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Thalidomide & its derivatives by Dr. Harmanjit Singh, Department of Pharmacology, GMC, Patiala

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Govt Medical College & Hospital, Sector-32
Govt Medical College & Hospital, Sector-32
Health & MedicineBusiness
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Thalidomide & its analogues: Importance in Pharmacology Dr. Harmanjit Singh Department of Pharmacology, GMC, Patiala
History ,[object Object],[object Object],[object Object],[object Object]
Thalidomide – the sleeping pill Hailed as a "wonder drug" that provided a "safe, sound sleep". However the drug was also found to cure morning sickness in pregnant women Was available as OTC drug
Chemistry of thalidomide ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object]
Pharmacokinetics ,[object Object],[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
The Thalidomide Disaster ,[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Symptom Pattern ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
MECHANISM OF TERATOGENICITY
MECHANISM OF TERATOGENICITY ,[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object],[object Object]
Thalidomide Today ,[object Object],[object Object],[object Object],[object Object],[object Object]
Thalidomide analogues ,[object Object],[object Object],[object Object],[object Object]
IMiDs – NOVEL THALIDOMIDE ANALOGUES AS ANTICANCER AGENTS ,[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
IMiDs as Immunomodulators ,[object Object],[object Object],[object Object],[object Object],[object Object]
IMiDs as Pro-apoptotic agents ,[object Object],[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Adverse effects of Thalidomide & its analogues ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Uses of Thalidomide & its analogues ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
ENL ( Erythema Nodosum Leprosum ) ,[object Object],[object Object],[object Object],[object Object],[object Object]
6 weeks 200 mg 1 week 200 mg ,[object Object],[object Object],[object Object],[object Object],Before
Multiple Myeloma ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Demonstrated Mechanisms of Action of Thalidomide/IMiDs in MM
[object Object],[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object],[object Object],[object Object]
Other Potential Uses ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Precautions and Concerns ,[object Object],[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
S.T.EP.S ,[object Object],[object Object],[object Object],[object Object]
Summary ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
[object Object]

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Thalidomide & its derivatives by Dr. Harmanjit Singh, Department of Pharmacology, GMC, Patiala

  • 1. Thalidomide & its analogues: Importance in Pharmacology Dr. Harmanjit Singh Department of Pharmacology, GMC, Patiala
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  • 3. Thalidomide – the sleeping pill Hailed as a "wonder drug" that provided a "safe, sound sleep". However the drug was also found to cure morning sickness in pregnant women Was available as OTC drug
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  • 29. Demonstrated Mechanisms of Action of Thalidomide/IMiDs in MM
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Editor's Notes

  1. “ what was once the most feared drug in pharmaceutical armory could become one of its most valuable.”
  2. Difficult for women of childbearing age Metabolism of thalidomide is not well understood and drug may be stored in fat in which case it could be in the body for years “ Thalidomide can take people out of wheelchairs but it can put people into wheelchairs, too.”