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Diagnostic and Interventional Imaging (2015) 96, 693ā€”706
CONTINUING EDUCATION PROGRAM: FOCUS. . .
Traumatic injuries of the thoracic aorta:
The role of imaging in diagnosis and
treatment
F.Z. Mokranea,āˆ—
, P. Revel-Mouroza
, B. Saint Lebesb
,
H. Rousseaua
a
Department of Radiology, CHU Rangueil Toulouse, 1, avenue du Professeur-Jean-PoulhĆØs,
TSA 50032, 31059 Toulouse cedex 9, France
b
Department of Vascular Surgery, CHU Rangueil Toulouse, 1, avenue du
Professeur-Jean-PoulhĆØs, TSA 50032, 31059 Toulouse cedex 9, France
KEYWORDS
Thoracic aorta;
Emergency medicine;
Trauma;
Endoprosthesis;
Stent graft
Abstract Traumatic injury of the thoracic aorta remains the leading cause of death in multiple
trauma patients and it requires urgent management. Computed tomography has a key diagnostic
role and allows the clinician to choose an appropriate treatment strategy. The development
of new classiļ¬cations, based on a better understanding of the mechanisms of these injuries,
has clariļ¬ed the indications for treatment. Advances in techniques, especially in endovascular
management, have contributed to improving prognosis for patients. Interventional radiology,
which usually consists of endovascular placement of a covered stent, now constitutes the gold
standard treatment in these injuries. Due to the potentially grave prognosis of these patients,
it is crucial to know how to detect these injuries and to describe the imaging signs of serious
damage.
Ā© 2015 Ɖditions francĀøaises de radiologie. Published by Elsevier Masson SAS. All rights reserved.
Road trafļ¬c accidents are the main cause of aortic trauma. Traumatic injury of the large
vessels is being seen with increasing incidence in tertiary trauma units. While during the
20th century this rise could be attributed to an increase in numbers of road trafļ¬c acci-
dents, today it is the improved initial management on the part of emergency care networks,
at the head of which are emergency ambulance services, that is responsible for a fall in
early deaths, and this explains why there is a growing number of patients who manage to
survive until they are admitted to a hospital unit [1,2].
āˆ— Corresponding author.
E-mail address: mokrane fatimazohra@yahoo.fr (F.Z. Mokrane).
http://dx.doi.org/10.1016/j.diii.2015.06.005
2211-5684/Ā© 2015 Ɖditions francĀøaises de radiologie. Published by Elsevier Masson SAS. All rights reserved.
694 F.Z. Mokrane et al.
These traumatic injuries have a signiļ¬cant mortality rate.
The Princeps study by Parmley et al. reported a death rate
of 80%, a survival rate of 20% and a development of chronic
disease rate of 5% [1]. The improvement shown by these
ļ¬gures is largely due to effective emergency management
and the expansion of treatment with stent grafts.
Indeed, although only 38% of patients survive follow-
ing aortic trauma, better management at the scene of the
accident and quicker transportation to hospitals has led to
improvements in overall survival. Speciļ¬cally, only 4% of
patients die on the way to the hospital. Nonetheless, mortal-
ity around the time of the injury remains high, estimated at
20% in the 24 hours following the hospital admission [1ā€”4].
This serious pathology therefore needs quick, effective
and consensual management.
Sites of predilection, mechanism and
pathophysiology
The pathophysiology of thoracic aorta trauma injury is com-
plex. The greater frequency of aortic isthmus damage is in
part related to its anatomical position, which is relatively
ļ¬xed within the rib cage [5]. In a high-velocity trauma, such
as a road trafļ¬c accident, the thoracic aorta is subjected to
rapid deceleration together with compression of the chest
wall. Associated with this are complex torsion or stretching
Figure 1. Multiplanar CT angiography reconstructions of the thoracic aorta. Illustration of the preferential topographical distribution of
traumatic injuries: a: accumulation of contrast material in a crevice in the ascending thoracic aorta wall, located at the aortic valve cusps
(white arrow); b: presence of two trauma injuries: an injury to the aortic root, located immediately above the sinus of Valsalva (white
circle); another injury to the descending thoracic aorta at its junction with the isthmus (black arrow); c: traumatic pseudoaneurysm (white
circle) of the aortic arch, originating between the left carotid artery (black arrow head) and left subclavian artery (white arrow head); d:
traumatic rupture of the descending thoracic aorta with signiļ¬cant extravasation of contrast material in the arterial phase (white circle),
explaining the abundant mediastinal haematoma (white star).
injuries to the aortic wall, especially at the points of ļ¬xa-
tion, which explains the increased frequency of injury to the
aortic isthmus [5,6] (Fig. 1).
By contrast, injuries to the ascending thoracic aorta
are probably just as common but they are seen less often
because they are so serious that they are frequently the
cause of immediate death [5,7].
The circumstances in which these injuries arise are, in
decreasing order of frequency: road trafļ¬c accidents, crus-
hing accidents, falls from a height and other deceleration
accidents that occur during sports such as skiing [2ā€”6].
Which examinations should be performed?
A crucial role for CT angiography
The management of a patient with thoracic aorta trauma
varies depending on their condition on arrival at hospital, as
well as whether there are any associated injuries. A care-
ful evaluation by the intensive care team allows the initial
assessment to be made, and as part of this the factors that
could worsen the prognosis must be clearly set out.
Although transoesophageal echocardiography used to be
considered to be the ļ¬rst line technique for exploring a
suspected traumatic aortic injury, recent data from the
literature has conļ¬rmed that CT angiography should take
the main role in the decision process when managing these
Traumatic injuries of the thoracic aorta 695
Figure 2. Artifact of the superior vena cava. Arterial phase CT
angiography of the chest. A part of the bolus of contrast material has
stagnated in the superior vena cava, producing a beam-hardening
artifact (black arrow). This artifact makes it difļ¬cult to assess the
posterior wall of the ascending thoracic artery.
injuries [8]. Initial investigations must therefore be carried
out by CT angiography as soon as the patientā€™s condition
allows [9].
This examination leads to both an accurate diagnosis of
thoracic aorta injuries and allows for a full investigation of
the patient in order to look for any associated injuries.
Given how computed tomography has advanced tech-
nologically and become more widespread, it is possible to
achieve a high quality exploration of the whole body in
the minutes that follow the patientā€™s arrival at the tertiary
trauma centre, and this is the case 24 hours a day.
The protocol that is classically followed is that of the
multiple trauma patient. This consists of a pre-contrast
acquisition of the head and neck, followed by an arterial
phase acquisition covering the neck, chest, abdomen and
pelvis. This is usually followed by a portal phase acquisition
of the abdomen and pelvis, so that any injuries to wholly
intra-abdominal organs can be better studied [10].
ECG-gated CT can only be considered when the team has
received training and the patient is haemodynamically sta-
ble. Nonetheless, this technique, which overcomes the issue
of artifacts related to movements caused by the patientā€™s
heartbeat, can prove to be very useful in some cases by
removing doubts over diagnosis.
A new protocol for computed tomography exploration in
multiple trauma patients has been put forward by Yaniv
et al. [11]. It allows for a single acquisition of the chest,
abdomen and pelvis with a triphasic contrast material injec-
tion. The advantages of this protocol are on the one hand it
entails lower doses of radiation for a population that con-
sists mainly of young people, and on the other there is a
clear reduction in beam-hardening artifacts caused by the
bolus of contrast material. These artifacts occur when the
contrast material stagnates in the superior vena cava, and
they can sometimes be a signiļ¬cant barrier to the accurate
assessment of the aortic arch (Fig. 2).
MRI combines safety with an acceptable diagnostic per-
formance [9]. Nonetheless, this technique is not at present
used in emergency situations. The duration of acquisitions
and the immobility required of the patient prohibit the
Figure 3. Classiļ¬cation of traumatic injuries of the thoracic
aorta. Diagram summarising the different grades (from Iā€”IV) of
traumatic injuries of the thoracic aorta.
According to Adams et al. Endovascular Today, September 2014,
38-42.
use of this modality. In addition, the availability of MRI
equipment means that it cannot be considered for ļ¬rst line
imaging investigations.
Finally, standard radiography is only of value for diagnos-
ing associated chest trauma injuries. Angiography must only
be used prior to the placement of a thoracic endoprosthesis.
How should trauma injury to the thoracic
aorta be classiļ¬ed?
Identifying the class of trauma injury to the thoracic aorta
is the principal purpose of CT angiography. This is because
this classiļ¬cation involves a morphological description of
the injuries that allows a suitable treatment to be chosen,
whether emergent or deferred.
Starnes et al. [12] have proposed a classiļ¬cation based
on the CT angiography images, allowing a distinction
to be made from the outset between two clear groups
(Figs. 3 and 4):
ā€¢ patients with no abnormality to the external contours of
the aorta (grades I and II);
ā€¢ patients with an external contour abnormality to the tho-
racic aorta (grades III and VI).
This classiļ¬cation looks at how serious the injuries are,
meaning it can assist in making decisions about treatment.
Rabin et al. suggested incorporating into this classiļ¬-
cation the following criteria for serious injury: signiļ¬cant
mediastinal haematoma, extent of left haemothorax and the
presence of pseudocoarctation (Figs. 5 and 6) [13].
It is crucial to look for these features that point to
a poor prognosis on CT angiography because they require
696 F.Z. Mokrane et al.
Figure 4. Summary table of the different grades of traumatic thoracic aorta injuries.
emergency treatment. Multiplanar reconstructions are sen-
sitive for the detection of small grade I or II lesions, which
are sometimes difļ¬cult to see on standard axial images. They
also allow the lesions and their extent to be better under-
stood. Finally, they are an essential tool for assessing the
required dimensions of an endoprosthesis when endovascu-
lar treatment is planned [14].
The treatment choice must take into account the rest
of the assessment and other trauma injuries: brain, spine,
abdomen and pelvis, as well as other chest injuries (Fig. 7).
This assessment of injuries will allow therapeutic man-
agement to be ordered in terms of priority, as some injuries
of the thoracic aorta are less urgent to manage than chest
or abdominal injuries.
What are the imaging pitfalls?
A number of artifacts can mimic a traumatic injury of
the thoracic aorta. The classic example is that of the
cardiac pulsation artifact, especially in the ascending
aorta (Fig. 8). If there is any doubt, CT angiography
with ECG-gating or a transoesophageal echocardiogram will
allow this pathology to be excluded in stable patients
[8ā€”15].
Nonetheless, there remain a number of pitfalls that
require particular attention:
ā€¢ pseudo ruptures: on lateral aortic imaging there is an
accumulation of contrast material in a wall crevice, and
this ļ¬nding varies in terms of whether or not it points to
Figure 5. Signs of serious injury: pseudocoarctation. MIP reconstruction of CT angiography of the chest in the oblique sagittal (a), oblique
axial (b) and oblique coronal planes (c). Signiļ¬cant pseudoaneurysm affecting over 50% of the aortic circumference (black stars). The injury
is therefore classiļ¬ed as grade III. However, the clear narrowing of the aorta secondary to compression from the pseudoaneurysm (white
arrows) is a criterion for serious injury and requires emergency treatment.
Traumatic injuries of the thoracic aorta 697
Figure 6. Criteria for serious injury: mediastinal haematoma and haemothorax. MIP reconstruction of CT angiography of the chestā€”axial
plane (a and b), sagittal plane (c) and angiogram image (d). Signiļ¬cant pseudoaneurysm affecting over 50% of the aortic circumference, caus-
ing aortic transection (white arrow); there is also abundant mediastinal haematoma (white stars) and left haemothorax with extravasation
of contrast material into the pleura (white arrow head).
a pathology. It is usually a congenital abnormality, such
as a dilation at the aortic insertion into an arterial canal,
known as ductus diverticulum. Sometimes these images
correspond to acquired conditions, such as aneurysms
or simple or complicated plaques of atherosclerosis
(Fig. 9);
ā€¢ mediastinal haematoma of venous origin: not all mediasti-
nal bleeding corresponds to aortic injury. The literature
Figure 7. Associated injuries: a: standard anteroposterior radiograph demonstrating a complete opacity of the right thoracic hemiļ¬eld
(black star), associated with an over-elevated homolateral diaphragmatic cupola (black arrow); bā€”d: portal phase chest and abdomen CT
angiography; b: sagittal reconstruction; c: coronal reconstruction and d: original axial image. Diaphragmatic rupture, the anterior (black
arrow) and posterior insertions encompass the apparently contused liver where it is displaced upwards into the chest (white stars).
698 F.Z. Mokrane et al.
Figure 8. Cardiac pulsation artifact. CT scan of the chest in
a trauma patient who was in a road trafļ¬c accident. Traumatic
injuries to the left lung (white circle) with bilateral pleural effusion
(white stars). There is an artifact in the ascending aorta: heartbeats
cause the aorta to move and the wall appears irregular, producing
a false image of dissection (white arrows).
describes trauma injuries to the great veins like the supe-
rior vena cava. These injuries are rare but they can be
life-threatening;
ā€¢ mediastinal haematoma secondary to an extra-aortic
injury. It is important to know how to detect abnormalities
of the supra-aortic vessels, possibly using 3D reconstruct-
ions. These dangerous lesions are a therapeutic challenge.
They are often associated with aortic injuries although
they can sometimes be isolated (Fig. 10).
Which injuries must be treated and within
what timeframe?
An assessment of how serious the injuries are is a crucial
factor for choosing treatment.
Figure 10. Imaging pitfall: lesions of the supra-aortic vessels.
Arterial phase MIP reconstruction of coronal CT angiography images
of the chest demonstrating a pseudoaneurysm-type lesion originat-
ing from the brachiocephalic vasculature, (white arrow), leading
to signiļ¬cant mediastinal haematoma (white star). The aorta is
normal.
Many studies have shown that not all traumatic injuries
of the thoracic aorta require emergency treatment and that
some can be treated medically (Figs. 11 and 12) [13]. Aside
from patients presenting signs of complications (signiļ¬cant
left haemothorax, pseudocoarctation or extensive mediasti-
nal haematoma), trauma injuries can be classiļ¬ed into two
distinct groups according to their course:
ā€¢ injuries in which the external wall of the aorta is spared:
these are grade I and II injuries and they can be treated
medically, combined with close monitoring (Fig. 13).
Grade III injuries with no signs of serious damage must
undergo invasive treatment, but this can sometimes be
deferred depending on the relative priority of treat-
ing other trauma injuries. It is, however, reasonable in
these cases to treat with placement of a stent graft in
Figure 9. Imaging pitfall: complicated atherosclerosis. Axial (a left) and oblique coronal reconstructions (b right) of a chest CT angiogram
with ECG-gating in an 83-year old woman hospitalised after a road trafļ¬c accident. On lateral aortic imaging there is an accumulation of
contrast material in a wall crevice that could be suggestive of a grade I trauma injury (white arrows). However, the irregular appearance of
the aorta wall (black arrow), the overall increase in the diameter of the aorta, and the presence of ļ¬ne calciļ¬cations (white arrow head)
all point primarily to plaque ulceration. A look at the patientā€™s previous imaging conļ¬rmed this diagnosis.
Traumatic injuries of the thoracic aorta 699
Figure 11. Grade I traumatic injuries. Arterial phase axial plane CT angiography of the chest (a and b), as well as a curvilinear recon-
struction of the aorta (c) highlighting multiple intimal ļ¬‚aps (black arrows), sparing the external wall of the aorta.
the 24 hours following the patient becoming haemody-
namically stable and surgical conditions being optimal.
Nonetheless, the intervention must not be delayed for too
long in order to avoid a secondary rupture;
ā€¢ grade III injuries with signs of serious damage must be
treated as grade IV injuries (Fig. 14) meaning that they
must be treated as an emergency. These injuries cause
increased mortality (Fig. 15).
This treatment decision tree is based on the natural his-
tory of thoracic aorta trauma. Indeed, over half of grade I
and II injuries will resolve spontaneously with medical treat-
ment only. Just 5% of grade I and II injuries deteriorate [16].
Furthermore, Harris et al. recently demonstrated that
a lactate level on admission exceeding 4 mmol/L, a pos-
terior mediastinal haematoma of over 10 mm in size, and
a ratio between lesion size and normal aortic diameter
Figure 12. Course of grade I traumatic injuries. Same patient as in Fig. 11. Repeat CT imaging after three months of medical treatment
only shows full resolution of images secondary to the trauma.
700 F.Z. Mokrane et al.
Figure 13. Follow-up of grade I and II injuries: a: CT angiography of the thoracic aorta demonstrating a small grade I injury to the
thoracic aorta (black arrow); medical treatment and close monitoring was chosen; b: MIP reconstruction of repeat axial CT angiography
images four months after the accident. The injury has deteriorated and pseudoaneurysm has worsened (white arrow). Placement of a
thoracic endovascular stent is chosen; c and d: MR angiography of the chest with volume reconstruction (left) and MIP reconstruction (right)
of sagittal views seven years after the treatment. The stent has expanded well and there is no leakage of note.
exceeding 1:4 are prognostic factors for aortic rupture
[16].
Once again, CT angiography ļ¬nds its place in the
pre-treatment assessment. The various multiplanar recons-
tructions allow the calibre of the aorta to be assessed, which
assists in the choice of aortic endoprosthesis. Abdominal and
pelvic images also mean that the various femoral or brachial
access routes can be assessed.
Which invasive treatment should be
offered?
The approach to treatment varies from one unit to another,
in spite of several attempts to bring practices in line [17].
However, over the last decade endovascular treatment
has clearly become the ļ¬rst line treatment over open
surgery, as long as it is technically possible in view of the
topography and extent of the injuries. This is because the
placement of an endovascular stent often leads to effective
repair of traumatic aortic injury, with a fall in morbidity and
mortality [18,19].
Indeed, the various studies from the literature all report
the same positive results where endovascular treatment is
concerned. The technical success rate often reaches 100%,
with cause-speciļ¬c mortality at 30 days hovering around
2.1%, and a two-year survival rate of 93.7%, and this comes
with no neurological deļ¬cits linked to the intervention
[20,21].
Nonetheless, as with any endovascular procedure, place-
ment of an aortic endoprosthesis is not devoid of risk,
with mortality during the intervention of around 4% and
periprocedural mortality of around 16%. This mortality rate
is of course more often attributable to the traumatic injury
itself rather than to an iatrogenic complication. Spinal
cord ischaemia remains a very rare complication in this
condition, estimated to arise in fewer than 1% of cases
[22,23].
Traumatic injuries of the thoracic aorta 701
Figure 14. Endovascular treatment. Same patient as in Fig. 5: a: angiography image after placement of the endovascular stent and
occlusion of the left subclavian artery (black arrow); b and c: repeat CT angiography seven years after the intervention, sagittal and axial
reconstructions. Optimum expansion of the endovascular stent, with retrograde circulation the left subclavian artery (white arrow).
While this technique is promising, there is a lack of ret-
rospective information meaning that its reliability in the
long-term cannot be assessed, especially in young patients,
so patients will require regular follow-up.
Technical aspects: what special
precautions should be taken?
When imaging examinations are carried out, the patientā€™s
state of haemodynamic shock associated with hypovolaemia
and vasoconstricition gives rise to the risk that the diameters
for the endoprosthesis may be underestimated. Because of
this, it is important to overestimate the size of the stent by
at least 15% in order to avoid the risk of secondary leakage.
Nonetheless, the data from the literature are not consistent,
and this remains an issue at present [24].
The existence of any anatomical variants must be noted
in the pre-treatment CT angiogram report. For example, an
arteria lusoria may need to be occluded before an endo-
prosthesis can be placed in the descending thoracic aorta
(Fig. 16). Angiography of the supra-aortic vessels is also
indispensable in order to check whether the circle of Willis
is complete, especially before the intentional occlusion of
the left subclavian artery, without prior stenting.
Figure 15. Endovascular treatment of a grade IV injury; a: arterial phase MIP reconstruction of coronal CT angiogram images of the
chest demonstrating a signiļ¬cant aortic dissection in the descending thoracic section, with massive extravasation of contrast material;
b: anteroposterior aortography demonstrating extravasation of contrast material; c: oblique aortography after placement of a thoracic
endovascular stent. Contrast material extravasation resolves conļ¬rming that the endovascular stent is positioned correctly.
702 F.Z. Mokrane et al.
Figure 16. Anatomical variant and aortic trauma. Arterial phase CT angiography of the chestā€”axial images (a and b) and MIP reconstruction
of coronal images (c). Grade III traumatic thoracic aorta injury (white arrow heads) associated with a mediastinal haematoma (white arrows).
Presence of restroesophageal right subclavian artery (black arrow).
How should traumatic injury of the
thoracic aorta be monitored?
A traumatic injury of the thoracic aorta must be moni-
tored closely in the period immediately after the trauma,
especially when it is a lower grade injury that has been
treated medically.
This follow-up should preferably be performed using CT
angiography (Fig. 17).
Later on, it is recommended that MR angiography
should be performed for follow-up. This is because MRI
Figure 17. CT angiography before and after treatment. Arterial phase CT angiography of the chest in the axial (a) and oblique sagittal
planes (b) demonstrating a grade III thoracic aorta injury (white arrows) with mediastinal haematoma (white star). Emergency endovascular
treatment is chosen. c-d: repeat CT angiography of the chest three years after endovascular stent placement: axial view (c) and MIP
reconstruction of oblique sagittal images (d) conļ¬rm that the stent has expanded correctly and there is no leakage.
Traumatic injuries of the thoracic aorta 703
offers acceptable sensitivity and speciļ¬city while avoiding
recourse to irradiating examinations.
Conclusion
Traumatic pathologies of the thoracic aorta are serious and
associated with signiļ¬cant mortality. CT angiography of the
chest is the ļ¬rst line examination to carry out in stable
patients. An improved understanding of the pathophysiology
of these injuries today allows endovascular treatment to be
offered only to patients with serious (grades III and IV) or
complicated injuries.
Grade I and II injuries can be treated medically combined
with close monitoring.
Later follow-up of these injuries should preferably use
MR angiography.
Take-home messages
Diagnosis
ā€¢ Thoracic aorta trauma injuries are a diagnostic
emergency.
ā€¢ CT angiography of the chest is the examination of
choice if there is any suspicion of traumatic injury to
the thoracic aorta in a haemodynamically stabilised
patient.
ā€¢ CT angiography allows a positive diagnosis of
traumatic injury to the thoracic aorta to be made, as
well as an exhaustive assessment of other associated
trauma injuries.
ā€¢ Modern imaging modalities usually allow imaging
pitfalls to be overcome, whether these are artifacts
or other issues.
ā€¢ If there is any doubt over diagnosis, a
transoesophageal echocardiogram (as an emergency)
or ECG-gated CT angiography (deferred) can resolve
this.
Management
ā€¢ It is important to accurately describe the traumatic
injuries in their entirety so that the overall
therapeutic management can be ordered in terms of
priority.
ā€¢ Classifying traumatic injuries to the thoracic aorta
means that they can be assessed in terms of how
serious they are, allowing appropriately emergent
treatment to be offered and possibly deferring
treatment.
ā€¢ Trauma injuries that spare the external wall of the
aorta (grades I and II) can be managed with medical
treatment only, as long as there are no signs of
serious injury.
ā€¢ Signs pointing to a serious aortic trauma injury are:
abundant left haemothorax, extensive mediastinal
haematoma and pseudocoarctation.
ā€¢ Trauma injuries involving the external wall of the
aorta (grades III and IV) constitute an indication for
endovascular treatment.
ā€¢ In grade III injuries, deferring treatment is possible
(for 24 hours), as long as there are no associated signs
of serious damage.
ā€¢ Grade IV injuries, and any other injury in which there
are signs of serious damage, require emergency
invasive management.
ā€¢ Endovascular stents are the gold standard treatment
for traumatic injuries to the thoracic aorta.
ā€¢ CT angiography prior to the procedure allows the
appropriate material to be chosen, the approach
routes to be assessed and the measurements for the
endoprosthesis to be made.
ā€¢ It is important to overestimate the stent
measurements by at least 15%.
Follow-up
ā€¢ Whether injuries are untreated (grades I and II with
no signs of complications) or treated (grades III and
IV with or without complications), they need close
follow-up at extremely regular intervals in the acute
phase.
ā€¢ Later on, aortic endovascular stents will need regular
annual monitoring.
ā€¢ In view of the young age of the target population and
the repeated examinations envisaged for follow-up,
it is desirable that these should be performed using
MR angiography.
Clinical case study
This 30-year-old male was brought to the emergency depart-
ment following multiple injuries due to a road trafļ¬c
accident. The angiogram images showing a grade III rupture
to the thoracic aorta and the outcome of the intervention
(stent graft) are provided (Fig. 18).
Questions
1) 12 hours after the stent graft has been inserted, an emer-
gent repeat CT scan is carried out due to persistence
of a state of shock. Based on the imaging you receive
(Fig. 19), what is your diagnosis? What management
would you suggest?
2) Angiography imaging is performed (Fig. 20). Describe the
abnormalities. What precautions would you take prior to
any intervention?
3) Repeat CT imaging is provided (Fig. 21). Describe the
abnormalities. How often would you continue with
follow-up imaging and using which modality?
Answers
1)
ā€¢ Leakage from around the stent fed by the left subclavian
artery.
ā€¢ Action to take: emergency embolisation of the left sub-
clavian artery.
2)
ā€¢ Conļ¬rmation that the leakage originates from the left
subclavian artery.
704 F.Z. Mokrane et al.
Figure 18. Initial treatment. Left: pseudoaneurysm deforming
the external contours of the aorta, affecting over 50% of the arte-
rial circumference (classiļ¬ed as grade III), straddling the origin of
the supra-aortic vessels. Right: Repeat imaging at the end of treat-
ment. The covered endovascular stent placed in the horizontal and
descending portions of the thoracic aorta leads to exclusion of the
pseudoaneurysm and recovery of a normal calibre, all the while
sparing the vasculature of the left brachiocephalic and common
carotid arteries. This result is achieved through the intentional
exclusion of the left subclavian artery, after having checked that
the right vertebral artery was patent.
ā€¢ Check that the rupture does indeed concern the aorta
rather than other vascular segments (supra-aortic vessels,
mediastinal veins).
ā€¢ Check the right vertebral artery and whether the circle of
Willis is complete before embolisation of the left subcla-
vian artery.
Figure 20. Angiography. Contrast material administered via the
brachial route to the left subclavian artery conļ¬rms the opaciļ¬-
cation of the pseudoaneurysm through a tear at the origin of this
artery, as well as a slight traumatic dissection of the artery down-
stream (left internal thoracic artery protrudes over the lesion).
ā€¢ The embolisation site must be before the vertebral artery.
3)
ā€¢ Complete occlusion of the left subclavian artery with
exclusion of the leak originating from this artery, the
Figure 19. CT angiography of the chest performed 12 hours after placement of a stent graft, carried out because the patient deteriorated
clinically. A bilateral pleural effusion of moderate abundance can be seen entailing collapse of the pulmonary parenchyma, and above all
a type II endoleak fed by the left subclavian artery which is making the pseudoaneurysm patent once again.
Traumatic injuries of the thoracic aorta 705
Figure 21. Repeat CT angiography. The pseudoaneurysm has been
excluded by coil embolisation in the proximal left subclavian artery.
The left subclavian artery ļ¬‚ow is rerouted by a reversal of the ļ¬‚ow
through the left vertebral artery.
distal left subclavian artery ļ¬‚ow is rerouted by an inver-
sion of the ļ¬‚ow in the vertebral artery.
ā€¢ Annual follow-up with MR angiography in view of the
patientā€™s young age.
Disclosure of interest
The authors declare that they have no conļ¬‚icts of interest
concerning this article.
References
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Diagnosing and Treating Thoracic Aorta Injuries

  • 1. Diagnostic and Interventional Imaging (2015) 96, 693ā€”706 CONTINUING EDUCATION PROGRAM: FOCUS. . . Traumatic injuries of the thoracic aorta: The role of imaging in diagnosis and treatment F.Z. Mokranea,āˆ— , P. Revel-Mouroza , B. Saint Lebesb , H. Rousseaua a Department of Radiology, CHU Rangueil Toulouse, 1, avenue du Professeur-Jean-PoulhĆØs, TSA 50032, 31059 Toulouse cedex 9, France b Department of Vascular Surgery, CHU Rangueil Toulouse, 1, avenue du Professeur-Jean-PoulhĆØs, TSA 50032, 31059 Toulouse cedex 9, France KEYWORDS Thoracic aorta; Emergency medicine; Trauma; Endoprosthesis; Stent graft Abstract Traumatic injury of the thoracic aorta remains the leading cause of death in multiple trauma patients and it requires urgent management. Computed tomography has a key diagnostic role and allows the clinician to choose an appropriate treatment strategy. The development of new classiļ¬cations, based on a better understanding of the mechanisms of these injuries, has clariļ¬ed the indications for treatment. Advances in techniques, especially in endovascular management, have contributed to improving prognosis for patients. Interventional radiology, which usually consists of endovascular placement of a covered stent, now constitutes the gold standard treatment in these injuries. Due to the potentially grave prognosis of these patients, it is crucial to know how to detect these injuries and to describe the imaging signs of serious damage. Ā© 2015 Ɖditions francĀøaises de radiologie. Published by Elsevier Masson SAS. All rights reserved. Road trafļ¬c accidents are the main cause of aortic trauma. Traumatic injury of the large vessels is being seen with increasing incidence in tertiary trauma units. While during the 20th century this rise could be attributed to an increase in numbers of road trafļ¬c acci- dents, today it is the improved initial management on the part of emergency care networks, at the head of which are emergency ambulance services, that is responsible for a fall in early deaths, and this explains why there is a growing number of patients who manage to survive until they are admitted to a hospital unit [1,2]. āˆ— Corresponding author. E-mail address: mokrane fatimazohra@yahoo.fr (F.Z. Mokrane). http://dx.doi.org/10.1016/j.diii.2015.06.005 2211-5684/Ā© 2015 Ɖditions francĀøaises de radiologie. Published by Elsevier Masson SAS. All rights reserved.
  • 2. 694 F.Z. Mokrane et al. These traumatic injuries have a signiļ¬cant mortality rate. The Princeps study by Parmley et al. reported a death rate of 80%, a survival rate of 20% and a development of chronic disease rate of 5% [1]. The improvement shown by these ļ¬gures is largely due to effective emergency management and the expansion of treatment with stent grafts. Indeed, although only 38% of patients survive follow- ing aortic trauma, better management at the scene of the accident and quicker transportation to hospitals has led to improvements in overall survival. Speciļ¬cally, only 4% of patients die on the way to the hospital. Nonetheless, mortal- ity around the time of the injury remains high, estimated at 20% in the 24 hours following the hospital admission [1ā€”4]. This serious pathology therefore needs quick, effective and consensual management. Sites of predilection, mechanism and pathophysiology The pathophysiology of thoracic aorta trauma injury is com- plex. The greater frequency of aortic isthmus damage is in part related to its anatomical position, which is relatively ļ¬xed within the rib cage [5]. In a high-velocity trauma, such as a road trafļ¬c accident, the thoracic aorta is subjected to rapid deceleration together with compression of the chest wall. Associated with this are complex torsion or stretching Figure 1. Multiplanar CT angiography reconstructions of the thoracic aorta. Illustration of the preferential topographical distribution of traumatic injuries: a: accumulation of contrast material in a crevice in the ascending thoracic aorta wall, located at the aortic valve cusps (white arrow); b: presence of two trauma injuries: an injury to the aortic root, located immediately above the sinus of Valsalva (white circle); another injury to the descending thoracic aorta at its junction with the isthmus (black arrow); c: traumatic pseudoaneurysm (white circle) of the aortic arch, originating between the left carotid artery (black arrow head) and left subclavian artery (white arrow head); d: traumatic rupture of the descending thoracic aorta with signiļ¬cant extravasation of contrast material in the arterial phase (white circle), explaining the abundant mediastinal haematoma (white star). injuries to the aortic wall, especially at the points of ļ¬xa- tion, which explains the increased frequency of injury to the aortic isthmus [5,6] (Fig. 1). By contrast, injuries to the ascending thoracic aorta are probably just as common but they are seen less often because they are so serious that they are frequently the cause of immediate death [5,7]. The circumstances in which these injuries arise are, in decreasing order of frequency: road trafļ¬c accidents, crus- hing accidents, falls from a height and other deceleration accidents that occur during sports such as skiing [2ā€”6]. Which examinations should be performed? A crucial role for CT angiography The management of a patient with thoracic aorta trauma varies depending on their condition on arrival at hospital, as well as whether there are any associated injuries. A care- ful evaluation by the intensive care team allows the initial assessment to be made, and as part of this the factors that could worsen the prognosis must be clearly set out. Although transoesophageal echocardiography used to be considered to be the ļ¬rst line technique for exploring a suspected traumatic aortic injury, recent data from the literature has conļ¬rmed that CT angiography should take the main role in the decision process when managing these
  • 3. Traumatic injuries of the thoracic aorta 695 Figure 2. Artifact of the superior vena cava. Arterial phase CT angiography of the chest. A part of the bolus of contrast material has stagnated in the superior vena cava, producing a beam-hardening artifact (black arrow). This artifact makes it difļ¬cult to assess the posterior wall of the ascending thoracic artery. injuries [8]. Initial investigations must therefore be carried out by CT angiography as soon as the patientā€™s condition allows [9]. This examination leads to both an accurate diagnosis of thoracic aorta injuries and allows for a full investigation of the patient in order to look for any associated injuries. Given how computed tomography has advanced tech- nologically and become more widespread, it is possible to achieve a high quality exploration of the whole body in the minutes that follow the patientā€™s arrival at the tertiary trauma centre, and this is the case 24 hours a day. The protocol that is classically followed is that of the multiple trauma patient. This consists of a pre-contrast acquisition of the head and neck, followed by an arterial phase acquisition covering the neck, chest, abdomen and pelvis. This is usually followed by a portal phase acquisition of the abdomen and pelvis, so that any injuries to wholly intra-abdominal organs can be better studied [10]. ECG-gated CT can only be considered when the team has received training and the patient is haemodynamically sta- ble. Nonetheless, this technique, which overcomes the issue of artifacts related to movements caused by the patientā€™s heartbeat, can prove to be very useful in some cases by removing doubts over diagnosis. A new protocol for computed tomography exploration in multiple trauma patients has been put forward by Yaniv et al. [11]. It allows for a single acquisition of the chest, abdomen and pelvis with a triphasic contrast material injec- tion. The advantages of this protocol are on the one hand it entails lower doses of radiation for a population that con- sists mainly of young people, and on the other there is a clear reduction in beam-hardening artifacts caused by the bolus of contrast material. These artifacts occur when the contrast material stagnates in the superior vena cava, and they can sometimes be a signiļ¬cant barrier to the accurate assessment of the aortic arch (Fig. 2). MRI combines safety with an acceptable diagnostic per- formance [9]. Nonetheless, this technique is not at present used in emergency situations. The duration of acquisitions and the immobility required of the patient prohibit the Figure 3. Classiļ¬cation of traumatic injuries of the thoracic aorta. Diagram summarising the different grades (from Iā€”IV) of traumatic injuries of the thoracic aorta. According to Adams et al. Endovascular Today, September 2014, 38-42. use of this modality. In addition, the availability of MRI equipment means that it cannot be considered for ļ¬rst line imaging investigations. Finally, standard radiography is only of value for diagnos- ing associated chest trauma injuries. Angiography must only be used prior to the placement of a thoracic endoprosthesis. How should trauma injury to the thoracic aorta be classiļ¬ed? Identifying the class of trauma injury to the thoracic aorta is the principal purpose of CT angiography. This is because this classiļ¬cation involves a morphological description of the injuries that allows a suitable treatment to be chosen, whether emergent or deferred. Starnes et al. [12] have proposed a classiļ¬cation based on the CT angiography images, allowing a distinction to be made from the outset between two clear groups (Figs. 3 and 4): ā€¢ patients with no abnormality to the external contours of the aorta (grades I and II); ā€¢ patients with an external contour abnormality to the tho- racic aorta (grades III and VI). This classiļ¬cation looks at how serious the injuries are, meaning it can assist in making decisions about treatment. Rabin et al. suggested incorporating into this classiļ¬- cation the following criteria for serious injury: signiļ¬cant mediastinal haematoma, extent of left haemothorax and the presence of pseudocoarctation (Figs. 5 and 6) [13]. It is crucial to look for these features that point to a poor prognosis on CT angiography because they require
  • 4. 696 F.Z. Mokrane et al. Figure 4. Summary table of the different grades of traumatic thoracic aorta injuries. emergency treatment. Multiplanar reconstructions are sen- sitive for the detection of small grade I or II lesions, which are sometimes difļ¬cult to see on standard axial images. They also allow the lesions and their extent to be better under- stood. Finally, they are an essential tool for assessing the required dimensions of an endoprosthesis when endovascu- lar treatment is planned [14]. The treatment choice must take into account the rest of the assessment and other trauma injuries: brain, spine, abdomen and pelvis, as well as other chest injuries (Fig. 7). This assessment of injuries will allow therapeutic man- agement to be ordered in terms of priority, as some injuries of the thoracic aorta are less urgent to manage than chest or abdominal injuries. What are the imaging pitfalls? A number of artifacts can mimic a traumatic injury of the thoracic aorta. The classic example is that of the cardiac pulsation artifact, especially in the ascending aorta (Fig. 8). If there is any doubt, CT angiography with ECG-gating or a transoesophageal echocardiogram will allow this pathology to be excluded in stable patients [8ā€”15]. Nonetheless, there remain a number of pitfalls that require particular attention: ā€¢ pseudo ruptures: on lateral aortic imaging there is an accumulation of contrast material in a wall crevice, and this ļ¬nding varies in terms of whether or not it points to Figure 5. Signs of serious injury: pseudocoarctation. MIP reconstruction of CT angiography of the chest in the oblique sagittal (a), oblique axial (b) and oblique coronal planes (c). Signiļ¬cant pseudoaneurysm affecting over 50% of the aortic circumference (black stars). The injury is therefore classiļ¬ed as grade III. However, the clear narrowing of the aorta secondary to compression from the pseudoaneurysm (white arrows) is a criterion for serious injury and requires emergency treatment.
  • 5. Traumatic injuries of the thoracic aorta 697 Figure 6. Criteria for serious injury: mediastinal haematoma and haemothorax. MIP reconstruction of CT angiography of the chestā€”axial plane (a and b), sagittal plane (c) and angiogram image (d). Signiļ¬cant pseudoaneurysm affecting over 50% of the aortic circumference, caus- ing aortic transection (white arrow); there is also abundant mediastinal haematoma (white stars) and left haemothorax with extravasation of contrast material into the pleura (white arrow head). a pathology. It is usually a congenital abnormality, such as a dilation at the aortic insertion into an arterial canal, known as ductus diverticulum. Sometimes these images correspond to acquired conditions, such as aneurysms or simple or complicated plaques of atherosclerosis (Fig. 9); ā€¢ mediastinal haematoma of venous origin: not all mediasti- nal bleeding corresponds to aortic injury. The literature Figure 7. Associated injuries: a: standard anteroposterior radiograph demonstrating a complete opacity of the right thoracic hemiļ¬eld (black star), associated with an over-elevated homolateral diaphragmatic cupola (black arrow); bā€”d: portal phase chest and abdomen CT angiography; b: sagittal reconstruction; c: coronal reconstruction and d: original axial image. Diaphragmatic rupture, the anterior (black arrow) and posterior insertions encompass the apparently contused liver where it is displaced upwards into the chest (white stars).
  • 6. 698 F.Z. Mokrane et al. Figure 8. Cardiac pulsation artifact. CT scan of the chest in a trauma patient who was in a road trafļ¬c accident. Traumatic injuries to the left lung (white circle) with bilateral pleural effusion (white stars). There is an artifact in the ascending aorta: heartbeats cause the aorta to move and the wall appears irregular, producing a false image of dissection (white arrows). describes trauma injuries to the great veins like the supe- rior vena cava. These injuries are rare but they can be life-threatening; ā€¢ mediastinal haematoma secondary to an extra-aortic injury. It is important to know how to detect abnormalities of the supra-aortic vessels, possibly using 3D reconstruct- ions. These dangerous lesions are a therapeutic challenge. They are often associated with aortic injuries although they can sometimes be isolated (Fig. 10). Which injuries must be treated and within what timeframe? An assessment of how serious the injuries are is a crucial factor for choosing treatment. Figure 10. Imaging pitfall: lesions of the supra-aortic vessels. Arterial phase MIP reconstruction of coronal CT angiography images of the chest demonstrating a pseudoaneurysm-type lesion originat- ing from the brachiocephalic vasculature, (white arrow), leading to signiļ¬cant mediastinal haematoma (white star). The aorta is normal. Many studies have shown that not all traumatic injuries of the thoracic aorta require emergency treatment and that some can be treated medically (Figs. 11 and 12) [13]. Aside from patients presenting signs of complications (signiļ¬cant left haemothorax, pseudocoarctation or extensive mediasti- nal haematoma), trauma injuries can be classiļ¬ed into two distinct groups according to their course: ā€¢ injuries in which the external wall of the aorta is spared: these are grade I and II injuries and they can be treated medically, combined with close monitoring (Fig. 13). Grade III injuries with no signs of serious damage must undergo invasive treatment, but this can sometimes be deferred depending on the relative priority of treat- ing other trauma injuries. It is, however, reasonable in these cases to treat with placement of a stent graft in Figure 9. Imaging pitfall: complicated atherosclerosis. Axial (a left) and oblique coronal reconstructions (b right) of a chest CT angiogram with ECG-gating in an 83-year old woman hospitalised after a road trafļ¬c accident. On lateral aortic imaging there is an accumulation of contrast material in a wall crevice that could be suggestive of a grade I trauma injury (white arrows). However, the irregular appearance of the aorta wall (black arrow), the overall increase in the diameter of the aorta, and the presence of ļ¬ne calciļ¬cations (white arrow head) all point primarily to plaque ulceration. A look at the patientā€™s previous imaging conļ¬rmed this diagnosis.
  • 7. Traumatic injuries of the thoracic aorta 699 Figure 11. Grade I traumatic injuries. Arterial phase axial plane CT angiography of the chest (a and b), as well as a curvilinear recon- struction of the aorta (c) highlighting multiple intimal ļ¬‚aps (black arrows), sparing the external wall of the aorta. the 24 hours following the patient becoming haemody- namically stable and surgical conditions being optimal. Nonetheless, the intervention must not be delayed for too long in order to avoid a secondary rupture; ā€¢ grade III injuries with signs of serious damage must be treated as grade IV injuries (Fig. 14) meaning that they must be treated as an emergency. These injuries cause increased mortality (Fig. 15). This treatment decision tree is based on the natural his- tory of thoracic aorta trauma. Indeed, over half of grade I and II injuries will resolve spontaneously with medical treat- ment only. Just 5% of grade I and II injuries deteriorate [16]. Furthermore, Harris et al. recently demonstrated that a lactate level on admission exceeding 4 mmol/L, a pos- terior mediastinal haematoma of over 10 mm in size, and a ratio between lesion size and normal aortic diameter Figure 12. Course of grade I traumatic injuries. Same patient as in Fig. 11. Repeat CT imaging after three months of medical treatment only shows full resolution of images secondary to the trauma.
  • 8. 700 F.Z. Mokrane et al. Figure 13. Follow-up of grade I and II injuries: a: CT angiography of the thoracic aorta demonstrating a small grade I injury to the thoracic aorta (black arrow); medical treatment and close monitoring was chosen; b: MIP reconstruction of repeat axial CT angiography images four months after the accident. The injury has deteriorated and pseudoaneurysm has worsened (white arrow). Placement of a thoracic endovascular stent is chosen; c and d: MR angiography of the chest with volume reconstruction (left) and MIP reconstruction (right) of sagittal views seven years after the treatment. The stent has expanded well and there is no leakage of note. exceeding 1:4 are prognostic factors for aortic rupture [16]. Once again, CT angiography ļ¬nds its place in the pre-treatment assessment. The various multiplanar recons- tructions allow the calibre of the aorta to be assessed, which assists in the choice of aortic endoprosthesis. Abdominal and pelvic images also mean that the various femoral or brachial access routes can be assessed. Which invasive treatment should be offered? The approach to treatment varies from one unit to another, in spite of several attempts to bring practices in line [17]. However, over the last decade endovascular treatment has clearly become the ļ¬rst line treatment over open surgery, as long as it is technically possible in view of the topography and extent of the injuries. This is because the placement of an endovascular stent often leads to effective repair of traumatic aortic injury, with a fall in morbidity and mortality [18,19]. Indeed, the various studies from the literature all report the same positive results where endovascular treatment is concerned. The technical success rate often reaches 100%, with cause-speciļ¬c mortality at 30 days hovering around 2.1%, and a two-year survival rate of 93.7%, and this comes with no neurological deļ¬cits linked to the intervention [20,21]. Nonetheless, as with any endovascular procedure, place- ment of an aortic endoprosthesis is not devoid of risk, with mortality during the intervention of around 4% and periprocedural mortality of around 16%. This mortality rate is of course more often attributable to the traumatic injury itself rather than to an iatrogenic complication. Spinal cord ischaemia remains a very rare complication in this condition, estimated to arise in fewer than 1% of cases [22,23].
  • 9. Traumatic injuries of the thoracic aorta 701 Figure 14. Endovascular treatment. Same patient as in Fig. 5: a: angiography image after placement of the endovascular stent and occlusion of the left subclavian artery (black arrow); b and c: repeat CT angiography seven years after the intervention, sagittal and axial reconstructions. Optimum expansion of the endovascular stent, with retrograde circulation the left subclavian artery (white arrow). While this technique is promising, there is a lack of ret- rospective information meaning that its reliability in the long-term cannot be assessed, especially in young patients, so patients will require regular follow-up. Technical aspects: what special precautions should be taken? When imaging examinations are carried out, the patientā€™s state of haemodynamic shock associated with hypovolaemia and vasoconstricition gives rise to the risk that the diameters for the endoprosthesis may be underestimated. Because of this, it is important to overestimate the size of the stent by at least 15% in order to avoid the risk of secondary leakage. Nonetheless, the data from the literature are not consistent, and this remains an issue at present [24]. The existence of any anatomical variants must be noted in the pre-treatment CT angiogram report. For example, an arteria lusoria may need to be occluded before an endo- prosthesis can be placed in the descending thoracic aorta (Fig. 16). Angiography of the supra-aortic vessels is also indispensable in order to check whether the circle of Willis is complete, especially before the intentional occlusion of the left subclavian artery, without prior stenting. Figure 15. Endovascular treatment of a grade IV injury; a: arterial phase MIP reconstruction of coronal CT angiogram images of the chest demonstrating a signiļ¬cant aortic dissection in the descending thoracic section, with massive extravasation of contrast material; b: anteroposterior aortography demonstrating extravasation of contrast material; c: oblique aortography after placement of a thoracic endovascular stent. Contrast material extravasation resolves conļ¬rming that the endovascular stent is positioned correctly.
  • 10. 702 F.Z. Mokrane et al. Figure 16. Anatomical variant and aortic trauma. Arterial phase CT angiography of the chestā€”axial images (a and b) and MIP reconstruction of coronal images (c). Grade III traumatic thoracic aorta injury (white arrow heads) associated with a mediastinal haematoma (white arrows). Presence of restroesophageal right subclavian artery (black arrow). How should traumatic injury of the thoracic aorta be monitored? A traumatic injury of the thoracic aorta must be moni- tored closely in the period immediately after the trauma, especially when it is a lower grade injury that has been treated medically. This follow-up should preferably be performed using CT angiography (Fig. 17). Later on, it is recommended that MR angiography should be performed for follow-up. This is because MRI Figure 17. CT angiography before and after treatment. Arterial phase CT angiography of the chest in the axial (a) and oblique sagittal planes (b) demonstrating a grade III thoracic aorta injury (white arrows) with mediastinal haematoma (white star). Emergency endovascular treatment is chosen. c-d: repeat CT angiography of the chest three years after endovascular stent placement: axial view (c) and MIP reconstruction of oblique sagittal images (d) conļ¬rm that the stent has expanded correctly and there is no leakage.
  • 11. Traumatic injuries of the thoracic aorta 703 offers acceptable sensitivity and speciļ¬city while avoiding recourse to irradiating examinations. Conclusion Traumatic pathologies of the thoracic aorta are serious and associated with signiļ¬cant mortality. CT angiography of the chest is the ļ¬rst line examination to carry out in stable patients. An improved understanding of the pathophysiology of these injuries today allows endovascular treatment to be offered only to patients with serious (grades III and IV) or complicated injuries. Grade I and II injuries can be treated medically combined with close monitoring. Later follow-up of these injuries should preferably use MR angiography. Take-home messages Diagnosis ā€¢ Thoracic aorta trauma injuries are a diagnostic emergency. ā€¢ CT angiography of the chest is the examination of choice if there is any suspicion of traumatic injury to the thoracic aorta in a haemodynamically stabilised patient. ā€¢ CT angiography allows a positive diagnosis of traumatic injury to the thoracic aorta to be made, as well as an exhaustive assessment of other associated trauma injuries. ā€¢ Modern imaging modalities usually allow imaging pitfalls to be overcome, whether these are artifacts or other issues. ā€¢ If there is any doubt over diagnosis, a transoesophageal echocardiogram (as an emergency) or ECG-gated CT angiography (deferred) can resolve this. Management ā€¢ It is important to accurately describe the traumatic injuries in their entirety so that the overall therapeutic management can be ordered in terms of priority. ā€¢ Classifying traumatic injuries to the thoracic aorta means that they can be assessed in terms of how serious they are, allowing appropriately emergent treatment to be offered and possibly deferring treatment. ā€¢ Trauma injuries that spare the external wall of the aorta (grades I and II) can be managed with medical treatment only, as long as there are no signs of serious injury. ā€¢ Signs pointing to a serious aortic trauma injury are: abundant left haemothorax, extensive mediastinal haematoma and pseudocoarctation. ā€¢ Trauma injuries involving the external wall of the aorta (grades III and IV) constitute an indication for endovascular treatment. ā€¢ In grade III injuries, deferring treatment is possible (for 24 hours), as long as there are no associated signs of serious damage. ā€¢ Grade IV injuries, and any other injury in which there are signs of serious damage, require emergency invasive management. ā€¢ Endovascular stents are the gold standard treatment for traumatic injuries to the thoracic aorta. ā€¢ CT angiography prior to the procedure allows the appropriate material to be chosen, the approach routes to be assessed and the measurements for the endoprosthesis to be made. ā€¢ It is important to overestimate the stent measurements by at least 15%. Follow-up ā€¢ Whether injuries are untreated (grades I and II with no signs of complications) or treated (grades III and IV with or without complications), they need close follow-up at extremely regular intervals in the acute phase. ā€¢ Later on, aortic endovascular stents will need regular annual monitoring. ā€¢ In view of the young age of the target population and the repeated examinations envisaged for follow-up, it is desirable that these should be performed using MR angiography. Clinical case study This 30-year-old male was brought to the emergency depart- ment following multiple injuries due to a road trafļ¬c accident. The angiogram images showing a grade III rupture to the thoracic aorta and the outcome of the intervention (stent graft) are provided (Fig. 18). Questions 1) 12 hours after the stent graft has been inserted, an emer- gent repeat CT scan is carried out due to persistence of a state of shock. Based on the imaging you receive (Fig. 19), what is your diagnosis? What management would you suggest? 2) Angiography imaging is performed (Fig. 20). Describe the abnormalities. What precautions would you take prior to any intervention? 3) Repeat CT imaging is provided (Fig. 21). Describe the abnormalities. How often would you continue with follow-up imaging and using which modality? Answers 1) ā€¢ Leakage from around the stent fed by the left subclavian artery. ā€¢ Action to take: emergency embolisation of the left sub- clavian artery. 2) ā€¢ Conļ¬rmation that the leakage originates from the left subclavian artery.
  • 12. 704 F.Z. Mokrane et al. Figure 18. Initial treatment. Left: pseudoaneurysm deforming the external contours of the aorta, affecting over 50% of the arte- rial circumference (classiļ¬ed as grade III), straddling the origin of the supra-aortic vessels. Right: Repeat imaging at the end of treat- ment. The covered endovascular stent placed in the horizontal and descending portions of the thoracic aorta leads to exclusion of the pseudoaneurysm and recovery of a normal calibre, all the while sparing the vasculature of the left brachiocephalic and common carotid arteries. This result is achieved through the intentional exclusion of the left subclavian artery, after having checked that the right vertebral artery was patent. ā€¢ Check that the rupture does indeed concern the aorta rather than other vascular segments (supra-aortic vessels, mediastinal veins). ā€¢ Check the right vertebral artery and whether the circle of Willis is complete before embolisation of the left subcla- vian artery. Figure 20. Angiography. Contrast material administered via the brachial route to the left subclavian artery conļ¬rms the opaciļ¬- cation of the pseudoaneurysm through a tear at the origin of this artery, as well as a slight traumatic dissection of the artery down- stream (left internal thoracic artery protrudes over the lesion). ā€¢ The embolisation site must be before the vertebral artery. 3) ā€¢ Complete occlusion of the left subclavian artery with exclusion of the leak originating from this artery, the Figure 19. CT angiography of the chest performed 12 hours after placement of a stent graft, carried out because the patient deteriorated clinically. A bilateral pleural effusion of moderate abundance can be seen entailing collapse of the pulmonary parenchyma, and above all a type II endoleak fed by the left subclavian artery which is making the pseudoaneurysm patent once again.
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