1. Biological Theories of Aging
Stop the Biological Clock
October 23, 2016
Dr. Jeeri R Reddy Sr. PhD
The President
Director Research & Development
Charles Rivers Institute
An Anti-Ageing & Human Longevity Organization
Website: http://www.charlesriverbiotech.org
www.charlesrivers.org
2. About
• Charles Rivers is an Anti-Aging Human Longevity Organization of
America. It's all about STOP BIOLOGICAL CLOCK therapy focused on
extending the healthy, high-performance human lifespan. Led by a world-
class team of scientific and medical visionaries, our mission is to identify
the therapeutically targetable mechanisms responsible for the age-
related human biological decline and to apply this intelligence to develop
innovative solutions to interrupt or block those processes, meaningfully
extending the human lifespan that has not ever been done before.
3. Biological Aging Defined
Aging is a complex biological process in
which changes at molecular, cellular, and
organ levels result in a progressive,
inevitable, and inescapable decrease in
the body's ability to respond appropriately
to internal and/or external stressors.
4. Myths About Aging – Physiological Aspects
Most adults past age 65 are so
physically incapacitated that they must
depend to a great extent on other
people.
Taking large doses of antioxidants (or
ginseng, selenium, pantothenic acid or
vitamin C) will extend the length of
your life.
Best Available Evidence
Most of our bodily functions reach their
maximum capacity prior to or during
early adulthood and begin a gradual
decline thereafter.
Age related physical changes do not
occur according to a strict timetable.
Adults age at different rates, and such
groupings as “the elderly” are more
heterogeneous than is commonly
believed.
Helplessness and dependency are not
characteristic of old age. Some 87% of
adults over 65 are able to cope more
than adequately with the demands of
everyday living.
There are no drugs, pills, powders,
vitamins, dietary supplements, or diets
with PROVEN anti-aging capacities.
Myth
Our physiological processes remain at
a fairly constant level of efficiency until
we approach old age, at which time
they undergo a drastic decline.
Most adults proceed at much the same
rate through a series of similar physical
changes.
5. Theories of Aging have been
around for more than 2000 years.
Galen (A.D. 129 –c. 199)
-Thought that aging was due to changes in body humors that
began in early life
-These changes caused a slow increase in dryness and
coldness of the body
Roger Bacon (c. 1220-1292)
- One of the first to suggest a “wear and tear” theory
- Aging is the result of abuses and insults to the body system
- Good hygiene might slow the aging process
Charles Darwin (1809-1892)
- Attributed aging to the loss of irritability in the nervous
and muscular tissue
6. Overview of three types of modern
biological theories of aging:
• Genetic Cellular theories
• Non genetic cellular theories
• Physiological System Theories
• Sleep theories
7. Genetic Cellular theories
Substantial evidence suggests that the life span of plants and
animals is under genetic control. Mammals all seem to have
relatively fixed life spans. At the same time, considerable
diversity exists among different species. This marked species
variability and specificity in longevity lend support to the notion
of genetic control of life span.
Theories that attribute aging to an innate genetic
program, much like a built in biological clock
8. Genetic Cellular theories
Findings that imply that cellular aging is programmed by
our genes:
• Humans with long lived parents and grandparents live an
average of 6 years longer than those whose parents die
before the age of 50.
• Human body cells grown in tissue cultures are able to
divide only about 50 times, after which they age and die.
• The reproductive capacity of cells taken from old animals
is even more limited; these cells can undergo only about
one half as many divisions as those obtained from young
animals.
9. Genetic Cellular theories
• Because a direct relationship exists
between the life span of a species and the
capacity of its cells to divide, this suggests
that age related changes are programmed
into the genes of each species.
• Thus, Genetic Cellular theories attribute
aging to changes in 2 kinds of molecules:
deoxyribonucleic acid (DNA) and
ribonucleic acid (RNA)
10. Genetic Cellular Theories
DNA – controls the
formation of proteins
required by the cell to
maintain life
RNA – transfers
information from the
DNA molecules to
another location in the
cell where proteins
are assembled
11. Genetic Cellular theories – DNA Damage
Theory
- Damage to the
DNA molecules is
responsible for
aging
- Caused by
exposure to
radiation or harmful
cellular mutations
12. Genetic Cellular theories – DNA Damage
Theory
• Important Contraindications:
- Mutations and radiation affect dividing cells, whereas
the physiological effects of aging are due primarily to
cells that are no longer able to divide. Mutations occur
too slowly to account for the pronounced physiological
changes that occur with increasing age
- Damage to DNA molecules is usually reversible
because most cells contain appropriate repair
mechanisms
13. Genetic Cellular Theories – Error Theory
• Errors in RNA transmission produce a protein or
enzyme that is not an exact copy of the original,
thus it cannot carry out its function in maintaining
life. As a result, cells grow older and die, and so
do we.
• Errors are likely because RNA molecules are
relatively unstable and formed continuously,
whereas DNA molecules are highly stable and
maintained throughout the lifespan of a cell
• Recent findings suggest possible relationships
between somatic mutations and age related
illnesses such as certain types of cancer
14. Non Genetic Cellular Theories
AKA “Wear and Tear Theories”
• Attribute aging to progressive cell damage
caused by the internal and external
environment, rather than to an innate
genetic program
• With the passage of time, changes occur
in the cells that impair their effectiveness.
Thus, aging is due to progressive damage.
15. Non Genetic Cellular Theories
– Cross Linkage Theory
• With age, our proteins, DNA and other structural
molecules develop inappropriate attachments or
cross-links to one another.
• These unnecessary links or bonds decrease the
mobility or elasticity of proteins and other molecules.
• Proteins that are damaged or no longer needed are
normally broken down by enzymes, but the presence
of cross-linkages inhibits the activity of the enzymes.
• These damaged and unneeded proteins, therefore,
stick around and can cause problems.
16. Physiological System Theories
• Attributes aging to the gradual failure of
certain physiological systems and to the
resulting inability of these systems to coordinate
important bodily functions
• In order for the body to function properly, both
cellular functions and organ systems have to
be carefully integrated and coordinated
• When one or more of the regulatory systems of
the body breaks down, the organism eventually
dies
17. Physiological System Theories
– Immunological Theories
• Autoimmune Theory: The body loses its ability to
distinguish between foreign agents/antigens and
necessary body cells. The immune system
becomes self-destructive and reacts against itself.
• Examples of autoimmune disease are lupus,
scleroderma and adult-onset diabetes
18. Physiological System Theories –
Neuroendocrine Theory
• Some researchers
speculate that our
“biological clock”
resides in the
hypothalamus and
controls the rate of
aging.
19. Life Lengthening Behaviours
• Psychological and social factors are
important determinants of human longevity
(ex. personality, marital status, social
relationships, depression etc.)
• Empirical evidence indicates that your
chances of remaining healthy and living
longer depend to a considerable extent on
your own behaviour.
20. You and Your Biological Clock –
HELATHY SLEEP
• Finding Your Sleep/Wake Rhythm
• launch interactive
• Two internal systems interact to regulate when we sleep and when
we are awake. These systems are the sleep/wake homeostat, which
monitors our need for sleep based on how long we have been awake;
and the circadian system, which regulates the cycling of numerous
functions, including when we sleep and wake, every 24 hours.
• These two systems usually counterbalance each other. However,
because they operate independently, they can become misaligned.
During jet lag or shift work, for instance, we might experience an
alerting signal when trying to sleep, or, conversely, a powerful drive
to sleep when we need to be awake.
• Take a tour of these systems, and then explore factors that disrupt
their normal interaction.
• Harvard University
22. Example 1 - Hydrolyzed COLLAGEN for Anti-Aging
Collagen: The Cure For Aging? Once we hit our mid-20s, our
collagen levels begin to decline. As compared to those in
their 20s, people in their 80s have about four times the
collagen breakdown. That’s why age brings wrinkles,
creases, and saggy areas around the mouth and neck.
Our bodies produce collagen in the underlying layer of the
skin, the dermis. Think of it as a mattress and our outer skin,
the epidermis, like bed sheets. When collagen starts to
break down, we end up with an old, saggy “mattress” that
wrinkles the sheets. We require taking Hydrolyzed collagen -
https://www.youtube.com/watch?v=S02GMfSlJlU
23.
24.
25. Anti-Oxidants
Human aging: usual and successful
Charles Rivers Biotech Research in aging has
emphasized average age-related losses and
neglected the substantial heterogeneity. The
effects of the aging process itself have been
exaggerated, and the modifying effects of
diet, exercise, personal habits, and
psychosocial factors underestimated.
26. Within the category of normal aging, a
distinction can be made between usual aging,
in which extrinsic factors heighten the effects
of aging alone, and successful aging, in which
extrinsic factors play a neutral or positive
role.
27. Our Research strategies to modify them
should help elucidate how a transition from
usual to successful aging can be facilitated.
28. For Example 2 - WILLOW BARK
Specific extract of willow bark (Salix alba), as
“the most
potent longevity-extending pharmacological
intervention yet
described in scientific literature.”
One of the study found that the willow bark
extract increased
the average chronological lifespan of yeast by
475%.
29. "Let thy Food be thy Medicine and thy Medicine
be thy Food".
30. Charles River Anti-Aging organization objectives are to
tackle some of the most vexing diseases like cancer, heart
disease and diabetes. We are blazing a new trail in science,
medicine and research and we need people who, like us,
want to change the world.
Our scientific and medical teams are impatient for the
healthcare of the future. That is why we are working to
change the way the life-style change through our nature-
focused, preventive, therapeutic model.
31. We are seeking world-class people
who share our passion and want to
play an integral role in executing
this new company’s vision by join
us as life member of our
organization and benefitted to live
longer and healthier.
32. Do these countries hold the secret to a
long and healthy life?
Read the article at
http://www.cnn.com/2015/12/11/health/ol
dest-countries-secret-longer-life
35. HEALTHY AGING
Preventing Age-
Related Illness
Age-related diseases
and illness like
diabetes, stroke,
cancer and heart
disease can be
prevented through
lifestyle changes.
Start your
36. 1) Prevention
2) Anti-Aging Foods
3) Solutions for Aging Problems
4) Life Expectancy Statistics
5) How to Live to 100
6) Keep Looking Good
7) Top Exotic Foods
8) Anti-Aging Science
9) Skin Aging
10) Exercise and Fitness
11) Why We Age
12) Promote Mental Health
13) Longest Living People
14) Optimizing Medical Care
15) Obesity and Longevity
Healthy Aging
Counseling
37. Get Started
We can help you meet the
challenges of aging
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