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A journal article describes Retro-1, a benzodiazepine compound that blocks the retrograde transport of Shiga toxins produced by pathogenic E. coli. Researchers synthesized and separated the compound into its S-enantiomer, which was found to more effectively protect human cells from Shiga toxins. For more details, see the communication by Daniel Gillet, Jean-Christophe Cintrat et al. on pages 1153 and following.
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couv chemmedchem
- 1. 7/2015 www.chemmedchem.org A Journal of The inside cover picture shows Retro-1, a benzodiazepine that blocks the retrograde transport in host cells of Shiga toxins, the virulence factors produced by pathogenic strains of E. coli responsible for food poisoning and hemolytic uremic syndrome. After synthesis and separation, the S-enantiomer was found to be more effective at protecting human cells from Shiga toxins. For further details, see the Communication by Daniel Gillet, Jean-Christophe Cintrat et al. on p. 1153 ff.