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Urinary-Incontinence-Murphy.pptx
1. Kathleen Pace Murphy, PhD, MS, APRN
Assistant Professor, UT Medical School
Geriatric and Palliative Medicine
2. Prevalence
Increases with age and affects women more than men
(2:1) until age 80
15-30% in community dwellers age 65 and older
60-70% in older adults age 65 and older in long term
care
Significantly impairs quality of life
4. Age related LUT changes
Bladder contractility decreases
Uninhibited bladder contractions increase
Diurnal urine output occurse later in day
Bladder capacity decreases
Sphincteric striated muscle attenuates
PVR increases
5. Age related LUT changes- Women
In addition to the physiologic changes already
discussed:
Urethral closure pressure decreases
Vaginal mucosal atrophy
6. Age related LUT changes- Men
In addition to the physiologic changes already
discussed:
Benign prostatic hyperplasia
Prostate hypertrophy
7. LUT Pathophysiology in UI
Urge UI
Urge UI with detrusor overactivity (uninhibited
bladder contractions)
40% on urodynamic testing
Suggest detrusor overactivity PLUS impaired
compensatory mechanisms.
Idiopathic, age-related, secondary to lesions in
cerebral and spinal pathways.
Due to bladder outlet obstruction or bladder irritation
(infection, stones, tumor)
8. LUT Pathophysiology in UI
Stress UI
Etiology
Damage to the pelvic floor supports
Sphincter failure
Leakage associated with coughing,
sneezing, laughing, physical activity
Second most common form in
women
Seen in men after prostectomy
9. LUT Pathophysiology in UI
Mixed UI with both detrusor overactivity
and impaired sphincter support
Leakage occurs with both urgency and activity
Seen in women
10. LUT Pathophysiology in UI
UI with impaired bladder emptying
Increase PVR (200mL)
Intermittent small dribbling
Frail elderly: coexistence of urge UI and PVR (in the
absence of bladder outlet obstruction)= detrusor
hyperactivity with impaired contractility (DHIC)
Men
prostate hypertrophy
Women
urethral surgical scarring
Large cytocele/prolapse
11. UI Screening and Evaluation
Multifactorial evaluation
Comorbidity
Funciton
Medication
Questions to ask
Do you have any problems with bladder control?
Do you have any problems making it to the bathroom on
time?
Do you ever leak urine?
17. UI Treatment and Management
Behavioral Therapies
A. Bladder training and pelvic muscle exercises
1. Effective urge, mixed, and stress UI (SOE=A)
B. Prompt timed voiding in cognitively impaired
C. Biofeedback for PME
1. Medicare covers (SOE=Unkown)
18. Medications
Anti Muscarinics
MOA
Increase bladder capacity by decreasing basal excretion of Ach from
urothelium
Contraindicated
Narrow angle glaucoma
Impaired gastric emptying
Known urinary retention
Patient taking cholinesterase inhibitor
Drugs
Oxybutynin
Tolterodine
Fesoterodine
Trospium
Darifenacin
Solifenacin
19. Medications
Rx UI and OAB
MOA
Stimulation of beta 3 receptors in the detruor mediates
bladder relaxation:
Myrbetriq 25-50mg QD
ADE
Increase blood pressure
Prescribe carefully in patient with renal and hepatic
impairment
Many drug-drug AE like muscarins
20. Other Treatments
Intravesical injection of botulinum toxin
Sacral nerve neuromodulation
Surgery (stress UI)
Colpsuspension (Burch Operation)
Slings (synthetic mesh, or autologus or cadaveric fascia)
21. References
Flaherty E & Resnick B Geriatric Nursing Review Syllabus (4th Ed). New
York: American Geriatric Society; 2014.
Gulur DM, Mevcha AM, Drake MJ. Nocturia as a manifestation of
systemic disease. BJU Int. 2011; 107 (50): 702-13.
Ham, RJ, Sloan, PD, Warshaw, GA, Potter, JE & Flaherty E. Primary
Care Geriatrics: A case-based approach (6th Ed.). 2014. Philadelphia:
Elsevier Saunders.
Holroyd-Leduc JM, Tannenbaum C, Thorpe KE, Strauss SE. What type
of urinariy incontinence does this woman have? JAMA, 2008 : 299:
1446-56.
Landefeld CS, Bowers BJ, Feld AD et al. NIH state-of-the-science-
conference statement: Prevention of fecal and urinary incontinence in
adults. Ann Intern Med 2008:148: 449-58.
Shamliyan T, Wyman J, Kane RL. Benefits and harms of pharmacologic
treatment for UI in women: A systematic review. Ann Intern Med 2012:
156(12): 861-74.
Research emphasizes the role of afferent stimulation from the bladder urothelium and impaired CNS control of urgency in DO and overactive bladder.
Occurs with urgency, a compelling and often sudden need to void; most common in both men and women.
Damage to pelvic floor supports (levator ani, CT) which compress the urethra when intrabdominal pressure increases.
Sphincter failure- surgical damage, severe atrophy, or (rare) subsacral SCI.
If yes to any question, ask:
When you are performing some physical activity, such as coughing, sneezing, lifting or exercising? (stress)
When you have the urge or feel that you need to empty your bladder but cannot get tot the toilet fast enough? (mixed)
With both physical activity and a sense of urgency? (mixed)
Without physical activity and without a sense of urgency? (other)