Measurement of Pulmonary artery pressure in a mechanically ventilated rat is described on couple slides with characterization of PA pressure wave

1. PULMONARY ARTERY
PRESSURE IN A
MECHANICALLY
VENTILATED RAT
Invasive catheterization/
open chest
Filip Konecny

2. Male, 270 g rat mechanically ventilated. Using solid state pressure sensor on 1.6 F
pressure catheter during open chest surgery, inserting catheter into Pulmonary artery.
Channels are as follows: Channel 1: PA pressure (mmHg); values p@ dp max
17.796mmHg and P@dp min 24.347mmHg, Channel 2: HR (bpm), Channel 3: first
derivate (PA dp/dt). Cursors are positioned on dp max and dp min

3. The 270 g SD male rat, mechanically ventilated using
100% oxygen in combination with Isoflurane anesthesia.
Data in table are collected from 10 heart beats and
expressed as Mean ± SD.
HR Systolic Diastolic dPmax dPmin
Mean
PAP Notch P Pulse P
bpm mmHg mmHg
mmHg/s
ec
mmHg/s
ec mmHg mmHg mmHg
451.803 28.14 12.208 646.158
-
368.108 17.519 19.867 15.932
6.965 0.431 1.151 57.209 31.534 0.723 1.072 0.945
PA Systolic peak
PA Systolic limb
decline
Dicrotic notch
(end of RV
systole) Diastolic decline
PA Systolic
upstroke
the Ascending
limb

4. DIASTOLIC PA PRESSURE DURING
MECHANICAL VENTILATION
SYSTOLIC PA PRESSURE DURING
MECHANICAL VENTILATION
Variation of peak systolic
pressure within 2 heart beats
was in this example 2.5mmHg
Variation of diastolic PA pressure within
1 heart beats was in this example 3
mmHg
To limit the PA systolic and
diastolic pressure variations,
mechanical ventilator can
temporarily turn off for about 5-
10 sec. to perform measurement

5. Complete transfer of the pressure sensor from RV into the PA
through PA valve
Incomplete transfer of the pressure sensor from RV into the PA, catheter in
contact with PA valve, P sensor still in RV