The document discusses several themes from Of Mice and Men including loneliness, friendship, fate and broken plans, masculinity, and nature. It provides analysis of how each theme is presented in the novel. For the theme of loneliness, it notes that loneliness is present in all the characters and discusses how specific characters like Candy, Crooks, and Curley's wife struggle against their isolation. For the theme of friendship, it examines the relationship between George and Lennie and how their friendship is unusual among the ranch workers. For the theme of fate and broken plans, it explains that the novel explores how the characters' dreams and plans are often destroyed by forces beyond their control.