algorithm A can be upper-bounded as
P(success) ≤
2TA
N
K
.
Leo Baldassini Rates and Algorithms for Group Testing 19 December 2014 9 / 24
Two important consequences
P(success) ≤
2TA
N
K
Leo Baldassini Rates and Algorithms for Group Testing 19 December 2014 10 / 24
Two important consequences
P(success) ≤
2TA
N
K
• Successful algorithms use T ≥ log2
N
K tests
optimal algorithms use T = c log2
N
K tests
Leo Baldassini Rates and Algorithms for Group Testing 19 December 2014 10 / 24
Two important consequences
P(success) ≤
2TA
N
K
• Successful algorithms use T ≥ log2
N
K tests
optimal algorithms use T = c log2
N
K tests
• R =
log2
N
K
T
“ranks” optimal algorithms
Leo Baldassini Rates and Algorithms for Group Testing 19 December 2014 10 / 24
Two important consequences
P(success) ≤
2TA
N
K
• Successful algorithms use T ≥ log2
N
K tests
optimal algorithms use T = c log2
N
K tests
• R =
log2
N
K
T
“ranks” optimal algorithms
• Successful algorithms have R∗
A (β) ≤ 1
Leo Baldassini Rates and Algorithms for Group Testing 19 December 2014 10 / 24
Capacity of GT
Leo Baldassini Rates and Algorithms for Group Testing 19 December 2014 11 / 24
Capacity of GT
C C + ε
C − ε
Leo Baldassini Rates and Algorithms for Group Testing 19 December 2014 11 / 24
Capacity of GT
C C + ε
C − ε
There exists an
algorithm with
lim inf
N→∞
log N
K
T
≥ C − ε
such that P(success) → 1
Direct part
Leo Baldassini Rates and Algorithms for Group Testing 19 December 2014 11 / 24
Capacity of GT
C C + ε
C − ε
There exists an
algorithm with
lim inf
N→∞
log N
K
T
≥ C − ε
such that P(success) → 1
Direct part
Any algorithm with
lim inf
N→∞
log N
K
T
≥ C + ε
has P(success) < 1 − η, η > 0
Converse part
Leo Baldassini Rates and Algorithms for Group Testing 19 December 2014 11 / 24
Capacity of GT
C C + ε
C − ε
There exists an
algorithm with
lim inf
N→∞
log N
K
T
≥ C − ε
such that P(success) → 1
Direct part
Any algorithm with
lim inf
N→∞
log N
K
T
≥ C + ε
has P(success) < 1 − η, η > 0
Converse part
• C is inherent in the GT
model
Leo Baldassini Rates and Algorithms for Group Testing 19 December 2014 11 / 24
Capacity of GT
C C + ε
C − ε
There exists an
algorithm with
lim inf
N→∞
log N
K
T
≥ C − ε
such that P(success) → 1
Direct part
Any algorithm with
lim inf
N→∞
log N
K
T
≥ C + ε
has P(success) < 1 − η, η > 0
Converse part
• C is inherent in the GT
model
• C measures the “hardness”
of a GT problem
Leo Baldassini Rates and Algorithms for Group Testing 19 December 2014 11 / 24
Capacity of GT
C C + ε
C − ε
There exists an
algorithm with
lim inf
N→∞
log N
K
T
≥ C − ε
such that P(success) → 1
Direct part
Any algorithm with
lim inf
N→∞
log N
K
T
≥ C + ε
has P(success) < 1 − η, η > 0
Converse part
• C is inherent in the GT
model
• C measures the “hardness”
of a GT problem
• C quantifies an
efficiency/effectiveness
trade-off
Leo Baldassini Rates and Algorithms for Group Testing 19 December 2014 11 / 24
Can we get to R = 1?
Leo Baldassini Rates and Algorithms for Group Testing 19 December 2014 12 / 24
Can we get to R = 1?
population
Leo Baldassini Rates and Algorithms for Group Testing 19 December 2014 12 / 24
Can we get to R = 1?
population
Positive, halve
Leo Baldassini Rates and Algorithms for Group Testing 19 December 2014 12 / 24
Can we get to R = 1?
population
Negative, discard
Leo Baldassini Rates and Algorithms for Group Testing 19 December 2014 12 / 24
Can we get to R = 1?
population
Positive, halve
Leo Baldassini Rates and Algorithms for Group Testing 19 December 2014 12 / 24
Can we get to R = 1?
population
Ok, this is easy
Leo Baldassini Rates and Algorithms for Group Testing 19 December 2014 12 / 24
Can we get to R = 1?
population
Can’t be this...
Leo Baldassini Rates and Algorithms for Group Testing 19 December 2014 12 / 24
Can we get to R = 1?
population
Must be this!
Leo Baldassini Rates and Algorithms for Group Testing 19 December 2014 12 / 24
Can we get to R = 1?
population
Put these back into
the population
Leo Baldassini Rates and Algorithms for Group Testing 19 December 2014 12 / 24
Can we get to R = 1?
population
• Hwang, 1972 (HGBS)
Leo Baldassini Rates and Algorithms for Group Testing 19 December 2014 12 / 24
Can we get to R = 1?
population
• Hwang, 1972 (HGBS)
• Achieves RHGBS = C = 1
THGBS ≤ K log2 N + (1 + log2 ln 2)K
− log K! + W
= O(K log N)
Leo Baldassini Rates and Algorithms for Group Testing 19 December 2014 12 / 24
Can we get to R = 1?
population
• Hwang, 1972 (HGBS)
• Achieves RHGBS = C = 1
• Careful choice of sample size
is key
Leo Baldassini Rates and Algorithms for Group Testing 19 December 2014 12 / 24
Can we get there...non-adaptively?
Leo Baldassini Rates and Algorithms for Group Testing 19 December 2014 13 / 24
Can we get there...non-adaptively?
• Maybe
Leo Baldassini Rates and Algorithms for Group Testing 19 December 2014 13 / 24
Can we get there...non-adaptively?
• Maybe
• What we did:
Leo Baldassini Rates and Algorithms for Group Testing 19 December 2014 13 / 24
Can we get there...non-adaptively?
• Maybe
• What we did:
• Introduced and studied DD (Definite Defectives) and SSS (Smallest
Satisfying Set)
• ...hence Bernoulli sampling, xij ∼ Bern(p), p = 1
K+1
• Showed limitation of Bernoulli-based algorithms
Leo Baldassini Rates and Algorithms for Group Testing 19 December 2014 13 / 24
DD: Definite Defectives
Leo Baldassini Rates and Algorithms for Group Testing 19 December 2014 14 / 24
DD: Definite Defectives
0 1 0 0 0 0 1 1 0 0 1 0
0 0 1 0 0 0 1 1 0 0 1 0
0 0 0 0 1 0 1 0 1 1 0 0
1 1 0 1 0 1 0 0 0 0 1 0
1 0 1 0 0 0 1 0 0 0 0 0
0 0 1 1 0 0 0 0 1 1 0 0
0 0 0 1 0 0 0 0 0 0 0 0
1 0 0 0 0 0 0 0 0 0 0 1
1 0 0 1 0 0 0 0 0 1 0 0
0 0 0 1 0 0 0 0 0 0 0 0
0 0 0 1 0 0 0 1 0 0 0 0
0 0 0 0 0 1 0 0 1 0 0 0
1
1
1
1
0
0
0
0
0
0
0
1. X Bernoulli design.
Leo Baldassini Rates and Algorithms for Group Testing 19 December 2014 14 / 24
DD: Definite Defectives
0 1 0 0 0 0 1 1 0 0 1 0
0 0 1 0 0 0 1 1 0 0 1 0
0 0 0 0 1 0 1 0 1 1 0 0
1 1 0 1 0 1 0 0 0 0 1 0
1 0 1 0 0 0 1 0 0 0 0 0
0 0 1 1 0 0 0 0 1 1 0 0
0 0 0 1 0 0 0 0 0 0 0 0
1 0 0 0 0 0 0 0 0 0 0 1
1 0 0 1 0 0 0 0 0 1 0 0
0 0 0 1 0 0 0 0 0 0 0 0
0 0 0 1 0 0 0 1 0 0 0 0
0 0 0 0 0 1 0 0 1 0 0 0
1
1
1
1
0
0
0
0
0
0
0
1. X Bernoulli design.
2. Look at negative tests. . .
Leo Baldassini Rates and Algorithms for Group Testing 19 December 2014 14 / 24
DD: Definite Defectives
0 1 0 0 0 0 1 1 0 0 1 0
0 0 1 0 0 0 1 1 0 0 1 0
0 0 0 0 1 0 1 0 1 1 0 0
1 1 0 1 0 1 0 0 0 0 1 0
1 0 1 0 0 0 1 0 0 0 0 0
0 0 1 1 0 0 0 0 1 1 0 0
0 0 0 1 0 0 0 0 0 0 0 0
1 0 0 0 0 0 0 0 0 0 0 1
1 0 0 1 0 0 0 0 0 1 0 0
0 0 0 1 0 0 0 0 0 0 0 0
0 0 0 1 0 0 0 1 0 0 0 0
0 0 0 0 0 1 0 0 1 0 0 0
1
1
1
1
0
0
0
0
0
0
0
1. X Bernoulli design.
2. Look at negative tests. . .
3. . . . classify items therein
as non-def. . . .
Leo Baldassini Rates and Algorithms for Group Testing 19 December 2014 14 / 24
DD: Definite Defectives
0 1 0 0 0 0 1 1 0 0 1 0
0 0 0 0 0 1 1 0 0 1 0
0 0 0 0 1 0 1 0 0 0
1 0 0 0 0 0 0 1 0
0 0 0 0 1 0 0 0 0 0
1
1
1
1
0
0
0
0
0
0
0
1. X Bernoulli design.
2. Look at negative tests. . .
3. . . . classify items therein
as non-def. . . .
4. . . . and remove them from
X.
Leo Baldassini Rates and Algorithms for Group Testing 19 December 2014 14 / 24
DD: Definite Defectives
0 1 0 0 0 0 1 1 0 0 1 0
0 0 0 0 0 1 1 0 0 1 0
0 0 0 0 1 0 1 0 0 0
1 0 0 0 0 0 0 1 0
0 0 0 0 1 0 0 0 0 0
1
1
1
1
0
0
0
0
0
0
0
1. X Bernoulli design.
2. Look at negative tests. . .
3. . . . classify items therein
as non-def. . . .
4. . . . and remove them from
X.
5. Look at positive tests with
1! unclassified item:
Leo Baldassini Rates and Algorithms for Group Testing 19 December 2014 14 / 24
DD: Definite Defectives
0 1 0 0 0 0 1 1 0 0 1 0
0 0 0 0 0 1 1 0 0 1 0
0 0 0 0 1 0 1 0 0 0
1 0 0 0 0 0 0 1 0
0 0 0 0 1 0 0 0 0 0
1
1
1
1
0
0
0
0
0
0
0
1. X Bernoulli design.
2. Look at negative tests. . .
3. . . . classify items therein
as non-def. . . .
4. . . . and remove them from
X.
5. Look at positive tests with
1! unclassified item:
6. That’s definite defective!
Leo Baldassini Rates and Algorithms for Group Testing 19 December 2014 14 / 24
DD: Definite Defectives
0 1 0 0 0 0 1 1 0 0 1 0
0 0 0 0 0 1 1 0 0 1 0
0 0 0 0 1 0 1 0 0 0
1 0 0 0 0 0 0 1 0
0 0 0 0 1 0 0 0 0 0
1
1
1
1
0
0
0
0
0
0
0
1. X Bernoulli design.
2. Look at negative tests. . .
3. . . . classify items therein
as non-def. . . .
4. . . . and remove them from
X.
5. Look at positive tests with
1! unclassified item:
6. That’s definite defective!
TDD ≤ max {β, 1 − β} eK ln N
R∗
DD(β) ≥
1
e ln 2
min 1,
β
1 − β
Leo Baldassini Rates and Algorithms for Group Testing 19 December 2014 14 / 24
What R∗
DD(β) looks like
0.0 0.2 0.4 0.6 0.8 1.0
β
0.0
0.2
0.4
0.6
0.8
1.0
Rate
Lower bound on R∗
DD(β)
Universal up-
per bound
Leo Baldassini Rates and Algorithms for Group Testing 19 December 2014 15 / 24
Computing R∗
DD(β): core of the proof - construction
Leo Baldassini Rates and Algorithms for Group Testing 19 December 2014 16 / 24
Computing R∗
DD(β): core of the proof - construction
• PD =
{items not in negative tests}
Leo Baldassini Rates and Algorithms for Group Testing 19 December 2014 16 / 24
Computing R∗
DD(β): core of the proof - construction
• PD =
{items not in negative tests}
• |PD | = K + G, G intruding
non-defectives
Leo Baldassini Rates and Algorithms for Group Testing 19 December 2014 16 / 24
Computing R∗
DD(β): core of the proof - construction
• PD =
{items not in negative tests}
• |PD | = K + G, G intruding
non-defectives
For every defective i ∈ K:
Li = # tests with i and no item
from PD
Leo Baldassini Rates and Algorithms for Group Testing 19 December 2014 16 / 24
Computing R∗
DD(β): core of the proof - construction
• PD =
{items not in negative tests}
• |PD | = K + G, G intruding
non-defectives
For every defective i ∈ K:
Li = # tests with i and no item
from PD
P(success) = P i∈K{Li = 0}
Leo Baldassini Rates and Algorithms for Group Testing 19 December 2014 16 / 24
Computing R∗
DD(β): core of the proof - construction
• PD =
{items not in negative tests}
• |PD | = K + G, G intruding
non-defectives
For every defective i ∈ K:
Li = # tests with i and no item
from PD
P(success) = P i∈K{Li = 0}
Bad news We can’t control G
Leo Baldassini Rates and Algorithms for Group Testing 19 December 2014 16 / 24
Computing R∗
DD(β): core of the proof - construction
• PD =
{items not in negative tests}
• |PD | = K + G, G intruding
non-defectives
For every defective i ∈ K:
Li = # tests with i and no item
from PD
P(success) = P i∈K{Li = 0}
Bad news We can’t control G
Good news We can control G | M0,
M0 = # negative tests.
Leo Baldassini Rates and Algorithms for Group Testing 19 December 2014 16 / 24
Computing R∗
DD(β): core of the proof - construction
• PD =
{items not in negative tests}
• |PD | = K + G, G intruding
non-defectives
For every defective i ∈ K:
Li = # tests with i and no item
from PD
P(success) = P i∈K{Li = 0}
Bad news We can’t control G
Good news We can control G | M0,
M0 = # negative tests.
P(success) =
T
m0=0
T
m0
(1 − p)Km0
1 − (1 − p)K T−m0
×
N−K
g=0
N − K
g
(1 − p)gm0
(1 − (1 − p)m0
)N−K−g
× P(success | M0 = m0, G = g)
Leo Baldassini Rates and Algorithms for Group Testing 19 December 2014 16 / 24
Computing R∗
DD(β): core of the proof - construction
• PD =
{items not in negative tests}
• |PD | = K + G, G intruding
non-defectives
For every defective i ∈ K:
Li = # tests with i and no item
from PD
P(success) = P i∈K{Li = 0}
Bad news We can’t control G
Good news We can control G | M0,
M0 = # negative tests.
P(success) =
T
m0=0
T
m0
(1 − p)Km0
1 − (1 − p)K T−m0
×
N−K
g=0
N − K
g
(1 − p)gm0
(1 − (1 − p)m0
)N−K−g
× P(success | M0 = m0, G = g)
there’s a sum in here, too!
Leo Baldassini Rates and Algorithms for Group Testing 19 December 2014 16 / 24
Computing R∗
DD(β): core of the proof - concentration
Leo Baldassini Rates and Algorithms for Group Testing 19 December 2014 17 / 24
Computing R∗
DD(β): core of the proof - concentration
N−K
g=0
N − K
g
(1 − p)gm0
(1 − (1 − p)m0
)N−K−g
× P(success | M0 = m0, G = g)
≥ max{0, 1 − K exp(Θ(T, m0))}
Leo Baldassini Rates and Algorithms for Group Testing 19 December 2014 17 / 24
Computing R∗
DD(β): core of the proof - concentration
N−K
g=0
N − K
g
(1 − p)gm0
(1 − (1 − p)m0
)N−K−g
× P(success | M0 = m0, G = g)
≥ max{0, 1 − K exp(Θ(T, m0))}
• M0 ∈ (EM0 − ε, EM0 + ε) w.h.p.
Leo Baldassini Rates and Algorithms for Group Testing 19 December 2014 17 / 24
Computing R∗
DD(β): core of the proof - concentration
N−K
g=0
N − K
g
(1 − p)gm0
(1 − (1 − p)m0
)N−K−g
× P(success | M0 = m0, G = g)
≥ max{0, 1 − K exp(Θ(T, m0))}
• M0 ∈ (EM0 − ε, EM0 + ε) w.h.p.
• Θ(T, m0) ≤ −(max{β, 1 − β}) ln N
for M0 close to EM0
Leo Baldassini Rates and Algorithms for Group Testing 19 December 2014 17 / 24
Computing R∗
DD(β): core of the proof - concentration
N−K
g=0
N − K
g
(1 − p)gm0
(1 − (1 − p)m0
)N−K−g
× P(success | M0 = m0, G = g)
≥ max{0, 1 − K exp(Θ(T, m0))}
• M0 ∈ (EM0 − ε, EM0 + ε) w.h.p.
• Θ(T, m0) ≤ −(max{β, 1 − β}) ln N
for M0 close to EM0
P(success) ≥ P T 1 − p)K
− ε/e ≤ M0 ≤ T (1 − p)K
+ ε/e (1−N−δ
)
Leo Baldassini Rates and Algorithms for Group Testing 19 December 2014 17 / 24
SSS: Smallest Satisfying Set
Group testing as LP:
Leo Baldassini Rates and Algorithms for Group Testing 19 December 2014 18 / 24
SSS: Smallest Satisfying Set
Group testing as LP:
minimize 1 z
subject to xt · z = 0 for t with yt = 0
xt · z ≥ 1 for t with yt = 1
(1 z ≥ K)
z ∈ {0, 1}N
Leo Baldassini Rates and Algorithms for Group Testing 19 December 2014 18 / 24
SSS: Smallest Satisfying Set
Group testing as LP:
minimize 1 z
subject to xt · z = 0 for t with yt = 0
xt · z ≥ 1 for t with yt = 1
(1 z ≥ K)
z ∈ {0, 1}N
• SSS brute-force searches
for a satisfying K
Leo Baldassini Rates and Algorithms for Group Testing 19 December 2014 18 / 24
SSS: Smallest Satisfying Set
Group testing as LP:
minimize 1 z
subject to xt · z = 0 for t with yt = 0
xt · z ≥ 1 for t with yt = 1
(1 z ≥ K)
z ∈ {0, 1}N
• SSS brute-force searches
for a satisfying K
• Best possible algorithm
(sample-complexity-wise)
Leo Baldassini Rates and Algorithms for Group Testing 19 December 2014 18 / 24
SSS: Smallest Satisfying Set
Group testing as LP:
minimize 1 z
subject to xt · z = 0 for t with yt = 0
xt · z ≥ 1 for t with yt = 1
(1 z ≥ K)
z ∈ {0, 1}N
• SSS brute-force searches
for a satisfying K
• Best possible algorithm
(sample-complexity-wise)
• Infeasible, but benchmark
Leo Baldassini Rates and Algorithms for Group Testing 19 December 2014 18 / 24
SSS: Smallest Satisfying Set
Group testing as LP:
minimize 1 z
subject to xt · z = 0 for t with yt = 0
xt · z ≥ 1 for t with yt = 1
(1 z ≥ K)
z ∈ {0, 1}N
• SSS brute-force searches
for a satisfying K
• Best possible algorithm
(sample-complexity-wise)
• Infeasible, but benchmark
R∗
SSS(β) ≥
1
ln 2
max
α∈[ln 2,1]
min 2αe−α β
2 − β
, − ln 1 − 2e−α
+ 2e−2α
.
Leo Baldassini Rates and Algorithms for Group Testing 19 December 2014 18 / 24
What R∗
SSS(β) looks like
0.0 0.2 0.4 0.6 0.8 1.0
β
0.0
0.2
0.4
0.6
0.8
1.0
Rate
Lower bound on R∗
SSS(β)
Leo Baldassini Rates and Algorithms for Group Testing 19 December 2014 19 / 24
Separability
SSS may fail if more than one
subset satisfies constraints
Leo Baldassini Rates and Algorithms for Group Testing 19 December 2014 20 / 24
Separability
SSS may fail if more than one
subset satisfies constraints
Question:
Can we enforce
uniqueness in X ?
Leo Baldassini Rates and Algorithms for Group Testing 19 December 2014 20 / 24
Separability
SSS may fail if more than one
subset satisfies constraints
Question:
Can we enforce
uniqueness in X ?
Definition
X is K-separable if, for any K-subsets L, M ⊂ {1, . . . , N}, it is
i∈M
x(i)
=
j∈L
x(j)
Leo Baldassini Rates and Algorithms for Group Testing 19 December 2014 20 / 24
Separability
SSS may fail if more than one
subset satisfies constraints
Question:
Can we enforce
uniqueness in X ?
Definition
X is K-separable if, for any K-subsets L, M ⊂ {1, . . . , N}, it is
i∈M
x(i)
=
j∈L
x(j)
Notice that y = K x(i)
.
Leo Baldassini Rates and Algorithms for Group Testing 19 December 2014 20 / 24
Almost separability
Building separable X requires
T = Ω(K2
log N) tests
Leo Baldassini Rates and Algorithms for Group Testing 19 December 2014 21 / 24
Almost separability
Building separable X requires
T = Ω(K2
log N) tests
Idea:
What if we re-
lax separability?
Leo Baldassini Rates and Algorithms for Group Testing 19 December 2014 21 / 24
Almost separability
Building separable X requires
T = Ω(K2
log N) tests
Idea:
What if we re-
lax separability?
Definition
X is ε-almost K-separable if there are at most ε N
K K-subsets that break
separability.
Leo Baldassini Rates and Algorithms for Group Testing 19 December 2014 21 / 24
Almost separability
Building separable X requires
T = Ω(K2
log N) tests
Idea:
What if we re-
lax separability?
Definition
X is ε-almost K-separable if there are at most ε N
K K-subsets that break
separability.
• Almost-separable matrices exist
• Need T = O(K log N) tests to get one
• A Bernoulli test design is almost-separable w.h.p. (via concentration)
Leo Baldassini Rates and Algorithms for Group Testing 19 December 2014 21 / 24
Family-wise upper bound via SSS
Leo Baldassini Rates and Algorithms for Group Testing 19 December 2014 22 / 24
Family-wise upper bound via SSS
Theorem (Aldridge, B., Johnson, 2014)
Consider SSS using TSSS tests. Then,
P(success) → 1 ⇒ TSSS >
(1 − β)e ln 2
β
log2
N
K
,
and, if the necessary condition is violated,
TSSS ≤
(1 − β)e ln 2
β
log2
N
K
⇒ P(success) ≤
2
3
.
Leo Baldassini Rates and Algorithms for Group Testing 19 December 2014 22 / 24
Family-wise upper bound via SSS
Theorem (Aldridge, B., Johnson, 2014)
Consider SSS using TSSS tests. Then,
P(success) → 1 ⇒ TSSS >
(1 − β)e ln 2
β
log2
N
K
,
and, if the necessary condition is violated,
TSSS ≤
(1 − β)e ln 2
β
log2
N
K
⇒ P(success) ≤
2
3
.
• “Weak converse”
Leo Baldassini Rates and Algorithms for Group Testing 19 December 2014 22 / 24
Family-wise upper bound via SSS
Theorem (Aldridge, B., Johnson, 2014)
Consider SSS using TSSS tests. Then,
P(success) → 1 ⇒ TSSS >
(1 − β)e ln 2
β
log2
N
K
,
and, if the necessary condition is violated,
TSSS ≤
(1 − β)e ln 2
β
log2
N
K
⇒ P(success) ≤
2
3
.
• “Weak converse”
• Applies to all Bernoulli-based algorithms
Leo Baldassini Rates and Algorithms for Group Testing 19 December 2014 22 / 24
Family-wise upper bound via SSS
Theorem (Aldridge, B., Johnson, 2014)
Consider SSS using TSSS tests. Then,
P(success) → 1 ⇒ TSSS >
(1 − β)e ln 2
β
log2
N
K
,
and, if the necessary condition is violated,
TSSS ≤
(1 − β)e ln 2
β
log2
N
K
⇒ P(success) ≤
2
3
.
• “Weak converse”
• Applies to all Bernoulli-based algorithms
• R∗
SSS(β) ≤ min 1, β
(1−β)e ln 2
Leo Baldassini Rates and Algorithms for Group Testing 19 December 2014 22 / 24
Adaptivity gap
0.0 0.2 0.4 0.6 0.8 1.0
β
0.0
0.2
0.4
0.6
0.8
1.0
Rate
SSS -based upper bound
Leo Baldassini Rates and Algorithms for Group Testing 19 December 2014 23 / 24
Adaptivity gap
0.0 0.2 0.4 0.6 0.8 1.0
β
0.0
0.2
0.4
0.6
0.8
1.0
Rate
SSS -based upper bound
Adaptivity gap
Leo Baldassini Rates and Algorithms for Group Testing 19 December 2014 23 / 24
Adaptivity gap
0.0 0.2 0.4 0.6 0.8 1.0
β
0.0
0.2
0.4
0.6
0.8
1.0
Rate
SSS -based upper bound
Adaptivity gap
Non-adaptive Bernoulli-
based algorithms
can’t achieve R = 1
Leo Baldassini Rates and Algorithms for Group Testing 19 December 2014 23 / 24
The moral
Leo Baldassini Rates and Algorithms for Group Testing 19 December 2014 24 / 24
The moral
• Group testing
Leo Baldassini Rates and Algorithms for Group Testing 19 December 2014 24 / 24
The moral
• Group testing
• Collective detection of sparse properties
• Information-poor tests
Leo Baldassini Rates and Algorithms for Group Testing 19 December 2014 24 / 24
The moral
• Group testing
• Collective detection of sparse properties
• Information-poor tests
• Rates and capacities
Leo Baldassini Rates and Algorithms for Group Testing 19 December 2014 24 / 24
The moral
• Group testing
• Collective detection of sparse properties
• Information-poor tests
• Rates and capacities
• Granular information
• Capacities bound performance of algorithms
Leo Baldassini Rates and Algorithms for Group Testing 19 December 2014 24 / 24
The moral
• Group testing
• Collective detection of sparse properties
• Information-poor tests
• Rates and capacities
• Granular information
• Capacities bound performance of algorithms
• SSS: bound the performance of any non-adaptive algorithm based on
Bernoulli sampling
Leo Baldassini Rates and Algorithms for Group Testing 19 December 2014 24 / 24
The moral
• Group testing
• Collective detection of sparse properties
• Information-poor tests
• Rates and capacities
• Granular information
• Capacities bound performance of algorithms
• SSS: bound the performance of any non-adaptive algorithm based on
Bernoulli sampling
• DD: order-optimal, rate-optimal (for dense problems)
Leo Baldassini Rates and Algorithms for Group Testing 19 December 2014 24 / 24
The moral
• Group testing
• Collective detection of sparse properties
• Information-poor tests
• Rates and capacities
• Granular information
• Capacities bound performance of algorithms
• SSS: bound the performance of any non-adaptive algorithm based on
Bernoulli sampling
• DD: order-optimal, rate-optimal (for dense problems)
• Future work: noise models, applications, non-identical GT,
non-independent GT, collateral open questions...
Leo Baldassini Rates and Algorithms for Group Testing 19 December 2014 24 / 24

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ProbSem191214

  • 1. Like a Needle in a Haystack: Rates and Algorithms for Group Testing Leonardo Baldassini Joint work with Oliver Johnson, Matthew Aldridge and Karen Gunderson 19 December 2014
  • 2. Warm-up examples • Molecular biology (DNA screening) • Recommender systems Leo Baldassini Rates and Algorithms for Group Testing 19 December 2014 1 / 24
  • 3. Warm-up examples • Molecular biology (DNA screening) • Recommender systems • Spectrum sensing • High-throughput screening techniques • Network tomography • Cryptography and cyber security Leo Baldassini Rates and Algorithms for Group Testing 19 December 2014 1 / 24
  • 4. DNA screening Problem Find a specific, rare sequence of nucleotides among many DNA samples Leo Baldassini Rates and Algorithms for Group Testing 19 December 2014 2 / 24
  • 5. DNA screening Problem Find a specific, rare sequence of nucleotides among many DNA samples Leo Baldassini Rates and Algorithms for Group Testing 19 December 2014 2 / 24
  • 6. DNA screening Problem Find a specific, rare sequence of nucleotides among many DNA samples 1 2 3 4 Leo Baldassini Rates and Algorithms for Group Testing 19 December 2014 2 / 24
  • 7. DNA screening Problem Find a specific, rare sequence of nucleotides among many DNA samples 1 2 3 4 qPCR Leo Baldassini Rates and Algorithms for Group Testing 19 December 2014 2 / 24
  • 8. DNA screening Problem Find a specific, rare sequence of nucleotides among many DNA samples 1 2 3 4 qPCR + ≥ 1 match in sample Leo Baldassini Rates and Algorithms for Group Testing 19 December 2014 2 / 24
  • 9. DNA screening Problem Find a specific, rare sequence of nucleotides among many DNA samples 1 2 3 4 qPCR + ≥ 1 match in sample − no match in sample Leo Baldassini Rates and Algorithms for Group Testing 19 December 2014 2 / 24
  • 10. Recommender systems Problem Suggest songs to a user based on his past preferences. Leo Baldassini Rates and Algorithms for Group Testing 19 December 2014 3 / 24
  • 11. Recommender systems Problem Suggest songs to a user based on his past preferences. User selects song Leo Baldassini Rates and Algorithms for Group Testing 19 December 2014 3 / 24
  • 12. Recommender systems Problem Suggest songs to a user based on his past preferences. User selects song RS proposes song Leo Baldassini Rates and Algorithms for Group Testing 19 December 2014 3 / 24
  • 13. Recommender systems Problem Suggest songs to a user based on his past preferences. User selects song RS proposes song + − Leo Baldassini Rates and Algorithms for Group Testing 19 December 2014 3 / 24
  • 14. Recommender systems Problem Suggest songs to a user based on his past preferences. User selects song RS proposes song + − RS adjusts guess on stylis- tic features Leo Baldassini Rates and Algorithms for Group Testing 19 December 2014 3 / 24
  • 15. Recommender systems Problem Suggest songs to a user based on his past preferences. User selects song RS proposes song + − RS adjusts guess on stylis- tic features Leo Baldassini Rates and Algorithms for Group Testing 19 December 2014 3 / 24
  • 16. What do they have in common? COMMON FEATURES Leo Baldassini Rates and Algorithms for Group Testing 19 December 2014 4 / 24
  • 17. What do they have in common? COMMON FEATURES • Search for sparse property Leo Baldassini Rates and Algorithms for Group Testing 19 December 2014 4 / 24
  • 18. What do they have in common? COMMON FEATURES • Search for sparse property • Property can be tested on groups Leo Baldassini Rates and Algorithms for Group Testing 19 December 2014 4 / 24
  • 19. What do they have in common? COMMON FEATURES • Search for sparse property • Property can be tested on groups GROUP TESTING Search methods to recover a sparse subset of items from a population that share a feature which can be detected on groups Leo Baldassini Rates and Algorithms for Group Testing 19 December 2014 4 / 24
  • 20. Boolean group testing 0 1 0 0 0 0 1 1 0 0 1 0 defectives K population N Leo Baldassini Rates and Algorithms for Group Testing 19 December 2014 5 / 24
  • 21. Boolean group testing 0 1 0 0 0 0 1 1 0 0 1 0 defectives K population N 0 0 0 0 0 0 1 1 0 0 1 0 0 0 0 0 1 0 1 0 1 1 0 0 0 1 0 1 0 0 0 0 0 0 1 0 1 0 1 0 0 0 1 1 0 0 0 0 0 0 1 1 0 0 0 0 1 1 0 0 0 0 0 1 0 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 1 1 0 0 1 0 0 0 0 0 1 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 test design X Leo Baldassini Rates and Algorithms for Group Testing 19 December 2014 5 / 24
  • 22. Boolean group testing 0 1 0 0 0 0 1 1 0 0 1 0 defectives K population N 0 0 0 0 0 0 1 1 0 0 1 0 0 0 0 0 1 0 1 0 1 1 0 0 0 1 0 1 0 0 0 0 0 0 1 0 1 0 1 0 0 0 1 1 0 0 0 0 0 0 1 1 0 0 0 0 1 1 0 0 0 0 0 1 0 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 1 1 0 0 1 0 0 0 0 0 1 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 test design X 1 1 1 1 0 0 0 0 0 0 0 test oucomes y Leo Baldassini Rates and Algorithms for Group Testing 19 December 2014 5 / 24
  • 23. Boolean group testing 0 1 0 0 0 0 1 1 0 0 1 0 defectives K population N 0 0 0 0 0 0 1 1 0 0 1 0 0 0 0 0 1 0 1 0 1 1 0 0 0 1 0 1 0 0 0 0 0 0 1 0 1 0 1 0 0 0 1 1 0 0 0 0 0 0 1 1 0 0 0 0 1 1 0 0 0 0 0 1 0 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 1 1 0 0 1 0 0 0 0 0 1 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 test design X 1 1 1 1 0 0 0 0 0 0 0 test oucomes y Leo Baldassini Rates and Algorithms for Group Testing 19 December 2014 5 / 24
  • 24. Boolean group testing 0 1 0 0 0 0 1 1 0 0 1 0 defectives K population N 0 0 0 0 0 0 1 1 0 0 1 0 0 0 0 0 1 0 1 0 1 1 0 0 0 1 0 1 0 0 0 0 0 0 1 0 1 0 1 0 0 0 1 1 0 0 0 0 0 0 1 1 0 0 0 0 1 1 0 0 0 0 0 1 0 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 1 1 0 0 1 0 0 0 0 0 1 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 test design X 1 1 1 1 0 0 0 0 0 0 0 test oucomes y Leo Baldassini Rates and Algorithms for Group Testing 19 December 2014 5 / 24
  • 25. Boolean group testing 0 1 0 0 0 0 1 1 0 0 1 0 defectives K population N 0 0 0 0 0 0 1 1 0 0 1 0 0 0 0 0 1 0 1 0 1 1 0 0 0 1 0 1 0 0 0 0 0 0 1 0 1 0 1 0 0 0 1 1 0 0 0 0 0 0 1 1 0 0 0 0 1 1 0 0 0 0 0 1 0 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 1 1 0 0 1 0 0 0 0 0 1 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 test design X 1 1 1 1 0 0 0 0 0 0 0 test oucomes y |N| = N, |K| = K K = N1−β , β > 0 Leo Baldassini Rates and Algorithms for Group Testing 19 December 2014 5 / 24
  • 26. Boolean group testing 0 1 0 0 0 0 1 1 0 0 1 0 defectives K population N 0 0 0 0 0 0 1 1 0 0 1 0 0 0 0 0 1 0 1 0 1 1 0 0 0 1 0 1 0 0 0 0 0 0 1 0 1 0 1 0 0 0 1 1 0 0 0 0 0 0 1 1 0 0 0 0 1 1 0 0 0 0 0 1 0 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 1 1 0 0 1 0 0 0 0 0 1 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 test design X 1 1 1 1 0 0 0 0 0 0 0 test oucomes y |N| = N, |K| = K K = N1−β , β > 0 particularly good for non-adaptive algorithms Leo Baldassini Rates and Algorithms for Group Testing 19 December 2014 5 / 24
  • 27. Anatomy of an algorithm N K possible defective subsets sequence of test groups X ∈ {0, 1}T×N Encoding Tests {xi yi }T i=1 → K Decoding adaptivity Recovered set K Leo Baldassini Rates and Algorithms for Group Testing 19 December 2014 6 / 24
  • 28. Anatomy of an algorithm N K possible defective subsets sequence of test groups X ∈ {0, 1}T×N Encoding Tests {xi yi }T i=1 → K Decoding adaptivity Recovered set K log2 N K bits label Leo Baldassini Rates and Algorithms for Group Testing 19 December 2014 6 / 24
  • 29. Anatomy of an algorithm N K possible defective subsets sequence of test groups X ∈ {0, 1}T×N Encoding Tests {xi yi }T i=1 → K Decoding adaptivity Recovered set K log2 N K bits label each test encodes part of the label Leo Baldassini Rates and Algorithms for Group Testing 19 December 2014 6 / 24
  • 30. Rate of group testing (algorithms) RA = log2 N K TA bits per test Leo Baldassini Rates and Algorithms for Group Testing 19 December 2014 7 / 24
  • 31. Rate of group testing (algorithms) RA = log2 N K TA bits per test RA measures how much we learn with each test, on average. Leo Baldassini Rates and Algorithms for Group Testing 19 December 2014 7 / 24
  • 32. Rate of group testing (algorithms) RA = log2 N K TA bits per test RA measures how much we learn with each test, on average. R∗ A (β) supremum of rates for algorithm A. Leo Baldassini Rates and Algorithms for Group Testing 19 December 2014 7 / 24
  • 33. Rate of group testing (algorithms) RA = log2 N K TA bits per test RA measures how much we learn with each test, on average. R∗ A (β) supremum of rates for algorithm A. (Yes, it’s bounded). Leo Baldassini Rates and Algorithms for Group Testing 19 December 2014 7 / 24
  • 34. WHY DO WE LIKE RATES? Leo Baldassini Rates and Algorithms for Group Testing 19 December 2014 8 / 24
  • 35. Universal upper bound for noiseless GT Theorem (Aldridge, B., Johnson, 2013) The probability of success of any algorithm A can be upper-bounded as P(success) ≤ 2TA N K . Leo Baldassini Rates and Algorithms for Group Testing 19 December 2014 9 / 24
  • 36. Two important consequences P(success) ≤ 2TA N K Leo Baldassini Rates and Algorithms for Group Testing 19 December 2014 10 / 24
  • 37. Two important consequences P(success) ≤ 2TA N K • Successful algorithms use T ≥ log2 N K tests optimal algorithms use T = c log2 N K tests Leo Baldassini Rates and Algorithms for Group Testing 19 December 2014 10 / 24
  • 38. Two important consequences P(success) ≤ 2TA N K • Successful algorithms use T ≥ log2 N K tests optimal algorithms use T = c log2 N K tests • R = log2 N K T “ranks” optimal algorithms Leo Baldassini Rates and Algorithms for Group Testing 19 December 2014 10 / 24
  • 39. Two important consequences P(success) ≤ 2TA N K • Successful algorithms use T ≥ log2 N K tests optimal algorithms use T = c log2 N K tests • R = log2 N K T “ranks” optimal algorithms • Successful algorithms have R∗ A (β) ≤ 1 Leo Baldassini Rates and Algorithms for Group Testing 19 December 2014 10 / 24
  • 40. Capacity of GT Leo Baldassini Rates and Algorithms for Group Testing 19 December 2014 11 / 24
  • 41. Capacity of GT C C + ε C − ε Leo Baldassini Rates and Algorithms for Group Testing 19 December 2014 11 / 24
  • 42. Capacity of GT C C + ε C − ε There exists an algorithm with lim inf N→∞ log N K T ≥ C − ε such that P(success) → 1 Direct part Leo Baldassini Rates and Algorithms for Group Testing 19 December 2014 11 / 24
  • 43. Capacity of GT C C + ε C − ε There exists an algorithm with lim inf N→∞ log N K T ≥ C − ε such that P(success) → 1 Direct part Any algorithm with lim inf N→∞ log N K T ≥ C + ε has P(success) < 1 − η, η > 0 Converse part Leo Baldassini Rates and Algorithms for Group Testing 19 December 2014 11 / 24
  • 44. Capacity of GT C C + ε C − ε There exists an algorithm with lim inf N→∞ log N K T ≥ C − ε such that P(success) → 1 Direct part Any algorithm with lim inf N→∞ log N K T ≥ C + ε has P(success) < 1 − η, η > 0 Converse part • C is inherent in the GT model Leo Baldassini Rates and Algorithms for Group Testing 19 December 2014 11 / 24
  • 45. Capacity of GT C C + ε C − ε There exists an algorithm with lim inf N→∞ log N K T ≥ C − ε such that P(success) → 1 Direct part Any algorithm with lim inf N→∞ log N K T ≥ C + ε has P(success) < 1 − η, η > 0 Converse part • C is inherent in the GT model • C measures the “hardness” of a GT problem Leo Baldassini Rates and Algorithms for Group Testing 19 December 2014 11 / 24
  • 46. Capacity of GT C C + ε C − ε There exists an algorithm with lim inf N→∞ log N K T ≥ C − ε such that P(success) → 1 Direct part Any algorithm with lim inf N→∞ log N K T ≥ C + ε has P(success) < 1 − η, η > 0 Converse part • C is inherent in the GT model • C measures the “hardness” of a GT problem • C quantifies an efficiency/effectiveness trade-off Leo Baldassini Rates and Algorithms for Group Testing 19 December 2014 11 / 24
  • 47. Can we get to R = 1? Leo Baldassini Rates and Algorithms for Group Testing 19 December 2014 12 / 24
  • 48. Can we get to R = 1? population Leo Baldassini Rates and Algorithms for Group Testing 19 December 2014 12 / 24
  • 49. Can we get to R = 1? population Positive, halve Leo Baldassini Rates and Algorithms for Group Testing 19 December 2014 12 / 24
  • 50. Can we get to R = 1? population Negative, discard Leo Baldassini Rates and Algorithms for Group Testing 19 December 2014 12 / 24
  • 51. Can we get to R = 1? population Positive, halve Leo Baldassini Rates and Algorithms for Group Testing 19 December 2014 12 / 24
  • 52. Can we get to R = 1? population Ok, this is easy Leo Baldassini Rates and Algorithms for Group Testing 19 December 2014 12 / 24
  • 53. Can we get to R = 1? population Can’t be this... Leo Baldassini Rates and Algorithms for Group Testing 19 December 2014 12 / 24
  • 54. Can we get to R = 1? population Must be this! Leo Baldassini Rates and Algorithms for Group Testing 19 December 2014 12 / 24
  • 55. Can we get to R = 1? population Put these back into the population Leo Baldassini Rates and Algorithms for Group Testing 19 December 2014 12 / 24
  • 56. Can we get to R = 1? population • Hwang, 1972 (HGBS) Leo Baldassini Rates and Algorithms for Group Testing 19 December 2014 12 / 24
  • 57. Can we get to R = 1? population • Hwang, 1972 (HGBS) • Achieves RHGBS = C = 1 THGBS ≤ K log2 N + (1 + log2 ln 2)K − log K! + W = O(K log N) Leo Baldassini Rates and Algorithms for Group Testing 19 December 2014 12 / 24
  • 58. Can we get to R = 1? population • Hwang, 1972 (HGBS) • Achieves RHGBS = C = 1 • Careful choice of sample size is key Leo Baldassini Rates and Algorithms for Group Testing 19 December 2014 12 / 24
  • 59. Can we get there...non-adaptively? Leo Baldassini Rates and Algorithms for Group Testing 19 December 2014 13 / 24
  • 60. Can we get there...non-adaptively? • Maybe Leo Baldassini Rates and Algorithms for Group Testing 19 December 2014 13 / 24
  • 61. Can we get there...non-adaptively? • Maybe • What we did: Leo Baldassini Rates and Algorithms for Group Testing 19 December 2014 13 / 24
  • 62. Can we get there...non-adaptively? • Maybe • What we did: • Introduced and studied DD (Definite Defectives) and SSS (Smallest Satisfying Set) • ...hence Bernoulli sampling, xij ∼ Bern(p), p = 1 K+1 • Showed limitation of Bernoulli-based algorithms Leo Baldassini Rates and Algorithms for Group Testing 19 December 2014 13 / 24
  • 63. DD: Definite Defectives Leo Baldassini Rates and Algorithms for Group Testing 19 December 2014 14 / 24
  • 64. DD: Definite Defectives 0 1 0 0 0 0 1 1 0 0 1 0 0 0 1 0 0 0 1 1 0 0 1 0 0 0 0 0 1 0 1 0 1 1 0 0 1 1 0 1 0 1 0 0 0 0 1 0 1 0 1 0 0 0 1 0 0 0 0 0 0 0 1 1 0 0 0 0 1 1 0 0 0 0 0 1 0 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 1 1 0 0 1 0 0 0 0 0 1 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 1 0 0 0 0 0 0 0 0 0 1 0 0 1 0 0 0 1 1 1 1 0 0 0 0 0 0 0 1. X Bernoulli design. Leo Baldassini Rates and Algorithms for Group Testing 19 December 2014 14 / 24
  • 65. DD: Definite Defectives 0 1 0 0 0 0 1 1 0 0 1 0 0 0 1 0 0 0 1 1 0 0 1 0 0 0 0 0 1 0 1 0 1 1 0 0 1 1 0 1 0 1 0 0 0 0 1 0 1 0 1 0 0 0 1 0 0 0 0 0 0 0 1 1 0 0 0 0 1 1 0 0 0 0 0 1 0 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 1 1 0 0 1 0 0 0 0 0 1 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 1 0 0 0 0 0 0 0 0 0 1 0 0 1 0 0 0 1 1 1 1 0 0 0 0 0 0 0 1. X Bernoulli design. 2. Look at negative tests. . . Leo Baldassini Rates and Algorithms for Group Testing 19 December 2014 14 / 24
  • 66. DD: Definite Defectives 0 1 0 0 0 0 1 1 0 0 1 0 0 0 1 0 0 0 1 1 0 0 1 0 0 0 0 0 1 0 1 0 1 1 0 0 1 1 0 1 0 1 0 0 0 0 1 0 1 0 1 0 0 0 1 0 0 0 0 0 0 0 1 1 0 0 0 0 1 1 0 0 0 0 0 1 0 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 1 1 0 0 1 0 0 0 0 0 1 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 1 0 0 0 0 0 0 0 0 0 1 0 0 1 0 0 0 1 1 1 1 0 0 0 0 0 0 0 1. X Bernoulli design. 2. Look at negative tests. . . 3. . . . classify items therein as non-def. . . . Leo Baldassini Rates and Algorithms for Group Testing 19 December 2014 14 / 24
  • 67. DD: Definite Defectives 0 1 0 0 0 0 1 1 0 0 1 0 0 0 0 0 0 1 1 0 0 1 0 0 0 0 0 1 0 1 0 0 0 1 0 0 0 0 0 0 1 0 0 0 0 0 1 0 0 0 0 0 1 1 1 1 0 0 0 0 0 0 0 1. X Bernoulli design. 2. Look at negative tests. . . 3. . . . classify items therein as non-def. . . . 4. . . . and remove them from X. Leo Baldassini Rates and Algorithms for Group Testing 19 December 2014 14 / 24
  • 68. DD: Definite Defectives 0 1 0 0 0 0 1 1 0 0 1 0 0 0 0 0 0 1 1 0 0 1 0 0 0 0 0 1 0 1 0 0 0 1 0 0 0 0 0 0 1 0 0 0 0 0 1 0 0 0 0 0 1 1 1 1 0 0 0 0 0 0 0 1. X Bernoulli design. 2. Look at negative tests. . . 3. . . . classify items therein as non-def. . . . 4. . . . and remove them from X. 5. Look at positive tests with 1! unclassified item: Leo Baldassini Rates and Algorithms for Group Testing 19 December 2014 14 / 24
  • 69. DD: Definite Defectives 0 1 0 0 0 0 1 1 0 0 1 0 0 0 0 0 0 1 1 0 0 1 0 0 0 0 0 1 0 1 0 0 0 1 0 0 0 0 0 0 1 0 0 0 0 0 1 0 0 0 0 0 1 1 1 1 0 0 0 0 0 0 0 1. X Bernoulli design. 2. Look at negative tests. . . 3. . . . classify items therein as non-def. . . . 4. . . . and remove them from X. 5. Look at positive tests with 1! unclassified item: 6. That’s definite defective! Leo Baldassini Rates and Algorithms for Group Testing 19 December 2014 14 / 24
  • 70. DD: Definite Defectives 0 1 0 0 0 0 1 1 0 0 1 0 0 0 0 0 0 1 1 0 0 1 0 0 0 0 0 1 0 1 0 0 0 1 0 0 0 0 0 0 1 0 0 0 0 0 1 0 0 0 0 0 1 1 1 1 0 0 0 0 0 0 0 1. X Bernoulli design. 2. Look at negative tests. . . 3. . . . classify items therein as non-def. . . . 4. . . . and remove them from X. 5. Look at positive tests with 1! unclassified item: 6. That’s definite defective! TDD ≤ max {β, 1 − β} eK ln N R∗ DD(β) ≥ 1 e ln 2 min 1, β 1 − β Leo Baldassini Rates and Algorithms for Group Testing 19 December 2014 14 / 24
  • 71. What R∗ DD(β) looks like 0.0 0.2 0.4 0.6 0.8 1.0 β 0.0 0.2 0.4 0.6 0.8 1.0 Rate Lower bound on R∗ DD(β) Universal up- per bound Leo Baldassini Rates and Algorithms for Group Testing 19 December 2014 15 / 24
  • 72. Computing R∗ DD(β): core of the proof - construction Leo Baldassini Rates and Algorithms for Group Testing 19 December 2014 16 / 24
  • 73. Computing R∗ DD(β): core of the proof - construction • PD = {items not in negative tests} Leo Baldassini Rates and Algorithms for Group Testing 19 December 2014 16 / 24
  • 74. Computing R∗ DD(β): core of the proof - construction • PD = {items not in negative tests} • |PD | = K + G, G intruding non-defectives Leo Baldassini Rates and Algorithms for Group Testing 19 December 2014 16 / 24
  • 75. Computing R∗ DD(β): core of the proof - construction • PD = {items not in negative tests} • |PD | = K + G, G intruding non-defectives For every defective i ∈ K: Li = # tests with i and no item from PD Leo Baldassini Rates and Algorithms for Group Testing 19 December 2014 16 / 24
  • 76. Computing R∗ DD(β): core of the proof - construction • PD = {items not in negative tests} • |PD | = K + G, G intruding non-defectives For every defective i ∈ K: Li = # tests with i and no item from PD P(success) = P i∈K{Li = 0} Leo Baldassini Rates and Algorithms for Group Testing 19 December 2014 16 / 24
  • 77. Computing R∗ DD(β): core of the proof - construction • PD = {items not in negative tests} • |PD | = K + G, G intruding non-defectives For every defective i ∈ K: Li = # tests with i and no item from PD P(success) = P i∈K{Li = 0} Bad news We can’t control G Leo Baldassini Rates and Algorithms for Group Testing 19 December 2014 16 / 24
  • 78. Computing R∗ DD(β): core of the proof - construction • PD = {items not in negative tests} • |PD | = K + G, G intruding non-defectives For every defective i ∈ K: Li = # tests with i and no item from PD P(success) = P i∈K{Li = 0} Bad news We can’t control G Good news We can control G | M0, M0 = # negative tests. Leo Baldassini Rates and Algorithms for Group Testing 19 December 2014 16 / 24
  • 79. Computing R∗ DD(β): core of the proof - construction • PD = {items not in negative tests} • |PD | = K + G, G intruding non-defectives For every defective i ∈ K: Li = # tests with i and no item from PD P(success) = P i∈K{Li = 0} Bad news We can’t control G Good news We can control G | M0, M0 = # negative tests. P(success) = T m0=0 T m0 (1 − p)Km0 1 − (1 − p)K T−m0 × N−K g=0 N − K g (1 − p)gm0 (1 − (1 − p)m0 )N−K−g × P(success | M0 = m0, G = g) Leo Baldassini Rates and Algorithms for Group Testing 19 December 2014 16 / 24
  • 80. Computing R∗ DD(β): core of the proof - construction • PD = {items not in negative tests} • |PD | = K + G, G intruding non-defectives For every defective i ∈ K: Li = # tests with i and no item from PD P(success) = P i∈K{Li = 0} Bad news We can’t control G Good news We can control G | M0, M0 = # negative tests. P(success) = T m0=0 T m0 (1 − p)Km0 1 − (1 − p)K T−m0 × N−K g=0 N − K g (1 − p)gm0 (1 − (1 − p)m0 )N−K−g × P(success | M0 = m0, G = g) there’s a sum in here, too! Leo Baldassini Rates and Algorithms for Group Testing 19 December 2014 16 / 24
  • 81. Computing R∗ DD(β): core of the proof - concentration Leo Baldassini Rates and Algorithms for Group Testing 19 December 2014 17 / 24
  • 82. Computing R∗ DD(β): core of the proof - concentration N−K g=0 N − K g (1 − p)gm0 (1 − (1 − p)m0 )N−K−g × P(success | M0 = m0, G = g) ≥ max{0, 1 − K exp(Θ(T, m0))} Leo Baldassini Rates and Algorithms for Group Testing 19 December 2014 17 / 24
  • 83. Computing R∗ DD(β): core of the proof - concentration N−K g=0 N − K g (1 − p)gm0 (1 − (1 − p)m0 )N−K−g × P(success | M0 = m0, G = g) ≥ max{0, 1 − K exp(Θ(T, m0))} • M0 ∈ (EM0 − ε, EM0 + ε) w.h.p. Leo Baldassini Rates and Algorithms for Group Testing 19 December 2014 17 / 24
  • 84. Computing R∗ DD(β): core of the proof - concentration N−K g=0 N − K g (1 − p)gm0 (1 − (1 − p)m0 )N−K−g × P(success | M0 = m0, G = g) ≥ max{0, 1 − K exp(Θ(T, m0))} • M0 ∈ (EM0 − ε, EM0 + ε) w.h.p. • Θ(T, m0) ≤ −(max{β, 1 − β}) ln N for M0 close to EM0 Leo Baldassini Rates and Algorithms for Group Testing 19 December 2014 17 / 24
  • 85. Computing R∗ DD(β): core of the proof - concentration N−K g=0 N − K g (1 − p)gm0 (1 − (1 − p)m0 )N−K−g × P(success | M0 = m0, G = g) ≥ max{0, 1 − K exp(Θ(T, m0))} • M0 ∈ (EM0 − ε, EM0 + ε) w.h.p. • Θ(T, m0) ≤ −(max{β, 1 − β}) ln N for M0 close to EM0 P(success) ≥ P T 1 − p)K − ε/e ≤ M0 ≤ T (1 − p)K + ε/e (1−N−δ ) Leo Baldassini Rates and Algorithms for Group Testing 19 December 2014 17 / 24
  • 86. SSS: Smallest Satisfying Set Group testing as LP: Leo Baldassini Rates and Algorithms for Group Testing 19 December 2014 18 / 24
  • 87. SSS: Smallest Satisfying Set Group testing as LP: minimize 1 z subject to xt · z = 0 for t with yt = 0 xt · z ≥ 1 for t with yt = 1 (1 z ≥ K) z ∈ {0, 1}N Leo Baldassini Rates and Algorithms for Group Testing 19 December 2014 18 / 24
  • 88. SSS: Smallest Satisfying Set Group testing as LP: minimize 1 z subject to xt · z = 0 for t with yt = 0 xt · z ≥ 1 for t with yt = 1 (1 z ≥ K) z ∈ {0, 1}N • SSS brute-force searches for a satisfying K Leo Baldassini Rates and Algorithms for Group Testing 19 December 2014 18 / 24
  • 89. SSS: Smallest Satisfying Set Group testing as LP: minimize 1 z subject to xt · z = 0 for t with yt = 0 xt · z ≥ 1 for t with yt = 1 (1 z ≥ K) z ∈ {0, 1}N • SSS brute-force searches for a satisfying K • Best possible algorithm (sample-complexity-wise) Leo Baldassini Rates and Algorithms for Group Testing 19 December 2014 18 / 24
  • 90. SSS: Smallest Satisfying Set Group testing as LP: minimize 1 z subject to xt · z = 0 for t with yt = 0 xt · z ≥ 1 for t with yt = 1 (1 z ≥ K) z ∈ {0, 1}N • SSS brute-force searches for a satisfying K • Best possible algorithm (sample-complexity-wise) • Infeasible, but benchmark Leo Baldassini Rates and Algorithms for Group Testing 19 December 2014 18 / 24
  • 91. SSS: Smallest Satisfying Set Group testing as LP: minimize 1 z subject to xt · z = 0 for t with yt = 0 xt · z ≥ 1 for t with yt = 1 (1 z ≥ K) z ∈ {0, 1}N • SSS brute-force searches for a satisfying K • Best possible algorithm (sample-complexity-wise) • Infeasible, but benchmark R∗ SSS(β) ≥ 1 ln 2 max α∈[ln 2,1] min 2αe−α β 2 − β , − ln 1 − 2e−α + 2e−2α . Leo Baldassini Rates and Algorithms for Group Testing 19 December 2014 18 / 24
  • 92. What R∗ SSS(β) looks like 0.0 0.2 0.4 0.6 0.8 1.0 β 0.0 0.2 0.4 0.6 0.8 1.0 Rate Lower bound on R∗ SSS(β) Leo Baldassini Rates and Algorithms for Group Testing 19 December 2014 19 / 24
  • 93. Separability SSS may fail if more than one subset satisfies constraints Leo Baldassini Rates and Algorithms for Group Testing 19 December 2014 20 / 24
  • 94. Separability SSS may fail if more than one subset satisfies constraints Question: Can we enforce uniqueness in X ? Leo Baldassini Rates and Algorithms for Group Testing 19 December 2014 20 / 24
  • 95. Separability SSS may fail if more than one subset satisfies constraints Question: Can we enforce uniqueness in X ? Definition X is K-separable if, for any K-subsets L, M ⊂ {1, . . . , N}, it is i∈M x(i) = j∈L x(j) Leo Baldassini Rates and Algorithms for Group Testing 19 December 2014 20 / 24
  • 96. Separability SSS may fail if more than one subset satisfies constraints Question: Can we enforce uniqueness in X ? Definition X is K-separable if, for any K-subsets L, M ⊂ {1, . . . , N}, it is i∈M x(i) = j∈L x(j) Notice that y = K x(i) . Leo Baldassini Rates and Algorithms for Group Testing 19 December 2014 20 / 24
  • 97. Almost separability Building separable X requires T = Ω(K2 log N) tests Leo Baldassini Rates and Algorithms for Group Testing 19 December 2014 21 / 24
  • 98. Almost separability Building separable X requires T = Ω(K2 log N) tests Idea: What if we re- lax separability? Leo Baldassini Rates and Algorithms for Group Testing 19 December 2014 21 / 24
  • 99. Almost separability Building separable X requires T = Ω(K2 log N) tests Idea: What if we re- lax separability? Definition X is ε-almost K-separable if there are at most ε N K K-subsets that break separability. Leo Baldassini Rates and Algorithms for Group Testing 19 December 2014 21 / 24
  • 100. Almost separability Building separable X requires T = Ω(K2 log N) tests Idea: What if we re- lax separability? Definition X is ε-almost K-separable if there are at most ε N K K-subsets that break separability. • Almost-separable matrices exist • Need T = O(K log N) tests to get one • A Bernoulli test design is almost-separable w.h.p. (via concentration) Leo Baldassini Rates and Algorithms for Group Testing 19 December 2014 21 / 24
  • 101. Family-wise upper bound via SSS Leo Baldassini Rates and Algorithms for Group Testing 19 December 2014 22 / 24
  • 102. Family-wise upper bound via SSS Theorem (Aldridge, B., Johnson, 2014) Consider SSS using TSSS tests. Then, P(success) → 1 ⇒ TSSS > (1 − β)e ln 2 β log2 N K , and, if the necessary condition is violated, TSSS ≤ (1 − β)e ln 2 β log2 N K ⇒ P(success) ≤ 2 3 . Leo Baldassini Rates and Algorithms for Group Testing 19 December 2014 22 / 24
  • 103. Family-wise upper bound via SSS Theorem (Aldridge, B., Johnson, 2014) Consider SSS using TSSS tests. Then, P(success) → 1 ⇒ TSSS > (1 − β)e ln 2 β log2 N K , and, if the necessary condition is violated, TSSS ≤ (1 − β)e ln 2 β log2 N K ⇒ P(success) ≤ 2 3 . • “Weak converse” Leo Baldassini Rates and Algorithms for Group Testing 19 December 2014 22 / 24
  • 104. Family-wise upper bound via SSS Theorem (Aldridge, B., Johnson, 2014) Consider SSS using TSSS tests. Then, P(success) → 1 ⇒ TSSS > (1 − β)e ln 2 β log2 N K , and, if the necessary condition is violated, TSSS ≤ (1 − β)e ln 2 β log2 N K ⇒ P(success) ≤ 2 3 . • “Weak converse” • Applies to all Bernoulli-based algorithms Leo Baldassini Rates and Algorithms for Group Testing 19 December 2014 22 / 24
  • 105. Family-wise upper bound via SSS Theorem (Aldridge, B., Johnson, 2014) Consider SSS using TSSS tests. Then, P(success) → 1 ⇒ TSSS > (1 − β)e ln 2 β log2 N K , and, if the necessary condition is violated, TSSS ≤ (1 − β)e ln 2 β log2 N K ⇒ P(success) ≤ 2 3 . • “Weak converse” • Applies to all Bernoulli-based algorithms • R∗ SSS(β) ≤ min 1, β (1−β)e ln 2 Leo Baldassini Rates and Algorithms for Group Testing 19 December 2014 22 / 24
  • 106. Adaptivity gap 0.0 0.2 0.4 0.6 0.8 1.0 β 0.0 0.2 0.4 0.6 0.8 1.0 Rate SSS -based upper bound Leo Baldassini Rates and Algorithms for Group Testing 19 December 2014 23 / 24
  • 107. Adaptivity gap 0.0 0.2 0.4 0.6 0.8 1.0 β 0.0 0.2 0.4 0.6 0.8 1.0 Rate SSS -based upper bound Adaptivity gap Leo Baldassini Rates and Algorithms for Group Testing 19 December 2014 23 / 24
  • 108. Adaptivity gap 0.0 0.2 0.4 0.6 0.8 1.0 β 0.0 0.2 0.4 0.6 0.8 1.0 Rate SSS -based upper bound Adaptivity gap Non-adaptive Bernoulli- based algorithms can’t achieve R = 1 Leo Baldassini Rates and Algorithms for Group Testing 19 December 2014 23 / 24
  • 109. The moral Leo Baldassini Rates and Algorithms for Group Testing 19 December 2014 24 / 24
  • 110. The moral • Group testing Leo Baldassini Rates and Algorithms for Group Testing 19 December 2014 24 / 24
  • 111. The moral • Group testing • Collective detection of sparse properties • Information-poor tests Leo Baldassini Rates and Algorithms for Group Testing 19 December 2014 24 / 24
  • 112. The moral • Group testing • Collective detection of sparse properties • Information-poor tests • Rates and capacities Leo Baldassini Rates and Algorithms for Group Testing 19 December 2014 24 / 24
  • 113. The moral • Group testing • Collective detection of sparse properties • Information-poor tests • Rates and capacities • Granular information • Capacities bound performance of algorithms Leo Baldassini Rates and Algorithms for Group Testing 19 December 2014 24 / 24
  • 114. The moral • Group testing • Collective detection of sparse properties • Information-poor tests • Rates and capacities • Granular information • Capacities bound performance of algorithms • SSS: bound the performance of any non-adaptive algorithm based on Bernoulli sampling Leo Baldassini Rates and Algorithms for Group Testing 19 December 2014 24 / 24
  • 115. The moral • Group testing • Collective detection of sparse properties • Information-poor tests • Rates and capacities • Granular information • Capacities bound performance of algorithms • SSS: bound the performance of any non-adaptive algorithm based on Bernoulli sampling • DD: order-optimal, rate-optimal (for dense problems) Leo Baldassini Rates and Algorithms for Group Testing 19 December 2014 24 / 24
  • 116. The moral • Group testing • Collective detection of sparse properties • Information-poor tests • Rates and capacities • Granular information • Capacities bound performance of algorithms • SSS: bound the performance of any non-adaptive algorithm based on Bernoulli sampling • DD: order-optimal, rate-optimal (for dense problems) • Future work: noise models, applications, non-identical GT, non-independent GT, collateral open questions... Leo Baldassini Rates and Algorithms for Group Testing 19 December 2014 24 / 24