2. Review the classification of antimicrobials
Define pharmacokinetic and pharmacodynamic principles and their
relationship to effective antimicrobial therapy
Review relevant microbiologic information as it relates to choosing an
antimicrobial
Discuss patient and drug related factors that influence the selection of the
appropriate antimicrobial agent
Identify monitoring parameters to evaluate antimicrobial therapy
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4. Antibiotics are anti-infective substances
(byproducts) derived from microbes and used
against microbial infections.
Bactericidal: kill the bacteria
Bacteriostatic: prevents the growth of
bacteria
MIC
MBC
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ANTIBIOSIS
SELECTIVE TOXICITY
5. Prophylaxis – prevention of serious infection at-
risk situation
Empiric therapy - management before confirming
the presence of infection or its cause
Directed-therapy – aim of treatment at micro-
organisms which have been confirmed
Narrow spectrum antibiotics
Extended spectrum
Broad spectrum , TETRACYCLINE,
CHLORAMPHENICOL.
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6. Inhibit cell wall synthesis-Penicillins,
Cephalosporins
Damage to cell membrane-Polymyxins
Inhibit protein synthesis- Tetracyclines
Inhibit DNA synthesis- Ciprofloxicin
Interference with RNA function-
Aminoglycossides
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10. Appropriate spectrum of activity for the clinical
setting.
No toxicity to the host, be well tolerated.
Low propensity for development of resistance
No hypersensitivity in the host
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11. USED WHEN NO ALTERNATIVE
Polymyxin B : neurotoxicity, nephrotoxicity
Vancomycin : Ototoxicity, nephrotoxicity
Amphotericin B : neurotoxicity, bone marrow
depression, nephrotoxicity,
Low therapeutic index
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High Therapeutic index- Penicillin,
Cephalosporins.
12. Used carefully
Low therapeutic index
Aminoglycosides: Ototoxicity, nephrotoxicity
Tetracyclines: hepatotoxicity, nephrotoxicity,
antianabolic effect
Chloramphenicol: bone marrow depression
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13. Hypersensitivity reactions
Penicillin, cephalosporin, sulfonamides etc.
ORGAN TOXICITY
Drug Resistance
Natural : G-ve bacilli resistance penicillins
: M.tuberculi resistance to
conventional antimicrobials.
Acquired : Mutation or gene transfer
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15. Causes for resistance:
DRUG TOLERANT : deviation of metabolic path e.g.
Sulfonamide
DRUG DESTROYING: beta-lactamase by staphylococci,
gonococci etc. Chloramphenicol acetyl transferase by
resistant E.coli, H.influenzae.
DRUG IMPERMEABILITY; Closure of porin (channel)
CROSS RESISTANCE: Erythromycin = Clindamycin
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PATKI
16. Avoid overuse or misuse of antimicrobials
Select rapidly acting selective drugs
Reserve the use of broad spectrum antimicrobials
Use antimicrobial-combination for prolonged use.
Follow intensive treatment for resistance
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17. Normal Flora, commensal organisms, opportunistic
Bacteriocins
Non-susceptible pathogens
Susceptible pathogens
Broad-spectrum
Antimicrobials
Emergence of
Superinfection
Prevention of infections
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18. Candida albicans: monilial diarrhea, thrush,
vulvovaginitis
Nystatin or clotrimazole
Staphylococci (resistance)
Cloxacillin
Clostridium difficile: Pseudo-membraneous
enterocolitis. common after colorectal surgery -
enterotoxin damages gut mucosa forming
plagues
Metronidazole and vancomycin.
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20. Local reaction at the site of administration
Oral: Gastric irritation
Local: Dermal/corneal
Intramuscular: abscess
Intravenous: thrombophlebitis
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21. 1. Synergism:
Sulfonamide with trimethoprim
Betalactamase inhibitor with penicillins
2. To reduce incidence of adverse effects:
Drug combination reduce the individual doses;
therefore side effects reduced
3. To reduce the duration of the course
Amphotericin B + flucytosine will reduce the
duration of the course
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22. 4. To prevent emergence of resistance:
Drug regimen in the treatment of
tuberculosis
5. To broaden the spectrum of antimicrobial
action:
Essential in mixed & severe infections.
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23. Rheumatic fever (streptococci): Peniciilin G
choice
Tuberculosis: Isoniazid with or without
rifampicin
Meningococcal meningitis (epidemic):
rifampicin/sufadiazine
Gonorrhoea/syphilis (before & after contact):
procaine penicillin
Malaria (endemic): chloroquine/mefloquine
Influenza A2 (epidemic): amantadine
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25. Improper selection of drug, dose, route or
duration
Late treatment
Poor host defense
Lack of adjuvant measures: drainage of
abscesses, control of diabetes, adjustment of pH
in UTI.
Dormant stage of organisms
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26. Identifying organism
Organisms susceptibility
Site of infection
Patients factor, immunity,renal, hepatic,age
Safety of antimicrobial
Cost of therapy
Pregnancy
Post antibiotic effect
Empirical therapy.02/28/19 PATKI 26