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Lecture 1. Chemistry of NA Purines & Pyrimidines.ppt
1. Dr. Vishnu Kumar
Professor & Head, Department of
Biochemistry, MPTMC, SIDDHARTH NAGAR
vkawasthi@hotmail.com
madhwapur1976@gmail.com
Nucleic Acid Chemistry
Competency Number BI: 7.1
CORE COMPETENCY
2. LEARNING OBJECTIVES
After completion of this lecture learner
should be able to define/describe:
Purines and Pyrimidines
Major & minor Purines
Major & Minor Pyrimidines
Nucleosides & Nucleotides
Synthetic Analogs of nucleotides
3. Purines & Pyrimidines
Cyclic compounds containing
Nitrogen, Carbon and other elements.
Their principal derivatives are
nucleosides and nucleotides.
11. Nucleosides & Nucleotides
Nucleosides – compounds containing
nitrogenous base and ribose or deoxy
ribose.
Nucleotides – N base + ribose or deoxy
ribose + phosphate.
12. Nucleosides
Purine or Pyrimidine bases & ribose or
deoxy ribose sugar linked by glycosidic
linkage.
Linkage is between N 9 of purine or N I
of pyramiding with carbon 1 of sugar.
21. Other important nucleotides.
GTP-- Energy Source.
CGMP--Acts as 2nd messenger in hormone
action.
UDP– UDP Glucose, UDP Glucuronic acid.
CTP– synthesis of phospholipids.
Vitamin nucleotides– NAD, NADP,
FAD,Coenzyme –A.
22.
23.
24. Synthetic Analogs of
nucleotides
5-Fluro uracil.
5 Iodo uracil.
6-thio guanine.
6- mercapto purine.
Allopurinol.
AZT– Azido di deoxy thymidine.
Di deoxy thymidine.
yS
25. Nucleic Acids
Polymers of Nucleotides, linked by phospo
diester linkages, which link successive
nucleotides in which 5’ phosphate group of
one nucleotide unit is joined to 3’ hydroxyl
group of the next nucleotide.
Prime ( ‘) means position on the ribose
molecule.
For example—3’ AMP means phosphate is
attached to the 3rd position of ribose.
26.
27. Deoxy ribonucleic acid.
(DNA)
Discovered in 1953 by Watson &Crick.
Function – stores and transmits genetic
information.
Evidenced by Avery ,Macleod & McCarty
in 1944.
28. Definition
Polymer of deoxy ribonucleotides
(A,G,C,T.) linked by phospho diester
linkage. Double stranded, two strands
are linked by hydrogen bonds.
Carries and transmits genetic
information.