This document lists 13 publications authored or co-authored by G.L. Gravatt related to organic synthesis and natural product chemistry. The publications span from 1985 to 1997 and cover topics including the synthesis of troponoid natural products like nezukone, oxidation of vicinal diols, asymmetric synthesis using chiral transition metal complexes, structure-activity relationships of DNA-directed alkylating agents, and synthesis of colchicine analogs. G.L. Gravatt's research focused on the total synthesis of complex natural products and development of DNA-targeted anticancer agents.
1. 1. Banwell, M. G., Gravatt, G. L. and Rickard, C. E. F. – A Novel Synthesis of Nezukone
via the Rearrangement of a Bicyclic Isomer: Evidence for the Intermediacy of
Heptafulvenes. J. Chem. Soc., Chem. Commun., pp. 514–515 (1985).
2. Amon, C. M., Banwell, M. G. and Gravatt, G. L. – Oxidation of Vicinal Diols to α-
Dicarbonyl Compounds by Trifluoroacetic Anhydride "Activated" Dimethyl
Sulfoxide. J. Org. Chem., 52: pp. 4851–4855 (1987).
3. Davies, S. G.; Gravatt, G. L. Asymmetric synthesis of phenyl alkyl sulfoxides via the
non-destructive mediation of the chiral iron acyl [(η5
-C5H5)Fe(CO)(PPh3)COCH2Me]
J. Chem. Soc., Chem. Commun. 1988, 780
4. Capon, R. J.; MacLeod, J. K.; Coote, S. J.; Davies, S. G.; Gravatt, G. L.; Dordor-
Hedgecock, I. M.; Whittaker M, Stereochemical studies on marine cyclic peroxides:
unequivocal assignment of absolute stereochemistry by asymmetric synthesis.
Tetrahedron 1988, 44, 1637
5. Davies, S. G.; Bashiardes, G.; Beckett, R. P.; Coote, S. J.; Dordor-Hedgecock, Isabelle
M.; Goodfellow, C. L.; Gravatt, G. L.; McNally, J. P.; Whittaker, M. Asymmetric
synthesis via chiral transition metal auxiliaries Philosophical Transactions of the
Royal Society of London, Series A1988, 326, 619
6. Banwell, M. G., Gravatt, G. L., Buckleton, J. S., Clark, G. R. and Rickard, C. E. F. – The
Development of a Fully Regiocontrolled Synthesis of (±)-12a,12b-
Monosecocolchicine using a Synthetic Equivalent for the 7-Methoxy-3-troponyl
Anion. J. Chem. Soc., Chem. Commun., pp. 865–867 (1989).
7. Gourdie TA1
, Valu KK, Gravatt GL, Boritzki TJ, Baguley BC, Wakelin LP, Wilson
WR, Woodgate PD, Denny WA. DNA-directed alkylating agents. 1. Structure-
activity relationships for acridine-linked aniline mustards: consequences of varying
the reactivity of the mustard. J Med Chem. 1990 Apr;33(4):1177-86.
8. Pyrazole analogues of the bispyrrolecarboxamide anti-tumour antibiotics:
synthesis, DNA binding and anti-tumour properties. Lee, HH ; Boyd, M ; Gravatt,
GL ; Denny, WA Anti-Cancer Drug Design 6(5):501-517 1991
2. 9. GL Gravatt, BC Baguley, WR Wilson. DNA-directed alkylating agents. 4. 4-
anilinoquinoline-based minor groove directed aniline mustards. Journal of
Medicinal Chemistry. 1991
10. Banwell, M. G., Cowden, C. J., Gravatt, G. L. and Rickard, C. E. F. – Synthesis of the
Troponoid Natural Product Nezukone via Sequential Rearrangement of Two
Isomeric Precursors. Aust. J. Chem., 46: pp. 1941–1954 (1993).
11. Banwell, M. G., Lambert, J. N. and Gravatt, G. L. – Fully Regiocontrolled Synthesis
of (±)-12a,12b-Secocolchicine and Studies Concerning its Cyclisation to the Alkaloid
Colchicine. J. Chem. Soc., Perkin Trans. 1, pp. 2817–2830 (1993).
12. GRAVATT GL; BAGULEY BC; WILSON WR; DENNY WA . DNA-DIRECTED ALKYLATING-
AGENTS .6. SYNTHESIS AND ANTITUMOR-ACTIVITY OF DNA MINOR GROOVE-
TARGETED ANILINE MUSTARD ANALOGS OF PIBENZIMOL Journal of Medicinal
Chemistry. (VOL37, PG 4338, 1994)
13. Banwell, M. G., Cameron, J. M., Collis, M. P. and Gravatt, G. L. – Syntheses and
ipsoSubstitution Reactions of Some C-Stannylated Troponoids. Aust. J. Chem., 50:
pp. 395– 407 (1997)