The document summarizes key findings from the Systolic Blood Pressure Intervention Trial (SPRINT).
[1] SPRINT randomly assigned over 9,000 adults to an intensive treatment target of systolic blood pressure under 120 mm Hg or a standard target under 140 mm Hg. [2] Those in the intensive group achieved an average systolic pressure of 121.5 mm Hg compared to 134.6 mm Hg in the standard group. [3] The intensive group experienced a 25% reduction in the primary composite cardiovascular outcome and a 27% reduction in all-cause mortality compared to the standard group.
1. Current Approaches to Detection, Evaluation,
and Management of High Blood Pressure
Presented by
Department of Epidemiology
Department of Medicine
Center for Continuing Education
Release Date: November 1, 2018
Expiration Date: March 31, 2021
Estimated time to complete the activity: 45 minutes
2. NOTES
Reference Materials may be found by clicking on the “Hypertension Guidelines” and
“Presentation Slides” buttons below the recording.
Complete CME and CEU Information may be found by clicking on the “CE Credit
Handout” button below the recording.
Technical requirements may be found by clicking on the “Viewing Requirements” link
below the recording.
Evaluation, Post-test, and Credit Claiming instructions and link will be available
following participation in the session.
If you have other questions, please contact Tulane University CCE at cme@tulane.edu or
504-988-5466.
This session was originally recorded between May and October 2018.
3. GRANT SUPPORT
IMPACTS is supported by a grant from the National Heart, Lung, and Blood Institute of
the National Institutes of Health under Award Number R01HL133790. The content is
solely the responsibility of the authors and does not necessarily represent the official
views of the National Institutes of Health.
4. TULANE UNIVERSITY CENTER FOR CONTINUING EDUCATION DISCLOSURE POLICY
• This activity has been planned and implemented in accordance with the ACCME®
and IACET Accreditation Requirements to ensure balance, independence,
objectivity, and scientific rigor.
• All individuals responsible for content, regardless of role(s), are required to
document financial relationships or the absence of relationships with commercial
interests, and all potential conflicts of interest must be resolved prior to the
activity.
• Disclosure of off-label, experimental or investigational use of drugs or devices
must also be made known to the audience.
5. DISCLOSURES
Listed below is information disclosed by those participating in the activity as presenters, moderators, and in other roles. Any real or apparent conflicts of interest related to the content of
their participation or presentations have been resolved.
Last Name First Name Role in the Activity Disclosure
Bouyelas Lindsey Committee Member Nothing to disclose
Brooks Kenya Facilitator Nothing to disclose
Chen Jing Co-activity Director Nothing to disclose
Epperson Melinda Director, Tulane CCE; Planning Committee Nothing to disclose
He Jiang Department Chair Epidemiology Nothing to disclose
Kleinpeter Myra Chair, Tulane CCE Advisory Committee
Grant: Amgen, Glaxo Smith Kline, Astra Zeneca;
Speakers Bureau: Gilead Sciences, Fresenius
Medical Care, OPKO; Stock: BD, Abbvie, P&G;
Board Member: Orleans Parish Medical Society,
New Orleans East Hospital
Krane N. Kevin
Vice Dean of Academic Affairs, Tulane University
School of Medicine
Nothing to disclose
Krousel-Wood Tonette Activity Director, Speaker Nothing to disclose
Lambuth Kailin Committee Member Nothing to disclose
Lind Caroline
Educational Evaluation & Research Specialist, Tulane
CCE
Nothing to disclose
Peacock Erin Committee Member Nothing to disclose
Refvem Sarah
Program Coordinator - Education & Evaluation, Tulane
CCE
Nothing to disclose
Schmidt Pamala Assistant Director, Tulane CCE Nothing to disclose
Sliwinski Roblynn Department Administrator, Tulane CCE Nothing to disclose
Whelton Paul Speaker
Chair, Writing committee, ACC/AHA Task Force
on Clinical Practice Guidelines; Chair, SPRINT,
ALLHAT, TOHP, and TONE trials
6. OBJECTIVES
At the conclusion of this educational activity, the participants should be
better able to effectively:
• Apply the new hypertension definition, classification and treatment target.
• Apply non-pharmacological treatments for hypertension management.
• Apply pharmacologic treatment for hypertension management.
• Treat special populations with high BP (African Americans, older persons) and with
comorbid conditions (Diabetes, CKD, CVD, CHF etc.).
7. Seminar on Current Approaches to Detection, Evaluation,
and Management of High Blood Pressure
Paul K. Whelton, MB, MD, MSc
Show Chwan Chair of Global Public Health
Tulane University School of Public Health and Tropical Medicine
Tulane University School of Medicine
Implementation of Multifaceted Patient-Centered Treatment
Strategies for Intensive Blood Pressure Control
(IMPACTS)
8. 2017 Guideline for the Prevention, Detection, Evaluation
and Management of High Blood Pressure in Adults
• Initiative lead by
– American College of Cardiology
– American Heart Association
• Nine additional partners
– American Academy of Physician Assistants
– American College of Preventive Medicine
– American Geriatrics Society
– American Pharmacists Association
– American Society of Hypertension
– American Society of Preventive Cardiology
– Association of Black Cardiologists
– National Medical Association
– Preventive Cardiovascular Nurses Association
• Writing committee
• Multidisciplinary (21 members)
• No relationships with industry
• Independent External Review Committee (10 members)
• Systematic review/meta-analyses (selected questions)
• Processes standardized
• ACC/AHA Guideline Task Force processes
• 15 easy to navigate self contained sections
• 106 recommendations (448 evidence tables)
• Each recommendation characterized by:
• Class (strength) of Recommendation (COR)
• Level of evidence (LOE)
• Extensive peer review (internal & external)
• Approved by 11 professional societies governing bodies
10. Key Points Specific Instructions
Step 1: Prepare patient -Have patient relax, sitting in a chair (feet on floor, back supported) for >5 min.
-Avoid caffeine, exercise, and smoking for ≥ 30 min before measurement.
-Ensure bladder emptied.
-No talking during rest period or measurement.
-Remove clothing covering location of cuff placement.
-Measurements while patient sitting/lying on exam table do not fulfill criteria.
Step 2: Use proper technique -Use validated BP measurement device that is calibrated periodically.
-Support patient’s arm (e.g., resting on a desk).
-Position middle of cuff on patient’s upper arm at mid-sternum (right atrium).
-Use correct cuff size, such that the bladder encircles 80% of the arm.
-Either stethoscope diaphragm or bell may be used for auscultatory readings.
Step 3: Take proper measurements -At first visit, record BP in both arms. Subsequently, use arm with higherBP.
-Separate repeated measurements by 1–2 min.
-For auscultatory readings, estimate SBP by palpation and inflate cuff 20–30
mm Hg above. Deflate 2 mm Hg per second and listen for Korotkoff sounds.
Step 4: Document BP readings -Note time of most recent BP medication before measurements.
-Record SBP and DBP.
Step 5: Average readings -Use average of ≥2 readings obtained on ≥2 occasions to estimate level of BP.
Step 6: Provide readings to patient -Provide patients SBP/DBP readings both verbally and in writing.
Office BP Readings: Checklist for Accurate Measurements
Whelton PK et al. Hypertension/J Am Coll Cardiol. 2017;Epub ahead of print
11. Basic and Optional Laboratory Tests for Primary Hypertension
Basic testing Fasting blood glucose*
Complete blood count
Lipid profile
Serum creatinine with eGFR*
Serum sodium, potassium, calcium*
Thyroid-stimulating hormone
Urinalysis
Electrocardiogram
Optional testing Echocardiogram
Uric acid
Urinary albumin to creatinine ratio
*May be included in metabolic panel. eGFR indicates estimated glomerular filtration rate.
Whelton PK et al. Hypertension/J Am Coll Cardiol. 2017 [Epub ahead of print].
13. BP Classification (JNC 7 and ACC/AHA Guidelines)
SBP DBP
<120 and <80
120–129 and <80
130–139 or 80–89
140–159 or 90-99
≥160 or ≥100
2003 JNC7
Normal BP
Prehypertension
Stage 1 hypertension
Stage 2 hypertension
2017 ACC/AHA
Normal BP
Elevated BP
Stage 1 hypertension
Stage 2 hypertension
Stage 2 hypertension
• Blood Pressure should be based on an average of ≥2 careful readings on ≥2 occasions
• Adults with SBP or DBP in two categories should be designated to the higher BP category
Whelton PK et al. Hypertension/J Am Coll Cardiol. 2017;Epub ahead of print
Major area
of
difference
14. Greater use of out of office BP measurements (ABPM or HBPM) for confirmation
of office hypertension and recognition of White Coat/Masked Hypertension
Out of Office BP Readings
In adults not taking antihypertensive medication
Masked Hypertension (MH)
• Normal office BP but out of office BP hypertension
• Present in about 10-25% of adults with normal office BP
• CVD risk profile more like adults with sustained hypertension than adults without hypertension
• Should be considered for antihypertensive drug therapy
Confirmed (Sustained) Hypertension
• Elevated office and out of office average BP
• Substantially higher risk of CVD compared to adults with normal office and out of office BPs
• Require therapy (nonpharmacological or combined nonpharmacological and antihypertensive drug therapy)
White Coat Hypertension (WCH)
• Office Hypertension not confirmed by out of office BP readings
• Present in about 10-25% of adults with office hypertension
• CVD risk profile more like adults with normal BP than adults with sustained hypertension
• May not need treatment for hypertension (should be monitored for development of sustained hypertension)
Whelton PK et al. Hypertension/J Am Coll Cardiol. 2017;Epub ahead of print
15. Secondary Hypertension
Common causes
Renal parenchymal disease
Renovascular disease
Primary aldosteronism
Obstructive sleep apnea
Drug or alcohol induced
Uncommon causes
Pheochromocytoma/paraganglioma
Cushing’s syndrome
Hypothyroidism
Hyperthyroidism
Aortic coarctation (undiagnosed or repaired)
Primary hyperparathyroidism
Congenital adrenal hyperplasia
Mineralocorticoid excess syndromes other than primary aldosteronism
Acromegaly
Whelton PK et al. Hypertension/J Am Coll Cardiol. 2017 [Epub ahead of print].
Underlying cause of high BP in about 10% of adults with hypertension
16. Threshold for Treatment
- Nonpharmacological (lifestyle change) therapy
- Nonpharmacological and antihypertensive drug therapy
17. IHD
mortality
(absolute risk
and 95% CI)
Usual SBP (mm Hg)
Lewington S. et al. Lancet. 2002;360:1903-1913.
Ischemic Heart Disease Mortality Rates, by Age
120 140 160 180
256
128
64
32
16
8
4
2
1
SBP
40-49 y
Age at risk:
70-79 y
60-69 y
50-59 y
80-89 y
Usual DBP (mm Hg)
70 80 90 110
100
256
128
64
32
16
8
4
2
1
DBP
Prospective Studies Collaboration (61 observational cohorts)
1 million adults (12.7 million person-years of follow-up), with 34,000 IHD Deaths
18. BP and Predicted Risk of Clinical Cardiovascular Disease
• ASCVD risk varies greatly at same level of BP
• With higher BP, increase in ASCVD risk:
– Small in adults at low risk for ASCVD
– Much greater in those at high risk for ASCVD
• In BP treatment trials with participants with different levels of CVD risk:
– Reduction in RR constant
– Reduction in absolute risk much greater in those at higher risk for ASCVD
Meta-analysis: 26 RCT groups (n = 51,917)
Adult CVD Risk at two levels of SBP
Muntner P, Whelton PK. JACC. 2017;69:2446-2456. BP Lowering Treat. Trialists’ Collab. Lancet.2014;384:591-598.
22. Systolic Blood Pressure Intervention Trial (SPRINT)
Examine effect of more intensive high blood pressure treatment
than is currently recommended
Randomized Controlled Trial
Target Systolic BP
Intensive Treatment
Goal SBP < 120 mm Hg
Standard Treatment
Goal SBP < 140 mm Hg
Research Question
9,361 randomized
Compare outcome experience
≥50 years
SBP 130-180 mm Hg
Additional CVD risk indicator
The SPRINT Research Group. N Engl J Med. 2015;373:2103-2116
23. Method of BP Measurement
• Five minutes of quiet rest prior to BP measurements
• Omron 907XL Electronic Oscillometric Sphygmomanometer
• Proper patient positioning and cuff size
• BP readings recorded automatically,
– With or without staff in attendance
• Readings averaged
Systolic Blood Pressure Intervention Trial (SPRINT)
The SPRINT Research Group. N Engl J Med. 2015;373:2103-2116
24. Systolic BP During Follow-up
Mean SBP/DBP
136.2/76.3 mm Hg
Mean SBP/DBP
121.4/68.7 mm Hg
Average SBP
(During Follow-up)
Standard: 134.6 mm Hg
Intensive: 121.5 mm Hg
Average number of
antihypertensive
medications
Number of
participants
Standard
Intensive
Year 1
The SPRINT Research Group. N Engl J Med. 2015;373:2103-2116
25. 0
0.2
0.4
0.6
0.8
1.0
Cumulative
Hazard
1 2 3 4 5
Years
0
0.2
0.4
0.6
0.8
1.0
Cumulative
Hazard
1 2 3 4 5
Years
0
0.02
0.04
0.06
0.08
0.1
1 2 3 4 5
0
0
0.02
0.04
0.06
0.08
0.1
1 2 3 4 5
0
Hazard ratio
0.75 (95% Cl, 0.64-0.89)
Hazard ratio
0.73 (95% Cl, 0.60-0.90)
Standard treatment
Intensive treatment
Standard treatment
Intensive treatment
Primary Outcome (CVD mortality, MI, non-MI ACS, Stroke, HF)
Death from any Cause
The SPRINT Research Group. N Engl J Med. 2015;373:2103-2116
25% reduction
27% reduction
Systolic BP Intervention Trial
26. SPRINT: PRIMARY OUTCOME
Subgroup
Previous CKD
No
Yes
Age
< 75 yr
≥ 75 yr
Sex
Female
Male
Race
Black
Nonblack
Previous cardiovascular disease
No
Yes
Overall
Systolic blood pressure
≤ 132 mm Hg
> 132 to < 145 mm Hg
≥ 145 mm Hg
Hazard Ratio (95% Cl)
0.50 0.75 1.00 1.20
Intensive Treatment Better Standard Treatment Better
The SPRINT Research Group. N Engl J Med.
2015;373:2103-2116
27. Hazard Ratios (95% CI) for Major Cardiovascular Disease
at Different Levels of Achieved Systolic BP
120-124 mm Hg vs. higher SBPs
130-134 mm Hg vs. higher SBPs
140-144 mm Hg vs. higher SBPs
150-154 mm Hg vs. higher SBPs
Key Findings
• In randomized comparisons,
progressive reduction in risk of
CVD at lower levels of achieved
SBP down to levels below current
US & European recommendations
• Similar findings for stroke, CHD
and all-cause mortality
• Similar pattern in sensitivity
analyses where
• SPRINT results excluded
• Results from four trials with
risk for bias excluded
• Consistent results with direct
meta-analysis
• Similar findings for CVD benefit
in several other meta-analyses
(e.g. Bangalore et al, Verdecchia
et al., and Thomopoluset al.)
Network Meta-analysis (42 RCTs: N = 144,220)
Bundy JD et al.
JAMA Cardiol.
2017;2:775-781.
28. 2017 ACC/AHA Evidence Review Committee
CV Event Relative Risk 95% CI
Major CVD 0.81 0.70-0.94
MI 0.86 0.76-0.99
Stroke 0.77 0.65-0.91
Heart failure 0.75 0.56-0.99
Based on the totality of the findings, the 2017 ACC/AHA BP Guideline Writing Committee
were unanimous in their opinion that a target of <130 mm Hg during antihypertensive
therapy is desirable for prevention of MI, stroke, heart failure, and major CVD events
Meta-analysis: 19 RCTs with 1.8-8.4y follow-up
Reboussin DM et al. J Am Coll Cardiol. 2017;Epub ahead of print
More intensive blood pressure lowering (including to SBP <130 mm Hg) significantly reduced CV risk
2017 ACC/AHA BP Guideline
Whelton PK et al. Hypertension/J Am Coll Cardiol 2017;Epub ahead of print
29. 2017 ACC/AHA BP Guideline: Treatment Targets
SBP DBP
<120 and <80
120–129 and <80
130-139 or 80-89
130–139 or 80–89
≥130 or ≥80
≥140 or ≥90
≥130
CVD Risk
N/A
N/A
No CVD and 10-year
ASCVD risk <10%
Clinical CVD or 10-year
ASCVD risk ≥ 10%
Diabetes or CKD
N/A
Age ≥65 years
Recommended Treatment
N/A
N/A
SBP <130 and DBP <80 mm Hg
SBP <130 mm Hg
Whelton PK et al. Hypertension/J Am Coll Cardiol 2017;Epub ahead of print
30. Whelton PK et al. Hypertension/J Am Coll Cardiol. 2017 [Epub ahead of print]
Why is 2017 ACC/AHA Guideline SBP target higher than in SPRINT?
31. BP Targets in other Guideline Recommendations
• 2016 Canadian Guidelines:
• Intensive BP treatment to target SBP ≤ 120 mm Hg in high risk patients (Grade B)
• Shared decision-making necessary for the safe implementation of intensive BP control
• 2016 Australian Guideline:
• High CVD risk, <120 mm Hg SBP target can improve CVD outcomes (Strong)
• Close follow-up is recommended to identify treatment-related adverse effects (Strong)
• 2017 ADA (Target BP <130/80 mm Hg in adult DM patients at high risk for CVD)
32. Adverse Events During Intensive Antihypertensive Drug Therapy
• Electrolyte abnormalities and small decrease in eGFR are possible
• Some risk of hospitalization
– Biological and clinical implications uncertain
• Balance of benefits and adverse effects
– Should not be equally weighted
» Preventing major CVD events and death more important than adverse events
– Even when equally weighted, cost effectiveness analysis suggests
benefits outweigh adverse effects by a substantial margin:
• Clinicians can manage/mitigate adverse effects
– By modifying intensity of treatment or discontinuing treatment
“cost-effective at typical thresholds for value in health care
and remains so even with substantially higher adverse event rates”
Richman IB et al. JAMA Cardiol. 2016;1:872-879
33. Best Proven Nonpharmacological Interventions for Prevention and Treatment of Hypertension
Intervention Dose Approximate Impact on SBP
Hypertension Normotension
Weight loss Calorie reduction
& physical activity
Best goal is ideal body weight. Expect about 1 mm
Hg for every 1-kg reduction in weight.
-5 mm Hg -2/3 mm Hg
Healthy diet DASH diet Diet rich in fruits, vegetables, whole grains, and low-
fat dairy products, with reduced saturated and total
fat.
-11 mm Hg -3 mm Hg
Dietary
sodium
Reduced intake Optimal goal <1500 mg/d, but at least a 1000-mg/d
reduction in most adults.
-5/6 mm Hg -2/3 mm Hg
Dietary
potassium
Enhanced intake
through diet
3500–5000 mg/d, preferably by diet rich in
potassium.
-4/5 mm Hg -2 mm Hg
Physical
activity
Aerobic ● 90–150 min/wk (65%–75% heart rate reserve) -5/8 mm Hg -2/4 mm Hg
Dynamic resistance ● 90–150 min/wk (50%–80% 1 rep maximum)
● 6 exercises, 3 sets/exercise, 10 repetitions/set
-4 mm Hg -2 mm Hg
Isometric resistance ● 4 × 2 min (hand grip), 1 min between exercises,
30%–40% max. voluntary contraction, 3 sessions/wk
(8–10 wk)
-5 mm Hg -4 mm Hg
Moderation
in alcohol
intake
Alcohol consumption In individuals who drink alcohol, reduce alcohol to:
● Men: ≤2 drinks daily
● Women: ≤1 drink daily
-4 mm Hg -3 mm Hg
Whelton PK et al. Hypertension/J Am Coll Cardiol. 2017;Epub ahead of print
34. • First-step agents:
– Compelling indication
• Use agent(s) that concurrently lower BP (e.g. post-MI, SIHD, HF)
– No compelling indication
• Achieving BP goal more important than choice of drug therapy
• Diuretic or CCB often good choice, but
• Drugs from following classes acceptable
– Diuretic (esp. long-acting thiazide-type agent such as chlorthalidone)
– Calcium channel blocker (CCB)
– Angiotensin converting enzyme inhibitor (ACEI)
– Angiotensin receptor blocker (ARB)
Choice of Drug Therapy in Treatment of Hypertension
Whelton PK et al. Hypertension/J Am Coll Cardiol. 2017 [Epub ahead of print].
35. • Combination drug therapy
– Initial treatment with two drugs in most patients
• esp. in blacks and adults with stage 2 hypertension with BP ≥20/10 above target
– Use agents with complimentary modes of action
• e.g. diuretic or CCB with ACEI or ARB
– Use combination pill when feasible
– In blacks with hypertension but without HF or CKD (including those with DM):
• Initial treatment should include thiazide-type diuretic or CCB
– Simultaneous use of ACEI and ARB not recommended
• Potentially harmful
Choice of Drug Therapy in Treatment of Hypertension
Whelton PK et al. Hypertension/J Am Coll Cardiol. 2017 [Epub ahead of print].
36. Antihypertensive Drug Treatment: Follow-up
• Adults initiating a new or adjusted drug regimen for
treatment of hypertension should have a follow-up
evaluation of adherence and response to treatment at
monthly intervals until control is achieved
Whelton PK et al. Hypertension/J Am Coll Cardiol. 2017 [Epub ahead of print].
37. • In adults ≥65 years, with average SBP ≥130 mm Hg:
– if noninstitutionalized ambulatory community-dwelling adult,
treat to <130 mm Hg
– If high burden of comorbidity and limited life expectancy,
treatment decisions should be based on clinical judgement
and patient preference, using a team-based approach to
assess risk/benefit of potential treatment
Whelton PK et al. Hypertension/J Am Coll Cardiol. 2017 [Epub ahead of print].
Antihypertensive Drug Treatment: Older Adults
38. • In adults with hypertension and DM,
• If average BP ≥130/90 mm Hg, initiate antihypertensive
drug therapy and treat to <130/90 mm Hg
• All first-line classes of antihypertensives (i.e., diuretics,
ACE inhibitors, ARBs, and CCBs) useful and effective
• Consider ACEI or ARBs in presence of albuminuria
Whelton PK et al. Hypertension/J Am Coll Cardiol. 2017 [Epub ahead of print].
Antihypertensive Drug Treatment: Diabetes Mellitus
39. Antihypertensive Drug Treatment: Heart Failure
• Prescribe guideline directed medical therapy (GDMT)
• Nondihydropyridine CCBs not recommended
• BP goal: <130/80 mm Hg
• If symptoms of volume overload, prescribe diuretics
• If high BP persists, prescribe ACE inhibitors or ARBs and beta blockers
• BP goal: <130 mm Hg
39
Whelton PK et al. Hypertension/J Am Coll Cardiol. 2017 [Epub ahead of print].
Hypertension and heart failure with preserved ejection factor (HFpEF)
Hypertension and heart failure with reduced ejection factor (HFrEF)
40. • Adults with hypertension and stable ischemic heart disease (SIHD)
– Use GDMT medications (e.g., beta blockers, ACE inhibitors, or ARBs) for compelling
indications (e.g., previous MI, stable angina)
– Add other drugs (e.g. dihydropyridine CCBs, thiazide diuretics, and/or mineralocorticoid
receptor antagonists) as needed to control hypertension
– If hypertension persistent and angina, add dihydropyridine CCBs to GDMT beta blockers
– In adults who have had an MI or ACS, reasonable to continue GDMT beta blockers for
treatment of hypertension beyond 3 years
– In patients with CAD (without HFrEF) and angina who had MI > 3 years previously,
consider beta blockers and/or CCBs
– BP target: <130/80 mm Hg
Whelton PK et al. Hypertension/J Am Coll Cardiol. 2017 [Epub ahead of print].
Antihypertensive Drug Treatment: Ischemic Heart Disease
41. • Adults with hypertension and CKD
– Treatment with ACE inhibitors reasonable to slow kidney disease progression:
• Stage 3 (eGFR 20 - <60 mL/min/1.73 M2) or higher
• Stage 1 or 2 with albuminuria ≥300 mg/d, or ≥300 mg/g albumin-to-
creatinine ratio [or equivalent in first morning void]
– Use of ARBs reasonable if ACE inhibitors not tolerated
– BP goal: SBP <130/80 mm Hg
Whelton PK et al. Hypertension/J Am Coll Cardiol. 2017 [Epub ahead of print].
Antihypertensive Drug Treatment: CKD
42. Strategies to Improve Hypertension Treatment and Control
• Adherence strategies
– Once daily dosing/combination pills
• Strategies to promote lifestyle modification
• Team-based care
– Health professionals: physicians, nurses, pharmacists
– Patient
– Staff: office staff and community health workers
– Others: spouse, relatives, friends
• Use (active) of EHR and Patient Registries
• Telehealth strategies
• Performance measures and quality Improvement initiatives
• Financial incentives
Shared Decision-making
43. Resistant Hypertension: Diagnosis, Evaluation, and Treatment
Whelton PK et al. Hypertension/J Am Coll Cardiol. 2017 [Epub ahead of print].
44. • Severe hypertension (BP >180/120 mmHg):
• Emergency: if acute, life-threatening manifestations of target organ damage
(hypertensive encephalopathy, subarachnoid or intracerebral hemorrhage, acute ischemic
stroke or MI, pulmonary edema, unstable angina, aortic dissection, acute renal failure),
severe preeclampsia/eclampsia, or pheochromocytoma crisis:
• Admit to ICU for continuous BP monitoring and parenteral
antihypertensive drug therapy
• Reduce SBP to <140 within first hour (<120 mm Hg for aortic dissection)
• Urgency: if no compelling indication:
• Reduce SBP no more than 25% in first hour and if stable to 160/100 within next 2-
6 hours and cautiously to normal during next 24-48 hours
Hypertensive Emergency and Urgency
Whelton PK et al. Hypertension/J Am Coll Cardiol. 2017 [Epub ahead of print].
45. Summary
• Accurate BP measurement to improve diagnosis and
management of hypertension
• More intensive BP control than previously
recommended to reduce risk of CVD and mortality
• Employ strategies known to improve BP contol
47. Evaluation, Post-test & Claiming Credit
Thank you for participating in the Current Approaches to Detection, Evaluation, and Management of
High Blood Pressure educational activity recorded between May and October 2018 and presented by the
Tulane University Center for Continuing Education, Department of Epidemiology, and Department of
Medicine.
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