Paper in press in Nature Reviews Drug Discovery

1. The Epigenome as the Anchor for
Next Generation CNS Drug Discovery
Higgins GA et al. Nature Reviews Drug Discovery, in press

2. Outline
I. Introduction
II. Keys to the Spatial and Temporal Dynamics of the Human CNS and Drug
Discovery Targets
III.Human Brain-Specific Mechanisms
A. Human brain-specific transcription factors and factories
B. Cerebral and cerebellar neurogenesis
C. Non-CpG methylation and the reactive 5-hmC
D. CNS epigenome variants and their clinical utility
V. Under development
A. HDAC inhibitors
B. PRMT5 inhibitors
C. NRSF inhibitors
D. Methylation inhibitors
E. Pro-acetylation
F. Nootropics
G. CNS drugs that target TAD boundaries
H. Inducers of neurogenesis in neurodegenerative disorders
VI. Resources and Tools
A. Human brain tissue biorepositories
B. Neuro-organoids
C. Human brain tissue chromatin capture methods
D. ISH of enhancer RNA
E. Single cell epigenome analysis