Dr. Pravin Patel's hospital uses stem cell therapy and other alternative treatments as possible cures for diabetes and arthritis without surgery or drugs. Their stem cell research aims to regenerate cells like pancreatic islet cells to cure Type 1 diabetes. They have seen success rates of 85% for diabetes and arthritis patients through combination therapies like ozone therapy, herbal preparations, and physiotherapy, reducing the need for insulin and pain medications. X-ray images show improvements in arthritis patients' joints after stem cell and other treatments.

1. Dr. Pravin Patel
Stem cell Possible cure for
Diabetes Mellitus & Arthritis
We make the people young, healthy without surgery or harmful drugs
Dr. Pravin Patel Innovative
Hospital & Research Labs

2. Diabetes
• A multisystem disease related to:
–Abnormal insulin production or
–Impaired insulin utilization or
–Both of the above
• Leading cause of heart disease, stroke,
adult blindness, and non-traumatic lower
limb amputations

3. Normal Insulin Metabolism
• Insulin
–Produced by the  cells in the islets of
Langherans of the pancreas
–Facilitates normal glucose range of 3.9 – 6.7
mmol/L

4. Diabetes Mellitus confirmatory Diagnosis
• Fasting plasma glucose level 7 mmol/L
• Random plasma glucose level  11.1 mmol/L plus
symptoms
• Impaired Glucose Tolerance Test – Diabetes if BG >
11.1 mmol /L 2 hr post challenge
• Hemoglobin A1C test (glycosylated Hgb)
– Reflects amount of glucose attached to Hgb over
life of RBC

5. HbA1c
By measuring glycated haemoglobin (HbA1c), clinicians are able to get an overall
picture of what our average blood sugar levels have been over a period of
weeks/months.
The diabetic people the HbA1c high reading, increases diabetes-related
complications risk.

6. Type 1 Diabetes Mellitus
Acute Complications
• Diabetic ketoacidosis
• Hyperglycemia hyperosmolar state
• Hypoglycemia

7. Chronic complications
Chronic complications-----------Vascular Disease
• Chronic elevation of blood glucose level
leads to damage of blood vessels
(angiopathy) cause the basement
membrane to grow thicker and weaker. In
diabetes, problems are micro and macro
vascular disease based on the damages to
small blood vessels or in the damage to the
arteries.
• The microvascular disease leads to a
microangiopathy complications like Diabetic
neuropathy, Diabetic nephropathy, Diabetic
retinopathy, Diabetic cardiomyopathy.

8. Diabetic Neuropathy
• The decreased sensation of the
foot abnormalities in other nerves,
extended later often to fingers
and hands. The damaged blood
vessels can lead to diabetic foot
ulcers .
• This disease complications may
lead to mononeuritis or autonomic
neuropathy.
• Diabetic severe neuropathic
complications attribute the
amyotrophic muscle weakness.

9. Diabetic Nephropathy
• Damage to the kidney which can lead to chronic renal failure,
eventually requiring dialysis.
• Diabetes mellitus is the most common cause of adult kidney
failure

10. Diabetic retinopathy
• Growth of crumbled and new blood vessels with inferior
quality in the retina and macular edema, which can lead to
blindness.
• Retinal damage through microangiopathy is the common
cause of blindness in adults.

11. Macrovascular disease
• The Macrovascular complication of coronary artery disease,
leading to myocardial infarction and Ischemic stroke
• Peripheral vascular disease associated with neuropathy
causes foot rot and leading to amputation .
• Diabetic myonecrosis and there appears to be a lower
prevalence of abdominal aortic aneurysm.
• Diabetes leads to higher morbidity, mortality and operative
risks.
• Diabetic encephalopathy increased the cognitive decline and
dementia.

12. Diabetic cardiomyopathy
• Damage to the heart, leading to diastolic dysfunction and
eventually heart failure.

13. Diabetic Angiopathy
• Diabetic gangrene referred to
as diabetic foot comes under
peripheral vascular diseases
categorized under macro
vascular diseases.

14. Cure for Diabetes Type 1
• Type 1 diabetes is due to the failure of of the beta
cells in the Islets of Langerhans this comlication can
be cured by Pancreas or a kidney-pancreas
transplant.
• Stem cell research has also been suggested a cure
since it may permit regrowth of Islet cells, perhaps
eliminating the need for immuno-suppressants.
• The immuno suppressive drug therapy have been
used for the Type I auto immune complications.

15. Cure for Diabetes Type 2
• Type 2 has had no definitive cure for the
patients with diabetes.
• There are drugs are available in the market to
reduce the blood glucose level.
• Some obese cases controlling the food habits
and other surgical procedures bring down the
glucose level considerable amount.

16. Stem cells & Regenerative medicine
• A form of cell based therapy with an objective of the
damaged organ or tissue to heal or regenerate the
activity by replacing with totipotent or pluripotent
cells and to treat disease, injury or ailment.
• Cell therapy is the only way to enable the body to
renew itself and regenerate into a healthier state due
to the renewed tissues or organs.
• Cell therapy is being carried out to cure various
disease around the world everyday.

17. Stem cell research on type I Diabetes

18. Indications Being Addressed using MSCs
in Clinical Trials
Data for 352 registered clinical trials.

19. Our Treatment methods
• We do combination of treatment to create
synergistic effect to recover the patients from the
problems
• We analyze the route cause and do treatment and
for the cause and effect
• We prefers the methods of alternative medicines
which does no side effects to our body

20. The Positive effective of Ozone treatment
92% of the insulin dependent and 88% of the insulin-
independent patients resulted decrease of the
hyperglycemia diminish of thirst Dis appearance of poly
urea, Skin itch, weakness.
Average level of hyperglycemia decreased by 26%.
The dose of insulin was reduced by 50% and diminished 2/3
of Treated patients.
The dose of oral sugar reducing remedies was reduced to
36%.

21. The intravenous infusions of Ozone found to be
effective elimination tissue hypoxia.
The application of Ozone treatment also helped the
patients to recover from foot with purulent necrotic
and other inflammatory lesions and also reduces the
endogenous intoxication.
The Ozone has Antimicrobial , anti inflammatory,
immunostimulating, antihypoxic and detoxicating,
biosynthetic, bio energetics, hemostatic properties etc
have been explored to cure various associated
secondary infection disease complications.

22. Age group Pre
treatment
HbA1c
scale
Treatment
Dose
Intervention Post
treatment
HbA1c
scale
25-30 7.8+ 1 7.8+ 1 1 million/Kg
BW
Ozone/
Herbal
preparation
Insulin
reduced
to 50%
5.1+ 1
30-45 8.1+2 8.1+2 1 million/Kg
BW
Ozone/
Herbal
preparation
Insulin
reduced
to 30%
5.5+0.75
45-65 9.1+2 9.1+2 1 million/Kg
BW
Ozone/
Herbal ppn
Chelation
Insulin
reduced
1/3 dose
6.1+.25
>65 9.6+2 9.6+2 1 million/Kg
BW
Ozone/
Herbal ppn
Chelation
Insulin
reduced
1/3 dose
7.6+0.2
Diabetes Treatment milestone Achievement
Total No of Patients Treated for Diabetes : 45
Type I : 08
Type ii : 37
Success percentage : 85%
Failure percentage : 13 %
Reason for failure: Poor cooperation by the patients and other associated

23. Ozone therapy effect in Patients with
Insulin –independent Diabetes
Ozone therapy effect in Patients with
Insulin –dependent Diabetes

24. Rheumatoid Arthritis
• Symptoms: Pain,
stiffness, swelling in
joints of hands, wrists,
elbows, feet, ankles,
knees, and neck
• Diagnosis: joint
examination, medical
history, several tests
• Risk Factors: Age,
Gender (female),
genetic susceptibility,
smoking

25. Arthritis
Age-associated degeneration of damage and
eventual loss of cartilage in joints, leading to
pain and restriction of joint mobility.
Over the years, doctors have elaborated many
cartilage repair procedures or to reduce the
pain in joints that help the patients to
postpone the joint replacement.
Own stem cells could drastically speed up the
healing process
The stem cells injected intravenously to assist in
generalized healing and inject the cells locally
and painlessly into joints as depicted.

26. Rheumatoid Arthritis
• Treatment:
– Physical Therapy: exercise, heat/cold, massage
– Occupational Therapy
– Biofeedback (to control pain)
– Counselling
– Accupuncture
– Supplements
– Blood Filtering (severe cases)

27. Osteoarthritis
• Treatment:
– Medications: NSAIDS, Acetomeniphen,
corticosteroids, hyaluron injections
– Surgery: arthroscopy, osteomoty, joint
replacement, hip replacement, arthrodesis
(fusing)

28. Repair
• The damaged Cartilage has limited repair capabilities,
chondrocytes are bound in lacunae, cannot migrate to
damaged areas.
• Hyaline cartilage does not have a blood supply, the
deposition of new matrix is slow or difficult. Damaged
hyaline cartilage is replaced or converted to
fibrocartilage scar tissue.
• In a 1994 trial, Swedish doctors repaired damaged
knee joints by implanting cells cultured from the
patient's own cartilage.
• In 1999 US chemists created an artificial liquid
cartilage for use in repairing torn tissue. The cartilage
is injected into a wound or damaged joint and will
harden with exposure to ultraviolet light

29. Arthritis Impact Measurement Scale
(AIMS) questionnaire

30. Arthritis Impact Measurement Scale (AIMS)
questionnaire

31. •Visual Analog Pain Scale [ Time Frame: Baseline, 6 weeks, 3 months, 1 year ]
Change in subjective pain, function, functional activity measurement and a clinical physical
exam
Preparing the chart based on the patient’s Statement Examination with the help of
Physiotherapist about their severity of the pain Intensity – Location – Onset – Duration –
Variation and Quality of Improvement
Rheumatoid Arthritis-Post cell
Treatment evaluation

32. •Physician Global Assessment
[ Time Frame: Baseline, 6 weeks, 3 months, 1 year ]
Change in physician rated disease activity measurement
Secondary Outcome Measures:
•Radiologic [ Time Frame: Baseline, 1 year ]
Radiographic changes of the knee
Rheumatoid Arthritis-Post cell
Treatment evaluation

33. Growth occurs by two mechanisms
Interstitial growth –
Chondroblasts within the existing cartilage divide and form
small groups of cells, isogenous groups, which produce matrix
to become separated from each other by a thin partition of
matrix. Immature cartilage shows Interstitial growth .
Appositional growth –
Mesenchymal cells surrounding the cartilage in the
perichondrium or in the chondrogenic layer differentiate into
chondroblasts. The mature cartilage shows Appositional
growth .
The differentiated Chondrocytes filled in the lacunae to form
the cartilage.
Cellular regeneration/ growth

34. Stem cell therapy using Stem cell

35. • Inhibit prostaglandins and cytokines and reduce oxidative
stress
• Degenerative, Inflammatory and Autoimmune Conditions
– Rheumatic and Rhenmatoid arthritis
– Arthrosis
– Psoriasis, MS
Anti-inflammatory, stimulation of antioxident capacity,
immuno-modulation, release of TGF-β
Role of Ozone in Arthritis Treatment

36. Age group No of patients
treated
Pain scale Treatment
Dose
Intervention Pain scale on
treated grps
45-55 12 3 and above 1million
cells per kg
Physiotherapy
ozone
2
55-65 23 5 1million
cells per kg
Physiotherapy
ozone
2
>65 24 5 1million
cells per kg
Physiotherapy
Ozone
1
Arthritis Treatment milestone Achievement
Total No of Patients Treated for Arthritis : 59
Success percentage : 85%
Failure percentage : 12 %
Reason for failure : Poor cooperation by the patients
and further damage poor exercise, weak muscle
Poor Physiotherapy and other associated problems

37. Pre and post Treatment X rays
37 years Female

38. 82 years Male
Pre and post Treatment X rays

39. 68 year old Male
Pre and post Treatment X rays

40. Pre Treatment X ray of patient from
USA
Recently treated 78 year old Male
Post treatment X ray we recommend after one year of post treatment