ANATOMY AND PHYSIOLOGY OF REPRODUCTIVE SYSTEM.pptx
Dr hamed aleraky metabolic acidosis
1. Dr. Hamed Ezzat El-Eraky
Nephrology Specialist
Mansoura International Hospital
2. PHPH
Is the –ve Log of H+ Concentration
Normal Plasma H+ Concentration is 40 nanomoles/litre
Thus, doubling or Halving H+ concentration Increases
or Decreases PH by Approximately 0.3
AcidAcid An H+ Donor
BaseBase An H+ Acceptor
3. Blood PH > 7.45AlkalaemiaAlkalaemia
Blood PH < 7.35AcidaemiaAcidaemia
AcidosisAcidosis
Is the Abnormal Process that Tends to
Lower the Blood PH
AlkalosisAlkalosis
Is the Abnormal Process that Tends to
Raise the Blood PH
4. PaO2PaO2
Is the Partial Pressure of O2 in arterial Blood Normal Value when Breathing Air: (Age Dependent(
95-100mmHg or 12.5-13 Kpa at Age of 20 Years - 80 mmHg or 10.8 Kpa at Age of 65 Years
A Substance that Counteracts the Effect of Acid or Base on Blood PHBufferBuffer
HCO3-HCO3- Is the Blood Bicarbonate Concentration Normal Value is : 22-26 mmol/l
PaCO2PaCO2 Is the Partial Pressure of CO2 in Arterial Blood Normal Value: 35-45 mmHg or 4.7-6 Kpa
Mixed DisorderMixed Disorder Two or More Primary Acid-Base Disorder Coexist
CompensationCompensation The Normal Body Processes that Returns Blood PH Towards Normal
6. Acid-base balance is assessed in terms of CO2-HCO3
buffer system. It is expressed in pH:
pH = 6.10 + log ([HCO3-] ÷ [0.03 x PCO2])
Large number of metabolic events are sensitive to pH
mainly brain and heart
That is why a number of mechanisms are present in acid
base regulation holding blood pH in narrow limits
7.38-7.42
7. An acidemia (low pH( can result from either a
low HCO3 or a high CO2 .
An alkalemia (high pH( can result from either
a
high HCO3 or a low CO2
8.
9. Continuous production of H+ from normal metabolism
Metabolic event Acid produced
Aerobic glycolysis CO2 (15,000 mmol/d)
Krebs Lactic acid
lipolysis Free FA
Hepatic metabolism ketones
Dietary protein amino acids
10. Immediately buffers in blood (NaHCO3)
change strong acid to weak acid
after several minutes this weak acid
decomposes to CO2 carried by Hb to be
expired by lungs
After several hours the kidney smoothly
reabsorbs the HCO3 wasted
11. Acidosis:
• hyperventilation to wash excess CO2 produced
• acidification of urine to remove H+
Alkalosis
• only alkalization of urine
• respiration cannot stop!!!
250 cases of acidosis for one case of alkalosis
12. Respiratory Acidosis
• CO2 retention due to hypoventilation: type II respiratory failure e.g.COPD
• there is conservation of HCO3 by the kidney
• new steady state of CO2 and HCO3 occurs
Metabolic Acidosis
• H+
buffered H2CO3 CO2 + H2O
• CO2 washed by hyperventilation CO2 falls
• HCO3 continuously consumed by H+ cannot raise and remains low HCO3
These compensatory mechanisms keep pH constant
When H+ production or CO2 retention > compensatory mechanisms fall in pH
acidosis
13. Fixed acids: which produces H+ cannot be excreted except
by kidneys e.g. lactic
Volatile acids can be changed into CO2 e.g. H2CO3 and
aerobic glycolysis
fixed : volatile = 100 : 15000 meq/day!!
Severe acidosis develops rapidly in respiratory
embarrassment
Acidosis develops slower in renal failure
14. HCl + NaHCO3 H2CO3 + Na Cl
Non volatile acids
Volatile acids
CO2H2O
HCO3
Kidney's
CO2 + H2O H2CO3
H+ Na+
CA
15. Normally blood is neutral
• amount of anions = amount of cations
Most abundant cations are
• Na+ 140 meq/L (135-145)
• K+ 4 meq/L (3.5-5.0)
Most abundant anions are
• HCO3 25 meq/L (22-26)
• Cl 104 meq/L (100-108)
16. If you measure all the anions they should be
equal to all the cations
• cations - anions = zero
it is difficult to measure them all.
An easy way is measure the most abundant
[Na + K] - [HCO3 + Cl] = [144] - [129] = 16
Why is this difference? Are the cations more?
Of course not
17. It is due to presence of unmeasured anions (and cations)
and if you measure them all definitely your sum will be zero
[Na + K + UC] - [HCO3 + Cl + UA] = 0
Unmeasured anions are mainly albumin and proteins
Unmeasured cations are mainly Ca and Mg
under normal conditions:
[Na + K] - [HCO3 + Cl] = 15 +/- 2
This is called normal anion gap
18. High Anion Gap Acidosis
Normal Anion Gap Acidosis
19. • There is a load of non chloride containing acid e.g. lactic
acid
• lactic acid + NaHCO3 Na lactate + H2CO3
• There is a fall in HCO3 conc and rise in lactate
• calc: [Na + K] - [HCO3 + Cl] = > 17
• The fall in HCO3 is compensated by the unmeasured
lactate
20. There is addition of a Cl acid e.g. HCl or Loss of
HCO3 (with renal absorption of chloride)
• HCl + NaHCO3 NaCl + H2CO3
• There is fall in HCO3 concentration and rise in chloride
• calc: [Na + K] - [HCO3 + Cl] = 15 +/- 2
since chloride is increased it is easier to name it
hyperchloremic acidosis
21. Three main causes (DAD)
1. Diversion of ureters (uretero-colic)
2. Diarrhea
3. Aldosterone deficiency (1ry or 2ry)
– Other less common causes (mainly drugs)
• RTA
• Diamox - ammonium chloride -arginine -Lysine
23. Sometimes you can get a mixed type
• renal failure due to obstructive uropathy
• Addison with pre-renal failure
• In such cases chloride is not that high and AG is just above
normal
If there is hypoalbuminemia
• less unmeasured negative charges available
• body has to get rid of Na to reach isoelectric
• anion gap will seem less than it should be
24. Kusmull’s respiration
• deep and rapid , shallow and rapid
Heart
• -ve inotrope , low AF threshold
Mental confusion
extracellular K shift
• Hyperkalemia
Effect on ODC
• Shift of ODC to the
right opposing 2-DPG
25. urine for ketones
+VE -VE
RBS
LOW OR N
STARVATION
high
DIABETES
Anion gap
high
renal failure
lactic acidosis
toxins
hyperchloremic
hypoaldosteronism
for workup
if renal function
and lactate
do not explain
send to toxicology
28. Hazards of giving
• hypertonic solution
volume overload (ESP IN RENAL FAILURE)
• Overshoot alkalosis :ketones and lactate could further be metabolized to
bicarbonates
• Rapid correction of acidosis may shift ODC to left and 2DPG will dominate
to cause hypoxia
• Bicarb will decompose to CO2 which passes easily to BBB and cause CSF
paradoxical acidification (the use of carbicarb)
29. Hazards of not giving
• effects on heart brain and muscle
At a certain stage with acidosis (pH7.15) all the
compensatory mechanisms are at their maximum
power
• No more compensatory mechanisms available:
• any mild change in concentrations of CO2 or HCO3 will
greatly affect the pH
30. Judge your decision by the pH and never by the HCO3
or CO2 levels
Do not give HCO3 unless pH is lower than 7.2 (7.1 by
some authors)
Calculate the deficit by the formula
[24-HCO3] x 50% of body weight
Correction should be slowly over 3 hours guided by
hourly blood gases and HCO3