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Atrial	
  Fibrilla*on	
  and	
  Stroke	
  
Dr.	
  Sunil	
  Garg	
  
Cardiologist	
  
ASAP	
  2014	
  
Atrial	
  Fibrilla*on	
  
•  Abnormal	
  rhythm	
  of	
  the	
  heart	
  
•  Very	
  common	
  problem	
  
•  Over	
  the	
  age	
  of	
  40	
  –	
  one	
  in	
  four	
  chance	
  of	
  
developing	
  atrial	
  fibrilla*on	
  
•  More	
  frequent	
  in	
  men	
  than	
  in	
  women	
  
Atrial	
  Fibrilla*on	
  
•  Affects	
  the	
  atria	
  or	
  upper	
  chambers	
  of	
  the	
  
heart	
  
•  Electrical	
  impulses	
  do	
  not	
  properly	
  circulate	
  
through	
  the	
  heart	
  
•  Make	
  your	
  heart	
  beat	
  too	
  quickly,	
  too	
  slowly	
  
or	
  in	
  an	
  uneven	
  fashion	
  
Electricity	
  of	
  the	
  Heart	
  
Atrial	
  Fibrilla*on	
  
•  Two	
  Forms	
  
•  IntermiQent	
  (Paroxysmal)	
  
– Episodes	
  that	
  occur	
  with	
  varying	
  frequency	
  or	
  last	
  
for	
  a	
  variable	
  period	
  of	
  *me	
  before	
  spontaneously	
  
stopping	
  
•  Chronic	
  (Persistent)	
  
– Sustained	
  and	
  usually	
  does	
  not	
  stop	
  
Cause	
  of	
  Atrial	
  Fibrilla*on	
  
•  Increases	
  in	
  frequency	
  with	
  aging	
  and	
  typically	
  
occurs	
  in	
  people	
  with	
  underlying	
  heart	
  disease	
  
•  Most	
  common	
  causes	
  
– Chronic	
  high	
  blood	
  pressure	
  (hypertensive	
  heart	
  
disease)	
  
– A	
  heart	
  aQack	
  
– Heart	
  Valve	
  Disease	
  (MS	
  or	
  MR)	
  
– A	
  complica*on	
  of	
  heart	
  surgery	
  
Atrial	
  Fibrilla*on	
  and	
  Alcohol	
  
•  Binge	
  drinkers	
  can	
  usually	
  develop	
  atrial	
  
fibrilla*on	
  that	
  is	
  usually	
  transient	
  
•  OWen	
  occurs	
  over	
  weekends	
  or	
  holidays	
  when	
  
alcohol	
  intake	
  is	
  excessive	
  
•  “Holiday	
  Heart	
  Syndrome”	
  
Atrial	
  Fibrilla*on	
  and	
  Hyperthyroidism	
  
•  Occurs	
  in	
  13	
  percent	
  of	
  people	
  with	
  an	
  
overac*ve	
  thyroid	
  
•  Accounts	
  for	
  5%	
  of	
  all	
  cases	
  of	
  atrial	
  
fibrilla*on	
  
•  Make	
  sure	
  your	
  thyroid	
  levels	
  are	
  checked	
  
•  Treatable	
  and	
  reversible	
  cause	
  
Atrial	
  Fibrilla*on	
  due	
  to	
  S*mulants	
  
•  Drugs	
  that	
  s*mulate	
  the	
  heart	
  can	
  contribute	
  
to	
  the	
  development	
  of	
  atrial	
  fibrilla*on	
  
•  Caffeine	
  
•  Tobacco	
  
Atrial	
  Fibrilla*on	
  and	
  Sleep	
  Apnea	
  
•  Condi*on	
  where	
  pa*ents	
  stop	
  breathing	
  for	
  
prolonged	
  periods	
  while	
  sleeping	
  
•  Overweight	
  
•  History	
  of	
  Snoring	
  
•  Excessive	
  Sleepiness	
  during	
  the	
  day*me	
  
•  Treatment	
  can	
  eliminate	
  atrial	
  fibrilla*on	
  
Atrial	
  Fibrilla*on	
  and	
  Lung	
  Disease	
  
•  Chronic	
  Lung	
  Diseases	
  
can	
  cause	
  Atrial	
  
Fibrilla*on	
  
•  Par*cularly	
  seen	
  in	
  
pa*ents	
  with	
  
emphysema	
  
Lone	
  Atrial	
  Fibrilla*on	
  
•  Some	
  people	
  with	
  atrial	
  fibrilla*on	
  have	
  no	
  
apparent	
  cause	
  
•  Structurally	
  normal	
  heart	
  
Atrial	
  Fibrilla*on	
  Symptoms	
  
•  Mild	
  Symptoms	
  
– Unpleasant	
  palpita*ons	
  or	
  irregularity	
  of	
  the	
  heart	
  
– Mild	
  chest	
  discomfort	
  /	
  sensa*on	
  of	
  *ghtness	
  
– A	
  sense	
  of	
  racing	
  heart	
  
– Lightheadedness	
  
– Mild	
  shortness	
  of	
  breath	
  and	
  fa*gue	
  that	
  limit	
  the	
  
ability	
  to	
  exercise	
  
Atrial	
  Fibrilla*on	
  and	
  Symptoms	
  
•  Severe	
  Symptoms	
  
– Difficulty	
  breathing	
  
– Shortness	
  of	
  breath	
  with	
  exer*on	
  
– Fain*ng	
  or	
  near	
  fain*ng	
  
– Confusion	
  
– Chest	
  Discomfort	
  
– Fa*gue	
  
Atrial	
  Fibrilla*on	
  and	
  Risk	
  of	
  Stroke	
  
•  Chao*c	
  rhythm	
  may	
  
cause	
  blood	
  to	
  pool	
  in	
  
your	
  hearts	
  upper	
  
chambers	
  
•  This	
  leads	
  to	
  clot	
  
forma*on	
  
Atrial	
  Fibrilla*on	
  and	
  Risk	
  of	
  Stroke	
  
•  Serious	
  complica*on	
  
from	
  Atrial	
  Fibrilla*on	
  
•  Can	
  lead	
  to	
  permanent	
  
brain	
  damage	
  
•  Clot	
  may	
  also	
  travel	
  to	
  
–  Eye	
  
–  Kidneys	
  
–  Spine	
  
–  Important	
  arteries	
  in	
  the	
  
arms	
  or	
  legs	
  
Risk	
  Factors	
  for	
  Stroke	
  
•  CHADS2	
  
–  Conges*ve	
  Heart	
  Failure	
  
–  Hypertension	
  
–  Age	
  (65	
  to	
  74	
  versus	
  
>75)	
  
–  Diabetes	
  
–  Previous	
  Stroke	
  or	
  TIA	
  
Atrial	
  Fibrilla*on	
  and	
  Heart	
  AQack	
  
•  People	
  who	
  have	
  a	
  heart	
  aQack	
  are	
  at	
  risk	
  for	
  
developing	
  Atrial	
  Fibrilla*on	
  
•  Having	
  atrial	
  fibrilla*on	
  doubles	
  your	
  chances	
  
of	
  having	
  a	
  heart	
  aQack	
  
Atrial	
  Fibrilla*on	
  and	
  Heart	
  Failure	
  
•  If	
  not	
  controlled,	
  can	
  weaken	
  the	
  heart	
  and	
  
lead	
  to	
  heart	
  failure	
  
•  Usually	
  improves	
  with	
  treatment	
  and	
  control	
  
of	
  the	
  heart	
  rate	
  
Atrial	
  Fibrilla*on	
  Diagnosis	
  
•  Electrocardiogram	
  
•  Holter	
  Monitor	
  
•  Event	
  Recorder	
  
•  Echocardiogram	
  
Atrial	
  Fibrilla*on	
  Treatment	
  
•  Short	
  Term	
  Treatment	
  
–  Rate	
  Control	
  
–  Cardioversion	
  
•  Transesophageal	
  
Echocardiogram	
  
Atrial	
  Fibrilla*on	
  Treatment	
  
•  Short	
  Term	
  Treatment	
  
–  Rate	
  Control	
  
–  Cardioversion	
  
•  Transesophageal	
  
Echocardiogram	
  
Atrial	
  Fibrilla*on	
  Treatment	
  
•  Long	
  Term	
  Treatment	
  
– Rhythm	
  Control	
  
•  Efforts	
  to	
  restore	
  and	
  maintain	
  a	
  normal	
  rhythm	
  are	
  
made	
  
•  Can	
  be	
  done	
  via	
  
–  Cardioversion	
  
–  An*arrhythmic	
  Drugs	
  
–  Abla*on	
  Procedure	
  
Rhythm	
  Control	
  
•  Advantages	
  
–  Improved	
  cardiac	
  
func*on	
  
–  Reduced	
  Symptoms	
  for	
  
some	
  people	
  
–  Reduced	
  need	
  for	
  
medica*ons	
  
•  Disadvantages	
  
–  High	
  rate	
  of	
  recurrence	
  
of	
  atrial	
  fibrilla*on	
  
–  Side	
  effects	
  of	
  
medica*ons	
  (AAD)	
  
–  Adverse	
  effects	
  of	
  
medica*ons	
  
Atrial	
  Fibrilla*on	
  Treatment	
  
•  Long	
  Term	
  Treatment	
  
– Rate	
  Control	
  
•  Con*nue	
  to	
  have	
  atrial	
  fibrilla*on	
  
•  Use	
  medica*on	
  to	
  slow	
  the	
  heart	
  rate	
  down	
  
•  Can	
  be	
  difficult	
  to	
  use	
  medica*ons	
  to	
  slow	
  the	
  heart	
  
rate	
  down	
  
Nonpharmacological	
  Treatment	
  
•  Radiofrequency	
  Abla*on	
  
– Developing	
  Procedure	
  
– Risk	
  of	
  Complica*ons	
  
•  Pacemaker	
  
– May	
  be	
  needed	
  for	
  a	
  slow	
  heart	
  beat	
  or	
  to	
  help	
  
with	
  medica*ons	
  
•  Surgical	
  Procedures	
  
– Complete	
  MAZE	
  Procedure	
  
Atrial	
  Fibrilla*on	
  and	
  An*coagula*on	
  
•  Increased	
  risk	
  of	
  stroke	
  as	
  a	
  result	
  of	
  blood	
  
clots	
  that	
  can	
  form	
  in	
  the	
  heart	
  
•  Most	
  people	
  are	
  advised	
  to	
  use	
  a	
  treatment	
  to	
  
reduce	
  the	
  risk	
  of	
  developing	
  blood	
  clots	
  
•  Most	
  commonly	
  used	
  treatments	
  include	
  
an*coagulants	
  or	
  an*platelet	
  drugs	
  
An*coagulant	
  Drugs	
  
•  Can	
  reduce	
  the	
  risk	
  of	
  stroke	
  by	
  50	
  to	
  70%	
  
– Warfarin	
  
– Dabigatran	
  (Pradaxa)	
  
– Apixaban	
  (Eliquis)	
  
– Rivaroxaban	
  (Xarelto)	
  
	
  
An*platelet	
  Drugs	
  
•  May	
  be	
  used	
  in	
  pa*ents	
  with	
  lower	
  risks	
  
•  May	
  be	
  used	
  in	
  pa*ents	
  who	
  are	
  intolerant	
  to	
  
an*coagulant	
  drugs	
  
– Increased	
  bleeding	
  risk	
  
– Recurrent	
  falls	
  
•  ASA	
  81	
  mg	
  daily	
  
•  Clopidogrel	
  (Plavix)	
  75	
  mg	
  daily	
  
What	
  Can	
  You	
  do?	
  
•  Monitor	
  Your	
  Blood	
  Pressure	
  
•  Control	
  Your	
  Diabetes	
  
•  Take	
  your	
  Medica*ons	
  /	
  Blood	
  Thinners	
  if	
  you	
  
have	
  been	
  diagnosed	
  with	
  Atrial	
  Fibrilla*on	
  
•  See	
  your	
  doctor	
  if	
  you	
  develop	
  the	
  symptoms	
  
listed	
  
Thank	
  You	
  

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Atrial fibrillation and stroke

  • 1. Atrial  Fibrilla*on  and  Stroke   Dr.  Sunil  Garg   Cardiologist   ASAP  2014  
  • 2. Atrial  Fibrilla*on   •  Abnormal  rhythm  of  the  heart   •  Very  common  problem   •  Over  the  age  of  40  –  one  in  four  chance  of   developing  atrial  fibrilla*on   •  More  frequent  in  men  than  in  women  
  • 3. Atrial  Fibrilla*on   •  Affects  the  atria  or  upper  chambers  of  the   heart   •  Electrical  impulses  do  not  properly  circulate   through  the  heart   •  Make  your  heart  beat  too  quickly,  too  slowly   or  in  an  uneven  fashion  
  • 5. Atrial  Fibrilla*on   •  Two  Forms   •  IntermiQent  (Paroxysmal)   – Episodes  that  occur  with  varying  frequency  or  last   for  a  variable  period  of  *me  before  spontaneously   stopping   •  Chronic  (Persistent)   – Sustained  and  usually  does  not  stop  
  • 6. Cause  of  Atrial  Fibrilla*on   •  Increases  in  frequency  with  aging  and  typically   occurs  in  people  with  underlying  heart  disease   •  Most  common  causes   – Chronic  high  blood  pressure  (hypertensive  heart   disease)   – A  heart  aQack   – Heart  Valve  Disease  (MS  or  MR)   – A  complica*on  of  heart  surgery  
  • 7. Atrial  Fibrilla*on  and  Alcohol   •  Binge  drinkers  can  usually  develop  atrial   fibrilla*on  that  is  usually  transient   •  OWen  occurs  over  weekends  or  holidays  when   alcohol  intake  is  excessive   •  “Holiday  Heart  Syndrome”  
  • 8. Atrial  Fibrilla*on  and  Hyperthyroidism   •  Occurs  in  13  percent  of  people  with  an   overac*ve  thyroid   •  Accounts  for  5%  of  all  cases  of  atrial   fibrilla*on   •  Make  sure  your  thyroid  levels  are  checked   •  Treatable  and  reversible  cause  
  • 9. Atrial  Fibrilla*on  due  to  S*mulants   •  Drugs  that  s*mulate  the  heart  can  contribute   to  the  development  of  atrial  fibrilla*on   •  Caffeine   •  Tobacco  
  • 10. Atrial  Fibrilla*on  and  Sleep  Apnea   •  Condi*on  where  pa*ents  stop  breathing  for   prolonged  periods  while  sleeping   •  Overweight   •  History  of  Snoring   •  Excessive  Sleepiness  during  the  day*me   •  Treatment  can  eliminate  atrial  fibrilla*on  
  • 11. Atrial  Fibrilla*on  and  Lung  Disease   •  Chronic  Lung  Diseases   can  cause  Atrial   Fibrilla*on   •  Par*cularly  seen  in   pa*ents  with   emphysema  
  • 12. Lone  Atrial  Fibrilla*on   •  Some  people  with  atrial  fibrilla*on  have  no   apparent  cause   •  Structurally  normal  heart  
  • 13. Atrial  Fibrilla*on  Symptoms   •  Mild  Symptoms   – Unpleasant  palpita*ons  or  irregularity  of  the  heart   – Mild  chest  discomfort  /  sensa*on  of  *ghtness   – A  sense  of  racing  heart   – Lightheadedness   – Mild  shortness  of  breath  and  fa*gue  that  limit  the   ability  to  exercise  
  • 14. Atrial  Fibrilla*on  and  Symptoms   •  Severe  Symptoms   – Difficulty  breathing   – Shortness  of  breath  with  exer*on   – Fain*ng  or  near  fain*ng   – Confusion   – Chest  Discomfort   – Fa*gue  
  • 15. Atrial  Fibrilla*on  and  Risk  of  Stroke   •  Chao*c  rhythm  may   cause  blood  to  pool  in   your  hearts  upper   chambers   •  This  leads  to  clot   forma*on  
  • 16. Atrial  Fibrilla*on  and  Risk  of  Stroke   •  Serious  complica*on   from  Atrial  Fibrilla*on   •  Can  lead  to  permanent   brain  damage   •  Clot  may  also  travel  to   –  Eye   –  Kidneys   –  Spine   –  Important  arteries  in  the   arms  or  legs  
  • 17. Risk  Factors  for  Stroke   •  CHADS2   –  Conges*ve  Heart  Failure   –  Hypertension   –  Age  (65  to  74  versus   >75)   –  Diabetes   –  Previous  Stroke  or  TIA  
  • 18. Atrial  Fibrilla*on  and  Heart  AQack   •  People  who  have  a  heart  aQack  are  at  risk  for   developing  Atrial  Fibrilla*on   •  Having  atrial  fibrilla*on  doubles  your  chances   of  having  a  heart  aQack  
  • 19. Atrial  Fibrilla*on  and  Heart  Failure   •  If  not  controlled,  can  weaken  the  heart  and   lead  to  heart  failure   •  Usually  improves  with  treatment  and  control   of  the  heart  rate  
  • 20. Atrial  Fibrilla*on  Diagnosis   •  Electrocardiogram   •  Holter  Monitor   •  Event  Recorder   •  Echocardiogram  
  • 21. Atrial  Fibrilla*on  Treatment   •  Short  Term  Treatment   –  Rate  Control   –  Cardioversion   •  Transesophageal   Echocardiogram  
  • 22. Atrial  Fibrilla*on  Treatment   •  Short  Term  Treatment   –  Rate  Control   –  Cardioversion   •  Transesophageal   Echocardiogram  
  • 23. Atrial  Fibrilla*on  Treatment   •  Long  Term  Treatment   – Rhythm  Control   •  Efforts  to  restore  and  maintain  a  normal  rhythm  are   made   •  Can  be  done  via   –  Cardioversion   –  An*arrhythmic  Drugs   –  Abla*on  Procedure  
  • 24. Rhythm  Control   •  Advantages   –  Improved  cardiac   func*on   –  Reduced  Symptoms  for   some  people   –  Reduced  need  for   medica*ons   •  Disadvantages   –  High  rate  of  recurrence   of  atrial  fibrilla*on   –  Side  effects  of   medica*ons  (AAD)   –  Adverse  effects  of   medica*ons  
  • 25. Atrial  Fibrilla*on  Treatment   •  Long  Term  Treatment   – Rate  Control   •  Con*nue  to  have  atrial  fibrilla*on   •  Use  medica*on  to  slow  the  heart  rate  down   •  Can  be  difficult  to  use  medica*ons  to  slow  the  heart   rate  down  
  • 26. Nonpharmacological  Treatment   •  Radiofrequency  Abla*on   – Developing  Procedure   – Risk  of  Complica*ons   •  Pacemaker   – May  be  needed  for  a  slow  heart  beat  or  to  help   with  medica*ons   •  Surgical  Procedures   – Complete  MAZE  Procedure  
  • 27. Atrial  Fibrilla*on  and  An*coagula*on   •  Increased  risk  of  stroke  as  a  result  of  blood   clots  that  can  form  in  the  heart   •  Most  people  are  advised  to  use  a  treatment  to   reduce  the  risk  of  developing  blood  clots   •  Most  commonly  used  treatments  include   an*coagulants  or  an*platelet  drugs  
  • 28. An*coagulant  Drugs   •  Can  reduce  the  risk  of  stroke  by  50  to  70%   – Warfarin   – Dabigatran  (Pradaxa)   – Apixaban  (Eliquis)   – Rivaroxaban  (Xarelto)    
  • 29. An*platelet  Drugs   •  May  be  used  in  pa*ents  with  lower  risks   •  May  be  used  in  pa*ents  who  are  intolerant  to   an*coagulant  drugs   – Increased  bleeding  risk   – Recurrent  falls   •  ASA  81  mg  daily   •  Clopidogrel  (Plavix)  75  mg  daily  
  • 30. What  Can  You  do?   •  Monitor  Your  Blood  Pressure   •  Control  Your  Diabetes   •  Take  your  Medica*ons  /  Blood  Thinners  if  you   have  been  diagnosed  with  Atrial  Fibrilla*on   •  See  your  doctor  if  you  develop  the  symptoms   listed